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Kv4.2 (KCND2) (NM_012281) Human Untagged Clone
CAT＃: SC115436
KCND2 (untagged)-Human potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2)
CNY 4,696.00
CNY 7,220.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | KV4.2; RK5 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC115436 sequence for NM_012281 edited (data generated by NextGen Sequencing)
ATGGCGGCGGGGGTGGCAGCGTGGCTGCCTTTTGCAAGGGCAGCGGCTATCGGGTGGATG CCTGTGGCCTCGGGGCCTATGCCGGCTCCCCCGAGGCAGGAGAGGAAAAGGACCCAAGAT GCTCTCATTGTGCTGAATGTGAGTGGCACCCGCTTCCAGACGTGGCAGGACACCCTGGAA CGTTACCCAGACACTCTACTGGGCAGTTCTGAGAGGGACTTTTTCTACCACCCAGAAACT CAGCAGTATTTCTTTGACCGTGACCCAGACATCTTCCGCCACATCCTGAATTTCTACCGC ACTGGGAAGCTCCACTATCCTCGCCACGAGTGCATCTCTGCTTACGATGAAGAACTGGCC TTCTTTGGCCTCATCCCGGAAATCATCGGCGACTGCTGTTATGAGGAGTACAAGGATCGC AGGCGAGAGAACGCCGAGCGCCTGCAGGACGACGCGGATACCGACACCGCTGGGGAGAGC GCCTTGCCCACCATGACTGCAAGGCAGAGGGTCTGGAGGGCCTTCGAGAACCCCCACACC AGCACGATGGCCCTGGTGTTCTACTATGTCACGGGGTTTTTCATTGCCGTCTCTGTCATC GCGAATGTGGTGGAAACAGTGCCGTGCGGATCAAGCCCAGGTCACATTAAAGAACTGCCC TGTGGAGAGCGGTATGCTGTGGCCTTCTTCTGCTTGGACACGGCCTGCGTCATGATCTTC ACAGTTGAGTATTTGCTTCGCCTGGCTGCAGCGCCTAGTCGTTACCGTTTTGTGCGTAGT GTCATGAGTATCATCGACGTGGTGGCCATCCTGCCTTATTACATTGGGCTGGTGATGACA GACAATGAGGACGTCAGCGGAGCCTTTGTCACACTCCGAGTCTTCCGGGTCTTCAGGATC TTTAAGTTTTCCCGCCACTCTCAAGGCCTGCGCATCCTGGGGTACACACTGAAGAGTTGT GCCTCAGAATTGGGCTTCTTGCTTTTCTCGCTCACCATGGCTATCATCATCTTCGCTACA GTTATGTTCTACGCAGAGAAGGGGTCTTCGGCTAGCAAGTTCACCAGCATCCCTGCAGCC TTCTGGTATACCATCGTCACCATGACAACACTAGGGTATGGTGACATGGTGCCAAAAACC ATAGCAGGGAAGATTTTTGGTTCTATCTGTTCGCTGAGTGGGGTCTTGGTCATTGCTCTA CCTGTTCCGGTGATTGTATCCAACTTCAGTCGCATCTACCACCAGAATCAACGAGCAGAC AAACGAAGGGCACAAAAGAAAGCTAGACTGGCCAGGATCCGGGCAGCCAAAAGCGGAAGC GCAAATGCTTACATGCAGAGCAAACGGAATGGTTTACTCAGTAATCAGCTGCAGTCCTCA GAGGATGAGCAGGCTTTTGTTAGCAAATCCGGCTCCAGCTTTGAAACCCAGCACCACCAC CTGCTTCACTGCCTGGAAAAAACCACGAATCACGAGTTTGTGGACGAACAAGTCTTTGAA GAAAGCTGCATGGAAGTTGCAACTGTTAATCGTCCTTCAAGTCACAGTCCTTCACTGTCT TCACAACAAGGAGTCACCAGCACCTGCTGTTCACGACGACACAAAAAAACTTTTCGCATC CCAAATGCCAATGTATCAGGAAGCCATCAAGGTAGTATACAAGAACTCAGCACGATTCAG ATCAGATGTGTGGAGAGAACACCTCTGTCTAACAGCCGATCCAGTTTAAATGCCAAAATG GAAGAGTGTGTTAAACTAAACTGTGAACAACCTTATGTGACTACAGCAATAATAAGCATC CCAACACCTCCAGTAACCACACCAGAAGGAGACGATAGGCCAGAATCCCCTGAGTACTCA GGAGGAAATATTGTCAGAGTTTCTGCTTTGTAA Clone variation with respect to NM_012281.2 >OriGene 5' read for NM_012281 unedited
GTTCAAATTAGTATACGACTCACTATAGGCGGCCGCGAAATTCGCACGAGGCCTCGTGCC GAATTCGGCACGAGGCGCGTTCTGCGCGGAAGCAGATGCTGCTGCCGCCACGGCGGCGGC GGCTGCCAGCTCCTGAGCTCTGTAACTGTCACACTGCACCTGAGCTGAACTTGAAAAGAG AGTGAAGGGGCGATTGGGCGAACGCTTTTGGCAGACACAGAGGGTGTTTGTAGACGTGGG GGAGGAGAATCTCTATTAACGCCCCCCACCGTAACCACTGCACATCACCTCCATCTCTGC AAATACAGCCCGAGGAGTAGAGGCAGCAGCAGCTGGACCCCCAAAGAGAGACGTGGGGCA GCGGCTGTGACCGCATCTCCTGAGCTACAACAACAGGTCGCCTTTTTGAGACTCCTTTGG CGGGAAGGGCTACTTGGAAAGGAAGGTTTGAAAGAGTGAGAAGGGTAGGTGTAAGGGTTC CCTAATTCGTCGAAAGAATTCTATTGGGTGACTCTCGTTCGTCTTCTCTATCCTACACTC CACATACTGACCCTATATTATCCAGACTGTGCCGGGGAGAAATCAAAAACACCTGTTTGA AGAAACGGCTGCACCTGTGTGCTTATTTGTGCCAGAAGGTGGCCTAGCCCACCTGCAGGA AGAGATTTGGCTGGGTTCTGTTGAGGGTGATTGTTANGACGTTGTATTTTGTTGCCATTA TTCCAAATACCTGTCTTGGGAGGAAAAAGTGCCTTCTGAGAACTGTGACTTTACCAGGAC CCTATCTTGGAATAAAATTACACCTCTGGACCAGTTTCTCACTAGTACTTTGCTTGACTG GGAGAAGTGGGTGACTTTTGGCTGCTTCNGTGACCCATTGTAGACGCCTCGTTCCCTTCT TTCTT >OriGene 3' read for NM_012281 unedited
