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RIC3 (NM_024557) Human Untagged Clone
CAT＃: SC112180
RIC3 (untagged)-Human resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 1
CNY 3,656.00
| Cited in 12 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AYST720; PRO1385 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC112180 sequence for NM_024557 edited (data generated by NextGen Sequencing)
ATGGCGTACTCCACAGTGCAGAGAGTCGCTCTGGCTTCTGGGCTTGTCCTGGCTCTGTCG CTGCTGCTGCCCAAGGCCTTCCTGTCCCGCGGGAAGCGGCAGGAGCCGCCGCCGACACCT GAAGGAAAATTGGGCCGATTTCCACCTATGATGCATCATCACCAGGCACCCTCAGATGGC CAGACTCCTGGGGCTCGTTTCCAGAGGTCTCACCTTGCCGAGGCATTTGCAAAGGCCAAA GGATCAGGTGGAGGTGCTGGAGGAGGAGGTAGTGGAAGAGGTCTGATGGGGCAGATTATT CCAATCTACGGTTTTGGGATTTTTTTATATATACTGTACATTCTATTTAAGCTCTCAAAG GGGAAAACAACTGCAGAGGATGGGAAATACTATACTGCCATGCCTGGAAACACCCACAGG AAAATTACCAGTTTTGAGCTTGCTCAACTGCAAGAAAAACTGAAGGAGACAGAAGCAGCC ATGGAAAAATTAATCAACAGAGTGGGACCTAATGGTGAGAGAGCACAGACTGTGACTTCT GACCAAGAGAAACGGTTGCTACATCAGCTCCGAGAAATCACCAGGGTCATGAAAGAAGGA AAATTCATTGACAGATTTTCTCCAGAGAAAGAAGCTGAGGAGGCCCCTTACATGGAGGAC TGGGAAGGTTACCCTGAAGAGACTTACCCAATTTATGACCTTTCAGACTGTATCAAGCGT AGGCAAGAAACAATCTTGGTGGATTACCCTGACCCAAAAGAACTTTCTGCTGAAGAAATA GCTGAAAGAATGGGAATGATAGAAGAGGAAGAATCAGATCATTTGGGTTGGGAAAGTCTG CCCACTGACCCCAGAGCCCAGGAAGATAATTCTGTTACCTCGTGTGATCCAAAGCCAGAA ACATGTTCCTGCTGTTTTCATGAAGACGAGGATCCTGCTGTCTTGGCAGAGAATGCTGGA TTCAGTGCAGATAGCTACCCTGAGCAAGAGGAAACCACCAAAGAAGAGTGGTCCCAAGAC TTTAAAGATGAAGGGTTGGGCATCAGCACCAATAAAGCATATACAGGCAGCATGCTGAGG AAGCGTAACCCCCAGGGTTTAGAGTGA Clone variation with respect to NM_024557.3 389 g=>a;1051 g=>a >OriGene 5' read for NM_024557 unedited
GTATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGGCTGGCGTC TGCACCTGCGACCACCGTGAGCAGTCATGGCGTACTCCACAGTGCAGAGAGTCGCTCTGG CTTCTGGGCTTGTCCTGGCTCTGTCGCTGCTGCTGCCCAAGGCCTTCCTGTCCCGCGGGA AGCGGCAGGAGCCGCCGCCGACACCTGAAGGAAAATTGGGCCGATTTCCACCTATGATGC ATCATCACCAGGCACCCTCAGATGGCCAGACTCCTGGGGCTCGTTTCCAGAGGTCTCACC TTGCCGAGGCATTTGCAAAGGCCAAAGGATCAGGTGGAGGTGCTGGAGGAGGAGGTAGTG GAAGAGGTCTGATGGGGCAGATTATTCCAATCTACGGTTTTGGGATTTTTTTATATATAC TGTACATTCTATTTAAGCTCTCAAAGGGGAAAACAACTGCAGAGGATGGGAAATACTATA CTGCCATGCCTGGAAACACCCACAGGAAAATTACCAGTTTTGAGCTTGCTCAACTGCAAG AAAAACTGAAGGAGACAGAAGCAGCCATGGAAAAATTAATCAACAGAGTGGGACCTAATG GTGAGAGAGCACAGACTGTGACTTCTGACCAAGAGAAACGGTTGCTACATCAGCTCCGAG AAATCACCAGGGTCATGAAAGAAGGAAAATTCATTGACAGATTTTCTCCAGAGAAGAAGC TGANGAGGCCCCTTACATGGANGACTGNGAAGGTTACCCTGAAGAGACTTACCCATTTAT GACCTTTCAGACTGTATCAAGCGTAGGCAAGAAACATCTGGTGGATTACCCTGACCAAAA GACTTTCTGCTGAAGAATANCTGAAGAATGGGATGATAGAGAGGAGAATAGATCATTTGG TG >OriGene 3' genomic read for NM_024557 unedited
