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TMEM127 (NM_017849) Human Untagged Clone
CAT＃: SC113895
TMEM127 (untagged)-Human transmembrane protein 127 (TMEM127), transcript variant 1
CNY 2,400.00
CNY 2,950.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC113895 sequence for NM_017849 edited (data generated by NextGen Sequencing)
ATGTACGCCCCCGGAGGCGCAGGGCTGCCCGGCGGGCGCCGGCGGAGGAGCCCGGGAGGC AGCGCTCTGCCCAAGCAGCCGGAGCGTAGCCTGGCCTCGGCCCTGCCTGGCGCCCTGTCT ATCACGGCGCTGTGCACTGCCCTCGCCGAGCCCGCCTGGTTGCACATCCACGGAGGCACC TGTTCGCGCCAGGAGCTGGGGGTCTCCGACGTGTTGGGCTATGTGCACCCGGACCTGCTG AAAGATTTCTGCATGAATCCCCAGACAGTGCTGCTCCTGCGGGTCATCGCCGCCTTCTGT TTCCTGGGCATCCTGTGTAGTCTCTCCGCTTTCCTTCTGGATGTCTTTGGGCCGAAGCAT CCTGCTCTGAAGATCACTCGTCGCTATGCCTTCGCCCATATCCTAACGGTTCTGCAGTGT GCCACCGTCATTGGCTTTTCTTATTGGGCTTCTGAACTCATCTTGGCCCAGCAGCAGCAG CATAAGAAGTACCATGGATCCCAGGTCTATGTCACCTTCGCCGTTAGCTTCTACCTGGTG GCAGGAGCTGGTGGAGCCTCAATCCTGGCCACGGCAGCCAACCTCCTGCGCCACTACCCC ACAGAGGAAGAGGAGCAGGCACTGGAGCTGCTCTCAGAGATGGAAGAGAACGAGCCCTAC CCGGCGGAATATGAGGTCATCAACCAGTTCCAGCCACCCCCTGCTTACACACCCTAA Clone variation with respect to NM_017849.3 621 g=>a >OriGene 5' read for NM_017849 unedited
AGTCAAATTTTGTATACGACTCATATAGGCGGCCGCGAATTCGGCACGAGGCGGGTCTGT CCGGGCGTTGCGGGATTGGGGCCTGGGAACGCTCGGCCCCCGGCAGCCGAGAAGCCCGTG ACTGGGCTGAGCAGCACCATCCCAGCCCTGGGGCCTGCTGACTGCGAACCCGGAGCGTTG CTATCCTCCACCGGACTGTCAGGCTCTGCGCGCCCCGCGGAGGTCGGCGGCGACCAGCAG CGACTGCGGAGCGACGGCGGGCGGCCCCGGGCATGTACGCCCCCGGAGGCGCAGGGCTGC CCGGCGGGCGCCGGCGGAGGAGCCCGGGAGGCAGCGCTCTGCCCAAGCAGCCGGAGCGTA GCCTGGCCTCGGCCCTGCCTGGCGCCCTGTCTATCACGGCGCTGTGCACTGCCCTCGCCG AGCCCGCCTGGTTGCACATCCACGGAGGCACCTGTTCGCGCCAGGAGCTGGGGGTCTCCG ACGTGTTGGGCTATGTGCACCCGGACCTGCTGAAAGATTTCTGCATGAATCCCCAGACAG TGCTGCTCCTGCGGGTCATCGCCGCCTTCTGTTTCCTGGGCATCCTGTGTAGTCTCTCCG CTTTCCTTCTGGATGTCTTTGGGCCGAAGCATCCTGCTCTGAAGATCACTCGTCGCTATG CCTTCGCCCATATCCTAACGGTTCTGCAGTGTGCCACCGTCATTGGCTTTTCTTATTGGG CTTCTGAACTCATCTTGGCCCAGCAGCAGCAGCATAAGAAGTACCATGGATCCCAGGTCT ATGTCACCTNTCGCCGTTAGCTTCTACCTGGTGGCANGAGCTGGTGGAGCCTCAATCTGG CCACGGCAGCCAACCTCCTGCGCCACTACCCACAGAGGAAGAGAGCANGCACTGGAGCTG CTCTCAGAGATGGAAGAGAACGANGCCTACCGA >OriGene 3' read for NM_017849 unedited
CGCTCTTTACAGCCGAGTTTTTTTTTTTTTTTTTTCCATTCTTATTCGTGGTTTCTGGTT TTTTTGGTTTTGCTTTCCCTTTTAATTTTTTTCTAGAAAAAAAAACACAACCCGGGGCAA TTTATATGACAAACTATCAGTGTCAGGATGGCACAGGGAAAGAGAAAGCAAGAGGAAGGC CAAAGACATGGGGAGTGAATAAAAAGTGGGTCCCGGATCGCGCGGAACACCCCACAGGGT CATGTACAGGTCCTCAGGAGATGACCAGCCCCTTTGGCATGCAGGCCCAGCGCCTGCTTT TCTGGTTTGCCTGCTCAGACACCCAAGGGCACAGAGAGTTGCCTACAAGCAAACTTGCCA ATGACAAACTCAGGACTTACCAGAAAGACTTAGTTCAGTTCCTTGCCTTTGTGCTCAGGT