TTTGTTCAGCTGCACAGTTTTATTAGTATTCTCCAAAGTCTATTTTTTTCCAGCATAATG CAGATATTATGGGCTATCCTTTAGAAATAAGATATATGAATTTCAAACAAAATTGTCAAA AACAATGACCTTAGTTACTCCATATGGTACACAGAAATAATTACATTTCACTTACAATAC AGATGCACTTAACACAGTCATCAATAGTCATTCACCACCAACACGGTATATTTTTAAATC ACCTAAAACATCAAAAAGTTTTTTTTCTTTTCCAAAAGCCTAATAAAATTAATAATTTTG GGTAAGTGATAAATCAAAAGAGGAGGCAGAATTGTCAATTGAAATAACCTAACTGCATTT TCTTGTATGTAATATTAAGAACATGAAAATAGAACTTCTCATTGGGAATCAAAAGACATA GTAATTCTGATTATGGTTTCCTTAGTCTACTTTTTAGAAGGTTTTCAATAAATGCCATCA GATAAGTTTCACTAGACATTGCTCTAGAAGCATAAACTGACATGAGGCAGGTGTTAATAT AATTGTTAATATTTGTACTGCTGGAAAATTAGTAACTTTTTAAAAGATGTACTAGGAATG AAGCCAGTTCTTCCCAAGAGATAGTTGAGTTTATCTTACTTTCACTCAGCAAATGTTTAT TAAGATCTAATATGTGCATAGCACTGTTCTAGAAACTATTCTAGAAATGGGAAGCAAGAA TTTCTGGCTCTACTAGAAAATGGTTGGATTAATCCCTTTTTATGATTAAATATCATAAGC ATTTAAAATCTCATCTCTGACAGAAGGATAATTATTAGCTCTTTCCATGTACAGAAGCTA ATGCTTATTCCTTACAGTGGTGGGCTGGGATGAATAAAAAACTTGCATTTGACATTAAAC TTTTTACACTGTCATGTGCAGACATGTCTGCTGAATATTTTAAGGTGAAAAGTATAAGAC C |
| Restriction Sites | NotI-NotI |
| ACCN | NM_012281 |
| Insert Size | 4600 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_012281.2, NP_036413.1 |
| RefSeq Size | 5333 bp |
| RefSeq ORF | 1893 bp |
| Locus ID | 3751 |
| UniProt ID | Q9NZV8 |
| Domains | BTB, K_tetra, ion_trans |
| Protein Families | Druggable Genome, Ion Channels: Potassium, Transmembrane |
| Gene Summary | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes
,Dustin Anderson, W Hamish Mehaffey, Mircea Iftinca, Renata Rehak, Jordan D T Engbers, Shahid Hameed, Gerald W Zamponi, Ray W Turner,
Nature Neuroscience 13, 333-337 (14 February 2010) doi:10.1038/nn.2493 Article
[KCND2]
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Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products
,Yuko Fujii, Shin-ichiro Numata, Yoko Nakamura, Takashi Honda, Keiko Furukawa, Takeshi Urano, Joelle Wiels, Makoto Uchikawa, Noriyuki Ozaki, Sei-ichi Matsuo, Yasuo Sugiura, and Koichi Furukawa,
Glycobiol. 2005 Dec;15(12):1257-67.
[KCND2]
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Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway
,Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne RD,
J Cell Biol. 2005 Nov 7;171(3):459-69.
[KCND2]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215266 | KCND2 (Myc-DDK-tagged)-Human potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2) |
CNY 4,688.00 |
|
| RC215266L1 | Lenti ORF clone of Human potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2), Myc-DDK-tagged |
CNY 7,088.00 |
|
| RC215266L2 | Lenti ORF clone of Human potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2), mGFP tagged |
CNY 5,890.00 |
|
| RC215266L3 | Lenti ORF clone of Human potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC215266L4 | Lenti ORF clone of Human potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2), mGFP tagged |
CNY 5,890.00 |
|
| RG215266 | KCND2 (tGFP-tagged) - Human potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2) |
CNY 6,288.00 |
