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FOXO3 (NM_001455) Human Untagged Clone
CAT＃: SC119227
FOXO3 (untagged)-Human forkhead box O3 (FOXO3), transcript variant 1
CNY 7,408.00
| Cited in 5 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001455 edited
CGGAGCCTTCGCGGCGTCCACGTCCCTCCCCCGCTGCACCCCGCCCCGGCGCGAGAGGAG AGCGCGAGAGCCCCAGCCGCGGGCGGGCGGGCGGCGAAGATGGCAGAGGCACCGGCTTCC CCGGCCCCGCTCTCTCCGCTCGAAGTGGAGCTGGACCCGGAGTTCGAGCCCCAGAGCCGT CCGCGATCCTGTACGTGGCCCCTGCAAAGGCCGGAGCTCCAAGCGAGCCCTGCCAAGCCC TCGGGGGAGACGGCCGCCGACTCCATGATCCCCGAGGAGGAGGACGATGAAGACGACGAG GACGGCGGGGGACGGGCCGGCTCGGCCATGGCGATCGGCGGCGGCGGCGGGAGCGGCACG CTGGGCTCCGGGCTGCTCCTTGAGGACTCGGCCCGGGTGCTGGCACCCGGAGGGCAAGAC CCCGGGTCTGGGCCAGCCACCGCGGCGGGCGGGCTGAGCGGGGGTACACAGGCGCTGCTG CAGCCTCAGCAACCGCTGCCACCGCCGCAGCCGGGGGCGGCTGGGGGCTCCGGGCAGCCG AGGAAATGTTCGTCGCGGCGGAACGCCTGGGGAAACCTGTCCTACGCGGACCTGATCACC CGCGCCATCGAGAGCTCCCCGGACAAACGGCTCACTCTGTCCCAGATCTACGAGTGGATG GTGCGTTGCGTGCCCTACTTCAAGGATAAGGGCGACAGCAACAGCTCTGCCGGCTGGAAG AACTCCATCCGGCACAACCTGTCACTGCATAGTCGATTCATGCGGGTCCAGAATGAGGGA ACTGGCAAGAGCTCTTGGTGGATCATCAACCCTGATGGGGGGAAGAGCGGAAAAGCCCCC CGGCGGCGGGCTGTCTCCATGGACAATAGCAACAAGTATACCAAGAGCCGTGGCCGCGCA GCCAAGAAGAAGGCAGCCCTGCAGACAGCCCCCGAATCAGCTGACGACAGTCCCTCCCAG CTCTCCAAGTGGCCTGGCAGCCCCACGTCACGCAGCAGTGATGAGCTGGATGCGTGGACG GACTTCCGTTCACGCACCAATTCTAACGCCAGCACAGTCAGTGGCCGCCTGTCGCCCATC ATGGCAAGCACAGAGTTGGATGAAGTCCAGGACGATGATGCGCCTCTCTCGCCCATGCTC TACAGCAGCTCAGCCAGCCTGTCACCTTCAGTAAGCAAGCCGTGCACGGTGGAACTGCCA CGGCTGACTGATATGGCAGGCACCATGAATCTGAATGATGGGCTGACTGAAAACCTCATG GACGACCTGCTGGATAACATCACGCTCCCGCCATCCCAGCCATCGCCCACTGGGGGACTC ATGCAGCGGAGCTCTAGCTTCCCGTATACCACCAAGGGCTCGGGCCTGGGCTCCCCAACC AGCTCCTTTAACAGCACGGTGTTCGGACCTTCATCTCTGAACTCCCTACGCCAGTCTCCC ATGCAGACCATCCAAGAGAACAAGCCAGCTACCTTCTCTTCCATGTCACACTATGGTAAC CAGACACTCCAGGACCTGCTCACTTCGGACTCACTTAGCCACAGCGATGTCATGATGACA CAGTCGGACCCCTTGATGTCTCAGGCCAGCACCGCTGTGTCTGCCCAGAATTCCCGCCGG AACGTGATGCTTCGCAATGATCCGATGATGTCCTTTGCTGCCCAGCCTAACCAGGGAAGT TTGGTCAATCAGAACTTGCTCCACCACCAGCACCAAACCCAGGGCGCTCTTGGTGGCAGC CGTGCCTTGTCGAATTCTGTCAGCAACATGGGCTTGAGTGAGTCCAGCAGCCTTGGGTCA GCCAAACACCAGCAGCAGTCTCCTGTCAGCCAGTCTATGCAAACCCTCTCGGACTCTCTC TCAGGCTCCTCCTTGTACTCAACTAGTGCAAACCTGCCCGTCATGGGCCATGAGAAGTTC CCCAGCGACTTGGACCTGGACATGTTCAATGGGAGCTTGGAATGTGACATGGAGTCCATT ATCCGTAGTGAACTCATGGATGCTGATGGGTTGGATTTTAACTTTGATTCCCTCATCTCC ACACAGAATGTTGTTGGTTTGAACGTGGGGAACTTCACTGGTGCTAAGCAGGCCTCATCT CAGAGCTGGGTGCCAGGCTGAAGGATCACTGAGGAAGGGGAAGTGGGCAAAGCAGACCCT CAAACTGACACAAGACCTACAGAGAAAACCCTTTGCCAAATCTGCTCTCAGCAAGTGGAC A >OriGene 5' read for NM_001455 unedited
