RRM2 Mouse Monoclonal Antibody [Clone ID: OTI1F2]

Specifications

Product Data
Clone Name	OTI1F2
Applications	IHC, WB
Recommend Dilution	WB 1:500, IHC 1:2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human RRM2 (NP_001025) produced in HEK293T.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ribonucleotide reductase regulatory subunit M2
Database Link	NP_001025 Entrez Gene 20135 MouseEntrez Gene 362720 RatEntrez Gene 6241 Human UniProt ID P31350
Background	This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Synonyms	R2; RR2; RR2M
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glutathione metabolism, Metabolic pathways, p53 signaling pathway, Purine metabolism, Pyrimidine metabolism

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