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ABAT (NM_000663) Human Untagged Clone
CAT＃: SC111922
ABAT (untagged)-Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2
CNY 3,728.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GABA-AT; GABAT; NPD009 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC111922 sequence for NM_000663 edited (data generated by NextGen Sequencing)
ATGGCCTCCATGTTGCTCGCCCAGCGCCTGGCCTGCAGCTTCCAGCACAGCTACCGCCTG CTGGTGCCTGGATCCAGACACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGAT TATGATGGGCCTCTGATGAAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAA CAGCTGAATATAATTCAGAATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGC CGAGGCAATTACCTGGTTGATGTGGACGGCAACCGAATGCTGGATCTTTATTCCCAGATC TCCTCTGTTCCCATAGGTTACAGCCACCCCGCCCTGCTGAAACTCATCCAACAGCCTCAA AATGCGAGCATGTTTGTCAACAGACCCGCCCTCGGAATCCTGCCTCCGGAGAACTTTGTG GAGAAGCTCCGGCAGTCCTTGCTCTCGGTGGCTCCCAAAGGGATGTCCCAGCTCATCACC ATGGCCTGCGGCTCCTGCTCCAATGAAAACGCCTTAAAGACCATCTTCATGTGGTACCGG AGCAAGGAAAGAGGGCAGAGGGGCTTCTCCCAGGAGGAGCTGGAGACGTGCATGATTAAC CAGGCCCCTGGCTGCCCCGACTACAGCATCCTCTCCTTCATGGGCGCGTTCCATGGGAGG ACCATGGGTTGCTTAGCGACCACGCACTCTAAAGCCATTCACAAGATCGACATCCCTTCC TTTGACTGGCCCATCGCACCGTTCCCACGGCTGAAATACCCTCTGGAAGAGTTTGTGAAA GAGAACCAACAGGAGGAGGCCCGCTGTCTGGAAGAGGTGGAGGATCTGATTGTGAAATAT CGGAAAAAGAAGAAGACGGTGGCCGGGATCATCGTGGAGCCCATCCAGTCCGAGGGTGGA GACAACCACGCATCCGATGACTTCTTTCGGAAGCTGAGAGACATCGCCAGGAAGCATGGC TGCGCCTTCTTGGTGGACGAGGTCCAGACCGGAGGAGGCTGCACGGGCAAGTTCTGGGCC CATGAGCACTGGGGCCTGGATGACCCAGCAGACGTGATGACCTTCAGCAAGAAGATGATG ACTGGGGGCTTCTTCCACAAGGAGGAGTTCAGGCCTAATGCTCCCTACCGGATCTTCAAC ACCTGGCTGGGGGACCCGTCCAAGAACCTGTTGCTGGCTGAGGTCATCAACATCATCAAG CGGGAGGACCTGCTAAATAATGCAGCCCATGCCGGGAAGGCCCTGCTCACAGGACTGCTG GACCTCCAGGCCCGGTACCCCCAGTTCATCAGCAGGGTGAGAGGACGAGGCACCTTTTGC TCCTTCGATACTCCCGATGATTCCATACGGAATAAGCTCATTTTAATTGCCAGAAACAAA GGTGTGGTGTTGGGTGGCTGTGGTGACAAATCCATTCGTTTCCGTCCCACGCTGGTCTTC AGGGATCACCACGCTCACCTGTTCCTCAATATTTTCAGTGACATCTTAGCAGACTTCAAG TAA Clone variation with respect to NM_000663.4 309 c=>t >OriGene 5' read for NM_000663 unedited
GTTCACATTTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACGAGGGCGAGTCGCT GGGGGAAGTCGAGCAGACACCCAGCGCTGCCGGAACTCGGGGCGCGCATCCCGCAAGTCG GAACCCGGCGGATCGGATCCCGCAGATCGGAGACGGGGCCTGGAGATGCGCCCATCCAGG GTCTAGCGGATTGCAAAGGGCCTGGTAGAATCAAAGAGGGATATACTAATGCAACTTCGA GGGTGGCAGCACGCAAAGGGTGTCCCTGTCCCTCAAGGGGTCATGGCCTCCATGTTGCTC GCCCAGCGCCTGGCCTGCAGCTTCCAGCACAGCTACCGCCTGCTGGTGCCTGGATCCAGA CACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGATTATGATGGGCCTCTGATG AAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAACAGCTGAATATAATTCAG AATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGCCGAGGCAATTACCTGGTT GATGTGGACGGCAACCGAATGCTGGATCTTTATTCCCAGATCTCCTCTGTTCCCATAGGT TACAGCCACCCCGCCCTGCTGAAACTCATCCAACAGCCTCAAAATGCGAGCATGTTTGTC AACAGACCCGCCCTCGGAATCCTGCCTCCGGAGAACTTTGTGGAGAAGCTCCGGCAGTCC TTGCTCTCGGTGGCTCCCNAGGGATGTCCCAGCTCATCACCATGGCCTGCGGCTCCTGCT CCAATGANACGCCTTNAAGACATCTTCATGTGGTACCGGAGCAGGAAAGAGGNCAGAGGG GCTTCTCCCAGGAGAGCTGGAGACGTGCATGATTAACCANGCCCCTGGCTGCCCNGATAC AGCATCCTCTTCTTATGGNGCGCG >OriGene 3' read for NM_000663 unedited
TGGTTTTTTTACGNATTCTTACTAACACAGGNAAACAGCATTTAATTCATGGGAATTGTG CATATGGTCATCCGTTACATTGTGACATGTTAATTTTTTTTTTATCATTTATTGGCACTG TCAACAGATTACTTGTGAACAAGATCACTTTGTACGCTTAAGTCTGCGATGCTACTTAGC TATGGTTTTCTACCATGAGCTTATATATAGATAGGTGTAGGTATGTAGATACATTAATGC TATACACAATTTTGCATGGTTACTGAGCGTCAGTAAAAATTATGAAAAAACACCCATTTA TAATAAAAGTGAGGATGTACTAAGACTTGCTATTACTGGACCTTGTTTTCTGTAAAAGTG ATGACACTTGCTGGACGGTTACTAAACTCTATGGCACTAATGTATGATGGATTCATTTCC AGACTGTCGGCCACGGAAGCACTTCTTCATGGCCTCTGCCCTGGACAGCAGCCTGTCCTC CGGGCTCCCCATGTTTTTACCAGCTTCTGCTGAGTTTCTACAATCTTGAGCTCTGCTGAG AATTCTTTTCCTTGAAATTCTTCTAGCTAAAGCCCCAGCCCCCAAAGGAGCATGTCTCAG GAACTCATTATGCCCTGAGTCAACAAGAACTTGTTGATAAATGGCTTAAAAGTTTTTACA AGAAGTAACTTCCCTTGGTAAGGAGTAAATAATAGCTCTGGAATTTTCCAGATAAAACTA TTTCATTTCTCTGTCAGTGCCCCATGGGGAGAGAACGAAATATTGGAGCCCCTCTCCCTA CCAAAGAGAGCCACTNTTCTGGTTGTGCCCTGGCTTAAACCCTTTGGACTCCGAGAACAT ACTGATATTTGACCCATGCTAAATTTTCAGGAGAAGCTACTTAAGCATAATGATATGGTT GGTTGATTTGCTGCTGCTAATAGCCTANTGACTTGGAGCTGCTGGGAACTGGCTCCAGGA AGAGTGAGC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000663 |
| Insert Size | 4880 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000663.2, NP_000654.2 |
| RefSeq Size | 4763 bp |
| RefSeq ORF | 1503 bp |
| Locus ID | 18 |
| UniProt ID | P80404 |
| Domains | aminotran_3 |
| Protein Families | Druggable Genome |
| Protein Pathways | Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Propanoate metabolism, Valine, leucine and isoleucine degradation |
| Gene Summary | 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC206793 | ABAT (Myc-DDK-tagged)-Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2 |
CNY 3,656.00 |
|
| RC206793L1 | Lenti ORF clone of Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC206793L2 | Lenti ORF clone of Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2, mGFP tagged |
CNY 6,460.00 |
|
| RC206793L3 | Lenti ORF clone of Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2, Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC206793L4 | Lenti ORF clone of Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2, mGFP tagged |
CNY 6,460.00 |
|
| RG206793 | ABAT (tGFP-tagged) - Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2 |
CNY 5,040.00 |
