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Elastin (ELN) (NM_000501) Human Untagged Clone
CAT＃: SC119860
ELN (untagged)-Human elastin (ELN), transcript variant 1
CNY 5,552.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ADCL1; SVAS; WBS; WS |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000501 |
| Insert Size | 3500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000501.1, NP_000492.1 |
| RefSeq Size | 2274 bp |
| RefSeq ORF | 2274 bp |
| Locus ID | 2006 |
| UniProt ID | P15502 |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Gene Summary | This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017] Transcript Variant: This variant (1) encodes isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Targeted Disruption of Fibulin-4 Abolishes Elastogenesis and Causes Perinatal Lethality in Mice
,Precious J. McLaughlin, Qiuyun Chen, Masahito Horiguchi, Barry C. Starcher, J. Brett Stanton, Thomas J. Broekelmann, Alan D. Marmorstein, Brian McKay, Robert Mecham, Tomoyuki,
Molecular and Cellular Biology, March 2006, p. 1700-1709, Vol. 26, No. 5
[ELN]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213603 | ELN (Myc-DDK-tagged)-Human elastin (ELN), transcript variant 1 |
CNY 5,552.00 |
|
| RC213603L3 | Lenti-ORF clone of ELN (Myc-DDK-tagged)-Human elastin (ELN), transcript variant 1 |
CNY 7,952.00 |
|
| RC213603L4 | Lenti-ORF clone of ELN (mGFP-tagged)-Human elastin (ELN), transcript variant 1 |
CNY 9,500.00 |
|
| RG213603 | ELN (tGFP-tagged) - Human elastin (ELN), transcript variant 1 |
CNY 7,152.00 |
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