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UGT1A6 (NM_001072) Human Untagged Clone
CAT＃: SC119463
UGT1A6 (untagged)-Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1
CNY 5,952.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GNT1; HLUGP; HLUGP1; hUG-BR1; UDPGT; UDPGT 1-6; UGT-1A; UGT-1C; UGT-1E; UGT-1F; UGT1; UGT1-01; UGT1-03; UGT1-05; UGT1-06; UGT1.1; UGT1.3; UGT1.5; UGT1.6; UGT1A; UGT1A1; UGT1A3; UGT1A5; UGT1A6S; UGT1C; UGT1E; UGT1F |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119463 sequence for NM_001072 edited (data generated by NextGen Sequencing)
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG AAGAGGAAAGACTTGTCTCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGA ATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCA ATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGA CCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTT GGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGC ATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCA AAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAA GATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATG CGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGG GTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTC ACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACA GTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAA GGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA Clone variation with respect to NM_001072.3 >OriGene 5' read for NM_001072 unedited
GGCCCCCGGGCCCNNNNNNNCCNCCTCCCCCCCCTGTTCAAATTTGTNATACGACTCATA TAGGCGGCCGCGNAATTCGCACGAGGTTAGTTTAGGGAAAATACCTAGAGCCCTGTGATT TGGAGAGTGAAAACTCTTTATTACCGTTGTTACTTTAACTCTTTCCAGGATGGCCTGCCT CCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTTTGGGGCATGGT TGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTTAGTATGAAGGA TATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTGCCTGAAGTTAA TTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTGCCGTATGACCA AGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCTGAGCGATCATT CCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGCCTGTACTTCAT CAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAGGAGAGCAAGTT TGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCTGAGTATTTGGG CCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCATACATTCAGCAG AAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCAGACCACATGAC TTTNTCCCAACGAGTGGCCAACTTCCTTGNTAATTTGTTGGAGCCCTATCTATTNTATTG NCTGTTTTCAAATATGAAAAACTCGCATCAGCTGTCCTCAGAAGAGATGTGGATATAATC ACCTATATCAGAA >OriGene 3' read for NM_001072 unedited
TCACTCTGGACCCGCGGCCGCAANCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTATAAAAATTAATTAATTTATTTTTAGTGGGAGGAAACATCAAAAAAA AATAAACTTGCCCAGCACTTCATAGCTGTATTTGGGGTTTTTATCAAATTCAGCTCCATT TGACATAAGCAATGATTATTTTCTCAAATACCCCACCCACCAATTTCATAGCATCATTTT TTTTCCCCAAAGCAAAAAATCATATGCTGTTCTCAGGGCACTCCAAGCCATTCATTCATT TCACCTACACTTTAAAGGGACAAAGCTTCCCTTTTTTAAACACACAAGGGGGCCCCTATG AAGCCCGACAGAGATGAGGACTGACCATTATTGGTTAAGGATCAATTGCAACCATCTGCA GAAGCCAAAAGATAAAATTAAAACTGCCATTTGCAGTAGGGGCAGCCGGGGGACCACCTT TGAATCCCGCACTCCCAAACAGGCCATGTTTCAAAGTAAAAAAAGTAATCTAAAATGCCA GCCTGTCTGCACGTCCTTTGAAAAATGGCACATGTCATCCTGATCAAAGACACCAGAGGG GGCACGATACATATTCAAATATCTTTACTGACTAGCGAGTCTATTATTTTTATTTAAAAG AATTTTTTAAAGCACTCTGGGGGCTGATATAATTATGCAAAGTATTTCCTTAATAAGATA AAATGAATTTACACTGATTCTGTTTTTCAGTTTGGAAAGACTAGGGAATGGTTCAAATTT TACCTTATTTCCACCCACTCTCATGGGTCTGGNATTTGGGGGCTTTCTTACTCGCCCTTT TTCCCAGCATTTTCGGTAGCTAGCACACATTTAAGTGATGAAGGCCCTGTANCACGACGC CAGAGAACCAATACGTCAGGATGTACTGTACAATGAGGTCCTGGCTGCGGCCCAAGGTGC GCCCCT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001072 |
| Insert Size | 2560 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001072.2, NP_001063.2 |
| RefSeq Size | 2435 bp |
| RefSeq ORF | 1599 bp |
| Locus ID | 54578 |
| UniProt ID | P19224 |
| Domains | UDPGT |
| Protein Families | Transmembrane |
| Protein Pathways | Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism |
| Gene Summary | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longer transcript. Its first exon contains both the 5' UTR and the 5' coding sequence, as is typical of the UGT1A genes. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines
,Dates, CR;Fahmi, T;Pyrek, SJ;Yao-Borengasser, A;Borowa-Mazgaj, B;Bratton, SM;Kadlubar, SA;Mackenzie, PI;Haun, RS;Radominska-Pandya, A;,
Cancer Biol. Ther.
,PubMed ID 25996841
[UGT1A6]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215957 | UGT1A6 (Myc-DDK-tagged)-Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1 |
CNY 5,944.00 |
|
| RC215957L1 | Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, Myc-DDK-tagged |
CNY 8,344.00 |
|
| RC215957L2 | Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC215957L3 | Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC215957L4 | Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG215957 | UGT1A6 (tGFP-tagged) - Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1 |
CNY 7,544.00 |
