EXOSC10 (NM_002685) Human Untagged Clone

CAT#: SC118513

EXOSC10 (untagged)-Human exosome component 10 (EXOSC10), transcript variant 2



  "NM_002685" in other vectors (4)

CNY 6,304.00


货期*
现货

规格
    • 10 ug

Product images

经常一起买 (4)
TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00


EXOSC10 rabbit polyclonal antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Synonyms p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC118513 sequence for NM_002685 edited (data generated by NextGen Sequencing)
ATGGCGCCACCCAGTACCCGGGAGCCCAGGGTCCTGTCGGCGACCAGCGCAACCAAATCC
GACGGAGAGATGGTGCTGCCAGGCTTCCCGGACGCCGACAGCTTTGTGAAGTTTGCTCTT
GGGTCCGTGGTGGCAGTCACCAAGGCATCTGGGGGCCTACCACAGTTTGGCGATGAGTAT
GATTTTTACCGAAGTTTTCCTGGCTTCCAAGCATTTTGCGAAACACAGGGAGACAGGTTG
CTTCAGTGCATGAGCAGAGTAATGCAGTACCATGGGTGTCGCAGCAACATTAAGGATCGA
AGTAAAGTGACTGAGCTGGAAGACAAGTTTGATTTACTAGTTGATGCCAATGATGTAATT
CTGGAGAGAGTGGGTATTTTACTGGATGAAGCCTCAGGTGTAAACAAGAATCAACAGCCT
GTCCTCCCTGCCGGCTTGCAGGTCCCCAAAACGGTAGTGTCCAGCTGGAACCGTAAGGCA
GCAGAATATGGCAAAAAAGCAAAATCTGAAACTTTCCGGCTGCTTCATGCAAAAAATATC
ATCCGACCTCAGCTCAAGTTTCGAGAGAAGATTGACAATTCCAACACACCATTTCTTCCT
AAAATCTTCATCAAACCCAATGCTCAGAAACCTCTCCCTCAAGCTCTCTCTAAGGAAAGG
CGGGAACGCCCACAGGATCGTCCTGAGGACTTGGACGTCCCCCCTGCACTGGCTGATTTC
ATCCATCAGCAGAGAACCCAGCAGGTTGAGCAAGACATGTTTGCACATCCTTATCAATAT
GAACTAAATCACTTTACCCCAGCAGATGCAGTGCTTCAAAAGCCACAACCCCAGTTATAC
AGACCTATAGAAGAGACACCATGCCATTTCATATCCTCCCTGGATGAACTCGTGGAACTC
AACGAAAAGCTCTTGAATTGTCAGGAATTTGCAGTTGACTTGGAGCACCACTCTTACAGG
AGCTTCCTGGGACTGACCTGCCTGATGCAAATTTCTACTCGGACGGAAGACTTCATCATT
GACACCCTCGAGCTTCGAAGTGACATGTACATTCTCAATGAGAGCCTCACAGACCCAGCC
ATCGTTAAGGTCTTTCATGGTGCTGATTCAGACATAGAATGGCTACAGAAAGACTTTGGG
TTGTATGTAGTAAACATGTTTGATACTCATCAGGCAGCACGCCTTCTTAACCTGGGCAGG
CACTCACTCGATCATCTCCTGAAACTCTACTGCAACGTGGACTCAAACAAGCAATATCAG
CTGGCTGATTGGAGAATACGCCCTCTGCCCGAGGAGATGCTCAGCTACGCCCGGGATGAC
ACCCATTACCTGCTATATATCTATGACAAAATGAGGCTGGAGATGTGGGAGCGCGGCAAC
GGGCAGCCCGTGCAGCTGCAGGTGGTGTGGCAACGGAGCAGGGACATCTGCCTCAAGAAA
TTCATCAAACCTATCTTCACGGATGAGTCCTACCTTGAACTCTATAGGAAGCAGAAGAAG
CACCTTAACACACAGCAGTTGACAGCCTTTCAGCTGCTGTTTGCCTGGAGGGATAAAACA
GCTCGCAGGGAAGATGAAAGTTACGGATATGTACTGCCAAACCACATGATGCTGAAAATA
GCTGAAGAACTGCCTAAGGAACCTCAGGGCATCATAGCTTGCTGCAACCCAGTACCGCCC
CTTGTGCGGCAGCAGATCAACGAAATGCACCTTTTAATCCAGCAGGCCCGAGAGATGCCC
CTGCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAG
AGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTAT
CCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGAT
GAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTA
TTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAA
GCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGNTCAGCAACCGTTGGAAG
CTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAG
CAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATC
TCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGC
GACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCA
AAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTC
AAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAG
ACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAA
AGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGA
TAG

