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IGFBP7 (NM_001553) Human Untagged Clone
CAT＃: SC119176
IGFBP7 (untagged)-Human insulin-like growth factor binding protein 7 (IGFBP7)
CNY 3,600.00
| Cited in 6 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v; IGFBPRP1; MAC25; PSF; RAMSVPS; TAF |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001553 edited
GAATTCGGCACGAGGCCGCTGCCACCGCACCCCGCCATGGAGCGGCCGTCGCTGCGCGCC CTGCTCCTCGGCGCCGCTGGGCTGCTGCTCCTGCTCCTGCCCCTCTCCTCTTCCTCCTCT TCGGACACCTGCGGCCCCTGCGAGCCGGCCTCCTGCCCGCCCCTGCCCCCGCTGGGCTGC CTGCTGGGCGAGACCCGCGACGCGTGCGGCTGCTGCCCTATGTGCGCCCGCGGCGAGGGC GAGCCGTGCGGGGGTGGCGGCGCCGGCAGGGGGTACTGCGCGCCGGGCATGGAGTGCGTG AAGAGCCGCAAGAGGCGGAAGGGTAAAGCCGGGGCAGCAGCCGGCGGTCCGGGTGTAAGC GGCGTGTGCGTGTGCAAGAGCCGCTACCCGGTGTGCGGCAGCGACGGCACCACCTACCCG AGCGGCTGCCAGCTGCGCGCCGCCAGCCAGAGGGCCGAGAGCCGCGGGGAGAAGGCCATC ACCCAGGTCAGCAAGGGCACCTGCGAGCAAGGTCCTTCCATAGTGACGCCCCCCAAGGAC ATCTGGAATGTCACTGGTGCCCAGGTGTACTTGAGCTGTGAGGTCATCGGAATCCCGACA CCTGTCCTCATCTGGAACAAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTC CTGCCTGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAA GTAACTGGCTGGGTGCTGGTATCTCCTCTAAGTAAGGAAGATGCTGGAGAATATGAGTGC CATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGATGCC TTACATGAAATACCAGTGAAAAAAGGTGAAGGTGCCGAGCTATAAACCTCCAGAATATTA TTAGTCTGCATGGTTAAAAGTAGTCATGGATAACTACATTACCTGTTCTTGCCTAATAAG TTTCTTTTAATCCAATCCACTAACACTTTAGTTATATTCACTGGTTTTACACAGAGAAAT ACAAAATAAAGATCACACATCAAGACTATCTACAAAAATTTATTATATATTTACAGAAGA AAAGCATGCATATCATTAAACAAATAAAATACTTTTTATCACAACACAAAAAAAAAAAAA AAAAAAAACTCGAC >OriGene 5' read for NM_001553 unedited
NGGGTTTTAGGATTTGTNATCCGACTTCACTATNAGGNNCGGCCGCGCAATTCGGCACGA GGCCGCTGCCACCGCACCCCGCCATGGAGCGGCCGTCGCTGCGCGCCCTGCTCCTCGGCG CCGCTGGGCTGCTGCTCCTGCTCCTGCCCCTCTCCTCTTCCTCCTCTTCGGACACCTGCG GCCCCTGCGAGCCGGCCTCCTGCCCGCCCCTGCCCCCGCTGGGCTGCCTGCTGGGCGAGA CCCGCGACGCGTGCGGCTGCTGCCCTATGTGCGCCCGCGGCGAGGGCGAGCCGTGCGGGG GTGGCGGCGCCGGCAGGGGGTACTGCGCGCCGGGCATGGAGTGCGTGAAGAGCCGCAAGA GGCGGAAGGGTAAAGCCGGGGCAGCAGCCGGCGGTCCGGGTGTAAGCGGCGTGTGCGTGT GCAAGAGCCGCTACCCGGTGTGCGGCAGCGACGGCACCACCTACCCGAGCGGCTGCCAGC TGCGCGCCGCCAGCCAGAGGGCCGAGAGCCGCGGGGAGAAGGCCATCACCCAGGTCAGCA AGGGCACCTGCGAGCAAGGTCCTTCCATAGTGACGCCCCCCAAGGACATCTGGAATGTCA CTGGTGCCCAGGTGTACTTGAGCTGTGAGGTCATCGGAATCCCGACACCTGTCCTCATCT GGAACAAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTCCTGCCTGGTGACC GGGACAACCCTGCCATTCAGACCCGGGGTGGCCCCAGAAAGCATGAAGTAACTGGCTGGG TGCTGGTATCTCCTCTAAGTAGGAAGATGCTGNAGAATATGAGTGCCATGCATCCAATTN CCAAGGACAGGCTTCAGCATCAGCAAAAATACAGTGGGTGATGCCCTACATGAATAACAG TGAAAAAAGTGAAAGTGCCCGA >OriGene 3' read for NM_001553 unedited
TTTAACGGCCTCTATGTACCGCGGCCGCTTTCNAAGATCGGTTTTTTCCTTTTTTTTTTT TTTGTGTTGTGATAAAAAGTTTTTATTTGTTTAATGATATGCATGCTTTTCTTCTGTAAA TATATAATAAATTTTTGTAGATAGTCTTGATGTGTGATCTTTATTTTGTATTTCTCTGTG TAAAACCAGTGAATATAACTAAAGTGTTAGTGGATTGGATTAAAAGAAACTTATTAGGCA AGAACAGGTAATGTAGTTATCCATGACTACTTTTAACCATGCAGACTAATAATATTCTGG AGGTTTATAGCTCGGCACCTTCACCTTTTTTCACTGGTATTTCATGTAAGGCATCAACCA CTGTAATTTTTGCTGATGCTGAAGCCTGTCCTTGGGAATTGGATGCATGGCACTCATATT CTCCAGCATCTTCCTTACTTAGAGGAGATACCAGCACCCAGCCAGTTACTTCATGCTTTT CTGGGCCACCCCGGGTCTGAATGGCCAGGTTGTCCCGGTCACCAAGCAGGAGTTCTGTCC TTTGAACTCCATAGTGACCCCTTTTTACCTTGTTCCAGATGAAGACAGGTGTCGGGATTC CGATGACCTCACAGCTCAAGTACACCTGGGCACCAGTGACATTCCAGATGTCCTTGGGGG GCGTCACTATGGAAAGACCTTGCTCGCAAGTGCCCTTGCTGACCTGGGTGATGGCCTTCT CCCCGCGGCTCTCGGCCCTCTGGCTGGCGGCGCGCATCTGGCAGCCGCTCGGTAAGTGGG TGGCCCGTCGCTGCCGCACACCGGGGTAGCGGNCTCTTGCACACGCACACGCCGCTTACA CCCTNACCGCCGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001553 |
