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Integrin beta 1 (ITGB1) (NM_002211) Human Untagged Clone
CAT＃: SC111935
ITGB1 (untagged)-Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A
CNY 8,776.00
| Cited in 5 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002211 edited
GAATTCGGCACGAGGGCGGGAGAGGCCCAGCGGGAGTCGCGGAACAGCAGGCCCGAGCCC ACCGCGCCGGGCCCCGGACGCCGCGCGGAAAAGATGAATTTACAACCAATTTTCTGGATT GGACTGATCAGTTCAGTTTGCTGTGTGTTTGCTCAAACAGATGAAAATAGATGTTTAAAA GCAAATGCCAAATCATGTGGAGAATGTATACAAGCAGGGCCAAATTGTGGGTGGTGCACA AATTCAACATTTTTACAGGAAGGAATGCCTACTTCTGCACGATGTGATGATTTAGAAGCC TTAAAAAAGAAGGGTTGCCCTCCAGATGACATAGAAAATCCCAGAGGCTCCAAAGATATA AAGAAAAATAAAAATGTAACCAACCGTAGCAAAGGAACAGCAGAGAAGCTCAAGCCAGAG GATATTACTCAGATCCAACCACAGCAGTTGGTTTTGCGATTAAGATCAGGGGAGCCACAG ACATTTACATTAAAATTCAAGAGAGCTGAAGACTATCCCATTGACCTCTACTACCTTATG GACCTGTCTTACTCAATGAAAGACGATTTGGAGAATGTAAAAAGTCTTGGAACAGATCTG ATGAATGAAATGAGGAGGATTACTTCGGACTTCAGAATTGGATTTGGCTCATTTGTGGAA AAGACTGTGATGCCTTACATTAGCACAACACCAGCTAAGCTCAGGAACCCTTGCACAAGT GAACAGAACTGCACCAGCCCATTTAGCTACAAAAATGTGCTCAGTCTTACTAATAAAGGA GAAGTATTTAATGAACTTGTTGGAAAACAGCGCATATCTGGAAATTTGGATTCTCCAGAA GGTGGTTTCGATGCCATCATGCAAGTTGCAGTTTGTGGATCACTGATTGGCTGGAGGAAT GTTACACGGCTGCTGGTGTTTTCCACAGATGCCGGGTTTCACTTTGCTGGAGATGGGAAA CTTGGTGGCATTGTTTTACCAAATGATGGACAATGTCACCTGGAAAATAATATGTACACA ATGAGCCATTATTATGATTATCCTTCTATTGCTCACCTTGTCCAGAAACTGAGTGAAAAT AATATTCAGACAATTTTTGCAGTTACTGAAGAATTTCAGCCTGTTTACAAGGAGCTGAAA AACTTGATCCCTAAGTCAGCAGTAGGAACATTATCTGCAAATTCTAGCAATGTAATTCAG TTGATCATTGATGCATACAATTCCCTTTCCTCAGAAGTCATTTTGGAAAACGGCAAATTG TCAGAAGGAGTAACAATAAGTTACAAATCTTACTGCAAGAACGGGGTGAATGGAACAGGG GAAAATGGAAGAAAATGTTCCAATATTTCCATTGGAGATGAGGTTCAATTTGAAATTAGC ATAACTTCAAATAAGTGTCCAAAAAAGGATTCTGACAGCTTTAAAATTAGGCCTCTGGGC TTTACGGAGGAAGTAGAGGTTATTCTTCAGTACATCTGTGAATGTGAATGCCAAAGCGAA GGCATCCCTGAAAGTCCCAAGTGTCATGAAGGAAATGGGACATTTGAGTGTGGCGCGTGC AGGTGCAATGAAGGGCGTGTTGGTAGACATTGTGAATGCAGCACAGATGAAGTTAACAGT GAAGACATGGATGCTTACTGCAGGAAAGAAAACAGTTCAGAAATCTGCAGTAACAATGGA GAGTGCGTCTGCGGACAGTGTGTTTGTAGGAAGAGGGATAATACAAATGAAATTTATTCT GGCAAATTCTGCGAGTGTGATAATTTCAACTGTGATAGATCCAATGGCTTAATTTGTGGA GGAAATGGTGTTTGCAAGTGTCGTGTGTGTGAGTGCAACCCCAACTACACTGGCAGTGCA TGTGACTGTTCTTTGGATACTAGTACTTGTGAAGCCAGCAACGGACAGATCTGCAATGGC CGGGGCATCTGTGAGTGTGGTGTCTGTAAGTGTACAGATCCGAAGTTTCAAGGGCAAACG TGTGAGATGTGTCAGACCTGCCTTGGTGTCTGTGCTGAGCATAAAGAATGTGTTCAGTGC AGAGCCTTCAATAAAGGAGAAAAGAAAGACACATGCACACAGGAATGTTCCTATTTTAAC ATTACCAAGGTAGAAAGTCGGGACAAATTACCCCAGCCGGTCCAACCTGATCCTGTGTCC CATTGTAAGGAGAAGGATGTTGACGACTGTTGGTTCTATTTTACGTATTCAGTGAATGGG AACAACGAGGTCATGGTTCATGTTGTGGAGAATCCAGAGTGTCCCACTGGTCCAGACATC ATTCCAATTGTAGCTGGTGTGGTTGCTGGAATTGTTCTTATTGGCCTTGCATTACTGCTG ATATGGAAGCTTTTAATGATAATTCATGACAGAAGGGAGTTTGCTAAATTTGAAAAGGAG AAAATGAATGCCAAATGGGACACGGGTGAAAATCCTATTTATAAGAGTGCCGTAACAACT GTGGTCAATCCGAAGTATGAGGGAAAATGAGTACTGCCCGTGCAAATCCCACAACACTGA