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TLR3 (NM_003265) Human Untagged Clone
CAT＃: SC112723
TLR3 (untagged)-Human toll-like receptor 3 (TLR3)
CNY 6,632.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD283; IIAE2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_003265 edited
GAATTCGGCACGAGGGAAATGTCTGGATTTGGACTAAAGAAAAAAGGAAAGGCTAGCAGT CATCCAAAAGAATCATGAGACAGACTTTGCCTTGTATCTACTTTTGGGGGGGCCTTTTGC CCTTTGGGATGCTGTGTGCATCCTCCACCACCAAGTGCACTGTTAGCCATGAAGTTGCTG ACTGCAGCCACCTGAAGTTGACTCAGGTACCCGATGATCTACCCACAAACATAACAGTGT TGAACCTTACCCATAATCAACTCAGAAGATTACCAGCCGCCAACTTCACAAGGTATAGCC AGCTAACTAGCTTGGATGTAGGATTTAACACCATCTCAAAACTGGAGCCAGAATTGTGCC AGAAACTTCCCATGTTAAAAGTTTTGAACCTCCAGCACAATGAGCTATCTCAACTTTCTG ATAAAACCTTTGCCTTCTGCACGAATTTGACTGAACTCCATCTCATGTCCAACTCAATCC AGAAAATTAAAAATAATCCCTTTGTCAAGCAGAAGAATTTAATCACATTAGATCTGTCTC ATAATGGCTTGTCATCTACAAAATTAGGAACTCAGGTTCAGCTGGAAAATCTCCAAGAGC TTCTATTATCAAACAATAAAATTCAAGCGCTAAAAAGTGAAGAACTGGATATCTTTGCCA ATTCATCTTTAAAAAAATTAGAGTTGTCATCGAATCAAATTAAAGAGTTTTCTCCAGGGT GTTTTCACGCAATTGGAAGATTATTTGGCCTCTTTCTGAACAATGTCCAGCTGGGTCCCA GCCTTACAGAGAAGCTATGTTTGGAATTAGCAAACACAAGCATTCGGAATCTGTCTCTGA GTAACAGCCAGCTGTCCACCACCAGCAATACAACTTTCTTGGGACTAAAGTGGACAAATC TCACTATGCTCGATCTTTCCTACAACAACTTAAATGTGGTTGGTAACGATTCCTTTGCTT GGCTTCCACAACTAGAATATTTCTTCCTAGAGTATAATAATATACAGCATTTGTTTTCTC ACTCTTTGCACGGGCTTTTCAATGTGAGGTACCTGAATTTGAAACGGTCTTTTACTAAAC AAAGTATTTCCCTTGCCTCACTCCCCAAGATTGATGATTTTTCTTTTCAGTGGCTAAAAT GTTTGGAGCACCTTAACATGGAAGATAATGATATTCCAGGCATAAAAAGCAATATGTTCA CAGGATTGATAAACCTGAAATACTTAAGTCTATCCAACTCCTTTACAAGTTTGCGAACTT TGACAAATGAAACATTTGTATCACTTGCTCATTCTCCCTTACACATACTCAACCTAACCA AGAATAAAATCTCAAAAATAGAGAGTGATGCTTTCTCTTGGTTGGGCCACCTAGAAGTAC TTGACCTGGGCCTTAATGAAATTGGGCAAGAACTCACAGGCCAGGAATGGAGAGGTCTAG AAAATATTTTTGAAATCTATCTTTCCTACAACAAGTACCTGCAGCTGACTAGGAACTCCT TTGCCTTGGTCCCAAGCCTTCAACGACTGATGCTCCGAAGGGTGGCCCTTAAAAATGTGG ATAGCTCTCCTTCACCATTCCAGCCTCTTCGTAACTTGACCATTCTGGATCTAAGCAACA ACAACATAGCCAACATAAATGATGACATGTTGGAGGGTCTTGAGAAACTAGAAATTCTCG ATTTGCAGCATAACAACTTAGCACGGCTCTGGAAACACGCAAACCCTGGTGGTCCCATTT ATTTCCTAAAGGGTCTGTCTCACCTCCACATCCTTAACTTGGAGTCCAACGGCTTTGACG AGATCCCAGTTGAGGTCTTCAAGGATTTATTTGAACTAAAGATCATCGATTTAGGATTGA ATAATTTAAACACACTTCCAGCATCTGTCTTTAATAATCAGGTGTCTCTAAAGTCATTGA