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BCL10 (NM_003921) Human Untagged Clone
CAT＃: SC117685
BCL10 (untagged)-Human B-cell CLL/lymphoma 10 (BCL10)
CNY 3,600.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | c-E10; CARMEN; CIPER; CLAP; IMD37; mE10 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC117685 sequence for NM_003921 edited (data generated by NextGen Sequencing)
ATGGAGCCCACCGCACCGTCCCTCACCGAGGAGGACCTCACTGAAGTGAAGAAGGACGCC TTAGAAAATTTACGTGTATACCTGTGTGAGAAAATCATAGCTGAGAGACATTTTGATCAT CTACGTGCAAAAAAAATACTCAGTAGAGAAGACACTGAAGAAATTTCTTGTCGAACATCA AGTAGAAAAAGGGCTGGAAAATTGTTAGACTACTTACAGGAAAACCCAAAAGGTCTGGAC ACCCTTGTTGAATCTATTCGGCGAGAAAAAACACAGAACTTCCTGATACAGAAGATTACA GATGAAGTGCTGAAACTTAGAAATATAAAACTAGAACATCTGAAAGGACTAAAATGTAGC AGTTGTGAACCTTTTCCAGATGGAGCCACGAACAACCTCTCCAGATCAAATTCAGATGAG AGTAATTTCTCTGAAAAACTGAGGGCATCCACTGTCATGTACCATCCAGAAGGAGAATCC AGCACGACGCCCTTTTTTTCTACTAATTCTTCTCTGAATTTGCCTGTTCTAGAAGTAGGC AGAACTGAAAATACCATCTTCTCTTCAACTACACTTCCCAGACCTGGGGACCCAGGGGCT CCTCCTTTGCCACCAGATCTACAGTTAGAAGAAGAAGGAACTTGTGCAAACTCTAGTGAG ATGTTTCTTCCCTTAAGATCACGTACTGTTTCACGACAATGA Clone variation with respect to NM_003921.4 >OriGene 5' read for NM_003921 unedited
NTTATACCCCCGCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATA AGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCC GCGAATTGGCACGAGGGCGGGGCGGCGCAGCCCGAGCTCCCGGACCCGGAAGAAGCGCCA TCTCCCGCCTCCACCATGGAGCCCACCGCACCGTCCCTCACCGAGGAGGACCTCACTGAA GTGAAGAAGGACGCCTTAGAAAATTTACGTGTATACCTGTGTGAGAAAATCATAGCTGAG AGACATTTTGATCATCTACGTGCAAAAAAAATACTCAGTAGAGAAGACACTGAAGAAATT TCTTGTCGAACATCAAGTAGAAAAAGGGCTGGAAAATTGTTAGACTACTTACAGGAAAAC CCAAAAGGTCTGGACACCCTTGTTGAATCTATTCGGCGAGAAAAAACACAGAACTTCCTG ATACAGAAGATTACAGATGAAGTGCTGAAACTTAGAAATATAAAACTAGAACATCTGAAA GGACTAAAATGTAGCAGTTGTGAACCTTTTCCAGATGGAGCCACGAACAACCTCTCCAGA TCAAATTCAGATGAGAGTAATTTCTCTGAAAAACTGAGGGCATCCACTGTCATGTACCAT CCAGAAGGAGAATCCAGCACGACGCCCTTTTTTCTACTAATTCTTCTCTGAAATTGCCTG TTCTAGAAGTAGGCAGAACTGAAAATACCATCTTTCTCTCAACTACACTTTCCCAGACCT GNGGGACCCACGGGCCTCCCTCCCTTGCCACCAGATCTACAGGTAGTAAGAGNAGGAAAC TTGTGCAAACCTCTAGTGAGATGTTTCTTTCCCTTAAGACACGTACTTGTTTACGACATG ACACTTTATTGCCTTTTATTNTTATG >OriGene 3' read for NM_003921 unedited
GGGTTGCCCCAATTTGGAAATTTTATGCGATGGCAATTTCCATTTCTTGTTTTTACAATT AATAATAGAAATTATAGGAGACAATGTCAGGAAACAGATAAAATTGTAATTTAAATAAAA ACAAACAGTGAGAGCATAAGATTTATAAACATGTAAAATTAGTCAAATTTTGTTTTACAA CAAAAAGACAAATCTGGCTAATGGCCCACTTGTTCAAATAGCATTAAAAACAGAATTGTC ACACACACCAAAAATAATTTGTTCCAGTTATTTCAACTGTACATTGGTCCTCATTAAAAG AGAATGAAAAGTACAGAGAAAATATTTTTTAAAAATCTCATCAGGCTAGGTGAGGTGGCT CGTGTCTGTAATCCCAGCACTTTGGGAGGCCACGCTGGGTAGGTTGCTTGAGTCCAGGAG TTCAAGACCAGCCTGGCCAACATGGCAAAACACCGTCTCTACAAAAATAATACAAAAATT AGTGAGGCATGGTGGCACACACTTGTAGTCTCAGCTATATTACTTGAGAGGCTGAGGTGA GAGGATCACGTAAGCATGGGAGGCAGAAGTTGCAGTGAGCCTAGAATGGGCCACTGCACT CCACCCTGGGCGATAGAAGCAGGACTGTCTCAAANAAAAAAAAACCGCTCAAGGAAAAGG GGAAAAATCCCTTATTCAATTACATGTAAATACTGAGGGTTAAGGCCAAAATATTTTTTT TTTGGGATGAAAATTGTTTAACCCCAAGATGGGAAAATTCTTACAAAAGTCTTTTAATTA GGTAGGTTAAATTAGAAATAAATTTTGGCAAACCCAAATTCCTGGGTGGGCAAACACCCC TTAAAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003921 |
| Insert Size | 2250 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003921.2, NP_003912.1 |
| RefSeq Size | 2809 bp |
| RefSeq ORF | 702 bp |
| Locus ID | 8915 |
| UniProt ID | O95999 |
| Domains | CARD |
| Protein Families | Druggable Genome |
| Protein Pathways | B cell receptor signaling pathway, T cell receptor signaling pathway |
| Gene Summary | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
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| RC208752L3 | Lenti ORF clone of Human B-cell CLL/lymphoma 10 (BCL10), Myc-DDK-tagged |
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| RC208752L4 | Lenti ORF clone of Human B-cell CLL/lymphoma 10 (BCL10), mGFP tagged |
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| RG208752 | BCL10 (tGFP-tagged) - Human B-cell CLL/lymphoma 10 (BCL10) |
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