United States
Germany
Japan
United Kingdom
China
Desmocollin 2 (DSC2) (NM_004949) Human Untagged Clone
CAT＃: SC112671
DSC2 (untagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2b
CNY 6,208.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ARVD11; CDHF2; DG2; DGII/III; DSC3 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_004949, the custom clone sequence may differ by one or more nucleotides
ATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTGACCCTCGCGA TCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAA ACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAATCTAATTCATTCAAGTGATCCTGAC TTCCAAATTTTGGAGGATGGTTCAGTCTATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTT TTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAAC AAAGGTCCTAAAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATT CCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTTCAATCTGACACGG CCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCTCGGAATTTATTTTA TGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCTGTAGATCGTGAGCAGTATGAATCTTTTGAG ATAATTGCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAG AGGATGAAAATGATAACTACCCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAG AGTGGGCACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTG AAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACTACAGGCGTGA TCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTACCAGTTGAAAATAAAAGTACAAGA CATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAATGAC CACTTGCCAACATTTACTCGTACTTCTTATGTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCT TACGAGTTACTGTTGAGGATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAA GGGCAATGAAAATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTT AAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAAGCTCCATTTT CCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGA GGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAAAATGCAGAAGTGGGAACAACAAGC AATGGATATAAAGCATATGACCCAGAAACAAGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACTGATC CAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGC AGAGACCATCAAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGTACG GGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAGACAGTGATCA TCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCTATCCATGGCCCACC CTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAGAGAATGTGGAGACTGAAAGCAATTAATGAT ACAGCAGCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAG ATAGACTTGGCATGTCTAGTGTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTG CACACATCGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATA TTGTTGGGCATAGCATTGCTCTTTTGCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCTAAAC AACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCAAACACAGAAGCTCCTGGAGA TGACAAAGTGTATTCTGCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGTGGC ACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCT CGGAATCCTGCCGGGGGGCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGA CAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAGAATCCATTAGA GGACACACTCTGATTAAAAATTAA >OriGene 5' read for NM_004949 unedited
GGGTCANAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGATGGGCCT TATAGGTGGCGTCCGCTGGTGAGAAACACCTTGCGCAGTAAAAGGTGGCGGCGAGAGGGA GTTCCCACCCGTGGCTTTCTTAGAGAAATGAAGTCTTAAGTCTTAAATAGACAACAAGGA GGGGCCGATCGGTGTCTTTTGGACGCGTCTGGAGCCCCTCCCTCCGCCAAAGGAAAAGCC CCTTGGATGAGAGGCAGGCGCTTCAGAGAAGCTAAGAAAAGCACCTCTCCGCGCGCCCCA CCTCCTCCGCCTCGCGCTCCTCCTGAGCAGCGGGCCCAGACTGCGCTCCGGCCGCGGCCC TCGCCCCGCGGAGCCCTCCTACCCCGGCCCGACGCTCGGCCCGCGACCTGCCCCGAGCCC TCTCCATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCC TGCTGACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATG TTCCCTCCAAACTAGATGCCGAGAAACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTA CAGCTGCAAATCTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAG TCTATACAACAAATACTATTCTATTGTCCTNCGAGAAGAGAAGTTNTACCATATTACTTT CNCACACTGAGAAACCAAGANAGAAAGAAATATTTNGTCTTTTTGGAGCATCANACANAG GTCCCCTAAAGAAAGACATACTATAGAAAAAGTTCTAAGGCGCGCCCAGAGAAGATGGGC TNCCATTCCTTGTTCGATGCTAGAAAACTNCTTGGGTCCTTTTTNCACTTTTCTTTNCAC AGGNTCATCTGACACGGCCCANAACTATACATATACTATT >OriGene 3' read for NM_004949 unedited
NCCCCTCNTATGNNACCGCGGCCGCAATTTANNATCGAGTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTATGACTAGCCATTTTATCTAAGTTATAAAATAGTTACCCCAGGGAG CCTTCAAGATCCCTATATTTTAAAGCTTATTTCAAAAACCATCACTACTTCACATTTTTA AACTGCATCCTTGCATTACAGAACTGTAAATGGGTTGTCATACAGTAAATATCCACATCC CAATTCTAATTACACCATTCTTGTTGTTAACACAGAGCACTGCTTCTAATAAAAGCATGG CATAGTTCTACAGTTTCAATGGCAAAATTAAAGGTTTTTTTTCTTGAAGAGATAATGAAG CACTCACCAAGATATTTGAAACAACAAAGTTAACATTACAATGATTTCAAGAAAAACTAA GAATATTTCCCCTTACCTAAAACAAAAAAAAGGAATAATTCCCTTTATGAGAGAAGAAAA GAGAGACAGATTTTTAAAATATTTGGATTCTTTAGCCCATATGGAAATTAAAAAAAAAAA AAACCTGGGGAGAGAACCACAAGGAGACCGAGAGAAAGAGAGAGATGCCTCTTGACATTT TAAAGACCAAAAACTTGCAGCAGTTAAAATCCATTCCGGAAAGTTTTTTACAACCTTACA TTTCACCTGCCCAAAGCTCGTACCCGAGGAGACACCGATTCACTGCAGGATTTTATATAC ATTAAACCCTAAACTTAACCTCCCCCAAATGAAATTGTAATACACAATGCCTGGCTAAAA TTTTCCTTTGCCCGCGAAAAGGCCCCTCCCAAAACCACATTTCCCAGCATGCCGCCCCAC ACCTTCAAATGTCCCGCGAACACCGTTCTCCACCCCTCTCCACCCTTATTAACCGCGAAT ACGCTAACCAGGCCACTCCCATTCTCTTG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004949 |
| Insert Size | 4640 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004949.2, NP_004940.1 |
| RefSeq Size | 5186 bp |
| RefSeq ORF | 2544 bp |
| Locus ID | 1824 |
| UniProt ID | Q02487 |
| Domains | CA |
| Protein Families | Transmembrane |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| Gene Summary | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] Transcript Variant: This variant (Dsc2b, also known as DGIII) contains an additional exon at the 3' end compared to transcript variant Dsc2a. This results in a frame-shift and a shorter isoform (Dsc2b) with a distinct C-terminus compared to isoform Dsc2a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222207 | DSC2 (Myc-DDK-tagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2b |
CNY 6,208.00 |
|
| RC222207L3 | Lenti ORF clone of Human desmocollin 2 (DSC2), transcript variant Dsc2b, Myc-DDK-tagged |
CNY 10,740.00 |
|
| RC222207L4 | Lenti ORF clone of Human desmocollin 2 (DSC2), transcript variant Dsc2b, mGFP tagged |
CNY 10,740.00 |
|
| RG222207 | DSC2 (tGFP-tagged) - Human desmocollin 2 (DSC2), transcript variant Dsc2b |
CNY 9,690.00 |
其它Desmocollin 2产品
