Nrf2 (NFE2L2) (NM_006164) Human Untagged Clone

Name: Nrf2 (NFE2L2) (NM_006164) Human Untagged Clone
SKU: SC116283
Price: 4512.00

CAT＃: SC116283

NFE2L2 (untagged)-Human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1

Datasheet

SDS

"NM_006164" in other vectors (6)

CNY 4,512.00

货期*

现货

规格

Cited in 14 publications.

Product images

经常一起买 (4)

TA805014

NFE2L2 mouse monoclonal antibody, clone OTI8A10 (formerly 8A10)

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【特别福利】购一抗正装产品（≥50ul或≥50ug），免费领10ul抗体试用装

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TurboFectin Transfection Reagent (1 mL in 1 vial)

CNY 4,090.00

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DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)

CNY 1,280.00

PRIMER

Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each

CNY 480.00

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HEBP1; IMDDHH; Nrf-2; NRF2
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene ORF within SC116283 sequence for NM_006164 edited (data generated by NextGen Sequencing) ATGATGGACTTGGAGCTGCCGCCGCCGGGACTCCCGTCCCAGCAGGACATGGATTTGATT GACATACTTTGGAGGCAAGATATAGATCTTGGAGTAAGTCGAGAAGTATTTGACTTCAGT CAGCGACGGAAAGAGTATGAGCTGGAAAAACAGAAAAAACTTGAAAAGGAAAGACAAGAA CAACTCCAAAAGGAGCAAGAGAAAGCCTTTTTCGCTCAGTTACAACTAGATGAAGAGACA GGTGAATTTCTCCCAATTCAGCCAGCCCAGCACATCCAGTCAGAAACCAGTGGATCTGCC AACTACTCCCAGGTTGCCCACATTCCCAAATCAGATGCTTTGTACTTTGATGACTGCATG CAGCTTTTGGCGCAGACATTCCCGTTTGTAGATGACAATGAGGTTTCTTCGGCTACGTTT CAGTCACTTGTTCCTGATATTCCCGGTCACATCGAGAGCCCAGTCTTCATTGCTACTAAT CAGGCTCAGTCACCTGAAACTTCTGTTGCTCAGGTAGCCCCTGTTGATTTAGACGGTATG CAACAGGACATTGAGCAAGTTTGGGAGGAGCTATTATCCATTCCTGAGTTACAGTGTCTT AATATTGAAAATGACAAGCTGGTTGAGACTACCATGGTTCCAAGTCCAGAAGCCAAACTG ACAGAAGTTGACAATTATCATTTTTACTCATCTATACCCTCAATGGAAAAAGAAGTAGGT AACTGTAGTCCACATTTTCTTAATGCTTTTGAGGATTCCTTCAGCAGCATCCTCTCCACA GAAGACCCCAACCAGTTGACAGTGAACTCATTAAATTCAGATGCCACAGTCAACACAGAT TTTGGTGATGAATTTTATTCTGCTTTCATAGCTGAGCCCAGTATCAGCAACAGCATGCCC TCACCTGCTACTTTAAGCCATTCACTCTCTGAACTTCTAAATGGGCCCATTGATGTTTCT GATCTATCACTTTGCAAAGCTTTCAACCAAAACCACCCTGAAAGCACAGCAGAATTCAAT GATTCTGACTCCGGCATTTCACTAAACACAAGTCCCAGTGTGGCATCACCAGAACACTCA GTGGAATCTTCCAGCTATGGAGACACACTACTTGGCCTCAGTGATTCTGAAGTGGAAGAG CTAGATAGTGCCCCTGGAAGTGTCAAACAGAATGGTCCTAAAACACCAGTACATTCTTCT GGGGATATGGTACAACCCTTGTCACCATCTCAGGGGCAGAGCACTCACGTGCATGATGCC CAATGTGAGAACACACCAGAGAAAGAATTGCCTGTAAGTCCTGGTCATCGGAAAACCCCA TTCACAAAAGACAAACATTCAAGCCGCTTGGAGGCTCATCTCACAAGAGATGAACTTAGG GCAAAAGCTCTCCATATCCCATTCCCTGTAGAAAAAATCATTAACCTCCCTGTTGTTGAC TTCAACGAAATGATGTCCAAAGAGCAGTTCAATGAAGCTCAACTTGCATTAATTCGGGAT ATACGTAGGAGGGGTAAGAATAAAGTGGCTGCTCAGAATTGCAGAAAAAGAAAACTGGAA