ACCTTCAGAAGAATCTCATAACATCCGTTGAGAAGAAGGTTTTCGGGCCAGCTTTCAGGA ACCTGACTGAGTTAGATATGCGCTTTAATCCCTTTGATTGCACGTGTGAAAGTATTGCCT GGTTTGTTAATTGGATTAACGAGACCCATACCAACATCCCTGAGCTGTCAAGCCACTACC TTTGCAACACTCCACCTCACTATCATGGGTTCCCAGTGAGACTTTTTGATACATCATCTT GCAAAGACAGTGCCCCCTTTGAACTCTTTTTCATGATCAATACCAGTATCCTGTTGATTT TTATCTTTATTGTACTTCTCATCCACTTTGAGGGCTGGAGGATATCTTTTTATTGGAATG TTTCAGTACATCGAGTTCTTGGTTTCAAAGAAATAGACAGACAGACAGAACAGTTTGAAT ATGCAGCATATATAATTCATGCCTATAAAGATAAGGATTGGGTCTGGGAACATTTCTCTT CAATGGAAAAGGAAGACCAATCTCTCAAATTTTGTCTGGAAGAAAGGGACTTTGAGGCGG GTGTTTTTGAACTAGAAGCAATTGTTAACAGCATCAAAAGAAGCAGAAAAATTATTTTTG TTATAACACACCATCTATTAAAAGACCCATTATGCAAAAGATTCAAGGTACATCATGCAG TTCAACAAGCTATTGAACAAAATCTGGATTCCATTATATTGGTTTTCCTTGAGGAGATTC CAGATTATAAACTGAACCATGCACTCTGTTTGCGAAGAGGAATGTTTAAATCTCACTGCA TCTTGAACTGGCCAGTTCAGAAAGAACGGATAGGTGCCTTTCGTCATAAATTGCAAGTAG CACTTGGATCCAAAAACTCTGTACATTAAATTTATTTAAATATTCAATTAGCAAAGGAGA AACTTTCTCAATTTAAAAAGTTCTATGGCAAATTTAAGTTTTCCATAAAGGTGTTATAAT TTGTTTATTCATATTTGTAAATGATTATATTCTATCACAATTACATCTCTTCTAGGAAAA TGTGTCTCCTTATTTCAGGCCTATTTTTGACAATTGACTTAATTTTACCCAAAATAAAAC ATATAAGCACGTAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_003265 unedited
TAGGGCGGCAACGCCAATTCGCACGAGGAAATGTCTGGATTTGGACTAAAGAAAAAAGGA AAGGCTAGCAGTCATCCAAAAGAATCATGAGACAGACTTTGCCTTGTATCTACTTTTGGG GGGGCCTTTTGCCCTTTGGGATGCTGTGTGCATCCTCCACCACCAAGTGCACTGTTAGCC ATGATATTTTCTGACTGCAGCCACCTGAAGTTGACTCAGGTACCCGATGATCTACCCACA AACATAACAGTGTTGAACCTTACCCATAATCAACTCAGAAGATTACCAGCCGCCAACTTC ACAAGGTATAGCCAGCTAACTAGCTTGGATGTAGGATTTAACACCATCTCAAAACTGGAG CCAGAATTGTGCCAGAAACTTCCCATGTTAAAAGTTTTGAACCTCCAGCACAATGAGCTA TCTCAACTTTCTGATAAAACCTTTGCCTTCTGCACGAATTTGACTGAACTCCATCTCATG TCCAACTCAATCCAGAAAATTAAAAATAATCCCTTTGTCAAGCAGAAGAATTTAATCACA TTAGATCTGTCTCATAATGGCTTGTCATCTACAAAATTAGGAACTCAGGTTCAGCTGGAA AATCTCCAAGAGCTTCTATTATCAAACAATAAAATTCAAGCGCTAAAAAGTGAAGAACTG GATATCTTTGCCAATTCATCTTTAANAAAATTAGAGTTGTCATCGAATCAAATTAAAGAG TTTTCTCCAGGGTGTTTTCACGCCATTGGAAGATTATTTGGCCTCTTTCTGAACATGTCC AGCTGGGTCCCAGCCTTACAGAGAAGCTATGTTTGGAATTAGCANNACACAGCATTCGGA ATCTGTCT >OriGene 3' read for NM_003265 unedited
