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TLR2 (NM_003264) Human Untagged Clone
CAT＃: SC112722
TLR2 (untagged)-Human toll-like receptor 2 (TLR2)
CNY 5,752.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD282; TIL4 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_003264 edited
GAATTCGGCACGAGGCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCTGCTCGGCGTTCTC TCAGGTGACTGCTCGGAGTTCTCCCAGTGTTTGGTGTTGCAAGCAGGATCCAAAGGAGAC CTATAGTGACTCCCAGGAGCTCTTAGTGACCAAGTGAAGGTACCTGTGGGGCTCATTGTG CCCATTGCTCTTTCACTGCTTTCAACTGGTAGTTGTGGGTTGAAGCACTGGACAATGCCA CATACTTTGTGGATGGTGTGGGTCTTGGGGGTCATCATCAGCCTCTCCAAGGAAGAATCC TCCAATCAGGCTTCTCTGTCTTGTGACCGCAATGGTATCTGCAAGGGCAGCTCAGGATCT TTAAACTCCATTCCCTCAGGGCTCACAGAAGCTGTAAAAAGCCTTGACCTGTCCAACAAC AGGATCACCTACATTAGCAACAGTGACCTACAGAGGTGTGTGAACCTCCAGGCTCTGGTG CTGACATCCAATGGAATTAACACAATAGAGGAAGATTCTTTTTCTTCCCTGGGCAGTCTT GAACATTTAGACTTATCCTATAATTACTTATCTAATTTATCGTCTTCCTGGTTCAAGCCC CTTTCTTCTTTAACATTCTTAAACTTACTGGGAAATCCTTACAAAACCCTAGGGGAAACA TCTCTTTTTTCTCATCTCACAAAATTGCAAATCCTGAGAGTGGGAAATATGGACACCTTC ACTAAGATTCAAAGAAAAGATTTTGCTGGACTTACCTTCCTTGAGGAACTTGAGATTGAT GCTTCAGATCTACAGAGCTATGAGCCAAAAAGTTTGAAGTCAATTCAGAATGTAAGTCAT CTGATCCTTCATATGAAGCAGCATATTTTACTGCTGGAGATTTTTGTAGATGTTACAAGT TCCGTGGAATGTTTGGAACTGCGAGATACTGATTTGGACACTTTCCATTTTTCAGAACTA TCCACTGGTGAAACAAATTCATTGATTAAAAAGTTTACATTTAGAAATGTGAAAATCACC GATGAAAGTTTGTTTCAGGTTATGAAACTTTTGAATCAGATTTCTGGATTGTTAGAATTA GAGTTTGATGACTGTACCCTTAATGGAGTTGGTAATTTTAGAGCATCTGATAATGACAGA GTTATAGATCCAGGTAAAGTGGAAACGTTAACAATCCGGAGGCTGCATATTCCAAGGTTT TACTTATTTTATGATCTGAGCACTTTATATTCACTTACAGAAAGAGTTAAAAGAATCACA GTAGAAAACAGTAAAGTTTTTCTGGTTCCTTGTTTACTTTCACAACATTTAAAATCATTA GAATACTTGGATCTCAGTGAAAATTTGATGGTTGAAGAATACTTGAAAAATTCAGCCTGT GAGGATGCCTGGCCCTCTCTACAAACTTTAATTTTAAGGCAAAATCATTTGGCATCATTG GAAAAAACCGGAGAGACTTTGCTCACTCTGAAAAACTTGACTAACATTGATATCAGTAAG AATAGTTTTCATTCTATGCCTGAAACTTGTCAGTGGCCAGAAAAGATGAAATATTTGAAC TTATCCAGCACACGAATACACAGTGTAACAGGCTGCATTCCCAAGACACTGGAAATTTTA GATGTTAGCAACAACAATCTCAATTTATTTTCTTTGAATTTGCCGCAACTCAAAGAACTT TATATTTCCAGAAATAAGTTGATGACTCTACCAGATGCCTCCCTCTTACCCATGTTACTA GTATTGAAAATCAGTAGGAATGCAATAACTACGTTTTCTAAGGAGCAACTTGACTCATTT CACACACTGAAGACTTTGGAAGCTGGTGGCAATAACTTCATTTGCTCCTGTGAATTCCTC TCCTTCACTCAGGAGCAGCAAGCACTGGCCAAAGTCTTGATTGATTGGCCAGCAAATTAC CTGTGTGACTCTCCATCCCATGTGCGTGGCCAGCAGGTTCAGGATGTCCGCCTCTCGGTG