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LATS1 (NM_004690) Human Untagged Clone
CAT＃: SC117200
LATS1 (untagged)-Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1)
CNY 11,808.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | WARTS; wts |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_004690 edited
ATGAAGAGGAGTGAAAAGCCAGAAGGATATAGACAAATGAGGCCTAAGACCTTTCCTGCC AGTAACTATACTGTCAGTAGCCGGCAAATGTTACAAGAAATTCGGGAATCCCTTAGGAAT TTATCTAAACCATCTGATGCTGCTAAGGCTGAGCATAACATGAGTAAAATGTCAACCGAA GATCCTCGACAAGTCAGAAATCCACCCAAATTTGGGACGCATCATAAAGCCTTGCAGGAA ATTCGAAACTCTCTGCTTCCATTTGCAAATGAAACAAATTCTTCTCGGAGTACTTCAGAA GTTAATCCACAAATGCTTCAAGACTTGCAAGCTGCTGGATTTGATGAGGATATGGTTATA CAAGCTCTTCAGAAAACTAACAACAGAAGTATAGAAGCAGCAATTGAATTCATTAGTAAA ATGAGTTACCAAGATCCTCGACGAGAGCAGATGGCTGCAGCAGCTGCCAGACCTATTAAT GCCAGCATGAAACCAGGGAATGTGCAGCAATCAGTTAACCGCAAACAGAGCTGGAAAGGT TCTAAAGAATCCTTAGTTCCTCAGAGGCATGGCCCGCCACTAGGAGAAAGTGTGGCCTAT CATTCTGAGAGTCCCAACTCACAGACAGATGTAGGAAGACCTTTGTCTGGATCTGGTATA TCAGCATTTGTTCAAGCTCACCCTAGCAACGGACAGAGAGTGAACCCCCCACCACCACCT CAAGTAAGGAGTGTTACTCCTCCACCACCTCCAAGAGGCCAGACTCCCCCTCCAAGAGGT ACAACTCCACCTCCCCCTTCATGGGAACCAAACTCTCAAACAAAGCGCTATTCTGGAAAC ATGGAATACGTAATCTCCCGAATCTCTCCTGTCCCACCTGGGGCATGGCAAGAGGGCTAT CCTCCACCACCTCTCAACACTTCCCCCATGAATCCTCCTAATCAAGGACAGAGAGGCATT AGTTCTGTTCCTGTTGGCAGACAACCAATCATCATGCAGAGTTCTAGCAAATTTAACTTT CCATCAGGGAGACCTGGAATGCAGAATGGTACTGGACAAACTGATTTCATGATACACCAA AATGTTGTCCCTGCTGGCACTGTGAATCGGCAGCCACCACCTCCATATCCTCTGACAGCA GCTAATGGACAAAGCCCTTCTGCTTTACAAACAGGGGGATCTGCTGCTCCTTCGTCATAT ACAAATGGAAGTATTCCTCAGTCTATGATGGTGCCAAACAGAAATAGTCATAACATGGAA CTATATAACATTAGTGTACCTGGACTGCAAACAAATTGGCCTCAGTCATCTTCTGCTCCA GCCCAGTCATCCCCGAGCAGTGGGCATGAAATCCCTACATGGCAACCTAACATACCAGTG AGGTCAAATTCTTTTAATAACCCATTAGGAAATAGAGCAAGTCACTCTGCTAATTCTCAG CCTTCCGCTACAACAGTCACTGCAATTACACCAGCTCCTATTCAACAGCCTGTGAAAAGT ATGCGTGTATTAAAACCAGAGCTACAGACTGCTTTAGCACCTACACACCCTTCTTGGATA CCACAGCCAATTCAAACTGTTCAACCCAGTCCTTTTCCTGAGGGAACCGCTTCAAATGTG ACTGTGATGCCACCTGTTGCTGAAGCTCCAAACTATCAAGGACCACCACCACCCTACCCA