TAGAGTCGAGTTTTTTTTTTTTTTTTTTACGTGCTTATATGTTTTATTTTGGGTAAAATT AAGTCAATTGTCAAAAATAGGCCTGAAATAAGGAGACACATTTTCCTAGAAGAGATGTAA TTGTGATAGAATATAATCATTTACAAATATGAATAAACAAATTATAACACCTTTATGGAA AACTTAAATTTGCCATAGAACTTTTTAAATTGAGAAAGTTTCTCCTTTGCTAATTGAATA TTTAAATAAATTTAATGTACAGAGTTTTTGGATCCAAGTGCTACTTGCAATTTATGACGA AAGGCACCTATCCGTTCTTTCTGAACTGGCCAGTTCAAGATGCAGTGAGATTTAAACATT CCTCTTCGCAAACAGAGTGCATGGTTCAGTTTATAATCTGGAATCTCCTCAAGGAAAACC AATATAATGGAATCCAGATTTTGTTCAATAGCTTGTTGAACTGCATGATGTACCTTGAAT CTTTTGCATAATGGGTCTTTTAATAGATGGTGTGTTATAACAAAAATAATTTTTCTGCTT CTTTTGATGCTGTTAACAATTGCTTCTAGTTCAAAAACACCCGCCTCAAAGTCCCTTTCT TCCAGACAAAATTTGAGAGATTGGTCTTCCTTTTCCATTGAAGAGAATGTTCCAGACCCA ATCTTATCTTTATAGGCATGAATATATATGCTGATATTCAACTGGTCTGGCTGCTGGCTA ATTCTTGAAACCAAAACTCGATGACTGAACATTNCATAAAGATATCTCAGCCTCAAGTGA TGAGAGTCATAAGATAAATCACAGATCTGTTTGACATGAAAAAGTCAGGGGCACTGCTGC AGAGATGTTCAAAGCTCTGGAACATGANTGAGGGGATGTCAAGTATGCTGACCTAGAGTG NTTGGTCTGTATCATACACAGCAACTCACGTGCTAGATAAGCTTTATCNCGTCTGAGGGC GACTTTTAGGGGTAATCTTGAGTAGCT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003265 |
| Insert Size | 3190 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003265.2, NP_003256.1 |
| RefSeq Size | 3057 bp |
| RefSeq ORF | 2715 bp |
| Locus ID | 7098 |
| UniProt ID | O15455 |
| Domains | TIR, LRRCT, LRR, LRR_TYP, LRR_PS |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Toll-like receptor signaling pathway |
| Gene Summary | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation
,H D Park, Y Lee, Y K Oh, J G Jung, Y W Park, K Myung, K-H Kim, S S Koh, D-S Lim,
Oncogene (30 August 2010) doi:10.1038/onc.2010.401 Original Article
[TLR3]
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Resources
Other Versions
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|---|---|---|---|
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| RC210497L1 | Lenti ORF clone of Human toll-like receptor 3 (TLR3), Myc-DDK-tagged |
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| RC210497L2 | Lenti ORF clone of Human toll-like receptor 3 (TLR3), mGFP tagged |
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| RC210497L3 | Lenti ORF clone of Human toll-like receptor 3 (TLR3), Myc-DDK-tagged |
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| RC210497L4 | Lenti ORF clone of Human toll-like receptor 3 (TLR3), mGFP tagged |
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| RG210497 | TLR3 (tGFP-tagged) - Human toll-like receptor 3 (TLR3) |
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