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BLK (NM_001715) Human Untagged Clone
CAT＃: SC119056
BLK (untagged)-Human B lymphoid tyrosine kinase (BLK)
CNY 3,768.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MODY11 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_001715 edited
GTTGGAAGTTGCTCGTTGTCGCTAGGAGCCTGCTCCACTGTAAGGGTGTCGGGATCTGAA GAGCTATGGTGAAACACCACTGAAGCATTGCCAAGGATGGGGCTGGTAAGTAGCAAAAAG CCGGACAAGGAAAAGCCGATCAAAGAGAAGGACAAGGGCCAATGGAGCCCCCTGAAGGTC AGCGCCCAAGACAAGGACGCCCCGCCACTGCCGCCCCTGGTTGTCTTCAACCACCTTACT CCTCCACCGCCCGATGAACACCTGGATGAAGACAAGCATTTCGTGGTGGCTCTGTATGAC TACACCGCTATGAATGATCGGGACCTGCAGATGCTGAAGGGGGAGAAGCTACAGGTCCTG AAGGGAACTGGAGACTGGTGGCTGGCCAGGTCACTCGTCACAGGAAGAGAAGGCTATGTG CCCAGTAACTTTGTGGCCCGAGTGGAGAGCCTGGAAATGGAAAGGTGGTTCTTTAGATCA CAGGGTCGGAAGGAGGCTGAGAGGCAGCTTCTTGCTCCAATCAACAAGGCCGGCTCCTTT CTTATCAGAGAGAGTGAAACCAACAAAGGTGCCTTCTCCCTGTCTGTGAAGGATGTCACC ACCCAGGGGGAGCTGATCAAGCACTATAAGATCCGCTGCCTGGATGAAGGGGGCTACTAC ATCTCCCCCCGGATCACCTTCCCCTCGCTCCAGGCCCTGGTGCAGCACTATTCTAAGAAG GGGGATGGTCTATGCCAGAGGCTGACCCTGCCCTGTGTGCGCCCGGCCCCGCAGAATCCC TGGGCCCAGGATGAATGGGAGATCCCCCGGCAGTCTCTCAGGCTGGTCAGGAAACTCGGG TCTGGACAATTCGGCGAAGTCTGGATGGGTTACTACAAAAACAACATGAAGGTGGCCATT AAGACGCTGAAGGAGGGAACCATGTCTCCAGAAGCCTTCCTGGGTGAGGCCAACGTGATG AAGGCTCTGCAGCACGAGCGGCTGGTCCGACTCTACGCAGTGGTCACCAAGGAGCCCATC TACATTGTCACCGAGTACATGGCCAGAGGATGCCTGCTGGATTTCCTGAAGACAGATGAA GGGAGCAGATTGTCACTCCCAAGGCTGATTGACATGTCGGCGCAGATTGCTGAAGGGATG GCATACATTGAGCGCATGAATTCCATCCACCGCGACCTGCGGGCGGCCAACATCCTGGTG TCTGAGGCCTTGTGCTGCAAAATTGCTGATTTTGGCTTGGCTCGAATCATCGACAGTGAA TACACGGCCCAAGAGGGGGCCAAGTTCCCCATCAAGTGGACAGCCCCGGAAGCCATCCAC TTCGGGGTCTTCACCATCAAAGCAGACGTGTGGTCGTTTGGAGTCCTCCTGATGGAAGTT GTCACTTATGGGCGGGTGCCATACCCAGGGATGAGCAACCCCGAGGTCATCCGCAACCTG GAGCGCGGCTACCGCATGCCGCGCCCCGACACCTGCCCGCCCGAGCTGTACCGCGGCGTC ATCGCCGAGTGCTGGCGCAGCCGGCCCGAGGAGCGGCCCACCTTCGAGTTCCTGCAGTCG GTGCTGGAGGACTTCTACACGGCCACCGAGCGGCAGTACGAGCTGCAGCCCTAGCCGGCC GCGCCCGCCTGCGCCCCGTGCCCACCTCTGCGCGGACGACCCCGACTTCCGTGCCATCCC AGACGGGCCGCGAAGGCGGGGTGTCGCCTGTGCCCTTTTCTCAGACCCGGAATCCAGTGG GCAGAGGCAGCTTCGCAGGGGGTCCCCGGACGGACTCCTTCACCGACTGTACCCCCGGGC GAGTTACGCGGCCTCTCTGTGCCGCTTCATTTGTAGAGGGCTGTAACAGTGACCTCGCAC GGTCATCCGGAGTACTAAGCCCCAGTAAGGTGTTCAGGACTGGTAAGCGACTGTCATCAA GTAAGGCCCCCGTGCTGGGCACCCCCCGTGCTGGCCGCGTCCCCGCCTCTGCGCCCTGCG TGGA >OriGene 5' read for NM_001715 unedited
CAGGATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGGAGGCTCT GATCGCAGACCGGGGGTGCTGCTACCTCTGTCTGCTGCCGGCAGAAAGCCACAAGCCATG AAAACTGATTGAGATGAGAAGAATTCATCTGGGACTGGCTTTTGCTTTAGGATGGTGTTG GAAGTTGCTCGTTGTCGCTAGGAGCCTGCTCCACTGTAAGGGTGTCGGGATCTGAAGAGC TATGGTGAAACACCACTGAAGCATTGCCAAGGATGGGGCTGGTAAGTAGCAAAAAGCCGG ACAAGGAAAAGCCGATCAAAGAGAAGGACAAGGGCCAATGGAGCCCCCTGAAGGTCAGCG CCCAAGACAAGGACGCCCCGCCACTGCCGCCCCTGGTTGTCTTCAACCACCTTACTCCTC CACCGCCCGATGAACACCTGGATGAAGACAAGCATTTCGTGGTGGCTCTGTATGACTACA CCGCTATGAATGATCGGGACCTGCAGATGCTGAAGGGGGAGAAGCTACAGGTCCTGAAGG GAACTGGAGACTGGTGGCTGGCCAGGTCACTCGTCACAGGAAGAGAAGGCTATGTGCCCA GTAACTTTGTGGCCCGAGTGGAGAGCCTGGAAATGGAAAGGTGGTTCTTTAGATCACAGG GTCGGAAGGAGGCTGAGAGGCAGCTTCTTGCTCCAATCAACAAGGCCGGCTCCTTTCTTA TCAGAGAGAGTGAANACCAACAAGGTGCCTTCTCCCTGTCTGTGAAGGATGTCACCACCC CNGGGGGAGCTGATCAAGCACTATNAGATCCGCTGCCTGGATGAAGGGGGCTACTACATC TCCCCCCGGATCACCTTNCCTCGCTNNCAGCCCTGGTGCAGCACTATTTCTAGAAGGGGG ATGGTCTATGCCAGAGCTGACCTGCCCTGTGTGCGCCCGGCCCGCAAATCCCTGGCCCAG ATGAATGGGGATCCCCGGCAGTCTTTCAGCTGGTAC >OriGene 3' read for NM_001715 unedited
