United States
Germany
Japan
United Kingdom
China
c Fos (FOS) (NM_005252) Human Untagged Clone
CAT＃: SC116873
FOS (untagged)-Human FBJ murine osteosarcoma viral oncogene homolog (FOS)
CNY 5,488.00
| Cited in 4 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AP-1; C-FOS; p55 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_005252 edited
GAATTCGGCACGAGGTGCCTAACCGCCACGATGATGTTCTCGGGCTTCAACGCAGACTAC GAGGCGTCATCCTCCCGCTGCAGCAGCGCGTCCCCGGCCGGGGATAGCCTCTCTTACTAC CACTCACCCGCAGACTCCTTCTCCAGCATGGGCTCGCCTGTCAACGCGCAGGACTTCTGC ACGGACCTGGCCGTCTCCAGTGCCAACTTCATTCCCACGGTCACTGCCATCTCGACCAGT CCGGACCTGCAGTGGCTGGTGCAGCCCGCCCTCGTCTCCTCTGTGGCCCCATCGCAGACC AGAGCCCCTCACCCTTTCGGAGTCCCCGCCCCCTCCGCTGGGGCTTACTCCAGGGCTGGC GTTGTGAAGACCATGACAGGAGGCCGAGCGCAGAGCATTGGCAGGAGGGGCAAGGTGGAA CAGTTATCTCCAGAAGAAGAAGAGAAAAGGAGAATCCGAAGGGAAAGGAATAAGATGGCT GCAGCCAAATGCCGCAACCGGAGGAGGGAGCTGACTGATACACTCCAAGCGGAGACAGAC CAACTAGAAGATGAGAAGTCTGCTTTGCAGACCGAGATTGCCAACCTGCTGAAGGAGAAG GAAAAACTAGAGTTCATCCTGGCAGCTCACCGACCTGCCTGCAAGATCCCTGATGACCTG GGCTTCCCAGAAGAGATGTCTGTGGCTTCCCTTGATCTGACTGGGGGCCTGCCAGAGGTT GCCACCCCGGAGTCTGAGGAGGCCTTCACCCTGCCTCTCCTCAATGACCCTGAGCCCAAG CCCTCAGTGGAACCTGTCAAGAGCATCAGCAGCATGGAGCTGAAGACCGAGCCCTTTGAT GACTTCCTGTTCCCAGCATCATCCAGGCCCAGTGGCTCTGAGACAGCCCGCTCCGTGCCA GACATGGACCTATCTGGGTCCTTCTATGCAGCAGACTGGGAGCCTCTGCACAGTGGCTCC CTGGGGATGGGGCCCATGGCCACAGAGCTGGAGCCCCTGTGCACTCCGGTGGTCACCTGT ACTCCCAGCTGCACTGCTTACACGTCTTCCTTCGTCTTCACCTACCCCGAGGCTGACTCC TTCCCCAGCTGTGCAGCTGCCCACCGCAAGGGCAGCAGCAGCAATGAGCCTTCCTCTGAC TCGCTCAGCTCACCCACGCTGCTGGCCCTGTGAGGGGGCAGGGAAGGGGAGGCAGCCGGC ACCCACAAGTGCCACTGCCCGAGCTGGTGCATTACAGAGAGGAGAAACACATCTTCCCTA GAGGGTTCCTGTAGACCTAGGGAGGACCTTATCTGTGCGTGAAACACACCAGGCTGTGGG CCTCAAGGACTTGAAAGCATCCATGTGTGGACTCAAGTCCTTACCTCTTCCGGAGATGTA GCAAAACGCATGGAGTGTGTATTGTTCCCAGTGACACTTCAGAGAGCTGGTAGTTAGTAG CATGTTGAGCCAGGCCTGGGTCTGTGTCTCTTTTCTCTTTCTCCTTAGTCTTCTCATAGC ATTAACTAATCTATTGGGTTCATTATTGGAATTAACCTGGTGCTGGATATTTTCAAATTG TATCTAGTGCAGCTGATTTTAACAATAACTACTGTGTTCCTGGCAATAGTGTGTTCTGAT TAGAAATGACCAATATTATACTAAGAAAAGATACGACTTTATTTTTTGGTAGATAGAAAT AAATAGCTATATCCATGTACTGTAGTTTTTCTTCAACATCAATGTTCATTGTAATGTTAC TGATCATGCATTGTTGAGGTGGTCTGAATGTTCTGACATTAACAGTTTTCCATGAAAACG TTTTATTGTGTTTTTAATTTATTTATTAAGATGGATTCTCAGATATTTATATTTTTATTT TATTTTTTTCTACCTTGAGGTCTTTTGACATGTGGAAAGTGAATTTGAATGAAAAATTTA AGCATTGTTTGCTTATTGTTCCAAGACATTGTCAATAAAAGCATTTAAGTTGAATGCGAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_005252 unedited
