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Neuropilin 1 (NRP1) (NM_003873) Human Untagged Clone
CAT＃: SC117726
NRP1 (untagged)-Human neuropilin 1 (NRP1), transcript variant 1
CNY 17,670.00
| Cited in 4 publications. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BDCA4; CD304; NP1; NRP; VEGF165R |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC117726 sequence for NM_003873 edited (data generated by NextGen Sequencing)
ATGGAGAGGGGGCTGCCGCTCCTCTGCGCCGTGCTCGCCCTCGTCCTCGCCCCGGCCGGC GCTTTTCGCAACGATAAATGTGGCGATACTATAAAAATTGAAAGCCCCGGGTACCTTACA TCTCCTGGTTATCCTCATTCTTATCACCCAAGTGAAAAATGCGAATGGCTGATTCAGGCT CCGGACCCATACCAGAGAATTATGATCAACTTCAACCCTCACTTCGATTTGGAGGACAGA GACTGCAAGTATGACTACGTGGAAGTCTTCGATGGAGAAAATGAAAATGGACATTTTAGG GGAAAGTTCTGTGGAAAGATAGCCCCTCCTCCTGTTGTGTCTTCAGGGCCATTTCTTTTT ATCAAATTTGTCTCTGACTACGAAACACATGGTGCAGGATTTTCCATACGTTATGAACTT TTCAAGAGAGGTCCTGAATGTTCCCAGAACTACACAACACCTAGTGGAGTGATAAAGTCC CCCGGATTCCCTGAAAAATATCCCAACAGCCTTGAATGCACTTATATTGTCTTTGCGCCA AAGATGTCAGAGATTATCCTGGAATTTGAAAGCTTTGACCTGGAGCCTGACTCAAATCCT CCAGGGGGGATGTTCTGTCGCTACGACCGGCTAGAAATCTGGGATGGATTCCCTGATGTT GGCCCTCACATTGGGCGTTACTGTGGACAGAAAACACCAGGTCGAATCCGATCCTCATCG GGCATTCTCTCCATGGTTTTTTACACCGACAGCGCGATAGCAAAAGAAGGTTTCTCAGCA AACTACAGTGTCTTGCAGAGCAGTGTCTCAGAAGATTTCAAATGTATGGAAGCTCTGGGC ATGGAATCAGGAGAAATTCATTCTGACCAGATCACAGCTTCTTCCCAGTATAGCACCAAC TGGTCTGCAGAGCGCTCCCGCCTGAACTACCCTGAGAATGGGTGGACTCCCGGAGAGGAT TCCTACCGAGAGTGGATACAGGTAGACTTGGGCCTTCTGCGCTTTGTCACGGCTGTCGGG ACACAGGGCGCCATTTCAAAAGAAACCAAGAAGAAATATTATGTCAAGACTTACAAGATC GACGTTAGCTCCAACGGGGAAGACTGGATCACCATAAAAGAAGGAAACAAACCTGTTCTC TTTCAGGGAAACACCAACCCTACAGATGTTGTGGTTGCAGTATTCCCCAAACCACTGATA ACTCGATTTGTCCGAATCAAGCCTGCAACTTGGGAAACTGGCATATCTATGAGATTTGAA GTATATGGTTGCAAGATAACAGATTATCCTTGCTCTGGAATGTTGGGTATGGTGTCTGGA CTTATTTCTGACTCCCAGATCACATCATCCAACCAAGGGGACAGAAACTGGATGCCTGAA AACATCCGCCTGGTAACCAGTCGCTCTGGCTGGGCACTTCCACCCGCACCTCATTCCTAC ATCAATGAGTGGCTCCAAATAGACCTGGGGGAGGAGAAGATCGTGAGGGGCATCATCATT CAGGGTGGGAAGCACCGAGAGAACAAGGTGTTCATGAGGAAGTTCAAGATCGGGTACAGC AACAACGGCTCGGACTGGAAGATGATCATGGATGACAGCAAACGCAAGGCGAAGTCTTTT GAGGGCAACAACAACTATGATACACCTGAGCTGCGGACTTTTCCAGCTCTCTCCACGCGA TTCATCAGGATCTACCCCGAGAGAGCCACTCATGGCGGACTGGGGCTCAGAATGGAGCTG CTGGGCTGTGAAGTGGAAGCCCCTACAGCTGGACCGACCACTCCCAACGGGAACTTGGTG GATGAATGTGATGACGACCAGGCCAACTGCCACAGTGGAACAGGTGATGACTTCCAGCTC ACAGGTGGCACCACTGTGCTGGCCACAGAAAAGCCCACGGTCATAGACAGCACCATACAA TCAGAGTTTCCAACATATGGTTTTAACTGTGAATTTGGCTGGGGCTCTCACAAGACCTTC TGCCACTGGGAACATGACAATCACGTGCAGCTCAAGTGGAGTGTGTTGACCAGCAAGACG GGACCCATTCAGGATCACACAGGAGATGGCAACTTCATCTATTCCCAAGCTGACGAAAAT CAGAAGGGCAAAGTGGCTCGCCTGGTGAGCCCTGTGGTTTATTCCCAGAACTCTGCCCAC TGCATGACCTTCTGGTATCACATGTCTGGGTCCCACGTCGGCACACTCAGGGTCAAACTG