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Granulin (GRN) (NM_002087) Human Untagged Clone
CNY 4,424.00
CNY 7,220.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CLN11; GEP; GP88; PCDGF; PEPI; PGRN |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118822 sequence for NM_002087 edited (data generated by NextGen Sequencing)
ATGTGGACCCTGGTGAGCTGGGTGGCCTTAACAGCAGGGCTGGTGGCTGGAACGCGGTGC CCAGATGGTCAGTTCTGCCCTGTGGCCTGCTGCCTGGACCCCGGAGGAGCCAGCTACAGC TGCTGCCGTCCCCTTCTGGACAAATGGCCCACAACACTGAGCAGGCATCTGGGTGGCCCC TGCCAGGTTGATGCCCACTGCTCTGCCGGCCACTCCTGCATCTTTACCGTCTCAGGGACT TCCAGTTGCTGCCCCTTCCCAGAGGCCGTGGCATGCGGGGATGGCCATCACTGCTGCCCA CGGGGCTTCCACTGCAGTGCAGACGGGCGATCCTGCTTCCAAAGATCAGGTAACAACTCC GTGGGTGCCATCCAGTGCCCTGATAGTCAGTTCGAATGCCCGGACTTCTCCACGTGCTGT GTTATGGTCGATGGCTCCTGGGGGTGCTGCCCCATGCCCCAGGCTTCCTGCTGTGAAGAC AGGGTGCACTGCTGTCCGCACGGTGCCTTCTGCGACCTGGTTCACACCCGCTGCATCACA CCCACGGGCACCCACCCCCTGGCAAAGAAGCTCCCTGCCCAGAGGACTAACAGGGCAGTG GCCTTGTCCAGCTCGGTCATGTGTCCGGACGCACGGTCCCGGTGCCCTGATGGTTCTACC TGCTGTGAGCTGCCCAGTGGGAAGTATGGCTGCTGCCCAATGCCCAACGCCACCTGCTGC TCCGATCACCTGCACTGCTGCCCCCAAGACACTGTGTGTGACCTGATCCAGAGTAAGTGC CTCTCCAAGGAGAACGCTACCACGGACCTCCTCACTAAGCTGCCTGCGCACACAGTGGGG GATGTGAAATGTGACATGGAGGTGAGCTGCCCAGATGGCTATACCTGCTGCCGTCTACAG TCGGGGGCCTGGGGCTGCTGCCCTTTTACCCAGGCTGTGTGCTGTGAGGACCACATACAC TGCTGTCCCGCGGGGTTTACGTGTGACACGCAGAAGGGTACCTGTGAACAGGGGCCCCAC CAGGTGCCCTGGATGGAGAAGGCCCCAGCTCACCTCAGCCTGCCAGACCCACAAGCCTTG AAGAGAGATGTCCCCTGTGATAATGTCAGCAGCTGTCCCTCCTCCGATACCTGCTGCCAA CTCACGTCTGGGGAGTGGGGCTGCTGTCCAATCCCAGAGGCTGTCTGCTGCTCGGACCAC CAGCACTGCTGCCCCCAGGGCTACACGTGTGTAGCTGAGGGGCAGTGTCAGCGAGGAAGC GAGATCGTGGCTGGACTGGAGAAGATGCCTGCCCGCCGGGCTTCCTTATCCCACCCCAGA GACATCGGCTGTGACCAGCACACCAGCTGCCCGGTGGGGCAGACCTGCTGCCCGAGCCTG GGTGGGAGCTGGGCCTGCTGCCAGTTGCCCCATGCTGTGTGCTGCGAGGATCGCCAGCAC TGCTGCCCGGCTGGCTACACCTGCAACGTGAAGGCTCGATCCTGCGAGAAGGAAGTGGTC TCTGCCCAGCCTGCCACCTTCCTGGCCCGTAGCCCTCACGTGGGTGTGAAGGACGTGGAG TGTGGGGAAGGACACTTCTGCCATGATAACCAGACCTGCTGCCGAGACAACCGACAGGGC TGGGCCTGCTGTCCCTACCGCCAGGGCGTCTGTTGTGCTGATCGGCGCCACTGCTGTCCT GCTGGCTTCCGCTGCGCAGCCAGGGGTACCAAGTGTTTGCGCAGGGAGGCCCCGCGCTGG GACGCCCCTTTGAGGGACCCAGCCTTGAGACAGCTGCTGTGA Clone variation with respect to NM_002087.2 >OriGene 5' read for NM_002087 unedited
TAGATTTTGTACACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGAGCGCTACCCG GTTGCTGCTGCCCAAGGACCGCGGAGTCGGACGCAGGCAGACCATGTGGACCCTGGTGAG CTGGGTGGCCTTAACAGCAGGGCTGGTGGCTGGAACGCGGTGCCCAGATGGTCAGTTCTG CCCTGTGGCCTGCTGCCTGGACCCCGGAGGAGCCAGCTACAGCTGCTGCCGTCCCCTTCT GGACAAATGGCCCACAACACTGAGCAGGCATCTGGGTGGCCCCTGCCAGGTTGATGCCCA CTGCTCTGCCGGCCACTCCTGCATCTTTACCGTCTCAGGGACTTCCAGTTGCTGCCCCTT CCCAGAGGCCGTGGCATGCGGGGATGGCCATCACTGCTGCCCACGGGGCTTCCACTGCAG TGCAGACGGGCGATCCTGCTTCCAAAGATCAGGTAACAACTCCGTGGGTGCCATCCAGTG CCCTGATAGTCAGTTCGAATGCCCGGACTTCTCCACGTGCTGTGTTATGGTCGATGGCTC