CGGGGCCCCACCTCCCCCTTCCCCCCCGGTTCAGAATTGTNATACAACTCATATAGGCGG CCGCGNAATTCGCACGAGGGGAGTGGCGGCAGCGGGCGAGGACTCGCCGAGGACGGGGCT CCGGCCCGGGATAACCAACTCTCCTTCTCTCTTCTTTGGTGCTTCCCCAGGCGGCGGCGG CGGCGCCCGGGAGCCGGAGCCTTCGCGGCGTCCACGTCCCTCCCCCGCTGCACCCCGCCC CGGCGCGAGAGGAGAGCGCGAGAGCCCCAGCCGCGGGCGGGCGGGCGGCGAAGATGGCAG AGGCACCGGCTTCCCCGGCCCCGCTCTCTCCGCTCGAAGTGGAGCTGGACCCGGAGTTCG AGCCCCAGAGCCGTCCGCGATCCTGTACGTGGCCCCTGCAAAGGCCGGAGCTCCAAGCGA GCCCTGCCAAGCCCTCGGGGGAGACGGCCGCCGACTCCATGATCCCCGAGGAGGAGGACG ATGAAGACGACGAGGACGGCGGNGGACGGGCCGGCTCGGCCATGGCGATCGGCGGCGGCG GCGGGAGCGGCACGCTGGGCTCCGGGCTGCTCCTTGAGGACTCGGCCCGGGTGCTGGCAC CCCGGAGGCAAGACCCCGGGTCTGGGCCAGCCACCGCNGCGGGCGGGCTGAGCGGGGTAC ACANGCGCTGCTGCAGCCTCAGCACCGCTGCCACCGNCGCCACCGGGGGCGGCTGGGGGC TTCCGGCAGCCGAGGAAAGGTTCGTCGCCGCGGAAACGCCTGGGAAAACTGTNCTACGCG GACCTGATCCCCCGCGCCATCCAGAGCTCCCCGGGACAACCGGTNACTCTGGCCCAAATC TACCAAGGGATGTGGCCGTTGCGTGCCTCAATTAAGGAATAAGGGCAACAGAAACAGATT TGCCGGGTGGAAGGACTCCATTCGGAACAACCTGAACTGAATTAACCAATCCTGCCGGGT CCCAAAGAAGGGAACTGGCAAAAGCCCTTGGGGAGACATAACCCCTGAGGG >OriGene 3' read for NM_001455 unedited
CTAGAGGCAGGGCGTCACAGGGAATGCCACCCGGACATCTGTGGCAGTAAAAGCTCTGAC CGAGGCCGCAATCTAAACCCAAGCCTCCAAAAAATCCTCCTCACTACTTCTGGAATAGCT CACCAGACAACGAAACCCTTTGGCGACGTTTGAAAAAGAAAGAAAAGCAGCCCTGGTGCC TTTACTGAAAAGAACAGGTCCGAGTTAGTAACCGGCAGACCAACACTGTTCACATTACCT GAGGACCCTGACAGGAAATCACAGGCCCTACTGATCTGGCACCCGTAGACTTGGCGCTGG GGTCCCGTCCAAAGATCACCCTGACTCAAAACCGGAAACACACTGGGCCGGACCCTGTGC TCCACTCCTTTTGCCTATGCACGGTTCTGGCCTGGACGGGTGCACATAGCAAACAATTGT GCCATTGTTCAATTTTTAGAAAAGGATAATTCCCTCCCAAACAAAAAAAGAAAGAAAATC CCCCCTTAGTTGATGCAATTTGTGAGCTTATGGAGTTCCATGCGCTCAAAAGCTTGTGAT GCTCGAACCCGGAATGGTAACTGGCACAACATTTTCTTTCTGTTTTTAAATTTGCTAGGG GAAGGACGGTTAACATTTTAACAGAAAAATACCGCAGTTATGCGTGTGAAAAACTCAGAA GCCCAAGGAAAACAAACGCCGGAACAACGCTTAAAACGTCCCATAAACCATCGCAATTTC AAAACACCACAGAATGGCCGACGGGGGCTCACGGTGGGCTCTGAAATGAGGTGGGTGGTG CCCAAGGGTCCTGTCCTCCACTGGCAGGCGGCTCACCCCCGGTCAAGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001455 |
| Insert Size | 3250 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | TrueClone. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001455.2, NP_001446.1 |
| RefSeq Size | 3338 bp |
| RefSeq ORF | 2022 bp |
| Locus ID | 2309 |
| UniProt ID | O43524 |
| Domains | FH |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Chemokine signaling pathway, Endometrial cancer, Neurotrophin signaling pathway, Non-small cell lung cancer |
