HLA-DRB3 (NM_022555) Human Untagged Clone
CAT#: SC112463
HLA (untagged)-Human major histocompatibility complex, class II, DR beta 3 (HLA-DRB3)
CNY 2,400.00
CNY 2,950.00
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Synonyms | DRB3; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DRB3* |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene ORF within SC112463 sequence for NM_022555 edited (data generated by NextGen Sequencing)
ATGGTGTGTCTGAAGCTCCCTGGAGGCTCCAGCTTGGCAGCGTTGACAGTGACACTGATG GTGCTGAGCTCCCGACTGGCTTTCGCTGGGGACACCCGACCACGTTTCTTGGAGCTGCTT AAGTCTGAGTGTCATTTCTTCAATGGGACGGAGCGGGTGCGGTTCCTGGAGAGACACTTC CATAACCAGGAGGAGTACNTGCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTGAGG GAGCTGGGGCGGCCTGNNGCCGAGTACTGGAACAGCCAGAAGGACCTCCTGGAGCAGAAG CGGGGCCAGGTGGACAATTACTGCAGACACAACTACGGGGTTGGTGAGAGCTTCACAGTG CAGCGGCGAGTCCATCCTCAGGTGACTGTGTATCCTGCAAAGACCCAGCCCCTGCAGCAC CACAACCTCCTGGTCTGCTCTGTGAGTGGTTTCTATCCAGGCAGCATTGAAGTCAGGTGG TTCCGGAACGGCCAGGAAGAGAAGGCTGGGGTGGTGTCCACGGGCCTGATCCAGAATGGA GACTGGACCTTCCAGACCCTGGTGATGCTAGAAACAGTTCCTCGGAGTGGAGAGGTTTAC ACCTGCCAAGTGGAGCACCCAAGCGTAACGAGCCCTCTCACAGTGGAATGGAGTGCACGG TCTGAATCTGCACAGAGCAAGATGCTGAGTGGAGTCGGGGGCTTTGTGCTGGGCCTGCTC TTCCTTGGGGCCGGGCTGTTCATCTACTTCAGGAATCAGAAAGGACACTCTGGACTTCAG CCAACAGGATTCCTGAGCTGA Clone variation with respect to NM_022555.3 119 g=>t;164 a=>t;171 c=>g;175 t=>c;197 t=>a;199 c=>n;239 c=>g;257 t=>n;258 c=>n;266 c=>a;308 g=>a;603 t=>c;634 g=>c;654 a=>t >OriGene 5' read for NM_022555 unedited
NNNNGGTTCGAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGGAGAC TTGCCTGCTCCTCTGGCCCCTGGTCCTGTCCTCTTCTCCAGCATGGTGTGTCTGAAGCTC CCTGGAGGCTCCAGCTTGGCAGCGTTGACAGTGACACTGATGGTGCTGAGCTCCCGACTG GCTTTCGCTGGGGACACCCGACCACGTTTCTTGGAGCTGCTTAAGTCTGAGTGTCATTTC TTCAATGGGACGGAGCGGGTGCGGTTCCTGGAGAGACACTTCCATAACCAGGAGGAGTAC GCGCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTGAGGGAGCTGGGGCGGCCTGAT GCCGAGTACTGGAACAGCCAGAAGGACCTCCTGGAGCAGAAGCGGGGCCAGGTGGACAAT TACTGCAGACACAACTACGGGGTTGGTGAGAGCTTCACAGTGCAGCGGCGAGTCCATCCT CAGGTGACTGTGTATCCTGCAAAGACCCAGCCCCTGCAGCACCACAACCTCCTGGTCTGC TCTGTGAGTGGTTTCTATCCAGGCAGCATTGAAGTCAGGTGGTTCCGGAACGGCCAGGAA GAGAAGGCTGGNGGTGGTGTCCACGGGCCTGATCCAGAATGGAGACTGGACCTTCCAGAC CCTGGTGATGCTAGAAACAGTTCCTCGGAGGGGNAGAAGGTTTTACACCTGCCAAGTGGA GCACCCAAGCGTAACGAGCCCTCTCAAGTGGAATGGAGTGCACGGGTCTGATCTGCACAG AGCAGATGCTGAGTGGAGTTCGGGGGCTTTGTGCTGGGCCTGCTCTTCCTGGNGCCCGGG CTGNTCATCTACTTCAGGAATCAGAAGACACTCTGGACTTAGCCACAGGATTCTGANCTC >OriGene 3' read for NM_022555 unedited
GCTATGGACCGCGGCACGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGATATTTAA CTCCATCTTTGAGAAAATTTAATAATGTAATGTGTTTGTGGTACAGGGTGAGTACAGATG CACAGGAGGCCATAGGGTTTAGGCAAAGGGGAGCACAAAAGTTGAAGATGAGGCGCTGCC ATCAATGCTGGGACTTCAGGCCAAGGGCAGGAACTGAGGAAGCCACAAGGGAGGACATTT TCTGCAGTTGCTGAACCAGTAGCAACTAGGTCCTGAGAAAGCCCTCTCTCGTGGAAGAAT AACAGCCAGGCGGGAAAGCTTTTCATCCTGCAAAGCTGGGGAAGAAGATTCTTCCTTAAA TTGTCATCTGCACTTCAGCTCAAGAATCCTGTTGGCTGAAGTCCAGAGTGTCCTTTCTGA TTCCTGAAGTAGATGAACAGCCCGGCCCCAAGGAAGAGCAGGCCCAGCACAAAGCCCCCG ACTCCACTCAGCATCTTGCTCTGTGCAGATTCAGACCGTGCACTCCATTCCACTGTGAGA GGGCTCGTTACGCTTGGGTGCTCCACTTGGCAGGTGTAAACCTCTCCACTCCGAGGAACT GTTTCTAGCATCACCAGGGTCTGGAAGGTCCAGTCTCCATTCTGGATCAGGCCCGTGGAC ACCACCCCAGCCTTCTCTTCCTGGCCGTTCCGGAACCACCTGACTTCAATGCTGCCTGGA TAGAAACCACTCACAGAGCAAACCANGAAGTTGTGGTGCTGCAGGGGCTGGGTCTTTGCA AGATACACAGTCACCCTGAGATGGACTCGCCGCTGCACTGTGAAGCTCTCACCAACCCCG TAGNTGTGTCTGCAGTAATTTGTCCACTGGNCCCGCTTCTGCTCCAGNAGGTCCTTCGGG CTGTTCAGTACTCGGNATTAAGCCGCCCCANTTCCTCACCGGCNGGTACTTCCCCACTGG CTTTTGAAACCCCGTTCTTCTCCTGTTTTGGAT |
Restriction Sites | NotI-NotI |
ACCN | NM_022555 |
Insert Size | 1240 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_022555.3, NP_072049.2 |
RefSeq Size | 1158 bp |
RefSeq ORF | 801 bp |
Locus ID | 3125 |
UniProt ID | P79483 |
Domains | MHC_II_beta, ig, IGc1 |
Protein Families | Transmembrane |
Protein Pathways | Allograft rejection, Antigen processing and presentation, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Hematopoietic cell lineage, Systemic lupus erythematosus, Type I diabetes mellitus, Viral myocarditis |
Gene Summary | HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
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RC210732 | HLA (Myc-DDK-tagged)-Human major histocompatibility complex, class II, DR beta 3 (HLA-DRB3) |
CNY 2,400.00 |
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RC210732L3 | Lenti-ORF clone of HLA (Myc-DDK-tagged)-Human major histocompatibility complex, class II, DR beta 3 (HLA-DRB3) |
CNY 5,890.00 |
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RC210732L4 | Lenti-ORF clone of HLA (mGFP-tagged)-Human major histocompatibility complex, class II, DR beta 3 (HLA-DRB3) |
CNY 5,890.00 |
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RG210732 | HLA (tGFP-tagged) - Human major histocompatibility complex, class II, DR beta 3 (HLA-DRB3) |
CNY 4,000.00 |
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SC322032 | HLA (untagged)-Human major histocompatibility complex, class II, DR beta 3 (HLA-DRB3) |
CNY 2,400.00 |
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