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Caspase 3 (CASP3) (NM_004346) Human Untagged Clone
CAT＃: SC117447
CASP3 (untagged)-Human caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant alpha
CN¥ 2,400.00
CN¥ 2,950.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CPP32; CPP32B; SCA-1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC117447 sequence for NM_004346 edited (data generated by NextGen Sequencing)
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT GACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCA CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA Clone variation with respect to NM_004346.3 >OriGene 5' read for NM_004346 unedited
ATATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGCGCGGCTCCT AGCGGATGGGTGCTATTGTGAGGCGGTTGTGGAAGTTAATAAAGGTATCCATGNGAGAAC ACTNGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATCATACATGG AAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGA GATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGAATGACATC TCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAACTTGAAATA TGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGCGTGATGT TTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGA AGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACAAACTTTTT CAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATTCAGGCCTG CCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGATGACATGGC GTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCACCTGGTTA TTATTCTTGGCGAAATCANAGGATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTG AAACAGTATGCCGGACAGCTTGAAATTATGCACATTCTTACCCGGGTAACCGCAAGGTGG GCACAGAATTTGAGTCCCTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGATTCCAT GGATTGGTTCCATGCTCACCAAAGAACTCTATTTNTATCACTAAAGAAAAGGGTGGNTTG GTGGGGTTTTTT >OriGene 3' read for NM_004346 unedited
ACTATGAACCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTAATTTTAAGTTTGAATGTATATTTTGGAAATAAAAATGGAAAA TAACAAATTTGTACAAAATTGTCACATAAAAACACACTTTAAAATACCATTACATGCTGG GGGTATTTACAAAAGTTACAGGTCTAGTAAAAAAAAAAAAACTGTCATTGACAAATGCGA GCTCATTTTTTGAGCAACAAAAAATCTCCCGTGAAATGTCATACTGACAGCCAGTGAAAC TTGGTGCAGTGACGGCTCCCCACCTGCTGAGGCCTGGAGCCTGCCTCCCGGGCTGAGTGC TCAACTTTGGCCTCCGGCTGGATGCCGTCTAAAGTCCTATGGGCTCATAGGTCTTTTTTT TTCAGTAAACAGTATAAAACATTACTATTTTCCTTTGATTGGAAACTTCAACAGAAAATA ACATACTTAAAAATTTTGCTACAAAAAGTACTATGATTTTTATTGCCTCACCACCTTTAA AACATTTCCACTTCACAAGTTTCTGATTTGCTTCACTTTCTTACTTGGCGATGGCGCCCT GGCAGCATCATCCACACATACCAGTGCGTATGGAAAAATGGGCTGTAGGCCCTTCCTGCG TGGTCCATGGCTCTGCCTTCATGGAACAGGCTGAGTCATGTCTCTGCTCAGGCTCAAACC ATCTACTCTCAAGTTACAGGCAGCTTAGCCCATTCATTTATTGCTTTCCTTATATTCCAC TGTTTATTATTATAAAGTTGGATTTCCATATGTTCCCTATAGAAATTATTCCACATTACC CTGCCTAATAATCCAACAAGTTGGGGGGTTTTTATATAATAGCTCTCAACATTATTGCTG GTTTTTGAAGCCTCACTGAATGCCTAGGGACAATCAAAGTATTTTTGCTTGGAGATCAGG GCATTGTACC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004346 |
| Insert Size | 2740 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004346.3, NP_004337.2 |
| RefSeq Size | 2689 bp |
| RefSeq ORF | 834 bp |
| Locus ID | 836 |
| UniProt ID | P42574 |
| Domains | CASc, ICE_p10, ICE_p20 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protease |
| Protein Pathways | Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis |
| Gene Summary | The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017] Transcript Variant: This variant (1, also known as alpha) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns
,Yoon, S;Park, SJ;Han, JH;Kang, JH;Kim, JH;Lee, J;Park, S;Shin, HJ;Kim, K;Yun, M;Chwae, YJ;,
Cell Death Dis
,PubMed ID 25356863
[CASP3]
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Other Versions
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| RC223662 | CASP3 (Myc-DDK-tagged)-Human caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant alpha |
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| RG223662 | CASP3 (tGFP-tagged) - Human caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant alpha |
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