TCGGAATGTCACAGGACAGCACTGGTGTCTGGCATGTGCTGTGCTCTGTTCCTGCTGATC CTGCTCACGGGGGTCCTGTGCCACCGTTTCCATGGCCTGTGGTATATGAAAATGATGTGG GCCTGGCTCCAGGCCAAAAGGAAGCCCAGGAAAGCTCCCAGCAGGAACATCTGCTATGAT GCATTTGTTTCTTACAGTGAGCGGGATGCCTACTGGGTGGAGAACCTTATGGTCCAGGAG CTGGAGAACTTCAATCCCCCCTTCAAGTTGTGTCTTCATAAGCGGGACTTCATTCCTGGC AAGTGGATCATTGACAATATCATTGACTCCATTGAAAAGAGCCACAAAACTGTCTTTGTG CTTTCTGAAAACTTTGTGAAGAGTGAGTGGTGCAAGTATGAACTGGACTTCTCCCATTTC CGTCTTTTTGATGAGAACAATGATGCTGCCATTCTCATTCTTCTGGAGCCCATTGAGAAA AAAGCCATTCCCCAGCGCTTCTGCAAGCTGCGGAAGATAATGAACACCAAGACCTACCTG GAGTGGCCCATGGACGAGGCTCAGCGGGAAGGATTTTGGGTAAATCTGAGAGCTGCGATA AAGTCCTAGGTTCCCATATTTAAGACCAGTCTTTGTCTAGTTGGGATCTTTATGTCACTA GTTATAGTTAAGTTCATTCAGACATAATTATATAAAAACTACGTGGATGTACCGTCATTT GAGGACTTGCTTACTAAAACTACAAAACTTCAAATTTTGTCTGGGGTGCTGTTTTATAAA CATATGCCAGATTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_003264 unedited
ATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCGGAGGCAGCGAGAAAGCGC AGCCAGGCGGCTGCTCGGCGTTCTCTCAGGTGACTGCTCGGAGTTCTCCCAGTGTTTGGT GTTGCAAGCAGGATCCAAAGGAGACCTATAGTGACTCCCAGGAGCTCTTAGTGACCAAGT GAAGGTACCTGTGGGGCTCATTGTGCCCATTGCTCTTTCACTGCTTTCAACTGGTAGTTG TGGGTTGAAGCACTGGACAATGCCACATACTTTGTGGATGGTGTGGGTCTTGGGGGTCAT CATCAGCCTCTCCAAGGAAGAATCCTCCAATCAGGCTTCTCTGTCTTGTGACCGCAATGG TATCTGCAAGGGCAGCTCAGGATCTTTAAACTCCATTCCCTCAGGGCTCACAGAAGCTGT AAAAAGCCTTGACCTGTCCAACAACAGGATCACCTACATTAGCAACAGTGACCTACAGAG GTGTGTGAACCTCCAGGCTCTGGTGCTGACATCCAATGGAATTAACACAATAGAGGAAGA TTCTTTTTCTTCCCTGGGCAGTCTTGAACATTTAGACTTATCCTATAATTACTTATCTAA TTTATCGTCTTCCTGGTTCAAGCCCCTTTCTTCTTTAACATTCTTAAACTTACTGGGAAA TCCTTANCAAACCCTAGGGGAAACATCTCTTTTTTCTCATCTCACAAAATTGCAAATCCT GAGAGTGGGAAATATGGACACCTTCACTAAGATTCAAAGAAAAGAATTTGCTGGACTTNA CCTTCCTTGAGAAACTGAGATTGATGCTTCAGATCTACAGAGCTATGAGCCANAANGGNT TGAAGTCAATTAGAANTGTAAGTCATCTGATCCTTATATGAAGCAGCATATTTACTGCTG GNAGATTNGGTAAAGGTACCAGTTCGGGGAATGTTTTGGAACTGGAGAACTGATTTGCAC CTTTCATTTTCAGACTACCC >OriGene 3' read for NM_003264 unedited
GCCGCTTCTAAAGTCGAGNTCTTTTTTTTTTTTTTTTTTTTTTTTTTAAATCTGGCATAT GTTTATAAAACAGCACCCCAGACAAAATTTGAAGTTTTGTAGTTTTAGTAAGCAAGTCCT CAAATGACGGCACATCCACGCAGTTTTTATATAATTATGCCTGAATGAACTTAACTATAA CTAGTGACATAAAGATCCCAACTAGACAAAGACTGGCCTTAAATATGGGAACCTAGGACT TTATCGCAGCTCTCAGATTTACCCAAAATACTTCCCGCTGAGCCTCGCCCATGGGCCACT CCAGGTAGGTCTTGGTGTTCATTATCTTCCGCAGCTTGCAAAAGCGCTGGGGAATGGCTT TTTTCTCAATGGGCTCCAGAAGAATGAGAATGGCAGCTTCATTGTTCTCATCAAAAATAC