CTGGGGGTGCTGCCCCATGCCCCAGGCTTCCTGCTGTGAAGACAGGGTGCACTGCTGTCC GCACGGTGCCTTCTGCGACCTGGTTCACACCCGCTGCATCACACCCACGGGCACCCACCC CCTGNCAAAGAAGCTCCCTGCCCAGAGGACTAACAGGGCAGTGGCCTTGTCCAGCTCGGT CATGTGTCCCGACGCACGGTCCCGGTGCCCTGATGGTTCTACCTGCTGTGAGCTTGCCAG TGGGAAGTATGGCTGCTGCCCATGCCCAAACGCCACTGCTGCTCCGATCACCTGCACTGC TGCCCCCAAGACACTGTGTGTGACCTGATCCANAGTTAGTGCCTCTCCAAGAGAACGCTA CACCGACCTCTCACTAGCTGNCTGCCAACATGGGGGGATGTGAA >OriGene 3' read for NM_002087 unedited
CCCCGCGCCGCCCCTCGCCCTCCCCCCTCCCCCCTCTCTTTACTTAGTACCCGGCCCGCA TACTACGATCGGTTTTTTTTTTTTTTTTTTCGAAGTGTACAAACTTTTATTGAAACGCAC ACGCGCACACACACAAACACCCCTGTGGTTAGGGAAAAGCACCTGCCCACAGGGTCCACT GAAACGGGGAGGGGATGGCAGCTTGTAATGTGGCTTTTGCCACAACCCCCTTCTGACAGG GAAGGCCTTAGATTGAGGCCCCACCTCCCATGGTGATGGGGAGCTCACAACGGTGCCCAG CGAGACTTTGGTTAGGGCGAGGTGCTAGGGAGGCCTGAGCATAGGGCACCTCTCCGAGTG GGGTCCCCACGCCTGCACAGTCTTCAGTACCTGCATCTCACAATACCTGTCTCAAGGCTG GGTCCCTTAAAGGGGCGCCCCCACGCGGGGCCTCCCTGTGCACACACTAGCTCCCCCTGG CTGCCCCGTGCCAGCCAATAAGACCAGCTGTGCTTTCCACTCGCCCAACAAACCTCCTGT CTGTAGGCGACCACCACATCAGCCCTTGCCCCTTGTCTCCCCTCCCATTCCCGTCTATTT ATGCCCCCACGGCCCCTGCTTTAATTCCACGCCCTTTTACACCCACTCCCGGTTCCCCGC CCCCGAACCCCTCACGTTGTCCACACCCACTTCCTTTTCCCCAGGACCGACCCTTCCCCC CTCCCCCCCCACCCCCCCGAACCCAACTTTTGCCACCCCCACAACCCACCTACCCGGCCC CCTTGTCCCTATGCCCCCCTCCATCCCCACCTTCCCCCCCTATTTCACTTCACCCCCCCC ATTTTTCTCTCCCCCCCCCCCCTTCATCTCACGCGCGCGACAAAGACACATTCTTTCCTC CTACTCCTCCATTACCCCACCCCCCCACCCCCTTTCTTTCCCCCCTCCCGACTATAAC |
| Restriction Sites | ECoRI-NOT |
| ACCN | NM_002087 |
| Insert Size | 2300 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002087.2, NP_002078.1 |
| RefSeq Size | 2323 bp |
| RefSeq ORF | 1782 bp |
| Locus ID | 2896 |
| UniProt ID | P28799 |
| Domains | GRAN |
| Protein Families | Druggable Genome, Secreted Protein |
| Gene Summary | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies
,Lang, I;Füllsack, S;Wajant, H;,
Front Immunol
,PubMed ID 29740434
[GRN]
|
|
miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease
,Wang-Xia Wang, Bernard R. Wilfred, Sindhu K. Madathil, Guiliang Tang, Yanling Hu, James Dimayuga, Arnold J. Stromberg, Qingwei Huang, Kathryn E. Saatman, and Peter T. Nelson,
Am. J. Pathol., Jul 2010; 177: 334 - 345
[GRN]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202139 | GRN (Myc-DDK-tagged)-Human granulin (GRN) |
CNY 4,416.00 |
|
| RC202139L1 | Lenti ORF clone of Human granulin (GRN), Myc-DDK-tagged |
CNY 6,816.00 |
|
| RC202139L2 | Lenti ORF clone of Human granulin (GRN), mGFP tagged |
CNY 6,460.00 |
|
| RC202139L3 | Lenti ORF clone of Human granulin (GRN), Myc-DDK-tagged |
CNY 6,816.00 |
|
| RC202139L4 | Lenti ORF clone of Human granulin (GRN), mGFP tagged |
CNY 6,816.00 |
|
| RG202139 | GRN (tGFP-tagged) - Human granulin (GRN) |
CNY 6,016.00 |
|
| SC323935 | GRN (untagged)-Human granulin (GRN) |
CNY 4,424.00 |
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