CGCTACCAGAAGCCAGAGGAGTACGATCAGCTGGTCTGGATGGCCATTGGACACCAAGGT GACCACTGGAAGGAAGGGCGTGTCTTGCTCCACAAGTCTCTGAAACTTTATCAGGTGATT TTCGAGGGCGAAATCGGAAAAGGAAACCTTGGTGGGATTGCTGTGGATGACATTAGTATT AATAACCACATTTCACAAGAAGATTGTGCAAAACCAGCAGACCTGGATAAAAAGAACCCA GAAATTAAAATTGATGAAACAGGGAGCACGCCAGGATACGAAGGTGAAGGAGAAGGTGAC AAGAACATCTCCAGGAAGCCAGGCAATGTGTTGAAGACCTTAGACCCCATCCTCATCACC ATCATAGCCATGAGCGCCCTGGGGGTCCTCCTGGGGGCTGTCTGTGGGGTCGTGCTGTAC TGTGCCTGTTGGCATAATGGGATGTCAGAAAGAAACTTGTCTGCCCTGGAGAACTATAAC TTTGAACTTGTGGATGGTGTGAAGTTGAAAAAAGACAAACTGAATACACAGAGTACTTAT TCGGAGGCATGA Clone variation with respect to NM_003873.5 418 a=>c;1161 c=>t;1266 c=>t;2595 t=>c >OriGene 5' read for NM_003873 unedited
CGGCACCAGGGGAAAAGGGAGAGGAAGCCGGAGCTAAATGACAGGATGCAGGCGACTTGA GACACAAAAAGAGAAGCGTTCCTCTCGGATCCAGGCATTGCCTCGCTGCTTTCTTTTCTC CAAGACGGGCTGAGGATTGTACAGCTCTAGGCGGAGTTGGGGCTCTTCGGATCGCTTAGA TTCTCCTCTTTGCTGCATTTCCCCCCACGTCCTCGTTCTCCCGCGTCTGCCTGCGGACCC GGAGAAGGGAGAATGGAGAGGGGGCTGCCGCTCCTCTGCGCCGTGCTCGCCCTCGTCCTC GCCCCGGCCGGCGCTTTTCGCAACGATAAATGTGGCGATACTATAAAAATTGAAAGCCCC GGGTACCTTACATCTCCTGGTTATCCTCATTCTTATCACCCAAGTGAAAAATGCGAATGG CTGATTCAGGCTCCGGACCCATACCAGAGAATTATGATCAACTTCAACCCTCACTTCGAT TTGGAGGACAGAGACTGCAAGTATGACTACGTGGAAGTCTTCGATGGAGAAAATGAANAT GGACATTTTAGGGGAAAGTTCTGTGGAAAGATAGCCCCTCCTCCTGTTGTGTCTTCAGGG CCATTTCTTTNTATCAAATTTGTCTCTGACTACGAAACACATGGTGCAGGATTTTCCATA CGTTATGAACTTTTCAAGAGAGGTCCCTGATGTTCCCAGAACTACCACACACCTAGTGGA GTGATAAAAGTCCCCGGATTCCCTGAAAATACCCNACAGCNCTGATGCACTATATTGCTT TGCGCAAGA >OriGene 3' read for NM_003873 unedited
GAACGCGGCACGCATCTATATCGAGTTTTTTTTTTTTTTTTTTTTACCAGTAAAATGAAA ACATTTTACTACAGAAAGTTTTATAGATTTCCATAAAGAAAAAAATGTTATTTTACACCT TTAAAAATTACAAAACAATCTAAAACAATATAAACTGAACATTTTGTAACACTGCCTTTA CAAATTAATAACTTTATAAACATACAATTTTTAAATATATTTATCAGTGCAAGATACTTT AAATTTTAAAGTTGCAGTATCATTTTTCCTTGGCTGAAGACAACTTTAAGTCTGTTGCCT TTAAAAACAACAAACGAGTGTTTCTTATAGCTTTCCTTCTGGTAGGATTATATCAACTAA ATGAATGTCTCTGGGGACAAAAAACTATTCTTCTTTCATGGAGATCAATATTTTCCTGGA AACAAAAGGCATTCTCAATCCAATTTAACTAAGATGAATGGACTGTCTCATCTATGATGC AAATGTGACTCCCAACAAATGTCTTTGAGTGAGACGTCTAGCAATGTGGGAAGGAAGATC TAAAAAATCTCATGTCCAACATGGCATGATAAAAATCCACCAAAACCAACCAAAGCTTCT TTGGGTTAATTCATAAGCTGCCTGNTAAGATATTAGCTTCCCTGTGCTGTTAGAAGCTTA AATGCTGCCAGCCCTTAAAGCAGTCCTTATTTCTTTGTGAGCCGCTGGGAAGTTCTAGAA ACACTCATTTAAGTCTATCTCTTCAAGCTTGCTGTTATGAATTTTAAAACATTTGTTTGA CTTTATGAGTTTTCCCCCTCTTATCTAAAATACTGACCCCCAAGCTCAAGATTATAGCTT CATTCCTAATTAACAGTCCTTCCTACACTCCCCTGTGGGAACTATTACAAAATAGAAAGT TCTCTGAGCCTTTTTCATATTTGGAAGAAAAATCCAGCCTTTGGATTTGAAAATTATCCG TTCTTCCTCGGCCCATTGAAACCATTAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003873 |
| Insert Size | 5480 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003873.3, NP_003864.3 |
| RefSeq Size | 5890 bp |