ATGCGAAGTAGCAATTTCCATAGTCACAGTTAGGTAGCTTTAGGGCAATATTGCCATGGT TTTACTCATGTGCAGGTTTTGAAAATGTACAATATGTATAATTTTTAAAATGTTTTATTA TTTTGAAAATAATGTTGTAATTCATGCCAGGGACTGACAAAAGACTTGAGACAGGATGGT TATTCTTGTCAGCTAAGGTCACATTGTGCCTTTTTGACCTTTTCTTCCTGGACTATTGAA ATCAAGCTTATTGGATTAAGTGATATTTCTATAGCGATTGAAAGGGCAATAGTTAAAGTA ATGAGCATGATGAGAGTTTCTGTTAATCATGTATTAAAACTGATTTTTAGCTTTACAAAT ATGTCAGTTTGCAGTTATGCAGAATCCAAAGTAAATGTCCTGCTAGCTAGTTAAGGATTG TTTTAAATCTGTTATTTTGCTATTTGCCTGTTAGACATGACTGATGACATATCTGAAAGA CAAGTATGTTGAGAGTTGCTGGTGTAAAATACGTTTGAAATAGTTGATCTACAAAGGCCA TGGGAAAAATTCAGAGAGTTAGGAAGGAAAAACCAATAGCTTTAAAACCTGTGTGCCATT TTAAGAGTTACTTAATGTTTGGTAACTTTTATGCCTTCACTTTACAAATTCAAGCCTTAG ATAAAAGAACCGAGCAATTTTCTGCTAAAAAGTCCTTGATTTAGCACTATTTACATACAG GCCATACTTTACAAAGTATTTGCTGAATGGGGACCTTTTGAGTTGAATTTATTTTATTAT TTTTATTTTGTTTAATGTCTGGTGCTTTCTATCACCTCTTCTAATCTTTTAATGTATTTG TTTGCAATTTTGGGGTAAGACTTTTTTTATGAGTACTTTTTCTTTGAAGTTTTAGCGGTC AATTTGCCTTTTTAATGAACATGTGAAGTTATACTGTGGCTATGCAACAGCTCTCACCTA CGCGAGTCTTACTTTGAGTTAGTGCCATAACAGACCACTGTATGTTTACTTCTCACCATT TGAGTTGCCCATCTTGTTTCACACTAGTCACATTCTTGTTTTAAGTGCCTTTAGTTTTAA CAGTTCACTTTTTACAGTGCTATTTACTGAAGTTATTTATTAAATATGCCTAAAATACTT AAATCGGAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_002211 unedited
CGCTGGTACAGGATTTTGTNATACGATTTCCTCTNAGGGCGGCCCGCGAATTCGCACGAG GGCGGGAGAGGCCCAGCGGGAGTCGCGNGACAGCAGGCCCGAGCCCACCGCGCCGGGCCC CGGACGCCGCGCGGAAAAGATGAATTTACAACCAATTTTCTGGATTGGACTGATCACTTC AGTTTGCTGTGTGTTTGCTCAAACAGATGAACATAGATGTTTAAAAGCAAATGCCAAATC ATGTGGAGAATGTATACAAGCAGGGCCAAATTGTGGGTGGTGCACAAATTCAACATTTTT ACAGGAAGGAATGCCTACTTCTGCACGATGTGATGATTTAGAAGCCTTAAAAAAGAAGGG TTGCCCTCCAGATGACATAGAAAATCCCAGAGGCTCCAAAGATATAAAGAAAAATAAAAA TGTAACCAACCGTAGCAAAGGAACAGCAGAGAAGCTCAAGCCAGAGGATATTACTCAGAT CCAACCACAGCAGTTGGTTTTGCGATTAAGATCAGGGGAGCCACAGACATTTACATTAAA ATTCAAGAGAGCTGAAGACTATCCCATTGACCTCTACTACCTTATGGACCTGTCTTACTC AATGAAAGACGATTTGGAGAATGTAAAAAGTCTTGGAACAGATCTGATGAATGAAATGAG GAGGATTACTTCGGACTTCAGAATTGGATTTGGCTCATTTGTGGAAAAGACTGTGATGCC TTACATTAGCACAACACCAGCTAAGCTCAGGAACCCTTGCACAAGTGAACAGAACTGCAC CAGCCCATTTAGCTACAAAAATGTGCTCAGTCTTACTAATAAAGGAGAAGTATTTAATGA CCTTGTTGGAAACAGCGCCATATCTGNAAATTTGCATTCTCCACAGGTGGTTTCA >OriGene 3' read for NM_002211 unedited
CTAGAGTCGAGTTTTTTTTTTTTTTTTTTCCGATTTAAGTATTTTAGGCATATTTAATAA ATAACTTCAGTAAATAGCACTGTAAAAAGTGAACTGTTAAAACTAAAGGCACTTAAAACA AGAATGTGACTAGTGTGAAACAAGATGGGCAACTCAAATGGTGAGAAGTAAACATACAGT GGTCTGTTATGGCACTAACTCAAAGTAAGACTCGCGTAGGTGAGAGCTGTTGCATAGCCA CAGTATAACTTCACATGTTCATTAAAAAGGCAAATTGACCGCTAAAACTTCAAAGAAAAA GTACTCATAAAAAAAGTCTTACCCCAAAATTGCAAACAAATACATTAAAAGATTAGAAGA GGTGATAGAAAGCACCAGACATTAAACAAAATAAAAATAATAAAATAAATTCAACTCAAA AGGTCCCCATTCAGCAAATACTTTGTAAAGTATGGCCTGTATGTAAATAGTGCTAAATCA AGGACTTTTTAGCAGAAAATTGCTCGGTTCTTTTATCTAAGGCTTGAATTTGTAAAGTGA AGGCATAAAAGTTACCAAACATTAAGTAACTCTTAAATGGCACACAGGTTTTAAAGCTAT TGGTTTTTCCTTCCTAACTCTCTGAATTTTTCCATGGCCTTTGTAGATCAACTATTTCAA ACGTATTTTACACCAGCAACTCTCAACATACTTTGTCTTTAGATATGTCCATAGCCATGT CTACAGGCAAATAGCAAAATACAGATTTAAACCATCCTTACTTACTAGCAGGACATTACT TTGATTCTGCTTACTGCAACTGCATATTTGGAAGCTAAAATCATTTTATACTGATTACAG AAACTTATATGCCCTTACTTAACATTGCCCTTNCAATGCTTAGAAAATCCTTATCCAAAG CTGTTTCATTGCCAGGATAAAGGAAAAGGCAATGGACCTACTGAAAAAAACCCCTGTTAA AGTTTTGCCCTTGTCCATCCAATTTCTCCAATTAACCTCCACCCACTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002211 |