AATATAGTAGAACTAGAGCAAGATTTAGATCATTTGAAAGATGAAAAAGAAAAATTGCTC AAAGAAAAAGGAGAAAATGACAAAAGCCTTCACCTACTGAAAAAACAACTCAGCACCTTA TATCTCGAAGTTTTCAGCATGCTACGTGATGAAGATGGAAAACCTTATTCTCCTAGTGAA TACTCCCTGCAGCAAACAAGAGATGGCAATGTTTTCCTTGTTCCCAAAAGTAAGAAGCCA GATGTTAAGAAAAACTAG Clone variation with respect to NM_006164.3 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for NM_006164 unedited ATTTTGTATACGACTCACTATAGGCGGCCGCGAATTCGGCACGAGGGGGAGCCCGGAGGA GCCGCCGACGCAGCCGCCACCGCCGCCGCCGCCACCAGAGCCGCCCTGTCCGCGCCGCGC CTCGGCAGCCGGAACAGGGCCGCCGTCGGGGAGCCCCAACACACGGTCCACAGCTCATCA TGATGGACTTGGAGCTGCCGCCGCCGGGACTCCCGTCCCAGCAGGACATGGATTTGATTG ACATACTTTGGAGGCAAGATATAGATCTTGGAGTAAGTCGAGAAGTATTTGACTTCAGTC AGCGACGGAAAGAGTATGAGCTGGAAAAACAGAAAAAACTTGAAAAGGAAAGACAAGAAC AACTCCAAAAGGAGCAAGAGAAAGCCTTTTTCGCTCAGTTACAACTAGATGAAGAGACAG GTGAATTTCTCCCAATTCAGCCAGCCCAGCACATCCAGTCAGAAACCAGTGGATCTGCCA ACTACTCCCAGGTTGCCCACATTCCCAAATCAGATGCTTTGTACTTTGATGACTGCATGC AGCTTTTGGCGCAGACATTCCCGTTTGTAGATGACAATGAGGTTTCTTCGGCTACGTTTC AGTCACTTGTTCCTGATATTCCCGGTCACATCGAGAGCCCAGTCTTCATTGCTACTAATC AGGCTCAGTCACCTGAAACTTCTGTTGCTCAGGTAGCCCCTGTTGATTTAGACGGTATGC AACAGGACATTGNAGCAGTTGGNGAGGAGCTATTATCCATTCCTGAGTTACAGTGTCTTA ATATTGAAAATNGACAGCTGGTTGAGACTACCATGGTTNCNAGTCCAGAAGCCAAACTGA CAGAAAGTGACANTNATCATTTTTACTCATCTATACCCCTCATGGGANAAGAAGTANNGT ACTGTAGTCCACATTTTCTTATGCTTNTGAG 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for NM_006164 unedited NNNCCCTTCTATGNNACCGCGGCCGCTATCTAGNATCGAGTTTTTTTTTTTTTTTTTTTT TAACAGTCATAATAATCCTTTATTAGTACCAGCTCTTAAAATTTTTTTTTTTTGCCAGAG CTAAACAATTTAATATAAAAAATGCCATTTTTTGTCCATACAGTATTTATAAAAAAGTAC ATAGTGGTTAGTTTTGCAATAATTTCTTTTTAGCCAGATGTCATATCATCATATAAATCT ATGAATATAACAAATGACATAAGAACAGTATAAATAAGTTTTTGTAGTATTTACACTTAC ACAGAAACTAGCCCAAATGGTGTCCTAAGAAATTGTTTACAGTTAAAGTGAAACTACTGA TTCAACATACTGACACTCCAATGCTTTTTAAAGTTTCGTATTATTTTCTATACTAGTTTT GGCTATGATTTTGCATAGAATTACTTATAAAGTATGAGCATTTCACATCACAGTAGGAGC TTTTAGTATATTAGTACAAAAAACTAGCTCAGAAAGGTCAAATCTCCCTAATCTAGTTTT TCTAACATCTGGCTCCTACTTTGGGGACAGGAAAAACTTGCCTTTTTTGTTTGCTGCAGG AGGTTTCCCTTAGGAAAAAAGGGTTCCCTCTTACTCAGGAACAGGCTGAAAATTCGAGAA TAAGGGGCTGGTTGGTTTTTCCGGGGGGAAGGCTTTTGGAATTTTCCCTTTCTTTGGGGC AATTTTTTTTTTACTTTAAAAAGGCCAAAAACGGGCCAAGGCCCCAAAATTTCCAGGTTT CTTTTTTTGGGAATTGGAAGACCCTTTTTTTTTCCCCCCCCTCTTTTTCCAAATAAAGCA AGGGGGGCTTTGGGACCGCTTTGGGCAAATATTTTGAAAAA
Restriction Sites	NotI-NotI
ACCN	NM_006164
Insert Size	1818 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_006164.2, NP_006155.2
RefSeq Size	2439 bp
RefSeq ORF	1818 bp
Locus ID	4780
UniProt ID	Q16236
Domains	BRLZ
Protein Families	Transcription Factors
Gene Summary	This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (14)

