United States
Germany
Japan
United Kingdom
China
E Cadherin (CDH1) (NM_004360) Human Untagged Clone
CAT＃: SC117413
CDH1 (untagged)-Human cadherin 1, type 1, E-cadherin (epithelial) (CDH1)
CNY 10,984.00
| Cited in 5 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_004360, the custom clone sequence may differ by one or more nucleotides
ACCAGGCTTGCGGAAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGC CTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCT GCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTAC ACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGCA CCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTAC AGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTAC AGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGCCT CCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTCCCAACTCCTCTCCTGGCCTCAGAAGACAGAAGAG AGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAAAGGCCCATTTCCTAAAAACCTGGTTCAG ATCAAATCCAACAAAGACAAAGAAGGCAAGGTTTTCTACAGCATCACTGGCCAAGGAGCTGACACACCCC CTGTTGGTGTCTTTATTATTGAAAGAGAAACAGGATGGCTGAAGGTGACAGAGCCTCTGGATAGAGAACG CATTGCCACATACACTCTCTTCTCTCACGCTGTGTCATCCAACGGGAATGCAGTTGAGGATCCAATGGAG ATTTTGATCACGGTAACCGATCAGAATGACAACAAGCCCGAATTCACCCAGGAGGTCTTTAAGGGGTCTG TCATGGAAGGTGCTCTTCCAGGAACCTCTGTGATGGAGGTCACAGCCACAGACGCGGACGATGATGTGAA CACCTACAATGCCGCCATCGCTTACACCATCCTCAGCCAAGATCCTGAGCTCCCTGACAAAAATATGTTC ACCATTAACAGGAACACAGGAGTCATCAGTGTGGTCACCACTGGGCTGGACCGAGAGAGTTTCCCTACGT ATACCCTGGTGGTTCAAGCTGCTGACCTTCAAGGTGAGGGGTTAAGCACAACAGCAACAGCTGTGATCAC AGTCACTGACACCAACGATAATCCTCCGATCTTCAATCCCACCACGTACAAGGGTCAGGTGCCTGAGAAC GAGGCTAACGTCGTAATCACCACACTGAAAGTGACTGATGCTGATGCCCCCAATACCCCAGCGTGGGAGG CTGTATACACCATATTGAATGATGATGGTGGACAATTTGTCGTCACCACAAATCCAGTGAACAACGATGG CATTTTGAAAACAGCAAAGGGCTTGGATTTTGAGGCCAAGCAGCAGTACATTCTACACGTAGCAGTGACG AATGTGGTACCTTTTGAGGTCTCTCTCACCACCTCCACAGCCACCGTCACCGTGGATGTGCTGGATGTGA ATGAAGCCCCCATCTTTGTGCCTCCTGAAAAGAGAGTGGAAGTGTCCGAGGACTTTGGCGTGGGCCAGGA AATCACATCCTACACTGCCCAGGAGCCAGACACATTTATGGAACAGAAAATAACATATCGGATTTGGAGA GACACTGCCAACTGGCTGGAGATTAATCCGGACACTGGTGCCATTTCCACTCGGGCTGAGCTGGACAGGG AGGATTTTGAGCACGTGAAGAACAGCACGTACACAGCCCTAATCATAGCTACAGACAATGGTTCTCCAGT TGCTACTGGAACAGGGACACTTCTGCTGATCCTGTCTGATGTGAATGACAACGCCCCCATACCAGAACCT CGAACTATATTCTTCTGTGAGAGGAATCCAAAGCCTCAGGTCATAAACATCATTGATGCAGACCTTCCTC CCAATACATCTCCCTTCACAGCAGAACTAACACACGGGGCGAGTGCCAACTGGACCATTCAGTACAACGA CCCAACCCAAGAATCTATCATTTTGAAGCCAAAGATGGCCTTAGAGGTGGGTGACTACAAAATCAATCTC AAGCTCATGGATAACCAGAATAAAGACCAAGTGACCACCTTAGAGGTCAGCGTGTGTGACTGTGAAGGGG