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RRM2 (NM_001034) Human Untagged Clone
CAT＃: SC119538
RRM2 (untagged)-Human ribonucleotide reductase M2 (RRM2), transcript variant 2
CNY 5,488.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C2orf48; R2; RR2; RR2M |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119538 sequence for NM_001034 edited (data generated by NextGen Sequencing)
ATGCTCTCCCTCCGTGTCCCGCTCGCGCCCATCACGGACCCGCAGCAGCTGCAGCTCTCG CCGCTGAAGGGGCTCAGCTTGGTCGACAAGGAGAACACGCCGCCGGCCCTGAGCGGGACC CGCGTCCTGGCCAGCAAGACCGCGAGGAGGATCTTCCAGGAGCCCACGGAGCCGAAAACT AAAGCAGCTGCCCCCGGCGTGGAGGATGAGCCGCTGCTGAGAGAAAACCCCCGCCGCTTT GTCATCTTCCCCATCGAGTACCATGATATCTGGCAGATGTATAAGAAGGCAGAGGCTTCC TTTTGGACCGCCGAGGAGGTGGACCTCTCCAAGGACATTCAGCACTGGGAATCCCTGAAA CCCGAGGAGAGATATTTTATATCCCATGTTCTGGCTTTCTTTGCAGCAAGCGATGGCATA GTAAATGAAAACTTGGTGGAGCGATTTAGCCAAGAAGTTCAGATTACAGAAGCCCGCTGT TTCTATGGCTTCCAAATTGCCATGGAAAACATACATTCTGAAATGTATAGTCTTCTTATT GACACTTACATAAAAGATCCCAAAGAAAGGGAATTTCTCTTCAATGCCATTGAAACGATG CCTTGTGTCAAGAAGAAGGCAGACTGGGCCTTGCGCTGGATTGGGGACAAAGAGGCTACC TATGGTGAACGTGTTGTAGCCTTTGCTGCAGTGGAAGGCATTTTCTTTTCCGGTTCTTTT GCGTCGATATTCTGGCTCAAGAAACGAGGACTGATGCCTGGCCTCACATTTTCTAATGAA CTTATTAGCAGAGATGAGGGTTTACACTGTGATTTTGCTTGCCTGATGTTCAAACACCTG GTACACAAACCATCGGAGGAGAGAGTAAGAGAAATAATTATCAATGCTGTTCGGATAGAA CAGGAGTTCCTCACTGAGGCCTTGCCTGTGAAGCTCATTGGGATGAATTGCACTCTAATG AAGCAATACATTGAGTTTGTGGCAGACAGACTTATGCTGGAACTGGGTTTTAGCAAGGTT TTCAGAGTAGAGAACCCATTTGACTTTATGGAGAATATTTCACTGGAAGGAAAGACTAAC TTCTTTGAGAAGAGAGTAGGCGAGTATCAGAGGATGGGAGTGATGTCAAGTCCAACAGAG AATTCTTTTACCTTGGATGCTGACTTCTAA Clone variation with respect to NM_001034.3 >OriGene 5' read for NM_001034 unedited
NTTGTCANAATTTGTATACGACTCATATAGGCGGCNCGCGAATTCGCACGAGGTCCTGTC CTGGCTGCTCGCTCTGCTTCGCTGCGCCTCCCTATGCTCTCCCTCCGTGTCCCGCTCGCG CCCATCACGGACCCGCAGCAGCTGCAGCTCTCGCCGCTGAAGGGGCTCAGCTTGGTCGAC AAGGAGAACACGCCGCCGGCCCTGAGCGGGACCCGCGTCCTGGCCAGCAAGACCGCGAGG AGGATCTTCCAGGAGCCCACGGAGCCGAAAACTAAAGCAGCTGCCCCCGGCGTGGAGGAT GAGCCGCTGCTGAGAGAAAACCCCCGCCGCTTTGTCATCTTCCCCATCGAGTACCATGAT ATCTGGCAGATGTATAAGAAGGCAGAGGCTTCCTTTTGGACCGCCGAGGAGGTGGACCTC TCCAAGGACATTCAGCACTGGGAATCCCTGAAACCCGAGGAGAGATATTTTATATCCCAT GTTCTGGCTTTCTTTGCAGCAAGCGATGGCATAGTAAATGAAAACTTGGTGGAGCGATTT AGCCAAGAAGTTCAGATTACAGAAGCCCGCTGTTTCTATGGCTTCCAAATTGCCATGGAA AACATACATTCTGAAATGTATAGTCTTCTTATTGACACTTACATAAAAGATCCCAAAGAA AGGGAATTTCTCTTCAATGCCATTGAAACGATGCCTTGTGTCAAGAAGAAGGCAGACTGG GCCTTGCGCTGGATTGGGGACANAGAGGCTACCTATGGTGAACGTNGTGTANCCTTTGCT GCAGTGGAAGGCATTNTCTTTTCCGGNTCTTTTGCGTCGATATTCTGGCTCAGAAACGAG GACTGATGCCTGGCCTCACATTNTCTAATGAACTATTAGCAGAGATGAGGTTTACACTGT GATTTTGCTTGCCTGATGNTCAACACCTGGTACCA >OriGene 3' read for NM_001034 unedited