CTTGGATTTGTAACCGACTTTATATAGGCGGCCGCGCAATTCGCACGAGGTGCCTAACCG CCACGATGATGTTCTCGGGCTTCAACGCAGACTACGAGGCGTCATCCTCCCGCTGCAGCA GCGCGTCCCCGGCCGGGGATAGCCTCTCTTACTACCACTCACCCGCAGACTCCTTCTCCA GCATGGGCTCGCCTGTCAACGCGCAGGACTTCTGCACGGACCTGGCCGTCTCCAGTGCCA ACTTCATTCCCACGGTCACTGCCATCTCGACCAGTCCGGACCTGCAGTGGCTGGTGCAGC CCGCCCTCGTCTCCTCTGTGGCCCCATCGCAGACCAGAGCCCCTCACCCTTTCGGAGTCC CCGCCCCCTCCGCTGGGGCTTACTCCAGGGCTGGCGTTGTGAAGACCATGACAGGAGGCC GAGCGCAGAGCATTGGCAGGAGGGGCAAGGTGGAACAGTTATCTCCAGAAGAAGAAGAGA AAAGGAGAATCCGAAGGGAAAGGAATAAGATGGCTGCAGCCAAATGCCGCAACCGGAGGA GGGAGCTGACTGATACACTCCAAGCGGAGACAGACCAACTAGAAGATGAGAAGTCTGCTT TGCAGACCGAGATTGCCAACCTGCTGAAGGAGAAGGAAAAACTAGAGTTCATCCTGGCAG CTCACCGACCTGCCTGNCAGATCCCTGATGACCTGNGCTTCCCAGAAGAGATGTCTGTGG CTTCCCTTGATCTGACTGGNGGCCTGCCAGAAGTTGCCACCCCGGAGTCTGNNAGAGCCT TCACCCTGCCTCTCCCTCATGACCCTGAGCCCCAGCCCTCAGTGGAACCCTGTCAGAGCA TCAGCAGCATGGAGCTGAAGACCGAGCCCTTTGATGACTTTCTGGTCCCAGCATCATCCA GGCCCAATGGCTCTGAAACAGCC >OriGene 3' read for NM_005252 unedited
CACTTAAATAGCTTTTTTGACATGTCTTGGNACAATAAGCAAACAATGCTTAAATTTTTC ATTCAAATNACTTTCCACATGTCAAAAGACCTCAAGGTAGAAAAAAATAAAATAAAAATA TAAATATCTGAGAATCCATCTTAATAAATAAATTAAAAACACAATAAAACGTTTTCATGG AAAACTGTTAATGTCAGAACATTCAGACCACCTCAACAATGCATGATCAGTAACATTACA ATGAACATTGATGTTGAAGAAAAACTACAGTACATGGATATAGCTATTTATTTCTATCTA CCAAAAAATAAAGTCGTATCTTTTCTTAGTATAATATTGGTCATTTCTAATCAGAACACA CTATTGCCAGGAACACAGTAGTTATTGTTAAAATCAGCTGCACTAGATACAATTTGAAAA TATCCAGCACCAGGTTAATTCCAATAATGAACCCAATAGATTAGTTAATGCTATGAGAAG ACTAAGGAGAAAGAGAAAAGAGACACAGACCCAGGCCTGGCTCAACATGCTACTAACTAC CAGCTCTCTGAAGTGTCACTGGGAACAATACACACTCCATGCGTTTTGCTACATCTCCGG AAGATGTAAAGACTTGAGTCCACACATGGATGCTTTCAAGTCCTTGAGGCCCACAGCCTG GTGTGTTTCACGCACAGATAATGTCCTCCCTATGTCTACAGGAACCCTCTAGGGAAGATG TGTTTCTCCTCTCTGTAATGCACCAGCTCGGGCAGTGGCACTTGTAGGTGCCAGCTGCCT CCNCTTNCCCTGCCCCTCACATGCCANCATCGTGGGTGAGCTGAGCGAGTCANAAGAATG CTCATTGCTGCTGCTGCCCTTGCNGTGGGCATCTGCACAGCTGGGGAAAGAGTCANCCTC GGGGGTAGTGAAAACCAATGGAGACGTGTTATCAGTGCAGCTGGGAGTACAGTGACCACC GNATGCCAAGGNGCTCACTCTGTGCCATGGGCCAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005252 |