CCGCCGGCGTCTGTAGGAAGGCACAGCCTGTCGAAGCAGGATTGCAAATTCCTGCCATTCTGGGGATTCT TGGAGGAATTCTTGCTTTGCTAATTCTGATTCTGCTGCTCTTGCTGTTTCTTCGGAGGAGAGCGGTGGTC AAAGAGCCCTTACTGCCCCCAGAGGATGACACCCGGGACAATGTTTATTACTATGATGAAGAAGGAGGCG GAGAAGAGGACCAGGACTTTGACTTGAGCCAGCTGCACAGGGGCCTGGACGCTCGGCCTGAAGTGACTCG TAACGACGTTGCACCAACCCTCATGAGTGTCCCCCGGTATCTTCCCCGCCCTGCCAATCCCGATGAAATT GGAAATTTTATTGATGAAAATCTGAAAGCGGCTGATACTGACCCCACAGCCCCGCCTTATGATTCTCTGC TCGTGTTTGACTATGAAGGAAGCGGTTCCGAAGCTGCTAGTCTGAGCTCCCTGAACTCCTCAGAGTCAGA CAAAGACCAGGACTATGACTACTTGAACGAATGGGGCAATCGCTTCAAGAAGCTGGCTGACATGTACGGA GGCGGCGAGGACGACTAGGGGACTCGAGAGAGGCGGGCCCCAGACCCATGTGCTGGGAAATGCAGAAATC ATGTTGCTGGTGGTTTTTCAGCTCCCTTCCCTTGAGATGAGTTTCTGG >OriGene 5' read for NM_004360 unedited
GGGTTGCAGNATTTTGTAATACGATTCACTATAGGCGGCCCGCGAATCGGCACCAGGCTT GCGGTAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCG CCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCG CTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCT GGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGC GTCCTGGGCAGAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCC CTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGG TTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTT TCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGCC TCCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTCCCAACTCCTCTCCTGGCCTCAGA AGACAGAAGAGAGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAAAGGCCCA TTTCCTAAAAACCTGGTTCAGATCAAATCCAACAAAGACAAAGAAGGCAAGGTTTTCTAC AGCATCACTGGCCAAGGAGCTGACACACCCCCTGTTGGTGTCTTTATTATTTGAAAGAGA ACAGTATGGCTGAAGGTGACAGAGCCTCTGCATAGAGAACGCACTGCCCCATACACTCTC TTTTCTCACGCTGTGTCATCCAACGGAAATGCCGTTGAGGATCCATGGAGAATTTGATCA CGGTACCGATCAAATGACAACAGCCCGAATCACCG >OriGene 3' read for NM_004360 unedited
TATGGACCGCGGCCGCATCTAAATCGAGTTTTTTTTTTTTTTTTTTAATGGTTTAACAAA ATTGTTTAATAAAATTTATAAAAATGCATCTTTGAGAATACTTTTCTCAGCTTGAATTGT TTTCCTTTTCCACCCCCAAAGAAAATACACAATTATCAGCACCCACACATGTATACACTC AAAACTACAGTGACATTCTCTACACAGAACTATATTCGATATAGCTTGAACTGCCGAAAA ATCAAGACAATTCCAAAAAGTGATTGCAGGGTTGATTTTTTTCTCCAAAACACTCGAGAA ACAGTAAAGCTATTTGAACAAAAGACTTTTGTTTGATTGCCAAAAGTCGAAATCCACATT TAAATGTACCGAGATGCAACGTCCGATGCCCGCTACCCTTTTTCCCCGCCCCACCCCCGT TTTTGGACCCACCCTCTTCACCGTTTTCCCCCCCTTTGTCCTTTTTTTCTTTTGCCTCCC CCCCCCCCCCCCTTTTTCCCCCGCTCCAGCCTAGTTCGCCCGCATATCCCCACCCCGCCC CGCCCATTGTCTCCCGCCTTGTGTGCCCAGCTGCCACCGCCCTACCCCCACTCCCCCGCG TATCTGCCAGATGTTGTTCGCGCGGCGGGGCGTCGCGGGGAGGTGCGCCCCCCGCCCCTC CATTCTGTCGCCGGTTTGCAGTCCCTCTTGTGTGCTTTTTTAGCGCGGGTGGCCTCCGTG GGGCAACCCGCCCACCCGTCCGCCCCTCTTTGTCTCCTCCAGTCTTGTACATAATCTCCA TAGTATGCCCTGAAGTCGTCGCTCCCACCCCCCCGCACCCATTGCGCCCCCTCGCGGTTC TCCCGCCTCATCTTGCCCCACTCCGTCGTCCCGTCGCGTTTCTCAACCAGTGGCGTTCTC ACCCCGCATCATTTCACCGCCCCCTCTTGTCCCAGCCCCCTTTGCTCCACCGCGGTTACG TCAGACCCTCACGTATTCCGCCGTCCGGGCCCTCCCGCTAGCCCACTTGCCGCCCTACG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004360 |
