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Axin 2 (AXIN2) (NM_004655) Human Untagged Clone
CNY 6,184.00
货期*
现货
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AXIL; ODCRCS |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>SC117255 representing NM_004655.
Blue=Insert sequence Red=Cloning site Green=Tag(s) CTCGCCGGGCGCCTGCCCCCTCCTCGGGGGCAAAGGCTTTGTGACCAAGCAGACGACGAAGCATGTCCA CCACCACTACATCCACCACCATGCCGTCCCCAAGACCAAGGAGGAGATCGAGGCGGAGGCCACGCAGCG GGTGCACTGCTTCTGCCCTGGGGGCAGCGAGTATTACTGCTACTCGAAATGCAAAAGCCACTCCAAGGC TCCGGAAACCATGCCCAGCGAGCAGTTTGGCGGCAGCAGAGGCAGTACCTTGCCCAAACGCAATGGGAA AGGCACGGAGCCGGGCCTGGCCCTGCCCGCCAGGGAAGGAGGGGCCCCCGGCGGAGCTGGGGCCCTGCA GCTTCCCCGGGAGGAAGGAGACAGGTCGCAGGATGTCTGGCAGTGGATGCTGGAGAGTGAGCGGCAGAG CAAGCCCAAGCCCCATAGTGCCCAAAGCACAAAAAAGGCCTACCCCTTGGAGTCTGCCCGCTCGTCTCC AGGCGAACGAGCCAGCCGGCACCATCTGTGGGGGGGCAACAGCGGGCACCCCCGCACCACCCCCCGTGC CCACCTGTTCACCCAGGACCCTGCGATGCCTCCCTTGACCCCACCCAACACGCTGGCTCAGCTGGAGGA GGCCTGTCGCAGGCTAGCTGAGGTGTCGAAGCCCCCAAAGCAGCGGTGCTGTGTGGCCAGTCAGCAGAG GGACAGGAATCATTCGGCCACTGTTCAGACGGGAGCCACACCCTTCTCCAATCCAAGCCTGGCTCCAGA AGATCACAAAGAGCCAAAGAAACTGGCAGGTGTCCACGCGCTCCAGGCCAGTGAGTTGGTTGTCACTTA CTTTTTCTGTGGGGAAGAAATTCCATACCGGAGGATGCTGAAGGCTCAGAGCTTGACCCTGGGCCACTT TAAAGAGCAGCTCAGCAAAAAGGGAAATTATAGGTATTACTTCAAAAAAGCAAGCGATGAGTTTGCCTG TGGAGCGGTGTTTGAGGAGATCTGGGAGGATGAGACGGTGCTCCCGATGTATGAAGGCCGGATTCTGGG CAAAGTGGAGCGGATCGATTGAGCCCTGGGGTCTGGCTTTGGTGAACTGTTGGAGCCCGAAGCTCTTGT GAACTGTCTTGGCTGTGAGCAACTGCGACAAAACATTTTGAAGGAAAATTAAACCAATGAAGAAGACAA AGTCTAAGGAAGAATCGGCCAGTGGGCCTTCGGGAGGGCGGGGGGAGGTTGATTTTCATGATTCATGAG CTGGGTACTGACTGAGATAAGAAAAGCCTGAACTATTTATTAAAAACATGACCACTCTTGGCTATTGAA GATGCTGCCTGTATTTGAGAGACTGCCATACATAATATATGACTTCCTAGGGATCTGAAATCCATAAAC TAAGAGAAACTGTGTATAGCTTACCTGAACAGGAATCCTTACTGATATTTATAGAACAGTTGATTTCCC CCATCCCCAGTTTATGGATATGCTGCTTTAAACTTGGAAGGGGGAGACAGGAAGTTTTAATTGTTCTGA CTAAACTTAGGAGTTGAGCTAGGAGTGCGTTCATGGTTTCTTCACTAACAGAGGAATTATGCTTTGCAC TACGTCCCTCCAAGTGAAGACAGACTGTTTTAGACAGACTTTTTAAAATGGTGCCCTACCATTGACACA TGCAGAAATTGGTGCGTTTTGTTTTTTTTTTTCCTATGCTGCTCTGTTTTGTCTTAAAGGTCTTGAGGG TTGACCATGTTGCGTCATCATCAACATTTTGGGGGTTGTGTTGGATGGGATGATCTGTTGCAGAGGGAG AGGCAGGGAACCCTGCTCCTTCGGGCCCCAGGTTGATCCTGTGACTGAGGCTCCCCCTCATGTAGCCTC CCCAGGCCCAGGGCCCTGAGGCCTGCTAGAATCACTGCCGCTGTGCTTTCGTGGAAATGACAGTTCCTT GTTTTTTTTGTTTCTGTTTTTGTTTTACATTAGTCATTGGACCACAGCCATTCAGGAACTACCCCCTGC CCCACAAAGAAATGAACAGTTGTAGGGAGACCCAGCAGCACCTTTCCTCCACACACCTTCATTTTGATG TTCGGGTTTTTGTGTTAAGTTAATCTGTACATTCTGTTTGCCATTGTTACTTGTACTATACATCTGTAT ATAGTGTACGGCAAAAGAGTATTAATCCACTATCTCTAGTGCTTGACTTTAAATCAGTACAGTACCTGT ACCTGCACGGTCACCCGCTCCGTGTGTCGCCCTATATTGAGGGCTCAAGCTTTCCCTTGTTTTTTGAAA GGGGTTTATGTATAAATATATTTTATGCCTTTTTATTACAAGTCTTGTACTCAATGACTTTTGTCATGA CATTTTGTTCTACTTATACTGTAAATTATGCATTATAAAGAGTTCATTTAAGGAAAATTACTTGGTACA ATAATTATTGTAATTAAGAGATGTAGCCTTTATTAAAATTTTATATTTTTCAAAA >OriGene 5' read for NM_004655 unedited