GGAAATGGGAGAATTTCAGCTCATACTTGCACCACTCACTCTTAACAAAGTTTTCATAAA GCCACAAAGACAGCTTTGGGGCTCTTTTCAATGGAGTCAATGATATTGTCAATGATCCAC TTGCCAGGAATGAAGCCCCGCTTATGAAGACACAACTTGAAGGGGGGATTGAAGTTCTCC AACTCCTGGACCATAAGGGCTCTCTCCCCAGCTAGCCTACCCGTTCACTGTAAGAAACAA ATGCCTTATACCAAATGTCCCTGCTGGGACCTTTCCTGGGCCTTCTTTTGGCCTGTAGCC AGCCCCCCTTATTTTCATTTCCCAAGGCCTGGAATCGGTGGCCACGACCCCCCGACCGGA TTACTTGAACAATCCAACCCTGCCAAAACCAGGCTGTCTGGAATTCCACCCGAAAGGGGC TTCTAACTGTGGCCCCCCTGGGAGGAATCCACAGTATTGCGGCCAAAATAAAATTTGGCC ATCTGTGTCCTGTGAAGAAGAATCACGACCACGTATTCGCCCACTCTCAACTAAGGT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003264 |
| Insert Size | 2810 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003264.3, NP_003255.2 |
| RefSeq Size | 3417 bp |
| RefSeq ORF | 2355 bp |
| Locus ID | 7097 |
| UniProt ID | O60603 |
| Domains | TIR, LRRCT, LRR, LRR_TYP, LRR_BAC, LRR_PS |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Toll-like receptor signaling pathway |
| Gene Summary | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
VB-201, an Oxidized Phospholipid Small Molecule, Inhibits CD14- and TLR2-Dependent Innate Cell Activation and Constrains Atherosclerosis
,Mendel, I;Feige, E;Yacov, N;Salem, Y;Levi, I;Propheta-Meiran, O;Shoham, A;Ishai, E;George, J;Harats, D;Breitbart, E;,
Clin Exp Immunol. 2013 Sep 30
,PubMed ID 24116867
[TLR2]
|
|
Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation
,H D Park, Y Lee, Y K Oh, J G Jung, Y W Park, K Myung, K-H Kim, S S Koh, D-S Lim,
Oncogene (30 August 2010) doi:10.1038/onc.2010.401 Original Article
[TLR2]
|
|
Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection
,Wenli Liu, Ming Yan, Yueqin Liu, Ruihong Wang, Cuiling Li, Chuxia Deng, Aparna Singh, William G. Coleman, Jr., and Griffin P. Rodgers,
PNAS, Jun 2010; 107: 11056 - 11061
[TLR2]
|
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Resources
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| RC207597L3 | Lenti ORF clone of Human toll-like receptor 2 (TLR2), Myc-DDK-tagged |
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| RC207597L4 | Lenti ORF clone of Human toll-like receptor 2 (TLR2), mGFP tagged |
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| RG207597 | TLR2 (tGFP-tagged) - Human toll-like receptor 2 (TLR2) |
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