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SOCS3 (NM_003955) Human Untagged Clone
CAT＃: SC117660
SOCS3 (untagged)-Human suppressor of cytokine signaling 3 (SOCS3)
CNY 3,600.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_003955 edited
GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCATTTAGGTGACACTATA GAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGGCTGCCGCTT CGGCCCCGCACGCAGCCAGCCGCCAGCCGCCCGCCCGGCCCAGCTCCCGCCGCGGCCCCT TGCCGCGGTCCCTCTCCTGGTCCCCTCCCGGTTGGTCCGGGGGTGCGCAGGGGGCAGGGC GGGCGCCCAGGGGAAGCTCGAGGGACGCGCGCGCGAAGGCTCCTTTGTGGACTTCACGGC CGCCAACATCTGGGCGCAGCGCGGGCCACCGCTGGCCGTCTCGCCGCCGCGTCGCCTTGG GGACCCGAGGGGGCTCAGCCCCAAGGACGGAGACTTCGATTCGGGACCAGCCCCCCGGGA TGCGGTAGCGGCCGCTGTGCGGAGGCCGCGAAGCAGCTGCAGCCGCCGCCGCGCAGATCC ACGCTGGCTCCGTGCGCCATGGTCACCCACAGCAAGTTTCCCGCCGCCGGGATGAGCCGC CCCCTGGACACCAGCCTGCGCCTCAAGACCTTCAGCTCCAAGAGCGAGTACCAGCTGGTG GTGAACGCAGTGCGCAAGCTGCAGGAGAGCGGCTTCTACTGGAGCGCAGTGACCGGCGGC GAGGCGAACCTGCTGCTCAGTGCCGAGCCCGCCGGCACCTTTCTGATCCGCGACAGCTCG GACCAGCGCCACTTCTTCACGCTCAGCGTCAAGACCCAGTCTGGGACCAAGAACCTGCGC ATCCAGTGTGAGGGGGGCAGCTTCTCTCTGCAGAGCGATCCCCGGAGCACGCAGCCCGTG CCCCGCTTCGACTGCGTGCTCAAGCTGGTGCACCACTACATGCCGCCCCCTGGAGCCCCC TCCTTCCCCTCGCCACCTACTGAACCCTCCTCCGAGGTGCCCGAGCAGCCGTCTGCCCAG CCACTCCCTGGGAGTCCCCCCAGAAGAGCCTATTACATCTACTCCGGGGGCGAGAAGATC CCCCTGGTGTTGAGCCGGCCCCTCTCCTCCAACGTGGCCACTCTTCAGCATCTCTGTCGG AAGACCGTCAACGGCCACCTGGACTCCTATGAGAAAGTCACCCAGCTGCCGGGGCCCATT CGGGAGTTCCTGGACCAGTACGATGCCCCGCTTTAAGGGGTAAAGGGCGCAAAGGGCATG GGTCGGGAGAGGGGACGCAGGCCCCTCTCCTCCGTGGCACATGGCACAAGCACAAGAAGC CAACCAGGAGAGAGTCCTGTAGCTCTGGGGGGAAAGAGGGCGGACAGGCCCCTCCCTCTG CCCTCTCCCTGCAGAATGTGGCAAGCGGACCTGGAATGTGTTGGAGGGAAGGGGGAGTAC CACCTGAGTCTCCAGCTTCTCCGGAAGAGCCAGCTGTCCTGGTGGGACGATAGCAACCAC AAGTGGATTCTCCTTCAATTCCTCAGCTTCCCCTCTG >OriGene 5' read for NM_003955 unedited
NNTTTCTTTCCCCCGCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGNGAGTCTAT ATAAGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCG GCCGCGAATTCGGCACGAGGGCTGCCGCTTCGGCCCCGCACGCAGCCAGCCGCCAGCCGC CCGCCCGGCCCAGCTCCCGCCGCGGCCCCTTGCCGCGGTCCCTCTCCTGGTCCCCTCCCG GTTGGTCCGGGGGTGCGCAGGGGGCAGGGCGGGCGCCCAGGGGAAGCTCGAGGGACGCGC GCGCGAAGGCTCCTTTGTGGACTTCACGGCCGCCAACATCTGGGCGCAGCGCGGGCCACC GCTGGCCGTCTCGCCGCCGCGTCGCCTTGGGGACCCGAGGGGGCTCAGCCCCAAGGACGG AGACTTCGATTCGGGACCAGCCCCCCGGGATGCGGTAGCGGCCGCTGTGCGGAGGCCGCG AAGCAGCTGCAGCCGCCGCCGCGCAGATCCACGCTGGCTCCGTGCGCCATGGTCACCCAC AGCAAGTTTCCCGCCGCCGGGATGAGCCGCCCCCTGGACACCAGCCTGCGCCTCAAGACC TTCAGCTCCAAGAGCGAGTACCAGCTGGTGGTGAACGCAGTGCGCAAGCTGCAGGAGAGC GGCTTCTACTGGAGCGCAGTGACCGGCGGCGAGGCGAACCTGCTGCTCAGTGCCGAGCCC GCCGGCACCTTTCTGATCCGCGACAGCTCGGACCAGCGCCACTTCTTCACGCTCAGCGTC AAGACCCAGTCTGGGACCAAGAACCTGCGCATCCAGTGTGGAGGGGGGCAGCTTCTCTCT GCAGAGCGATCCCCGGAGCACGCAGCCCGTGCCCCGCTTCGACTGCGTGCTCAAGCTGGT GCACCAC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003955 |
| Insert Size | 2900 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003955.3, NP_003946.3 |
| RefSeq Size | 2746 bp |
| RefSeq ORF | 678 bp |
| Locus ID | 9021 |
| UniProt ID | O14543 |
| Domains | SH2, SOCS |
| Protein Families | Druggable Genome |
| Protein Pathways | Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis |
| Gene Summary | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Gprc5a Deletion Enhances the Transformed Phenotype in Normal and Malignant Lung Epithelial Cells by Eliciting Persistent Stat3 Signaling Induced by Autocrine Leukemia Inhibitory Factor
,Yulong Chen, Jiong Deng, Junya Fujimoto, Humam Kadara, Taoyan Men, Dafna Lotan, and Reuben Lotan,
Cancer Res., Nov 2010; 70: 8917 - 8926
[SOCS3]
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|
Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway
,Jeong-Ho Kim, Jae Eun Kim, Hui-Yu Liu, Wenhong Cao, and Jie Chen,
J. Biol. Chem. 2008; 283(2): p. 708-715
[SOCS3]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209305 | SOCS3 (Myc-DDK-tagged)-Human suppressor of cytokine signaling 3 (SOCS3) |
CNY 3,600.00 |
|
| RC209305L1 | Lenti ORF clone of Human suppressor of cytokine signaling 3 (SOCS3), Myc-DDK-tagged |
CNY 6,000.00 |
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| RC209305L2 | Lenti ORF clone of Human suppressor of cytokine signaling 3 (SOCS3), mGFP tagged |
CNY 6,000.00 |
|
| RC209305L3 | Lenti ORF clone of Human suppressor of cytokine signaling 3 (SOCS3), Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC209305L4 | Lenti ORF clone of Human suppressor of cytokine signaling 3 (SOCS3), mGFP tagged |
CNY 6,000.00 |
|
| RG209305 | SOCS3 (tGFP-tagged) - Human suppressor of cytokine signaling 3 (SOCS3) |
CNY 5,200.00 |