AAACATCTGCTGCACCAAAACCCATCTGTTCCTCCATACGAGTCAATCAGTAAGCCTAGC AAAGAGGATCAGCCAAGCTTGCCCAAGGAAGATGAGAGTGAAAAGAGTTATGAAAATGTT GATAGTGGGGATAAAGAAAAGAAACAGATTACAACTTCACCTATTACTGTTAGGAAAAAC AAGAAAGATGAAGAGCGAAGGGAATCTCGTATTCAAAGTTATTCTCCTCAAGCATTTAAA TTCTTTATGGAGCAACATGTAGAAAATGTACTCAAATCTCATCAGCAGCGTCTACATCGT AAAAAACAATTAGAGAATGAAATGATGCGGCTGATTTAAACTTTTATGGTGTTGGAAGCT TTGCTGACTTCTGTAGTCTCCATTACTGTGTAGGTTGGATTATCTCAAGATGCCCAGGAT CAAATGAGAAAGATGCTTTGCCAAAAAGAATCTAATTACATCCGTCTTAAAAGGGCTAAA ATGGACAAGTCTATGTTTGTGAAGATAAAGACACTAGGAATAGGAGCATTTGGTGAAGTC TGTCTAGCAAGAAAAGTAGATACTAAGGCTTTGTATGCAACAAAAACTCTTCGAAAGAAA GATGTTCTTCTTCGAAATCAAGTCGCTCATGTTAAGGCTGAGAGAGATATCCTGGCTGAA GCTGACAATGAATGGGTAGTTCGTCTATATTATTCATTCCAAGATAAGGACAATTTATAC TTTGTAATGGACTACATTCCTGGGGGTGATATGATGAGCCTATTAATTAGAATGGGCATC TTTCCAGAAAGTCTGGCACGATTCTACATAGCAGAACTTACCTGTGCAGTTGAAAGTGTT CATAAAATGGGTTTTATTCATAGAGATATTAAACCTGATAATATTTTGATTGATCGTGAT GGTCATATTAAATTGACTGACTTTGGCCTCTGCACTGGCTTCAGATGGACACACGATTCT AAGTACTATCAGAGTGGTGACCATCCACGGCAAGATAGCATGGATTTCAGTAATGAATGG GGGGATCCCTCAAGCTGTCGATGTGGAGACAGACTGAAGCCATTAGAGCGGAGAGCTGCA CGCCAGCACCAGCGATGTCTAGCACATTCTTTGGTTGGGACTCCCAATTATATTGCACCT GAAGTGTTGCTACGAACAGGATACACACAGTTGTGTGATTGGTGGAGTGTTGGTGTTATT CTTTTTGAAATGTTGGTGGGACAACCTCCTTTCTTGGCACAAACACCATTAGAAACACAA ATGAAGGTTATCAACTGGCAAACATCTCTTCACATTCCACCACAAGCTAAACTCAGTCCT GAAGCTTCTGATCTTATTATTAAACTTTGCCGAGGACCCGAAGATCGCTTAGGCAAGAAT GGTGCTGATGAAATAAAAGCTCATCCATTTTTTAAAACAATTGATTTCTCCAGTGACCTG AGACAGCAGTCTGCTTCATACATTCCTAAAATCACACACCCAACAGATACATCAAATTTT GATCCTGTTGATCCTGATAAATTATGGAGTGATGATAACGAGGAAGAAAATGTAAATGAC ACTCTCAATGGATGGTATAAAAATGGAAAGCATCCTGAACATGCATTCTATGAATTTACC TTCCGAAGGTTTTTTGATGACAATGGCTACCCATATAATTATCCGAAGCCTATTGAATAT GAATACATTAATTCACAAGGCTCAGAGCAGCAGTCGGATGAAGATGATCAAAACACAGGC TCAGAGATTAAAAATCGCGATCTAGTATATGTTTAACACACTAGTAAATAAATGTAATGA GGATTTGTAAAAGGGCCTGAAATGCGAGGTGTTTTGAGGTTCTGAGAGTAAAATTATGCA AATATGACAGAGCTATATATGTGTGCTCTGTGTACAATATTTTATTTTCCTAAATTATGG GAAATCCTTTTAAAATGTTAATTTATTCCAGCCGTTTAAATCAGTATTTAGAAAAAAATT GTTATAAGGAAAGTAAATTATGAACTGAATATTATAGTCAGTTCTTGGTACTTAAAGTAC