NNAAAATACTTGNACCGCGCCGCATTCTAGNGACTAGTCTCGATTTTTTTTTTTTTTTTT TTTTTTTCGAACGCTCGTGACTTTATTGCAAAAAAGCCCCGCAGTGCTGGAGCGCAGCCT AGGCTGGGGCTGCCCCTGCTGGCGTCCGCGGGACCCAGTCTGGCTTCTGTAGCGGGGCAG GGCGGGGTCCACGCAGGGCGCAAAGGCGGGGACGCGGCCAGCACGGGGGGTGCCCAGCAC GGGGGCCTTACTTGATGACAGTCGCTTACCAGTCCTGAACACCTTACTGGGGCTTAGTAC TCCGGATGACCGTGCGAGGTCACTGTTACAGCCCTCTACAAATGAAGCGGCACAGAGAGG CCGCGTAACTCGCCCGGGGGTACAGTCGGTGAAGGAGTCCGTCCGGGGACCCCCTGCGAA GCTGCCTCTGCCCACTGGATTCCGGGTCTGAGAAAAGGGCACAGGCGACACCCCGCCTTC GCGGCCCGTCTGGGATGGCACGGAAGTCGGGGTCGTCCGCGCAAAGGTGGGCACGGGGCG CAGGCGGGCGCGGCCGGCTAGGGCTGCAGCTCGTACTGCCGCTCGGTGGCCGTGTAGAAG TCCTCCAGCACCGACTGCAGGAACTCGAAGGTGGGCCGCTCCTCGGGCCGGCTGCGCCAG CACTCGGCGATGACGCCGCGGTACAGCTCGGGCGGGCAGGNTGTCGGGGCGCGGCATGCG GTAGCCGCGCTCCAGGTTGCGGATGACCTCGGGGTTGCTCATCCCTGGGTATGGCACCCG CCCATAAGTGACAACTTCCATCAGGAGGACTCCAACGACCACACGTCTGCTTTGATGGTG AAGACCCCCGAGTGGATGGCTTCCGGGGCTGTCCACTTGATGGGGAAACTTGGCCCCCTC TGGGGCCGTGTATTCACTGTCGATGATTCN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001715 |
| Insert Size | 2500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001715.2, NP_001706.2 |
| RefSeq Size | 2642 bp |
| RefSeq ORF | 1518 bp |
| Locus ID | 640 |
| UniProt ID | P51451 |
| Domains | pkinase, SH2, TyrKc, SH3, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| Gene Summary | This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus
,Jiang, SH;Athanasopoulos, V;Ellyard, JI;Chuah, A;Cappello, J;Cook, A;Prabhu, SB;Cardenas, J;Gu, J;Stanley, M;Roco, JA;Papa, I;Yabas, M;Walters, GD;Burgio, G;McKeon, K;Byers, JM;Burrin, C;Enders, A;Miosge, LA;Canete, PF;Jelusic, M;Tasic, V;Lungu, AC;Alexander, SI;Kitching, AR;Fulcher, DA;Shen, N;Arsov, T;Gatenby, PA;Babon, JJ;Mallon, DF;de Lucas Collantes, C;Stone, EA;Wu, P;Field, MA;Andrews, TD;Cho, E;Pascual, V;Cook, MC;Vinuesa, CG;,
Nat Commun
,PubMed ID 31101814
[BLK]
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Resources
Other Versions
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| RC207123L4 | Lenti-ORF clone of BLK (mGFP-tagged)-Human B lymphoid tyrosine kinase (BLK). Note: ORF is codon optimized |
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| RG207123 | BLK (tGFP-tagged) - Human B lymphoid tyrosine kinase (BLK). Note: ORF is codon optimized |
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| SC323504 | BLK (untagged)-Kinase deficient mutant (K269M) of Human B lymphoid tyrosine kinase (BLK) |
CNY 3,768.00 |
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| SC323517 | BLK (untagged)-Kinase deficient mutant (K269M) of Human B lymphoid tyrosine kinase (BLK) |
CNY 3,768.00 |