GGACTACTTGNCCGCGGCCGCNGTCNANGATCGGTTTTTTTTTTTTTTTTTTGGTTAACA AATATTTTAATTCTTAAATAAAACTTAAAAATTACATGCTTAGTCTACACAAGTTTAACT TACTTTAGTCACTTAGTGAATTGTGAATTGGCTCCCATTAGTGGTCAGGAGAATGTATTT GGTGTAGAAACCAAATAAATCAAGCTATTATCGCCTTGTGAGTACAAACAATGTTTATTT GTTTGTAAAGTGCCAGGTTTATATTTAAGTAAACATTAAAATCTGCGTTGAAGCAGTGAG GCTGCATCTTTTAACTGGCTGTGCTGGTTAAAGGACTGTTTAATCCCGCTATGCTAAGCT CACTAAAGGGTCACCCCTCACTTTAAAGCCAAGACTGCCATTGTCACTGCTATGGTAAGT CACAGCCAGCCAGGCCTTCTGGCAAAAGGTGATACTACCAGCACTATAAACAGACAGGAC TGGTTGTGAGGTAGCTACACAGTTTTAAAGATGCTGTTAATGAACATTACGGACAATTCA TGGTGTGGCTAGTTGGTAACACTTCAGCTGATTTTTCTTATGAGATGGAAAAAAAAAATC AGCCAAGTAAGGGCACATCTTCAGTTCATTTAGAAGTCAGCATCCAAGGTAAAAGAATTC TCTGTTGGACTTGACATCACTCCCATCCTCTGATACTCGCCTACTCTCTTCTCAAAGAAG TTAGTCCTTCCTTCCAGNGAAATATTCTCCATAAAGTCAATGGGTTCTCTACTCTGAAAA CCTGCTAAACCCAGTNNCAGCATAGTCTGTCTGCACAAACTCATGTATTGCTTCATAGAG TGCATTCATCCCATGAGCTTCACAGCAAGGGCTCATGAGGGACTCCTGTTCTATTCGACA GCATTGAAAATATTTCTCTTACTTCT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001034 |
| Insert Size | 1770 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001034.1, NP_001025.1 |
| RefSeq Size | 2500 bp |
| RefSeq ORF | 1170 bp |
| Locus ID | 6241 |
| UniProt ID | P31350 |
| Domains | ribonuc_red_sm |
| Protein Families | Druggable Genome |
| Protein Pathways | Glutathione metabolism, Metabolic pathways, p53 signaling pathway, Purine metabolism, Pyrimidine metabolism |
| Gene Summary | This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] Transcript Variant: This variant (2) uses an alternative downstream promoter, and it thus has a shorter 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. CCDS Note: This CCDS represents the transcript derived from the downstream promoter of this gene. Studies in both PMIDs 10631117 and 11978970 support the presence of the downstream promoter, as do the 5' extents of several human and homologous transcripts. PMID:11978970 also provides evidence for an upstream promoter; the transcript derived from the upstream promoter would encode a protein that is 60 aa longer at the N-terminus. |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205718 | RRM2 (Myc-DDK-tagged)-Human ribonucleotide reductase M2 (RRM2), transcript variant 2 |
CNY 5,488.00 |
|
| RC205718L1 | Lenti ORF clone of Human ribonucleotide reductase M2 (RRM2), transcript variant 2, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC205718L2 | Lenti ORF clone of Human ribonucleotide reductase M2 (RRM2), transcript variant 2, mGFP tagged |
CNY 7,888.00 |
|
| RC205718L3 | Lenti ORF clone of Human ribonucleotide reductase M2 (RRM2), transcript variant 2, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC205718L4 | Lenti ORF clone of Human ribonucleotide reductase M2 (RRM2), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG205718 | RRM2 (tGFP-tagged) - Human ribonucleotide reductase M2 (RRM2), transcript variant 2 |
CNY 7,088.00 |