GTTAAAAACCTTTTTTTTTGGCAACAAAAACCTGACCCATGATTTTGTCATCCTGGGTTG TATATACACATATAACTGTCATCCCCAAAGGATAAAATAATTCTGGAAAATCCAAAAAGA ATTTTCTAAATCCTAAATAACTGAAAGGTACATCCAAATGTCTGATATATAAATACACAA ATATATTCCTTATATATAAACCAACCAAGAGCTAGGGCAGGAAGAACCACCATAAGGGCT TAGTACTTCTGGCAGGAATTTCCATAAGCCAATTTTCCCCAAAGACCAACAACACTTTAC ATAACAGCCTCACCAAAATACTTGAACATCCATGTATTTTCACACCCTACTGCTTTTTTC AACAACTCTTTCTGCCAAGAGTGTCCTCTCTTCTTTGCCTACCTGAAGAAGTTCTTTGCA TGCCTCAAGGCCCACCTCCCAAGAAACTGTGAAGTTTCTTGGCAATACTTTAGCAAAAAC AATTTATCTTTCCTGTAGTTTTGGGCCCATGTCTGAATTACAGCATAGCCCTTATAATAA AAACATAATTACCACTTAATGAGTGGTTATCATGTATGAGCTAGAACCAATGCTGTTTTA CACACACTGATGATTTCATTTAACCAGGACCTTTAATACCCCTCCCTTTACTACCCTGAA GCCAAAGCTCAGACCAGTTAAGGAGCTGACCCAAGATTCCACAGCTAGGAAATGCAGGGA CAGATCATGGCTCATGTTTCTCTGCCTGCAAGATTCACCAATCTGAGCCCTCTTACAGGG GCATAGTTCATTTTATCTGGCAAGCTCTCTCTCGTCACACTGAGTTTTTTGAGGGTAGAG ATTGACCTCTGTTCCTAAACCCGGCACTGAACATTGACTGCTTAATGATGAATGAACTTC AGAAACCACCCTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_024557 |
| Insert Size | 1107 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_024557.2, NP_078833.2 |
| RefSeq Size | 2907 bp |
| RefSeq ORF | 1107 bp |
| Locus ID | 79608 |
| UniProt ID | Q7Z5B4 |
| Protein Families | Transmembrane |
| Gene Summary | This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] Transcript Variant: This variant (1) encodes isoform c. The isoform designation was changed from 'a' to 'c' to be consistent with isoforms cited in PMID 18691158. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (12)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly
,Kweon, HJ;Gu, S;Witham, E;Dhara, M;Yu, H;Mandon, ED;Jawhari, A;Bredt, DS;,
Cell Rep
,PubMed ID 32783947
[RIC3]
|
|
Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain?
,null,
Biomolecules
,PubMed ID 32204458
[RIC3]
|
|
Oligoarginine Peptides, a New Family of nAChR Inhibitors
,Lebedev, D;Kryukova, E;Ivanov, I;Egorova, N;Timofeev, N;Spirova, E;Tufanova, E;Siniavin, A;Kudryavtsev, D;Kasheverov, I;Zouridakis, M;Katsarava, R;Zavradashvili, N;Iagorshvili, I;Tzartos, S;Tsetlin, V;,
Mol. Pharmacol.