TTAAAATAAGTAGTGCTTTGTTTAAAAGGAGAAACCTGGTATCTATTTGTATATATGCTA AATAATTTTAAAATACAAGAGTTTTTGAAATTTTTTTGAAAGACAGTTTTAGTTTTATCT TGCTTTAACCAAATATGAAACATACCCCCTATTTTACAGAGCTCTTTTTTCCCCTCATAA CCTCGTTTTTGGTAGAAAATAAGCTAGAGAAATTAAGCCATCGTGTTGGTGAGTGTTCCT AGGCTAATGATAATCTGTATAATTCACATCCTGAAACTAAGGAATACAGGGTTGAAAAAA TATTAATATGTTTGTCAGAAGGAAAAATAATGCATTTATCTTCCCCCCCCACCCCCCGCC CCATGGAATATTTAATCTATTTAATCTTCTTGCATTTATTTCTCAAGAATTACTGGCTTT AAAAGAAGCCAAAGCACTACTAGCTTTTTTTCCATATTGGTATTTTTGATGCTGCTTCCA ATTTTAAAAGGGAACAAAGCTGCCATAAATCGAAATGTTCAATACTAAAAGCTAAAATAT TTCTCACCATCCTAAGCAGATAATTATTTTAATTTTCATATACTTTTCCTGTATAGTAAC TATTTTGATTATATCATCAATGTTACCTGTTTCCTCTTTCAGAACAGTGCTGCATATACA GATTGTTATTGGCAAAGGAAAATCTGGCTATCTGGCAATATTTTACCTAAGCGCAGATTA ATTGGTGAAAAAATTAACTCTTAAGATGGCCATTAATAATTAGGAAAGTTTACAGAGTGG TCTTAGTAGAAAATTCAAGTCCTCCTAATTTATTTAAGGTTCAATAATGCGTTCAACATG CCTGTTATGTATAACGCTTAGGTTCTAAGGAAGATTAAGGTTTCATACCAAAATACATGT AGCTTATCTTTTAGGAAGGGGAAAAAGGCTCCATTTTGACCATAGTAAAATTTGTGTTGT GTTTTATTTCCTTTTCTTAAGCTCCACTGATAAGGGATTGTTTTTATCAAAAGTTACTAT TTGTAGATTGGAGGCATAATTTTAGTGATTTTCATACTTTTAGCTTTCTTCGCATAAAAG CTAATTGAAACCGTATATGTAGTAAAATTAAAGGCAGAGCTGTTGCAGTTGAATTGGAGA GTCAGGGCAAAGAACACTTATTAGCCCACACTTCCCACCTTTCTACAGGTGGTCCTTTCA GAGCTCAGCCTGGAAAACCCACTACTGTGTTATCGTGCGTCTTTTGGGGTTAGTGGKTCT TTTGAGAATCTGAAGGAAGCTGTGGACTCTTCCTAGAAAAAAAAACCACACATACACATA CAATGTTGCATGCAGTTTCAAGGGATTTTGGACATATTGAAACCTATCACAGGCTGTAGG TTATGGACCTCTGTGCCATGAGAAAATTGATACATTAAACTAAGAACTTTGTTTTTAACT TACCAATCACTACTCAGCACATCTTATATAAGCTGATAATTTGTGATGGAAAAGGTCTGT AGCATGTGATATAAGGTGACCTTATGAATGCCTCTCTTGCTGGTACATTAAGTTGTTTTA ATATATCATTTGGAGGGGACTGAAATGTTAGGCTCATTACAAGCTTGATACAGAAATATT TCTGAAGGATTTCTAATCAGAATTGTAAAACAATGTGCTATCATGAAATCGCAGTCTTCA CCTCATGGTTCATGGAACATTTGGTTAGTCCCATAAAATCCTATGCAAAACAAAGTAGTT CAAGAATTTTTAGGTGGGTAGTCACATTTATAAGGTATTCCTCTTACTCTTTGGGCTTTT TCAGTCTGATTTATTTAAATTTTCATTTAGTTGTTTTACTTTTGGACTAAGGTGCAATAC AGTAGAAGATAACTTCGTTACATTTATGTTGTAGGAAAACTAAGGTGCTGTCTCCTCCCC CTTCCCTTCCCACAAAATCTGTATTCCCCCTATTGCTGAAATGTAACAGACACTACAAAT TTTGTATTCTTTTTTTGTTTTTTGTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCTGG AGGGCAGTGGCGCTTCACAGCTCACTGCATCCTCAACCTTGGGGGCTCACGCAGTCCTCC CGCCTCAGCCTCCCAAGTAGCTGGGCATGCGCCACCAAGCCCAGCTAATGTTTGTATCTT TAGTAGAGATGGGGTTTCGCCATGTTGCCCAGGTTGGTGTGGAATTCCTGGGCTCCAGTT ATATGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGACCCACCGCGCCTGGC GCAAATATGTATTCTTTTAAAATTTCCTCTGATACTATAAGCTTTTTGCATTTATCTGAA GCAGTATACATGCCTTTGGTATCAGCAATTTTAACAGTTTGGATATACTTATCAGCTATC TTATTCCAAAACTACATCTACTTCTTCCAGTATAGAATCTGGTGCTTCCTGACCAAAAAG ATGAGAAAAACAATGTTAAAAATATAGATGCTTTCCATTGAAATGGAGTGAAAACATTGG TTCTATATGTTTTCTTTTAAAATAATTTTCTTATTAAAAACTTGCTGTCTTTATTATACT TACCCTTTTTATGCATATCAATAGTATTTATAAGATGTGTTCTATAATTATGTAATTGTA GATACTGTTATGCATTGTCCAGTGACATCATAAGGCAGGCCCTACTGCTGTATCTTTTCT ACTTTCTTATTTGTAATAGAAACTATAGAATGTATGACTAAAAAGTCACTTTGAGATTGA CTTTTTTAAAAAGTTATTACCTTCTGCTGTTGCAAAGTGCAAAACTGTGAGTGGAATTGT TTTATTCTGACTTAATGTGTTAGAAATTAGAGAATACAGTGGGAGGATTTTTAGACATTG CTGCTGCTGTTACCCAAGGTATTTTAGATAAAAAATTTTAAATAAACATCCCTTTGGTAT TTAAAGTGGAACATTTAGCCTGTTCATTTTAATCTAAAGCAAAAAGTAATTTGGGTCAAA ATATTGGTATATTTGTAAAGCGCCTTAATATATCCCTTTGTGGAAGGCACTACACAGTTT ACTTTTATATTGTATTGTGTATATAAGTATTTTGTATTAAAATTGAATCAGTGGCAACAT TAAAGTTTTATAAAATCATGCTTTGTTAGAAAAAGAATTACAGCTTTGCAATATAACTAA TTGTTTTGCATAATTCTGAATGTAATAGATATGAATAATCAGCCTGTGTTTTTAATGAAC TTACTTTGTATTTTCCCAATCATTTTCTCTAGTGTAATGTTTGCTGGGATAATAAAAAAA ATTCAAATCTTTCAAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCGGTCATA GCTGTTTCCTGAACAGATCCCGGGTGGCATCCCTGTGACCCCTCCCCAGTGCCTCTCCGG CCCGAG >OriGene 5' read for NM_004690 unedited
GTCAGATTTTGTAATACGACTTACTATAGGGCGGCCGCGAAATTCGCACCAGGCGGCGGC GGCGGTGGCCTGGTGTTAAGGGGAGAGCCAGGTCCTTACGACCCCTGGGACGGGCCGCGC TGGCCCGCGGCAGCCCCCCCGTTCGTCTCCCCGCTCTGCCCCACCAGGGATACTTGGGGT TGCTGGGACGGACTCTGGCCGCCTCAGCGTCCGCCCTCAGGCCCGTGGCCGCTGTCCAGG AGCTCTGCTCTCCCCTCCAGAGTTAATTATTTATATTGTAAAGAATTTTAACAGTCCTGG GGACTTCCTTGAAGCATCATTTTCACTTTTGCTCAGAAGAAAGCTCTGGATCTATCAAAT AAAGAAGTCCTTCGTGTGGGCTACATATATAGATGTTTTCATGAAGAGGAGTGAAAAGCC AGAAGGATATAGACAAATGAGGCCTAAGACCTTTCCTGCCAGTAACTATACTGTCAGTAG CCGGCAAATGTTACAAGAAATTCGGGAATCCCTTAGGAATTTATCTAAACCATCTGATGC