| Gene Summary | This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) differs in the 5' end and represents the longer transcript compared to variant 2. Both variants encode the same protein. |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
,Emery, A;Hardwick, BS;Crooks, AT;Milech, N;Watt, PM;Mithra, C;Kumar, V;Giridharan, S;Sadasivam, G;Mathivanan, S;Sudhakar, S;Bairy, S;Bharatham, K;Hurakadli, MA;Prasad, TK;Kamariah, N;Muellner, M;Coelho, M;Torrance, CJ;McKenzie, GJ;Venkitaraman, AR;,
Cell chemical biology
,PubMed ID 34111400
[FOXO3]
|
|
miR-199a-3p Modulates MTOR and PAK4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model
,Callegari, E;D'Abundo, L;Guerriero, P;Simioni, C;Elamin, BK;Russo, M;Cani, A;Bassi, C;Zagatti, B;Giacomelli, L;Blandamura, S;Moshiri, F;Ultimo, S;Frassoldati, A;Altavilla, G;Gramantieri, L;Neri, LM;Sabbioni, S;Negrini, M;,
Mol Ther Nucleic Acids
,PubMed ID 29858083
[FOXO3]
|
|
FOXO3a modulates WNT/ß-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate cancer cells
,Liu, H;Yin, J;Wang, H;Jiang, G;Deng, M;Zhang, G;Bu, X;Cai, S;Du, J;He, Z;,
Cell. Signal.
,PubMed ID 25578861
[FOXO3]
|
|
A Novel Role for FOXO3 in Human Labor: Increased Expression in Laboring Myometrium, and Regulation of Proinflammatory and Prolabor Mediators in Pregnant Human Myometrial Cells
,Ratana Lim, Gillian Barker, and Martha Lappas,
Biol Reprod, Jun 2013; 88: 156.
,PubMed ID 23636809
[FOXO3]
|
|
Multiple Translational Isoforms Give Functional Specificity to Serum- and Glucocorticoid-induced Kinase 1
,Maria Francisca Arteaga, Diego Alvarez, Jose A Alvarez, and Cecilia M Canessa,
Mol Biol Cell. 2007 Jun;18(6):2072-80.
[FOXO3]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209846 | FOXO3 (Myc-DDK-tagged)-Human forkhead box O3 (FOXO3), transcript variant 1 |
CNY 7,392.00 |
|
| RC209846L1 | Lenti ORF clone of Human forkhead box O3 (FOXO3), transcript variant 1, Myc-DDK-tagged |
CNY 9,792.00 |
|
| RC209846L2 | Lenti ORF clone of Human forkhead box O3 (FOXO3), transcript variant 1, mGFP tagged |
CNY 9,792.00 |
|
| RC209846L3 | Lenti ORF clone of Human forkhead box O3 (FOXO3), transcript variant 1, Myc-DDK-tagged |
CNY 9,792.00 |
|
| RC209846L4 | Lenti ORF clone of Human forkhead box O3 (FOXO3), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG209846 | FOXO3 (tGFP-tagged) - Human forkhead box O3 (FOXO3), transcript variant 1 |
CNY 8,992.00 |