The use of this cDNA Clones has been cited in the following citations:
Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor‐4 inhibition in hepatocellular carcinoma, et al. Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor‐4 inhibition in hepatocellular carcinoma ,null, Cancer Science ,PubMed ID 35466502 [NFE2L2]
Impact of Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocellular Carcinoma: Cancer Metabolism and Immune Status ,null, Hepatology Communications ,PubMed ID 34687175 [NFE2L2]
Bach2 is a potent repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neurons ,Waxman, EA;, bioRxiv [NFE2L2]
Activation of the Nrf2-ARE Signaling Pathway Prevents Hyperphosphatemia-Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells ,Yao, L;Wang, J;Tian, BY;Xu, TH;Sheng, ZT;, J. Cell. Biochem. ,PubMed ID 28513870 [NFE2L2]
Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo ,He, Y;Li, S;Zhang, W;Dai, W;Cui, T;Wang, G;Gao, T;Li, C;, Sci Rep ,PubMed ID 28186139 [NFE2L2]
An oxidative stress mechanism of shikonin in human glioma cells ,Yang, JT;Li, ZL;Wu, JY;Lu, FJ;Chen, CH;, PLoS ONE e94180 9 4. April 2014 ,PubMed ID 24714453 [NFE2L2]
Impaired Activation of the Nrf2-ARE Signaling Pathway Undermines H2O2-Induced Oxidative Stress Response: A Possible Mechanism for Melanocyte Degeneration in Vitiligo ,Jian, Z;Li, K;Song, P;Zhu, G;Zhu, L;Cui, T;Liu, B;Tang, L;Wang, X;Wang, G;Gao, T;Li, C;, J. Invest. Dermatol. March 2014 ,PubMed ID 24662764 [NFE2L2]
Nrf1 and nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells ,Schultz, MA;Hagan, SS;Datta, A;Zhang, Y;Freeman, ML;Sikka, SC;Abdel-Mageed, AB;Mondal, D;, PLoS ONE, Jan 2014. ,PubMed ID 24466341 [NFE2L2]
Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress ,Lamonte, G;Tang, X;Chen, JL;Wu, J;Ding, CK;Keenan, MM;Sangokoya, C;Kung, HN;Ilkayeva, O;Boros, LG;Newgard, CB;Chi, JT;, Cancer Metab Dec 2013. ,PubMed ID 24359630 [NFE2L2]
Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene ,Qiaoqiao Wang, Jiyu Li, Xinmiao Yang, Hefen Sun, Shuiping Gao, Hua Zhu, Jiong Wu, and Wei Jin, Acta Biochim Biophys Sin, Mar 2013; 45: 179 - 187. [NFE2L2]
Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injury ,Q Cai, Z Lu, G Hong, X Jiang, Z Wu, J Zheng, Q Song, and Z Chang, Human and Experimental Toxicology, Nov 2012; 31: 1102 - 1112. [NFE2L2]
Heme Oxygenase-1 Protects Human Melanocytes from H2O2-Induced Oxidative Stress via the Nrf2-ARE Pathway ,Zhe Jian, Kai Li, Ling Liu, Ying Zhang, Zhou Zhou, Chunying Li, Tianwen Gao, Journal of Investigative Dermatology (17 March 2011) doi:10.1038/jid.2011.56 Original Article [NFE2L2]
Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound ß-phenylethyl isothiocyanate ,Yumin Hu, Weiqin Lu, Gang Chen, Hui Zhang, Yu Jia, Yue Wei, Hui Yang, Wan Zhang, Warren Fiskus, Kapil Bhalla, Michael Keating, Peng Huang, and Guillermo Garcia-Manero, Blood, Oct 2010; 116: 2732 - 2741 [NFE2L2]
*CYP2C91B Promoter Polymorphisms, in Linkage with CYP2C192, Affect Phenytoin Autoinduction of Clearance and Maintenance Dose* ,Amarjit S. Chaudhry, Thomas J. Urban, Jatinder K. Lamba, Angela K. Birnbaum, Rory P. Remmel, Murali Subramanian, Stephen Strom, Joyce H. You, Dalia Kasperaviciute, Claudia B. Catarino, Rodney A. Radtke, Sanjay M. Sisodiya, David B. Goldstein, and Erin G. Schuetz, J. Pharmacol. Exp. Ther., Feb 2010; 332: 599 - 611 [NFE2L2]

