United States
Germany
Japan
United Kingdom
China
PRCP (NM_005040) Human Untagged Clone
CAT＃: SC116956
PRCP (untagged)-Human prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 1
CNY 3,656.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HUMPCP; PCP |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_005040 edited
GAATTCGGCACGAGGGTCTCCAGCCTGAGCCATGGGCCGCCGAGCCCTCCTGCTCCTGCT TCTGTCTTTTCTGGCGCCCTGGGCCACCATAGCCCTCCGGCCGGCCTTAAGGGCCCTCGG CAGCCTACACTTGCCAACCAACCCCACATCCCTCCCGGCTGTAGCCAAGAACTATTCGGT TCTCTACTTCCAACAGAAGGTTGATCATTTTGGATTTAATACTGTGAAAACTTTTAATCA GCGGTACCTAGTAGCTGATAAATACTGGAAGAAAAATGGTGGATCAATACTTTTCTACAC TGGTAATGAAGGGGACATTATCTGGTTTTGTAATAACACGGGGTTCATGTGGGATGTGGC TGAGGACCTGAAAGCTATGTTGGTGTTTGCTGAACATCGATACTATGGAGAGTCTCTCCC CTTTGGTGACAACTCATTCAAGGATTCCAGACACTTGAATTTCCTGACATCAGAACAAGC TCTGGCTGATTTTGCAGAGTTAATCAAACACTTGAAAAGAACAATCCCAGGAGCTGAAAA TCAACCTGTCATTGCCATAGGAGGCTCCTATGGTGGCATGCTTGCCGCCTGGTTTAGGAT GAAATATCCTCATATGGTAGTTGGAGCTCTTGCAGCTTCTGCCCCTATCTGGCAGTTTGA GGATTTAGTACCTTGTGGTGTATTTATGAAGATCGTAACTACAGATTTTAGGAAAAGCGG TCCACATTGTTCAGAGAGCATCCACAGGTCCTGGGATGCCATTAATCGACTCTCAAATAC TGGCAGTGGTTTGCAGTGGCTTACTGGAGCCCTTCACTTATGCAGCCCATTAACTTCTCA GGACATCCAACATTTGAAAGACTGGATCTCTGAAACCTGGGTGAATCTGGCAATGGTGGA CTATCCTTATGCCTCTAACTTTTTACAGCCTTTGCCTGCTTGGCCTATCAAGGTAGTGTG CCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTTCCAAGC TCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGC AACTAGCAGTCTGGGAACACTGGGTTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCC CTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACT TTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTAT GTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGA CCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCAT CTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGT GCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGA CAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTC ACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATC ATTAGATTTGATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGT GTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAAGAATCT TCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGC TTTTCATAAGAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGT TTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACACAAAGTA AAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATC CAGGAAGTGAGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAAT AAATAATACAGCTGGACCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_005040 unedited
GGGTGTCANAATTGTAAACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGTCTCCA GCCTGAGCCTGGGCCGCCGAGCCCTCCTGCTCCTGCTTCTGTCTTTTCTGGCGCCCTGGG CCACCATAGCCCTCCGGCCGGCCTTAAGGGCCCTCGGCAGCCTACACTTGCCAACCAACC CCACATCCCTCCCGGCTGTAGCCAAGAACTATTCGGTTCTCTACTTCCAACAGAAGGTTG ATCATTTTGGATTTAATACTGTGAAAACTTTTAATCAGCGGTACCTAGTAGCTGATAAAT ACTGGAAGAAAAATGGTGGATCAATACTTTTCTACACTGGTAATGAAGGGGACATTATCT GGTTTTGTAATAACACGGGGTTCATGTGGGATGTGGCTGAGGACCTGAAAGCTATGTTGG TGTTTGCTGAACATCGATACTATGGAGAGTCTCTCCCCTTTGGTGACAACTCATTCAAGG ATTCCAGACACTTGAATTTCCTGACATCAGAACAAGCTCTGGCTGATTTTGCAGAGTTAA TCAAACACTTGAAAAGAACAATCCCAGGAGCTGAAAATCAACCTGTCATTGCCATAGGAG GCTCCTATGGTGGCATGCTTGCCGCCTGGTTTAGGATGAAATATCCTCATATGGTAGTTG GAGCTCTTGCAGCTTCTGCCCCTATCTGGCAGTTTGAGGATTTAGTACCTTGGTGGTGTA TTTATGAAAGATCGTAACTACAGATTNTAGGAAAAGCGGTCCACATTGTTCAGAGAGCAT NCACAGGTCCTGGGATGCCATTAATCGACTCTCAAATACTGGCAGTGGTTTTGCAGTGGC TTACTGGAGCCCTTCCTTATGCAGCCCATTAACTTCTCAGGACTCCACATTTGAAGNATG G >OriGene 3' read for NM_005040 unedited
GGGGCGGCCGAANGNNNGNTCTCCCTTCNNNNNNNNGNNTTGCGTAGNCNCNCGGACCCG CATTTTANGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTAAAGGGCCCGCTGTTTTATTTATTTACCGCACAGTTCAAAGTCTTTAA ATCCGGGCCAAAAAAAAGGGCTCTCACTTCCTGGATGGGCCCCAAACATCCTACCAGCTG CAATTACATCATTTTTTATCTATCTTTTGCTTTTACTTTGGGGAGGGTAGGGAGGGGGAC TTACAAAGGGGCCAAAAACCCTTTAACCTCAAAACCAAAAAAAAATCTTTGCTTGCAAAA ATACAAAAAAAGTAACTCTCCCTTTTATGAAAAGCACCCCGGAACTCTTCTCCAGTTATG AGGGCCCCTGATGGGGGGGGAAAGCTATCAAAAAAATTCTTCCTAAACGGGGGGCAAAGA CAGGGAAAACCCAGGAAATCCATTCATGGGACACTTGCTCTTACCGTCATCACCCTCTAT TTTATCTCAACTTTGGCCCCATCAAATCTAATGATAAACAAAAGAAGGTAATTACCTGTA AAAAACCAAAGTGAATGGGAATGTGGTGGGTGTGAACCTAAAAGAAAAAATTGAAAACAC TCAAAAGTTTCTCAGTGCTGCTTTCCCCGCCCTGTCATAAGAAATCTCTTGACCCAATTT TTCATATGGCTTACCTTCCAAGGAGCGGGCTTAACAGCCCAAACATTTGATCCCAGGGCT TTTTTGGTGCGGAAAACTAAAGGGGGGGGCCCCCTTTGAGATGGGGACTGCACCCCAGGG GCGGGGAAACCCTTAGCTCACCCCCCTCCTGCCCAGGGGTTTATTTCCCCTTGGTGAAAA CAAGTGTGGGGGGGAACCAGGGTTTTGCCCCCATCCAAANAAGGACCCCGGAGGCCTTTG TTCTCCCCCCCCTGTGAAAACGCCTTCAAAAGGCCCTTTTAGTCCCTGGGGGGGGCCA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005040 |
| Insert Size | 2140 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_005040.2, NP_005031.1 |
| RefSeq Size | 2161 bp |
| RefSeq ORF | 1491 bp |
| Locus ID | 5547 |
| UniProt ID | P42785 |
| Domains | abhydrolase |
| Protein Families | Druggable Genome, Protease, Transmembrane |
| Gene Summary | This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Transcript Variant: This variant (1) encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200677 | PRCP (Myc-DDK-tagged)-Human prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 1 |
CNY 3,656.00 |
|
| RC200677L3 | Lenti ORF clone of Human prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC200677L4 | Lenti ORF clone of Human prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG200677 | PRCP (tGFP-tagged) - Human prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 1 |
CNY 5,256.00 |