ATCACATACCAGCCAGCCTGCAGTCTTTTTTGCCTGACACAAGAGCCCAGACCAGCAGGA GAGCCCCCTTTGAACACATTCTGTCATCCACAGTAGTGAACTGCAAGTAGCCACTGGCTC GTGTGCAGATGCGCCCCTCACCACCCATGCAGGCATCCGTCTGGACATCCCCAGTCAATT TGGCCAAAGGACGGTACATGACCGCCTCTTTCTAGCCACAGGTTTATAGTGCTGCCCATT TTCCACGCTGGCTCAAACTATCTATTACCTTTAAAGCNTGTAAGAGCTTTGCCATACATT TCCCTTTTAGTTCACCACGGGCCCCTGATTCTTAACAGCCCGTTTTCTACAGGGCCCGTC TGCCCATCCTGAACCACACTGAAGGGTTTCAGGCTCTTCCACTTTCGCTCCATCCCCAGT CAAAAACTCCCCCTACCCATACACCACGCCCCACATACGTGGCTGTCCTTCACCCTTTCT CCCCCTCCAATCCTATCCCCCAAAAGCGCTTGTCTCCCCTCTTTCCCCTCCCCACACTTC TTCTTCTCTGTCCTCCTTACACCACATCCCTCACCTACCTATTG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_017849 |
| Insert Size | 3240 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_017849.1, NP_060319.1 |
| RefSeq Size | 4223 bp |
| RefSeq ORF | 717 bp |
| Locus ID | 55654 |
| UniProt ID | O75204 |
| Protein Families | Transmembrane |
| Gene Summary | This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010] Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Functional characterization of TMEM127 variants reveals novel insights into its membrane topology and trafficking
,Flores, SK;Deng, Y;Cheng, Z;Zhang, X;Tao, S;Saliba, A;Chu, I;Burnichon, N;Gimenez-Roqueplo, AP;Wang, E;Aguiar, RCT;Dahia, PLM;,
J. Clin. Endocrinol. Metab.
,PubMed ID 32575117
[TMEM127]
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Functional characterization of germline variants in the TMEM127 tumor suppressor reveals novel insights into its membrane topology and trafficking
,Flores, SK;Deng, Y;Cheng, ZM;Zhang, X;Tao, S;,
bioRxiv
[TMEM127]
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Germline mutations in TMEM127 confer susceptibility to pheochromocytoma
,Yuejuan Qin, Li Yao, Elizabeth E King, Kalyan Buddavarapu, Romina E Lenci, E Sandra Chocron, James D Lechleiter, Meghan Sass, Neil Aronin, Francesca Schiavi, et al.,
Nature Genetics 42, 229-233 (14 February 2010) doi:10.1038/ng.533 Letter
[TMEM127]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205233 | TMEM127 (Myc-DDK-tagged)-Human transmembrane protein 127 (TMEM127), transcript variant 1 |
CNY 2,400.00 |
|
| RC205233L3 | Lenti ORF clone of Human transmembrane protein 127 (TMEM127), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC205233L4 | Lenti ORF clone of Human transmembrane protein 127 (TMEM127), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG205233 | TMEM127 (tGFP-tagged) - Human transmembrane protein 127 (TMEM127), transcript variant 1 |
CNY 4,370.00 |
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