| Insert Size | 3800 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002211.2, NP_002202.2 |
| RefSeq Size | 3700 bp |
| RefSeq ORF | 2397 bp |
| Locus ID | 3688 |
| UniProt ID | P05556 |
| Domains | INB, PSI |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axon guidance, Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer |
| Gene Summary | Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1A) represents the longest transcript and encodes the shorter isoform (1A). Both variants 1A and 1E encode the same isoform. |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network
,Yang, J;Hou, Y;Zhou, M;Wen, S;Zhou, J;Xu, L;Tang, X;Du, YE;Hu, P;Liu, M;,
Int. J. Biochem. Cell Biol.
,PubMed ID 26693891
[ITGB1]
|
|
Gln-362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with a5ß1 Integrin
,Lee, HS;Oh, SJ;Lee, KH;Lee, YS;Ko, E;Kim, KE;Kim, HC;Kim, S;Song, PH;Kim, YI;Kim, C;Han, S;,
J. Biol. Chem.
,PubMed ID 25237190
[ITGB1]
|
|
Development of Transgenic Cloned Pig Models of Skin Inflammation by DNA Transposon-Directed Ectopic Expression of Human ?1 and ?2 Integrin
,null,
PLoS ONE
,PubMed ID 22590584
[ITGB1]
|
|
SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways
,Florian Steinberg, Kate J. Heesom, Mark D. Bass, and Peter J. Cullen,
J. Cell Biol., Apr 2012; 197: 219 - 230.
[ITGB1]
|
|
N-Glycosylation of the I-like Domain of ß1 Integrin Is Essential for ß1 Integrin Expression and Biological Function: IDENTIFICATION OF THE MINIMAL N-GLYCOSYLATION REQUIREMENT FOR 5ß1
,Tomoya Isaji, Yuya Sato, Tomohiko Fukuda, and Jianguo Gu,
J. Biol. Chem., May 2009; 284: 12207 - 12216.
[ITGB1]
|
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Resources
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| RC203818L1 | Lenti ORF clone of Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, Myc-DDK-tagged |
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| RC203818L2 | Lenti ORF clone of Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, mGFP tagged |
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| RC203818L3 | Lenti ORF clone of Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, Myc-DDK-tagged |
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| RC203818L4 | Lenti ORF clone of Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, mGFP tagged |
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| RG203818 | ITGB1 (tGFP-tagged) - Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A |
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