,PubMed ID 31492697
[RIC3]
|
|
Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors
,Spirova, EN;Ivanov, IA;Kasheverov, IE;Kudryavtsev, DS;Shelukhina, IV;Garifulina, AI;Son, LV;Lummis, SCR;Malca-Garcia, GR;Bussmann, RW;Hennig, L;Giannis, A;Tsetlin, VI;,
PLoS ONE
,PubMed ID 30608952
[RIC3]
|
|
Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant
,Shelukhina, IV;Zhmak, MN;Lobanov, AV;Ivanov, IA;Garifulina, AI;Kravchenko, IN;Rasskazova, EA;Salmova, MA;Tukhovskaya, EA;Rykov, VA;Slashcheva, GA;Egorova, NS;Muzyka, IS;Tsetlin, VI;Utkin, YN;,
Toxins (Basel) 2018
,PubMed ID 29316656
[RIC3]
|
|
Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors
,Durek, T;Shelukhina, IV;Tae, HS;Thongyoo, P;Spirova, EN;Kudryavtsev, DS;Kasheverov, IE;Faure, G;Corringer, PJ;Craik, DJ;Adams, DJ;Tsetlin, VI;,
Sci Rep
,PubMed ID 29192197
[RIC3]
|
|
Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants
,Shelukhina, I;Spirova, E;Kudryavtsev, D;Ojomoko, L;,
PloS one
,PubMed ID 28797116
[RIC3]
|
|
Peptides from puff adder Bitis arietans venom, novel inhibitors of nicotinic acetylcholine receptors
,Vulfius, CA;Spirova, EN;Serebryakova, MV;Shelukhina, IV;Kudryavtsev, DS;Kryukova, EV;Starkov, VG;Kopylova, NV;Zhmak, MN;Ivanov, IA;Kudryashova, KS;Andreeva, TV;Tsetlin, VI;Utkin, YN;,
Toxicon
,PubMed ID 27576061
[Ric3]
|
|
New quinoline derivatives as nicotinic receptor modulators
,Manetti, D;Bellucci, C;Dei, S;Teodori, E;Varani, K;Spirova, E;Kudryavtsev, D;Shelukhina, I;Tsetlin, V;Romanelli, MN;,
Eur J Med Chem
,PubMed ID 26840365
[RIC3]
|
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6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human a7 Nicotinic Acetylcholine Receptor
,Kasheverov, IE;Shelukhina, IV;Kudryavtsev, DS;Makarieva, TN;Spirova, EN;Guzii, AG;Stonik, VA;Tsetlin, VI;,
Mar Drugs
,PubMed ID 25775422
[RIC3]
|
|
Amyloid ß Peptides, Signalling and Trafficking of the a7 Nicotine Receptor
,Young, K;,
Thesis Jan 2015
[RIC3]
|
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Role of {alpha}7 Nicotinic Acetylcholine Receptor in Calcium Signaling Induced by Prion Protein Interaction with Stress-inducible Protein 1
,Flavio H. Beraldo, Camila P. Arantes, Tiago G. Santos, Nicolle G. T. Queiroz, Kirk Young, R. Jane Rylett, Regina P. Markus, Marco A. M. Prado, and Vilma R. Martins,
J. Biol. Chem., Nov 2010; 285: 36542 - 36550
[RIC3]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205179 | RIC3 (Myc-DDK-tagged)-Human resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 1 |
CNY 3,656.00 |
|
| RC205179L1 | Lenti ORF clone of Human resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC205179L2 | Lenti ORF clone of Human resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC205179L3 | Lenti ORF clone of Human resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC205179L4 | Lenti ORF clone of Human resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG205179 | RIC3 (tGFP-tagged) - Human resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 1 |
CNY 5,256.00 |
