United States
Germany
Japan
United Kingdom
China
IMPA1 (NM_005536) Human Untagged Clone
CAT＃: SC116674
IMPA1 (untagged)-Human inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1), transcript variant 1
CNY 2,400.00
CNY 2,950.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IMP; IMPA; MRT59 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC116674 sequence for NM_005536 edited (data generated by NextGen Sequencing)
ATGGCTGATCCTTGGCAGGAATGCATGGATTATGCAGTAACTCTAGCAAGACAAGCTGGA GAGGTAGTTTGTGAAGCTATAAAAAATGAAATGAATGTTATGCTGAAAAGTTCTCCAGTT GATTTGGTAACTGCTACGGACCAAAAAGTTGAAAAAATGCTTATCTCTTCCATAAAGGAA AAGTATCCATCTCACAGTTTCATTGGTGAAGAATCTGTGGCAGCTGGGGAAAAAAGTATC TTAACCGACAACCCCACATGGATCATTGACCCTATTGATGGAACAACTAACTTTGTACAT AGATTTCCTTTTGTAGCTGTTTCAATTGGCTTTGCTGTAAATAAAAAGATAGAATTTGGA GTTGTGTACAGTTGTGTGGAAGGCAAGATGTACACTGCCAGAAAAGGAAAAGGTGCCTTT TGTAATGGTCAAAAACTACAAGTTTCACAACAAGAAGATATTACCAAATCTCTCTTGGTG ACTGAGTTGGGCTCTTCCAGAACACCAGAGACTGTGAGAATGGTTCTTTCTAATATGGAA AAGCTTTTTTGCATTCCTGTTCATGGGATCCGGAGTGTTGGAACAGCAGCTGTTAATATG TGCCTTGTGGCAACTGGCGGAGCAGATGCATATTATGAAATGGGAATTCACTGCTGGGAT GTTGCAGGAGCTGGCATTATTGTTACTGAAGCTGGTGGCGTGCTAATGGATGTTACAGGT GGACCATTTGATTTGATGTCACGAAGAGTAATTGCTGCAAATAATAGAATATTAGCAGAA AGGATAGCTAAAGAAATTCAGGTTATACCTTTGCAACGAGACGACGAAGATTAA Clone variation with respect to NM_005536.3 >OriGene 5' read for NM_005536 unedited
TTCGGATTTGTATACGACTCCTATAGGGCGGCCGCGAATCGGCACGAGGCTCTACCTCCG GAAGAGACGAGTGCGGTAACACCGTTCACAGAGCTAGCCGGACGTCCTCCGACTCAAGAT ATTTGTCAAATATTTTCAGAAGATGGCTGATCCTTGGCAGGAATGCATGGATTATGCAGT AACTCTAGCAAGACAAGCTGGAGAGGTAGTTTGTGAAGCTATAAAAAATGAAATGAATGT TATGCTGAAAAGTTCTCCAGTTGATTTGGTAACTGCTACGGACCAAAAAGTTGAAAAAAT GCTTATCTCTTCCATAAAGGAAAAGTATCCATCTCACAGTTTCATTGGTGAAGAATCTGT GGCAGCTGGGGAAAAAAGTATCTTAACCGACAACCCCACATGGATCATTGACCCTATTGA TGGAACAACTAACTTTGTACATAGATTTCCTTTTGTAGCTGTTTCAATTGGCTTTGCTGT AAATAAAAAGATAGAATTTGGAGTTGTGTACAGTTGTGTGGAAGGCAAGATGTACACTGC CAGAAAAGGAAAAGGTGCCTTTTGTAATGGTCAAAAACTACAAGTTTCACAACAAGAAGA TATTACCAAATCTCTCTTGGTGACTGAGTTGNGCTCTTCCAGAACACCAGAGACTGTGAG AATGGNTCTTTCTAATATGGAAAAGCCTTTTTGCATTCCTGTTCATGGGATCCGGAGTGT TGGAACAGCAGCTGTTAATATGTGCCTTGTGGGCACTGGCGGAGCAGATGCATATTATGA AATGGGAATTTCACTGCTGGGATGTTGCCAGAGCTGCCATTATTGNTACTGAAAGCTGTG GCGTGCTAATGGATGTTACCAGNTGCACCATTGGATTTGATGCCCCGAAGAGTAATTGCT GCAATAATTAGATTATAGCCGAAAGAATACCTAAG >OriGene 3' read for NM_005536 unedited
CCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTATCAATTTAAAGTTTTA TTCATGATCGTCTTATTAAAATAAATTTAATTGCAAAAACAACCTGTCTTAGAATACAGT ATCAGATGTTTTAAGTACATGTGATCAACAGTACAAATAATTATAGCAGTCAAACCTTAG TATCACACATACTTAATATATTAGATATACACAATAATAAAATCACTCCCTACCTTGAAA ACTTTACAGAAGCATTTTTAATTTTACAACACAAAGCTCAAACGAACCTACAATAAGTCT AGTAGTCTGTTTACGTGCCAAGGGATAAGGCTGAACAATAAATTAACCCTTTAAAAATGT CTATGAACAAGTACAATTTTCTTTTTGAGTTCTGCAGAGCAATGACCACTAAGAAATATT TTTAAAGGCTGAACAGAATCCAGCGGCAATGAAGTTAATTAAATAAGAAGACTAAGAGAA AAATAAACAGTTCAATATTAACAATACAGTATATTTGCCAGCACAATCAAATCAGTATAA ACACCTTTAAAACATGAATACTGAACTTAGTAAAATGTTATATTGTATCTAATTATGTCA GATATCTGATGAGAGTGCTTTTTATTATAGAAATAGTTTCTTCTCTCTTACACAAGACTT TAAAGCAAATCCAAACAGACAATTTAACTGTTTTGGAAAATGTATTCACTGCAGAAATGC CCACAATAAGCCATGCTATCTGATGGTATGGTAATGTGAAATGGCATGGGTACGTGAATA AAAAAAATTAACTAGATAATTTTACTTCAAACCTGAGCAAAGTACAGAAGCTGAGTTCAT ACTTTAGTATCTATTGGACTAGGAATACTACATTAAATATTCATTCTACAAGGTTGTTTT TATTGCTAAATTGTATGGGCCCAGTGCTATATGACACTGN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005536 |
| Insert Size | 2360 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005536.2, NP_005527.1 |
| RefSeq Size | 2349 bp |
| RefSeq ORF | 834 bp |
| Locus ID | 3612 |
| UniProt ID | P29218 |
| Domains | inositol_P |
| Protein Families | Druggable Genome |
| Protein Pathways | Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system |
| Gene Summary | This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014] Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202784 | IMPA1 (Myc-DDK-tagged)-Human inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1), transcript variant 1 |
CNY 2,400.00 |
|
| RC202784L3 | Lenti ORF clone of Human inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC202784L4 | Lenti ORF clone of Human inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG202784 | IMPA1 (tGFP-tagged) - Human inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1), transcript variant 1 |
CNY 4,000.00 |