TGCTAAGGCTGAGCATAACATGAGTAAAATGTCAACCGAAGATCCTCGACAAGTCAGAAA TCCACCCAAATTTGGGACGCATCATAAAGCCTTGCAGGAAATTCGAAACTCTCTGCTTCC ATTTGCAAATGAAACAAATTCTTCTCGGAGTACTTCAGAAGTTAATCCACAAATGCTTCA AGACTTGCAAGCTGCTGGATTTGATGAGGATATGGTTATACAAGCTCTTCAGAAACTAAC ACAGAATATAGAAGCAGCAATTGAATCATTAGTAAATGAGTACCAAGATCCTCGACGAGA GCAGATGCTGCAGCAGCTGCCAGACCTATTATGCCAGCATGAAACCGGGGATGTGCAGNC ATCAGTTAACCGCANACAGAGCTGGAAAGGGTCTAAAGATNCCTATTCCTCAGAGCATGG NCCGCCN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004690 |
| Insert Size | 4700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004690.2, NP_004681.1 |
| RefSeq Size | 4756 bp |
| RefSeq ORF | 3393 bp |
| Locus ID | 9113 |
| UniProt ID | O95835 |
| Domains | UBA, pkinase |
| Protein Families | Druggable Genome, Protein Kinase |
| Gene Summary | The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017] Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Actin-binding and Cell Proliferation Activities of Angiomotin Family Members are Regulated by Hippo Pathway-mediated Phosphorylation
,Chan, SW;Lim, CJ;Guo, F;Tan, I;Leung, T;Hong, W;,
J. Biol. Chem.
,PubMed ID 24225952
[LATS1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223650 | LATS1 (Myc-DDK-tagged)-Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) |
CNY 11,800.00 |
|
| RC223650L1 | Lenti-ORF clone of LATS1 (Myc-DDK-tagged)-Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) |
CNY 14,200.00 |
|
| RC223650L2 | Lenti-ORF clone of LATS1 (mGFP-tagged)-Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) |
CNY 13,210.00 |
|
| RC223650L3 | Lenti-ORF clone of LATS1 (Myc-DDK-tagged)-Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) |
CNY 14,200.00 |
|
| RC223650L4 | Lenti-ORF clone of LATS1 (mGFP-tagged)-Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) |
CNY 14,200.00 |
|
| RG223650 | LATS1 (tGFP-tagged) - Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) |
CNY 13,400.00 |
|
| SC323703 | LATS1 (untagged)-Kinase deficient mutant (K734M) of Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) |
CNY 21,850.00 |