| Insert Size | 1200 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001553.1, NP_001544.1 |
| RefSeq Size | 1124 bp |
| RefSeq ORF | 849 bp |
| Locus ID | 3490 |
| UniProt ID | Q16270 |
| Domains | IB, kazal, IG |
| Protein Families | Secreted Protein |
| Gene Summary | This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011] Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). |
Citations (6)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis
,Verhagen, HJMP;van Gils, N;Martiañez, T;van Rhenen, A;Rutten, A;Denkers, F;de Leeuw, DC;Smit, MA;Tsui, ML;de Vos Klootwijk, LLE;Menezes, RX;Çil, M;Roemer, MGM;Vermue, E;Heukelom, S;Zweegman, S;Janssen, JJWM;Ossenkoppele, GJ;Schuurhuis, GJ;Smit, L;,
Cell Rep
,PubMed ID 30540936
[IGFBP7]
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MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1
,null,
International Journal of Molecular Medicine
,PubMed ID 30221686
[IGFBP7]
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Methylation status of insulin-like growth factor-binding protein 7 concurs with the malignance of oral tongue cancer
,null,
Journal of Experimental & Clinical Cancer Research : CR
,PubMed ID 25880247
[IGFBP7]
|
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IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival
,Verhagen, HJ;de Leeuw, DC;Roemer, MG;Denkers, F;Pouwels, W;Rutten, A;Celie, PH;Ossenkoppele, GJ;Schuurhuis, GJ;Smit, L;,
Cell Death Dis
,PubMed ID 24967962
[IGFBP7]
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Insulin-like Growth Factor–Binding Protein-7 Functions as a Potential Tumor Suppressor in Hepatocellular Carcinoma
,Dong Chen, Byoung Kwon Yoo, Prasanna Kumar Santhekadur, Rachel Gredler, Sujit K. Bhutia, Swadesh K. Das, Christine Fuller, Zao-zhong Su, Paul B. Fisher, and Devanand Sarkar,
Clin. Cancer Res., Nov 2011; 17: 6693 - 6701.
[IGFBP7]
|
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Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells
,Y Tomimaru, H Eguchi, H Wada, T Noda, M Murakami, S Kobayashi, S Marubashi, Y Takeda, M Tanemura, K Umeshita, et al.,
British Journal of Cancer (20 April 2010) doi:10.1038/sj.bjc.6605669 Full Paper
[IGFBP7]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209844 | IGFBP7 (Myc-DDK-tagged)-Human insulin-like growth factor binding protein 7 (IGFBP7) |
CNY 3,600.00 |
|
| RC209844L1 | Lenti ORF clone of Human insulin-like growth factor binding protein 7 (IGFBP7), Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC209844L2 | Lenti ORF clone of Human insulin-like growth factor binding protein 7 (IGFBP7), mGFP tagged |
CNY 6,000.00 |
|
| RC209844L3 | Lenti ORF clone of Human insulin-like growth factor binding protein 7 (IGFBP7), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC209844L4 | Lenti ORF clone of Human insulin-like growth factor binding protein 7 (IGFBP7), mGFP tagged |
CNY 6,000.00 |
|
| RG209844 | IGFBP7 (tGFP-tagged) - Human insulin-like growth factor binding protein 7 (IGFBP7) |
CNY 5,200.00 |
