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TNFRSF1B (NM_001066) Human Untagged Clone
CAT＃: SC119459
TNFRSF1B (untagged)-Human tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B)
CNY 3,656.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>SC119459 representing NM_001066.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCGGCCGCGAATTCGGCACGAGGCGAGCGCAGCGGAGCCTGGAGAGAAGGCGCTGGGCTGCGAGGGCGC GAGGGCGCGAGGGCAGGGGGCAACCGGACCCCGCCCGCACCCATGGCGCCCGTCGCCGTCTGGGCCGCG CTGGCCGTCGGACTGGAGCTCTGGGCTGCGGCGCACGCCTTGCCCGCCCAGGTGGCATTTACACCCTAC GCCCCGGAGCCCGGGAGCACATGCCGGCTCAGAGAATACTATGACCAGACAGCTCAGATGTGCTGCAGC AAATGCTCGCCGGGCCAACATGCAAAAGTCTTCTGTACCAAGACCTCGGACACCGTGTGTGACTCCTGT GAGGACAGCACATACACCCAGCTCTGGAACTGGGTTCCCGAGTGCTTGAGCTGTGGCTCCCGCTGTAGC TCTGACCAGGTGGAAACTCAAGCCTGCACTCGGGAACAGAACCGCATCTGCACCTGCAGGCCCGGCTGG TACTGCGCGCTGAGCAAGCAGGAGGGGTGCCGGCTGTGCGCGCCGCTGCGCAAGTGCCGCCCGGGCTTC GGCGTGGCCAGACCAGGAACTGAAACATCAGACGTGGTGTGCAAGCCCTGTGCCCCGGGGACGTTCTCC AACACGACTTCATCCACGGATATTTGCAGGCCCCACCAGATCTGTAACGTGGTGGCCATCCCTGGGAAT GCAAGCATGGATGCAGTCTGCACGTCCACGTCCCCCACCCGGAGTATGGCCCCAGGGGCAGTACACTTA CCCCAGCCAGTGTCCACACGATCCCAACACACGCAGCCAACTCCAGAACCCAGCACTGCTCCAAGCACC TCCTTCCTGCTCCCAATGGGCCCCAGCCCCCCAGCTGAAGGGAGCACTGGCGACTTCGCTCTTCCAGTT GGACTGATTGTGGGTGTGACAGCCTTGGGTCTACTAATAATAGGAGTGGTGAACTGTGTCATCATGACC CAGGTGAAAAAGAAGCCCTTGTGCCTGCAGAGAGAAGCCAAGGTGCCTCACTTGCCTGCCGATAAGGCC CGGGGTACACAGGGCCCCGAGCAGCAGCACCTGCTGATCACAGCGCCGAGCTCCAGCAGCAGCTCCCTG GAGAGCTCGGCCAGTGCGTTGGACAGAAGGGCGCCCACTCGGAACCAGCCACAGGCACCAGGCGTGGAG GCCAGTGGGGCCGGGGAGGCCCGGGCCAGCACCGGGAGCTCAGATTCTTCCCCTGGTGGCCATGGGACC CAGGTCAATGTCACCTGCATCGTGAACGTCTGTAGCAGCTCTGACCACAGCTCACAGTGCTCCTCCCAA GCCAGCTCCACAATGGGAGACACAGATTCCAGCCCCTCGGAGTCCCCGAAGGACGAGCAGGTCCCCTTC TCCAAGGAGGAATGTGCCTTTCGGTCACAGCTGGAGACGCCAGAGACCCTGCTGGGGAGCACCGAAGAG AAGCCCCTGCCCCTTGGAGTGCCTGATGCTGGGATGAAGCCCAGTTAACCAGGCCGGTGTGGGCTGTGT CGTAGCCAAGGTGGGCTGAGCCCTGGCAGGATGACCCTGCGAAGGGGCCCTGGTCCTTCCAGGCCCCCA CCACTAGGACTCTGAGGCTCTTTCTGGGCCAAGTTCCTCTAGTGCCCTCCACAGCCGCAGCCTCCCTCT GACCTGCAGGCCAAGAGCAGAGGCAGCGAGTTGGGGAAAGCCTCTGCTGCCATGGCGTGTCCCTCTCGG AAGGCTGGCTGGGCATGGACGTTCGGGGCATGCTGGGGCAAGTCCCTGACTCTCTGTGACCTGCCCCGC CCAGCTGCACCTGCCAGCCTGGCTTCTGGAGCCCTTGGGTTTTTTGTTTGTTTGTTTGTTTGTTTGTTT GTTTCTCCCCCTGGGCTCTGCCCCAGCTCTGGCTTCCAGAAAACCCCAGCATCCTTTTCTGCAGAGGGG CTTTCTGGAGAGGAGGGATGCTGCCTGAGTCACCCATGAAGACAGGACAGTGCTTCAGCCTGAGGCTGA GACTGCGGGATGGTCCTGGGGCTCTGTGCAGGGAGGAGGTGGCAGCCCTGTAGGGAACGGGGTCCTTCA AGTTAGCTCAGGAGGCTTGGAAAGCATCACCTCAGGCCAGGTGCAGTGGCTCACGCCTATGATCCCAGC ACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTTAGGAGTTCGAGACCAGCCTGGCCAACATGGTA AAACCCCATCTCTACTAAAAATACAGAAATTAGCCGGGCGTGGTGGCGGGCACCTATAGTCCCAGCTAC TCAGAAGCCTGAGGCTGGGAAATCGTTTGAACCCGGGAAGCGGAGGTTGCAGGGAGCCGAGATCACGCC ACTGCACTCCAGCCTGGGCGACAGAGCGAGAGTCTGTCTCAAAAAAAAAAAAAAAAAAACTCGACTCTA GATTGCGGCCGC >OriGene 5' read for NM_001066 unedited
NNGGTTAAAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGGCACGAGGCGAGCG CAGCGGAGCCTGGAGAGAAGGCGCTGGGCTGCGAGGGCGCGAGGGCGCGAGGGCAGGGGG CAACCGGACCCCGCCCGCACCCATGGCGCCCGTCGCCGTCTGGGCCGCGCTGGCCGTCGG ACTGGAGCTCTGGGCTGCGGCGCACGCCTTGCCCGCCCAGGTGGCATTTACACCCTACGC CCCGGAGCCCGGGAGCACATGCCGGCTCAGAGAATACTATGACCAGACAGCTCAGATGTG CTGCAGCAAATGCTCGCCGGGCCAACATGCAAAAGTCTTCTGTACCAAGACCTCGGACAC CGTGTGTGACTCCTGTGAGGACAGCACATACACCCAGCTCTGGAACTGGGTTCCCGAGTG CTTGAGCTGTGGCTCCCGCTGTAGCTCTGACCAGGTGGAAACTCAAGCCTGCACTCGGGA ACAGAACCGCATCTGCACCTGCAGGCCCGGCTGGTACTGCGCGCTGAGCAAGCAGGAGGG GTGCCGGCTGTGCGCGCCGCTGCGCAAGTGCCGCCCGGGCTTCGGCGTGGCCAGACCAGG AACTGAAACATCAGACGTGGTGTGCAAGCCCTGTGCCCCGGNGACGTTCTCCAACACGAC TTCATCCACGGATATTTGCAGGCCCCACCAGATCTGTAACGTGGTGGCCATCCCTGGGAA TGCAAGCATGGATGCAGTCTGCACGTCCACGTCCCCCACCGGNAGTATGGCCCCAGGGGC AGTACACTTACCCCAGCCAGTGTCCACACGATCCCAACACACGCAGCCAACTCCAGAACC CAGCACTGCTCCCAGCACCTNCTTCCTGCGTCCATGGGCCCCAGCCCCCAGCTGAAGGNA GCACT >OriGene 3' read for NM_001066 unedited
TATGGACCGCGGGCCGCAATCTAGNGTCGAGTTTTTTTTTTTTTTTTTTGAGACAGACTC TCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCCCTGCAACCTCCGCT TCCCGGGTTCAAACGATTTCCCAGCCTCAGGCTTCTGAGTAGCTGGGACTATAGGTGCCC GCCACCACGCCCGGCTAATTTCTGTATTTTTAGTAGAGATGGGGTTTTACCATGTTGGCC AGGCTGGTCTCGAACTCCTAACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTG GGATCATAGGCGTGAGCCACTGCACCTGGCCTGAGGTGATGCTTTCCAAGCCTCCTGAGC TAACTTGAAGGACCCCGTTCCCTACAGGGCTGCCACCTCCTCCCTGCACAGAGCCCCAGG ACCATCCCGCAGTCTCAGCCTCAGGCTGAAGCACTGTCCTGTCTTCATGGGTGACTCAGG CAGCATCCCTCCTCTCCAGAAAGCCCCTCTGCAGAAAAGGATGCTGGGGTTTTCTGGAAG CCAGAGCTGGGGCAGAGCCCAGGGGGAGAAACAAACAAACAAACAAACAAACAAACAAAA AACCCAAGGGCTCCAGAAGCCAGGCTGGCAGGTGCAGCTGGGCGGGGCAGGTCACAGAGA GTCAGGGACTTGCCCCAGCATGCCCCCGACGTCCATGCCCAGCCAGCCTTTCGAGAGGGA CACGCCATGCCAGCAGAGGCTTTCCCCAACTCGCTGCCTCTGCTCTGGCCTGCAGTCAAA GGGAGCTGNNCGCTGTGAGCCACTANAGAACTTGGCCCAGAAGAGCCTANAGTCCTATGT GGGGGCCTGGAAGACAGGCCCCTTCCAGGTTCACCTGCCAGCCTCANCCACTTTGGTACC AAAGCCCAACCGCCTGGNTACTGGCTCATCCACATCAGCCTCCAGGGCAGGGCTTCTTCG GTCTCCCAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001066 |
| Insert Size | 2427 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001066.2 |
| RefSeq Size | 3682 bp |
| RefSeq ORF | 2427 bp |
| Locus ID | 7133 |
| UniProt ID | P20333 |
| Domains | TNFR |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Adipocytokine signaling pathway, Amyotrophic lateral sclerosis (ALS), Cytokine-cytokine receptor interaction |
| MW | 84.9 kDa |
| Gene Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD
,Andrew J Mhyre, A. Mario Marcondes, Emily Y Spaulding, and H Joachim Deeg,
Blood, Oct 2008; 10.1182/blood-2008-04-152686.
[TNFRSF1B]
|
|
Interaction between Transmembrane TNF and TNFR1/2 Mediates the Activation of Monocytes by Contact with T Cells
,M Rossol, U Meusch, M Pierer, S Kaltenhauser, H Hantzschel, S Hauschildt, and U Wagner,
J Immunol. 2007 Sep 15;179(6):4239-48.
[TNFRSF1B]
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