Clone variation with respect to NM_002685.2
1389 g=>c;2083 a=>n;2094 c=>t
>OriGene 5' read for NM_002685 unedited
GTAATACGACTCACTTATAGGGCGGCCGCGATTCGGCACGAGGTGAAAAATGGCGCCACC
CAGTACCCGGGAGCCCAGGGTCCTGTCGGCGACCAGCGCAACCAAATCCGACGGAGAGAT
GGTGCTGCCAGGCTTCCCGGACGCCGACAGCTTTGTGAAGTTTGCTCTTGGGTCCGTGGT
GGCAGTCACCAAGGCATCTGGGGGCCTACCACAGTTTGGCGATGAGTATGATTTTTACCG
AAGTTTTCCTGGCTTCCAAGCATTTTGCGAAACACAGGGAGACAGGTTGCTTCAGTGCAT
GAGCAGAGTAATGCAGTACCATGGGTGTCGCAGCAACATTAAGGATCGAAGTAAAGTGAC
TGAGCTGGAAGACAAGTTTGATTTACTAGTTGATGCCAATGATGTAATTCTGGAGAGAGT
GGGTATTTTACTGGATGAAGCCTCAGGTGTAAACAAGAATCAACAGCCTGTCCTCCCTGC
CGGCTTGCAGGTCCCCAAAACGGTAGTGTCCAGCTGGAACCGTAAGGCAGCAGAATATGG
CAAAAAAGCAAAATCTGAAACTTTCCGGCTGCTTCATGCAAAAAATATCATCCGACCTCA
GCTCAAGTTTCGAGAGAAGATTGACAATTCCAACACACCATTTCTTCCTAAAATCTTCAT
CAAACCCAATGCTCAGAAACCTCTCCCTCAAGCTCTCTCTAAGGAAGGCGGGAACGCCCA
CAGGATCGTCCTGAGACTTGGACGTCCCCCCTGCACTGGCTGATTTCATCCATCAGCAGA
GAACCCAGCANGTTGAGCAAGAACATGTTGCACATNCCTATCAATATGAACTANATCACC
TTTACCCCAGCAGATGCAGTGCTTCAAAAGCCACACCCNCAGTATACAGACTATAGAAGA
GACACATGCCATTTCTNATCCTNCCTGGATGGACTCGTGGGACTCACC
>OriGene 3' read for NM_002685 unedited
CCGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TCTTCAGAAAAAATTTTAATGGTTTAAAAATATGTTTGTACAAAAGCAGCACCAGCTTTT
GGGGCTTCCGGTCCACAGGCGCCACGTGTTTTCCAGGACTATTTTTGGGGCCAGTTGTAC
CTGAAGCCTTTGTCTGACTTTCCAGTTGGAAAGGACATGCTTTTGTTTCCCACCGACTGT
TTAATTTTTTTGGCTGCAATGCATTTTTTGCCAAACGGGGTCTGTTTATTTGGATCAAAC
TGAAAAAAAACTTTGGATTTGCTGTTTCCAGCAAAAGCCTTGAAGTCTGACTGGCTGTAG
TCGTAAGGCGTAAACTCTTTTTCTGGGGGCTCTGGGTCCTTTGGCTTCTTGGAAATTTTG
AGTCGTTTCTTCTCTTGTTTCTGTTCTGGGGCCCTTGGGTCGCTTGTTGCTCGCTCTCTC
TTCTTTGCAGCATTTTCTAACACGACCTGCTGTCGGACGGAAATGGCCTGTTCTGCTGCA
GCTTTGCACGCCTCCTTTGCCTGTTCCCGGGCAGCTGTTTGCTCAACTGCCTTCTTCTTG
ACAGCTTCTTTAGAGCCTTTTTGCCCTTGCACCTGGGCCAACTTCCAACGGTTGCTGATT
TCATAAAATTTGGTGGATGGATCCAACCTTCCTGCCTGAAAACGGAAGCCCGGTGGCCCA
ATGAGGGCAAAAACCTCCTTAAAGGGTTTTTAAAGGACCCCATGATGTTCTCGGGTTTTT
TTTCGGGCACCTGGAAAGGGACCCTTTTTACTGTTTTAACACTTAGGCCATTAAAAAACC
GGAAGACCAGCGGGGCAATAGAGCTGGGGGCCCCAACCAGTTATTTCTTTTTAACGGGAA
AAGGTCCCCTTCTT
Restriction Sites NotI-NotI     
ACCN NM_002685
Insert Size 2880 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_002685.2, NP_002676.1
RefSeq Size 2759 bp
RefSeq ORF 2583 bp
Locus ID 5394
UniProt ID Q01780
Domains HRDC, 3_5_exonuclease
Protein Pathways RNA degradation
Gene Summary Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.[UniProtKB/Swiss-Prot Function]
Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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