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LONP1 (NM_004793) Human Untagged Clone
CAT＃: SC117111
LONP1 (untagged)-Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein
CNY 10,304.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CODASS; hLON; LON; LonHS; LONP; PIM1; PRSS15 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_004793, the custom clone sequence may differ by one or more nucleotides
ATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGC TGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCAGCGGACCTGCGA CGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGGGGCCAATGGCGGGGGTTTTGGGAA GCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAG CCGGCGGCGCGGGGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGAT CCCCGATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAG ATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATG TCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCA CACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGA CACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACA AGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGA GCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCAC GAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCA TTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAA CCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTG GAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCA AGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCA GGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAG TTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCA AGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTC CATCCCTTGGGGCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGAC CACTACGGCATGGAGGACGTCAAGAAACGCATCCTGGAGTTCATTGCCGTTAGCCAGCTCCGCGGCTCCA CCCAGGGCAAGATCCTCTGCTTCTATGGCCCCCCTGGCGTGGGTAAGACCAGCATTGCTCGCTCCATCGC CCGCGCCCTGAACCGAGAGTACTTCCGCTTCAGCGTCGGGGGCATGACTGACGTGGCTGAGATCAAGGGC CACAGGCGGACCTACGTGGGCGCCATGCCCGGGAAGATCATCCAGTGTTTGAAGAAGACCAAGACGGAGA ACCCCCTGATCCTCATCGACGAGGTGGACAAGATCGGCCGAGGCTACCAGGGGGACCCGTCGTCGGCACT GCTGGAGCTGCTGGACCCAGAGCAGAATGCCAACTTCCTGGACCACTACCTGGACGTGCCCGTGGACTTG TCCAAGGTGCTGTTCATCTGCACGGCCAACGTCACGGACACCATCCCCGAGCCGCTGCGAGACCGTATGG AGATGATCAACGTGTCGGGCTACGTGGCCCAGGAGAAGCTGGCCATTGCGGAGCGCTACCTGGTGCCCCA GGCTCGCGCCCTGTGTGGCTTGGATGAGAGCAAGGCCAAGCTGTCATCGGACGTGCTGACGCTGCTCATC AAGCAGTACTGCCGCGAGAGCGGTGTCCGCAACCTGCAGAAGCAAGTGGAGAAGGTGTTACGGAAATCGG CCTACAAGATTGTCAGCGGCGAGGCCGAGTCCGTGGAGGTGACGCCCGAGAACCTGCAGGACTTCGTGGG GAAGCCCGTGTTCACCGTGGAGCGCATGTATGACGTGACACCGCCCGGCGTGGTCATGGGGCTGGCCTGG ACCGCAATGGGAGGCTCCACGCTGTTTGTGGAGACATCCCTGAGACGGCCACAGGACAAGGATGCCAAGG GTGACAAGGATGGCAGCCTGGAGGTGACAGGCCAGCTGGGGGAGGTGATGAAGGAGAGCGCCCGCATAGC CTACACCTTCGCCAGAGCCTTCCTCATGCAGCACGCCCCCGCCAATGACTACCTGGTGACCTCACACATC CACCTGCATGTGCCCGAGGGCGCCACCCCCAAGGACGGCCCAAGCGCAGGCTGCACCATCGTCACGGCCC TGCTGTCCCTGGCCATGGGCAGGCCTGTCCGGCAGAATCTGGCCATGACTGGCGAAGTCTCCCTCACGGG CAAGATCCTGCCTGTTGGTGGCATCAAGGAGAAGACCATTGCGGCCAAGCGCGCAGGGGTGACGTGCATC GTCCTGCCAGCCGAGAACAAGAAGGACTTCTACGACCTGGCAGCCTTCATCACCGAGGGCCTGGAGGTGC ACTTCGTGGAACACTACCGGGAGATCTTCGACATCGCCTTCCCGGACGAGCAGGCAGAGGCGCTGGCCGT GGAACGGTGA >OriGene 5' read for NM_004793 unedited
GTAACGTCAAAATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACCAGTGGCG GCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCG ATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGC CAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGG GGCCAATGGCGGGGGTTTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGC GAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGGGGGGCAGCGCGGGC GCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCG CACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATC GAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCT TATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTG GATGAAATCTACCACACGGNGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGA CAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGT GGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTNCAAGCGGGG CAAGAAGGAGGCGGAAGACGAGCTGAGCGCCGGCACCCGGCGGAGCTGGCGATGGAGCCC ACCCTGAGCTCCCGGCTGAGTGCTCAGGTTGGAGGTAGAAAACGTTGTCCA >OriGene 3' read for NM_004793 unedited
CTTGGACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTACGGCAAAGGACTTTAATCATTAAATACCTTTTAT GCCACACTTTGATTAACCCCACTGAGGCCCCTGGGATCTGGGTCACTGGACCAAACTGCT CGCTCGGGGGCTCCACTGCCAGGTCCGGGCCCCCTCCCCACAGCGCTAATTTTTGGCCCA AACAGGGCCTGACATCCCCCCCCTGCAGTCCCGGGGGGGCCGTCACCGTTCCACGGCCAG CGCCTTTGCCTGTTTTTCCGGAAAGGCAATGTCAAAAATCTCCCGGTAGTGTTCCACAAA GGGCACCTCCAGGCCCTCGGGGATAAAGGCTGCCAGGTCAAAAAAATCCTTTTTGTTTTC GGTTGGCAGGACAATGCACGTCACCCCTGCCCCCTTGGCCGAAATGGTTTTTTCCTTGAT GCCACCAACAGGCAGGATCTTGCCCGGGAGGGAAACTTCCCCAGTCATGGCCAAATTTTG CCGGACAGGCCTGCCCATGGCCAGGGACAACAGGGCCGTAACAATGGGGCAACCTGCCCT TGGGCCGTCCTTGGGGGGGGCCCCCTCGGGCCATGCAGGGGGATGTGTGAGGCCCCAGGT ATTATTGGCGGGGGGCGTGCTGCATAGAGGAGGCTCTGGCCAAGGTTAGGCTATGCGGGC GCTTTCCTTATCACCCCCCCAGGTGGCCTGTCACTCCAGCTGGCATCCTTGCACCCTTGC ATCCTTGGCTTGGGGCCGTTAAAGGGATGCCCCCAAAACGGGGGAACCTCCCTTGGNGGT CCGGCCAACCCATACACCCGGGGGGGGGTGACATTTAAATGCCCTCCCGGGGAACCGGCT CCCCAAAAACCCGGGGTTTTTGGGCGACCTCCCAGGTCTGCCTCGCGGTGAATTTTTAGG CCTATTCCAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004793 |
| Insert Size | 3460 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004793.1, NP_004784.1 |
| RefSeq Size | 3221 bp |
| RefSeq ORF | 2814 bp |
| Locus ID | 9361 |
| UniProt ID | P36776 |
| Domains | LON, AAA, AAA |
| Protein Families | Druggable Genome, Protease |
| Gene Summary | This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis
,Luo, B;Wang, M;Hou, N;Hu, X;Jia, G;Qin, X;Zuo, X;Liu, Y;Luo, K;Song, W;Wang, K;Pang, M;,
Neoplasia
,PubMed ID 27108387
[LONP1]
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Other Versions
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|---|---|---|---|
| RC200359 | LONP1 (Myc-DDK-tagged)-Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein |
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| RC200359L1 | Lenti ORF clone of Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein, Myc-DDK-tagged |
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| RC200359L2 | Lenti ORF clone of Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein, mGFP tagged |
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| RC200359L3 | Lenti ORF clone of Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein, Myc-DDK-tagged |
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| RC200359L4 | Lenti ORF clone of Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein, mGFP tagged |
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| RG200359 | LONP1 (tGFP-tagged) - Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein |
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| SC318414 | LONP1 (untagged)-Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein |
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| SC320641 | LONP1 (untagged)-Human lon peptidase 1, mitochondrial (LONP1), nuclear gene encoding mitochondrial protein |
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