Documents

Product Manuals
TrueORFs: Open Reading Frame Clones - 10 ug in PrecisionShuttle Vector System pLenti-ORF destination vector Transfection - TurboFectin 8.0 Transfection Reagent Plasmid Preparation - PowerPrep Plasmid Purification Kits
FAQs
TrueORF Clones/PrecisionShuttle Organelle Marker Transfection Reagent
SDS
TrueORF SDS

Resources

cDNA 克隆相关资源
Video Tutorial: Clone Selection Guide Product Video: What is TrueORF GOLD and why it is the most popular type of clone Video Tutorial: How to make Lentivirus particles Video Tutorial: Is the Lentivirus Safe Product Brochure: cDNA clones $98 Clones. Download the List of 15,000 Protocol: Lentivirus packaging

Other Versions

SKU	Description	Size	Price
RC204140	NFE2L2 (Myc-DDK-tagged)-Human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1	10 ug 产品选项验证失败所有选项都是必需的	CNY 4,504.00
RC204140L1	Lenti ORF clone of Human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1, Myc-DDK-tagged	10 ug 产品选项验证失败所有选项都是必需的	CNY 6,904.00
RC204140L2	Lenti ORF clone of Human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1, mGFP tagged	10 ug 产品选项验证失败所有选项都是必需的	CNY 6,904.00
RC204140L3	Lenti ORF clone of Human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1, Myc-DDK-tagged	10 ug 产品选项验证失败所有选项都是必需的	CNY 6,904.00
RC204140L4	Lenti ORF clone of Human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1, mGFP tagged	10 ug 产品选项验证失败所有选项都是必需的	CNY 5,890.00
RG204140	NFE2L2 (tGFP-tagged) - Human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1	10 ug 产品选项验证失败所有选项都是必需的	CNY 6,104.00

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