| Insert Size | 5000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004360.2, NP_004351.1 |
| RefSeq Size | 4815 bp |
| RefSeq ORF | 4815 bp |
| Locus ID | 999 |
| UniProt ID | P12830 |
| Domains | Cadherin_C_term, CA |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer |
| Gene Summary | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma
,Giovannini, C;Minguzzi, M;Genovese, F;Baglioni, M;Gualandi, A;Ravaioli, M;Milazzo, M;Tavolari, S;Bolondi, L;Gramantieri, L;,
Oncotarget
,PubMed ID 27167202
[CDH1]
|
|
Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer
,null,
BMC Cancer
,PubMed ID 25879941
[CDH1]
|
|
Nuclear Factor I-C (NFIC) Regulates Dentin Sialophosphoprotein (DSPP) and E-cadherin via Control of Kru00fcppel-like Factor 4 (KLF4) During Dentinogenesis
,null,
The Journal of Biological Chemistry
,PubMed ID 25138274
[CDH1]
|
|
Epigenetic loss of CDH1 correlates with multidrug resistance in human hepatocellular carcinoma cells.
,null,
Biochemical and biophysical research communications
,PubMed ID 22634315
[CDH1]
|
|
Downregulation of E-cadherin is an essential event in activating bold beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells
,Q Wang, Z -X Sun, H Allgayer and H -S Yang,
Oncogene advance online publication 28 September 2009; doi: 10.1038/onc.2009.302
[CDH1]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220731 | CDH1 (Myc-DDK-tagged)-Human cadherin 1, type 1, E-cadherin (epithelial) (CDH1) |
CNY 6,464.00 |
|
| RC220731L1 | Lenti-ORF clone of CDH1 (Myc-DDK-tagged)-Human cadherin 1, type 1, E-cadherin (epithelial) (CDH1) |
CNY 8,864.00 |
|
| RC220731L2 | Lenti-ORF clone of CDH1 (mGFP-tagged)-Human cadherin 1, type 1, E-cadherin (epithelial) (CDH1) |
CNY 11,210.00 |
|
| RC220731L3 | Lenti-ORF clone of CDH1 (Myc-DDK-tagged)-Human cadherin 1, type 1, E-cadherin (epithelial) (CDH1) |
CNY 8,864.00 |
|
| RC220731L4 | Lenti-ORF clone of CDH1 (mGFP-tagged)-Human cadherin 1, type 1, E-cadherin (epithelial) (CDH1) |
CNY 8,864.00 |
|
| RG220731 | CDH1 (tGFP-tagged) - Human cadherin 1, type 1, E-cadherin (epithelial) (CDH1) |
CNY 8,064.00 |
其它E Cadherin产品