| Insert Size | 2190 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | A TrueClone. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005252.2, NP_005243.1 |
| RefSeq Size | 2084 bp |
| RefSeq ORF | 1143 bp |
| Locus ID | 2353 |
| UniProt ID | P01100 |
| Domains | BRLZ |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | B cell receptor signaling pathway, Colorectal cancer, MAPK signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway |
| Gene Summary | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008] |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
,Liu, R;Zhang, T;Zhu, G;Xing, M;,
Nat Commun
,PubMed ID 29422527
[FOS]
|
|
The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS
,Ting, CH;Huang, HN;Huang, TC;Wu, CJ;Chen, JY;,
Biomaterials, Jan 2014.
,PubMed ID 24477193
[FOS]
|
|
The Nuclear Import of Oncoprotein Hepatitis B X-interacting Protein Depends on Interacting with c-Fos and Phosphorylation of Both Proteins in Breast Cancer Cells
,Yingyi Zhang, Yu Zhao, Hang Li, Yinghui Li, Xiaoli Cai, Yu Shen, Hui Shi, Leilei Li, Qian Liu, Xiaodong Zhang, and Lihong Ye,
J. Biol. Chem., Jun 2013; 288: 18961 - 18974.
,PubMed ID 23667255
[FOS]
|
|
Latency of Epstein–Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA
,Kuan-Ping Yu, Lee Heston, Richard Park, Zhaowei Ding, Ruth Wang’ondu, Henri-Jacques Delecluse, and George Miller,
PNAS, May 2013; 110: 8176 - 8181.
,PubMed ID 23625009
[FOS]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202597 | FOS (Myc-DDK-tagged)-Human FBJ murine osteosarcoma viral oncogene homolog (FOS) |
CNY 5,488.00 |
|
| RC202597L1 | Lenti ORF clone of Human FBJ murine osteosarcoma viral oncogene homolog (FOS), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC202597L2 | Lenti ORF clone of Human FBJ murine osteosarcoma viral oncogene homolog (FOS), mGFP tagged |
CNY 5,890.00 |
|
| RC202597L3 | Lenti ORF clone of Human FBJ murine osteosarcoma viral oncogene homolog (FOS), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC202597L4 | Lenti ORF clone of Human FBJ murine osteosarcoma viral oncogene homolog (FOS), mGFP tagged |
CNY 7,888.00 |
|
| RG202597 | FOS (tGFP-tagged) - Human FBJ murine osteosarcoma viral oncogene homolog (FOS) |
CNY 7,088.00 |
