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DUSP1 (NM_004417) Human Untagged Clone
CAT＃: SC117410
DUSP1 (untagged)-Human dual specificity phosphatase 1 (DUSP1)
CNY 3,656.00
| Cited in 3 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CL100; HVH1; MKP-1; MKP1; PTPN10 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004417 edited
GAATTCGGCACGGGCGCAGAGAGACCCGGGGGTCTAGCTTTTCCTCGAAAAGCGCCGCCC TGCCCTTGGCCCCGAGAACAGACAAAGAGCACCGCAGGGCCGATCACGCTGGGGGCGCTG AGGCCGGCCATGGTCATGGAAGTGGGCACCCTGGACGCTGGAGGCCTGCGGGCGCTGCTG GGGGAGCGAGCGGCGCAATGCCTGCTGCTGGACTGCCGCTCCTTCTTCGCTTTCAACGCC GGCCACATCGCCGGCTCTGTCAACGTGCGCTTCAGCACCATCGTGTGGCGCCGGGCCAAG GGCGCCATGGGCCTGGAGCACATCGTGCCCAACGCCGAGCTCCGCGGCCGCCTGCTGGCC GGCGCCTACCACGCCGTGGTGTTGCTGGACGAGCGCAGCGCCGCCCTGGACGGCGCCAAG CGCGACGGCACCCTGGCCCTGGCGGCCGGCGCGCTCTGCCGCGAGGCGCGCGCCGCGCAA GTCTTCTTCCTCAAAGGAGGATACGAAGCGTTTTCGGCTTCCTGCCCGGAGCTGTGCAGC AAACAGTCGACCCCCATGGGGCTCAGCCTTCCCCTGAGTACTAGCGTCCCTGACAGCGCG GAATCTGGGTGCAGTTCCTGCAGTACCCCACTCTACGATCAGGGTGGCCCGGTGGAAATC CTGCCCTTTCTGTACCTGGGCAGTGCGTATCACGCTTCCCGCAAGGACATGCTGGATGCC TTGGGCATAACTGCCTTGATCAACGTCTCAGCCAATTGTCCCAACCATTTTGAGGGTCAC TACCAGTACAAGAGCATCCCTGTGGAGGACAACCACAAGGCAGACATCAGCTCCTGGTTC AACGAGGCCATTGACTTCATAGACTCCATCAAGAATGCTGGAGGAAGGGTGTTTGTCCAC TGCCAGGCAGGCATTTCCCGGTCAGCCACCATCTGCCTTGCTTACCTTATGAGGACTAAT CGAGTCAAGCTGGACGAGGCCTTTGAGTTTGTGAAGCAGAGGCGAAGCATCATCTCTCCC AACTTCAGCTTCATGGGCCAGCTGCTGCAGTTTGAGTCCCAGGTGCTGGCTCCGCACTGT TCGGCAGAGGCTGGGAGCCCCGCCATGGCTGTGCTCGACCGAGGCACCTCCACCACCACC GTGTTCAACTTCCCCGTCTCCATCCCTGTCCACTCCACGAACAGTGCGCTGAGCTACCTT CAGAGCCCCATTACGACCTCTCCCAGCTGCTGAAAGGCCACGGGAGGTGAGGCTCTTCAC ATCCCATTGGGACTCCATGCTCCTTGAGAGGAGAAATGCAATAACTCTGGGAGGGGCTCG AGAGGGCTGGTCCTTATTTATTTAACTTCACCCGAGTTCCTCTGGGTTTCTAAGCAGTTA TGGTGATGACTTAGCGTCAAGACATTTGCTGAACTCAGCACATTCGGGACCAATATATAG TGGGTACATCAAGTCCATCTGACAAAATGGGGCAGAAGAGAAAGGACTCAGTGTGTGATC CGGTTTCTTTTTGCTCGCCCCTGTTTTTTGTAGAATCTCTTCATGCTTGACATACCTACC AGTATTATTCCCGACGACACATATACATATGAGAATATACCTTATTTATTTTTGTGTAGG TGTCTGCCTTCACAAATGTCATTGTCTACTCCTAGAAGAACCAAATACCTCAATTTTTGT TTTTGAGTACTGTACTATCCTGTAAATATATCTTAAGCAGGTTTGTTTTCAGCACTGATG GAAAATACCAGTGTTGGGTTTTTTTTTAGTTGCCAACAGTTGTATGTTTGCTGATTATTT ATGACCTGAAATAATATATTTCTTCTTCTAAGAAGACATTTTGTTACATAAGGATGACTT TTTTATACAATGGAATAAATTATGGCATTTCTATTGAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAACTCGAC >OriGene 5' read for NM_004417 unedited
CAAAATTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACGGGCGCAGAGAGACCC GGGGGTCTAGCTTTTCCTCGAAAGCGCCGCCCTGCCCTTGGCCCCGAGAACAGACAAAGA GCACCGCAGGGCCGATCACGCTGGGGGCGCTGAGGCCGGCCATGGTCATGGAAGTGGGCA CCCTGGACGCTGGAGGCCTGCGGGCGCTGCTGGGGGAGCGAGCGGCGCAATGCCTGCTGC TGGACTGCCGCTCCTTCTTCGCTTTCAACGCCGGCCACATCGCCGGCTCTGTCAACGTGC GCTTCAGCACCATCGTGTGGCGCCGGGCCAAGGGCGCCATGGGCCTGGAGCACATCGTGC CCAACGCCGAGCTCCGCGGCCGCCTGCTGGCCGGCGCCTACCACGCCGTGGTGTTGCTGG ACGAGCGCAGCGCCGCCCTGGACGGCGCCAAGCGCGACGGCACCCTGGCCCTGGCGGCCG GCGCGCTCTGCCGCGAGGCGCGCGCCGCGCAAGTCTTCTTCCTCAAAGGAGGATACGAAG CGTTTTCGGCTTCCTGCCCGGAGCTGTGCAGCAAACAGTCGACCCCCATGGGGCTCAGCC TTCCCCTGAGTACTAGCGTCCCTGACAGCGCGGAATCTGGGTGCAGTTCCTGCAGTACCC CACTCTACGATCAGGGTGGCCCGGTGGAAATCCTGCCCTTTCTGTACCTGGGCAGTGCGT ATCACGCTTCCCGCAGGACATGCTGGATGCCTTGGCATAACTGCCTTGATCAACGTCTCA GCCAATTGTCCCACCATTTTTGGGGTCACTACCAGTACAGAGCATCCCGGTGGGAGACAC CCCCAAGCAGACTCAGCTCCTGGTTAACGAGCCATTGACTCATAACTCATCAGAGCTGAG GAAAGGGGGGTGGTCCACTGCAGCAGCATTCN >OriGene 3' read for NM_004417 unedited
AATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCAATAAAAATGCCA TAATTTATTCCATTGTATAAAAAAGTCATCCTTATGTAACAAAATGTCTTCTTAAAAAAA AAAATATATTATTTCAGGTCATAAATAATCAGCAAACATACAACTGTTGGCAACTAAAAA AAAACCCAACACTGGTATTTTCCATCAGGGCTGAAAACAAACCTGCTTAAAATATATTTA CAGGATAGTACAGTCCTCAAAAACAAAAATTGAGGTATTTGGTTCTTCTAGGAGTAAACA ATGACATTTGTGAAGGCAAACCCCTACACAAAAATAAATAAGGTATATTCTCATATGTAT ATGGGCCGCCGGGAATAATACTGGTAGGTATGTCAAGCATGAAAAGATTCTACAAAAAAC AGGGGCGAGCAAAAAGAAACCGGATCACACACTGAGTCCTTTCTCTTCTGCCCCATTTTG TCAAATGGACTTGATGTACCCACTATATATTGGTCCCGAATGTGCTGAGTTCAGCAAATG TCTTGACGCTAAGTCATCACCATAACTGCTTAGAAACCCAGAGGAACTCGGGTGAAGTTA AATAAATAAGGACCAGCCCTCTAGAGCCCTTCCCAGATTATTGCATTTCTCCTCTCAAGA GCATGGAGTCCCAATGGGATGTGAAGAGCCTCACCTCCCGTGGCCTTTCANCAGCTGGGA AAAGGTCCTAATGGGGCTCTGAAGGTANCTCACCCCCCTTGTTCTGGAGTGAACAGGGAT GGAACCGGGAANTTAACANCGGGGTGGTGGAGGTGCTTCGTCCAACCAGCCTGCGGGGCT CCCACCTTTGCCAAAGTGCGAACCACACCTGGACTTAATGCNACACTGCCCATGAATTAA TTGGGAAATTATCTCCTCTTGTTAAAAATAAAGGCTTGCCACTTGCTCCATATCCCTAAG GAACAAGCAAATGGGCTACCGAAATCCTCTGAATG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004417 |
| Insert Size | 1104 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004417.2, NP_004408.1 |
| RefSeq Size | 2015 bp |
| RefSeq ORF | 1104 bp |
| Locus ID | 1843 |
| UniProt ID | P28562 |
| Domains | DSPc, RHOD, PTPc_motif |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | MAPK signaling pathway |
| Gene Summary | The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection
,Robitaille, AC;Caron, E;Zucchini, N;Mukawera, E;Adam, D;Mariani, MK;Gélinas, A;Fortin, A;Brochiero, E;Grandvaux, N;,
Sci Rep
,PubMed ID 29234123
[DUSP1]
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DUSP1 promotes apoptosis and suppresses cell migration, while leaving the JIP1-protected cytokine production intact, during paramyxovirus infection
,Robitaille, AC;Caron, E;Zucchini, N;Mukawera, E;Adam, D;Mariani, MK;Gélinas, A;Fortin, A;Brochiero, E;Grandvaux, N;,
bioRxiv
[DUSP1]
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Progesterone Receptor Inhibits Proliferation of Human Breast Cancer Cells via Induction of MAPK Phosphatase 1 (MKP-1/DUSP1)
,Chien-Cheng Chen, Daniel B. Hardy, and Carole R. Mendelson,
J. Biol. Chem., Dec 2011; 286: 43091 - 43102.
[DUSP1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205220 | DUSP1 (Myc-DDK-tagged)-Human dual specificity phosphatase 1 (DUSP1) |
CNY 3,656.00 |
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| RC205220L1 | Lenti ORF clone of Human dual specificity phosphatase 1 (DUSP1), Myc-DDK-tagged |
CNY 6,056.00 |
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| RC205220L2 | Lenti ORF clone of Human dual specificity phosphatase 1 (DUSP1), mGFP tagged |
CNY 5,890.00 |
|
| RC205220L3 | Lenti ORF clone of Human dual specificity phosphatase 1 (DUSP1), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC205220L4 | Lenti ORF clone of Human dual specificity phosphatase 1 (DUSP1), mGFP tagged |
CNY 6,056.00 |
|
| RG205220 | DUSP1 (tGFP-tagged) - Human dual specificity phosphatase 1 (DUSP1) |
CNY 5,256.00 |