| RefSeq ORF | 2772 bp |
| Locus ID | 8829 |
| UniProt ID | O14786 |
| Domains | F5_F8_type_C, CUB, MAM |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Axon guidance |
| Gene Summary | This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020] Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a). |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
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AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice
,James C Dodge, Christopher M Treleaven, Jonathan A Fidler, Mark Hester, Amanda Haidet, Chalonda Handy, Meghan Rao, Amy Eagle, Jennifer C Matthews, Tatyana V Taksir, et al.,
Molecular Therapy (21 September 2010) doi:10.1038/mt.2010.206 Original Article
[NRP1]
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Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway
,Paul Frankel, Caroline Pellet-Many, Pauliina Lehtolainen, Giovanna M D'Abaco, Michelle L Tickner, Lili Cheng, Ian C Zachary,
EMBO reports 9, 983 - 989 (01 Oct 2008), doi: 10.1038/embor.2008.151,
[NRP1]
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Sulfated polysaccharides identified as inducers of Neuropilin-1 internalization and functional inhibition of VEGF165 and Semaphorin3A
,Masashi Narazaki, Marta Segarra, and Giovanna Tosato,
Blood. April 2008; 111(8): p. 4126-4136
[NRP1]
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Tuftsin Binds Neuropilin-1 through a Sequence Similar to That Encoded by Exon 8 of Vascular Endothelial Growth Factor
,Mathew A. von Wronski, Natarajan Raju, Radhakrishna Pillai, Nancy J. Bogdan, Edmund R. Marinelli, Palaniappa Nanjappan, Kondareddiar Ramalingam, Thangavel Arunachalam, Steve Eaton, Karen E. Linder, Feng Yan, Sibylle Pochon, Michael F. Tweedle, and Adrian D. Nunn,
J. Biol. Chem., Vol. 281, Issue 9, 5702-5710, March 3, 2006
[NRP1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217035 | NRP1 (Myc-DDK-tagged)-Human neuropilin 1 (NRP1), transcript variant 1 |
CNY 10,136.00 |
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| RC217035L1 | Lenti ORF clone of Human neuropilin 1 (NRP1), transcript variant 1, Myc-DDK-tagged |
CNY 12,536.00 |
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| RC217035L2 | Lenti ORF clone of Human neuropilin 1 (NRP1), transcript variant 1, mGFP tagged |
CNY 12,536.00 |
|
| RC217035L3 | Lenti ORF clone of Human neuropilin 1 (NRP1), transcript variant 1, Myc-DDK-tagged |
CNY 12,536.00 |
|
| RC217035L4 | Lenti ORF clone of Human neuropilin 1 (NRP1), transcript variant 1, mGFP tagged |
CNY 12,536.00 |
|
| RG217035 | NRP1 (tGFP-tagged) - Human neuropilin 1 (NRP1), transcript variant 1 |
CNY 11,736.00 |
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