TGGCGGCACAGCAATTCGGCACGAGGGCCCGAGTAGCCGGGNAAATAAAAATAACCCCTC AGAGCGATGGATTTCGGGGCCGCCCGGCGGCCGAGGCGCCCGCCGAAGGCCCTGCTGTAA AAGAGAGGAGGTTCAGATGAGCCCCTGCTGACTTGAGAGAGACAGAGAGACCACGCCGAT TGCTGAGAGGTACTATGAAGAAGAAAAATTCCCAGACTCAGTGGGAAGAGCTCCCTCACC ATGAGTAGCGCTATGTTGGTGACTTGCCTCCCGGACCCCAGCAGCAGCTTCCGTGAGGAT GCCCCGCGGCCCCCAGTGCCAGGGGAAGAAGGGGAGACCCCACCGTGTCAGCCAGGGATG GGCAAGGGCCAGGTCACCAAACCCATGCCTGTCTCTTCCAACACCAGGCGGAACGAAGAT GGGTTGGGGGAGCCGGAGGGGCGGGCATCTCCGGATTCCCCTCTGACCCGGTGGACCAAG TCCTTACACTCCTTATTGGGCGATCAAGACGGTGCTTACCTGTTCCGAACTTACTCGGAG AGGGAGAAATGCGTGGATACCTTAAACTTCTGGTTTGCCTGCAATGGATTCAGGCAGATG AACCTGAACGATACCCAAACTTTTCCAGGTGGCAAAGCGATACTACAAAAGGTACTTTGG GAACAACAGCATTGTTTTCAAACGATTTAAGCCTGCCCCAAAACCTACTTAAAGAAGGCA TCAAGGAGCAGCAGGATGGTTCCCTCAATGTTATCCACGCCCCAGACCTGGATTCCACTC GCGGATTGGGAGGACAATGCCCTTCCACAGTTGCTGGGCCTCTTGTTTTTTCTCCTCGAT TTTCGTGGGGGCGGCGGCGAAAACACCCTTTTCTTTCG >OriGene 3' read for NM_004655 unedited
TAGCTCTGGACCGCGGCACGCAATCTAGTGATCGGTTTTTTTTTTTTTTTTTTGAAAAAA TAAAATTTTAATAAAGGCTACATCTCTTAATTACAATAATTATTGTACCAAGTAATTTTC CTTAAATGAACTCTTTATAATGCATAATTTACAGTATAAGTAGAACAAAATGTCATGACA AAAGTCATTGAGTACAAGACTTGTAATAAAAAGGCATAAAATATATTTATACATAAACCC CTTTCAAAAAACAAGGGAAAGCTTGAGCCCTCAATATAGGGCGACACACGGAGCGGGTGA CCGTGCAGGTACAGGTACTGTACTGATTTAAAGTCAAGCACTAGAGATAGTGGATTAATA CTCTTTTGCCGTACACTATATACAGATGTATAGTACAAGTAACAATGGCAAACAGAATGT ACAGATTAACTTAACACAAAAACCCGAACATCAAAATGAAGGTGTGTGGAGGAAAGGTGC TGCTGGGTCTCCCTACAACTGTTCATTTCTTTGTGGGGCAGGGGGTAGTTCCTGAATGGC TGTGGTCCAATGACTAATGTAAAACAAAAACAGAAACAAAAAAAACAAGGAACTGTCATT TCCACGAAAGCACAGCGGCAGTGATTCTAGCAGGCCTCAGGGCCCTGGGCCTGGGGAGGC TACATGAGGGGGAGCCTCAGTCACAGGATCAACCTGNGGCCCGAATGAGCAGGGTTCCCT GCCTCTCCCTCTGCAACAGATCATCCCATCCAACACAACCCCCAAATGTTGATGATGACG CAACATGGTCAACCCTCAAGACCTTTAAGACAAACAGAGCAGCCTAGGAAAAAAAAAACA AAACGCACCAATTTCTGCATGTGTCAATGGTAGGGCACCATTTTAAAAAGTCTGTCTAAA CAGTCTGTCTCACCTGGNAGGACGANTGCAAGCATAATTCTCTGTTATGAAGAACATGAA CCACCCTAGCTAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004655 |
| Insert Size | 4156 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004655.2 |
| RefSeq Size | 4259 bp |
| RefSeq ORF | 4156 bp |
| Locus ID | 8313 |
| UniProt ID | Q9Y2T1 |
| Domains | RGS, DAX |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells |
| Protein Pathways | Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Wnt signaling pathway |
| MW | 153.3 kDa |
| Gene Summary | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210931 | AXIN2 (Myc-DDK-tagged)-Human axin 2 (AXIN2) |
CNY 6,176.00 |
|
| RC210931L3 | Lenti ORF clone of Human axin 2 (AXIN2), Myc-DDK-tagged |
CNY 8,576.00 |
|
| RC210931L4 | Lenti ORF clone of Human axin 2 (AXIN2), mGFP tagged |
CNY 8,576.00 |
|
| RG210931 | AXIN2 (tGFP-tagged) - Human axin 2 (AXIN2) |
CNY 7,776.00 |
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