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PANK2 (NM_024960) Human Untagged Clone
CAT＃: SC111841
PANK2 (untagged)-Human pantothenate kinase 2 (PANK2), transcript variant 3
CNY 2,400.00
CNY 6,270.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C20orf48; HARP; HSS; NBIA1; PKAN |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC111841 sequence for NM_024960 edited (data generated by NextGen Sequencing)
ATGCCTGCTTTTATTCAAATGGGCAGAGATAAAAACTTCTCGAGTCTCCACACTGTCTTT TGTGCCACTGGAGGTGGAGCGTACAAATTTGAGCAGGATTTTCTCACAATAGGTGATCTT CAGCTTTGCAAACTGGATGAACTAGATTGCTTGATCAAAGGAATTTTATACATTGACTCA GTCGGATTCAATGGACGGTCACAGTGCTATTACTTTGAAAACCCTGCTGATTCTGAAAAG TGTCAGAAGTTACCATTTGATTTGAAAAATCCGTATCCTCTGCTTCTGGTGAACATTGGC TCAGGGGTTAGCATCTTAGCAGTATATTCCAAAGATAATTACAAACGGGTCACAGGTACT AGTCTTGGAGGAGGAACTTTTTTTGGTCTCTGCTGTCTTCTTACTGGCTGTACCACTTTT GAAGAAGCTCTTGAAATGGCATCTCGTGGAGATAGCACCAAAGTGGATAAACTAGTACGA GATATTTATGGAGGGGACTATGAGAGGTTTGGACTGCCAGGCTGGGCTGTGGCTTCAAGC TTTGGAAACATGATGAGCAAGGAGAAGCGAGAGGCTGTCAGTAAAGAGGACCTGGCCAGA GCGACTTTGATCACCATCACCAACAACATTGGCTCAATAGCAAGAATGTGTGCCCTTAAT GAAAACATTAACCAGGTGGTATTTGTTGGAAATTTCTTGAGAATTAATACGATCGCCATG CGGCTTTTGGCATATGCTTTGGATTATTGGTCCAAGGGGCAGTTGAAAGCACTTTTTTCG GAACACGAGGGTTATTTTGGAGCTGTTGGAGCACTCCTTGAGCTGTTGAAGATCCCGTGA Clone variation with respect to NM_024960.4 >OriGene 5' read for NM_024960 unedited
TGTATACGACTCCTATAGGCGGCCGCGAATTCGGCACGAGGGCGAGAAGGAATCCGACGC TGGGGGGCTTGCTCGGGCGGCAGCGACTGCTGCTGCGGATGGGAGCGGGCCGGCTCGGCG CGCCCATGGAGCGCCACGGCAGGGCTTCCGCCACCTCCGTCTCGTCGGCTGGGGAGCAGG CGGCCGGGGACCGCGNAGGGCGGCGGCAGGAGCCACTGCGGCGCCGGGCGAGCAGCGCGT CGGTGCCCGCGGTCGGGGCCTCGGCTGAGGGCACGAGGCGGGATCGACTGGGCTCTTACA GCGGCCCCACCTCGGTCTCCCGCCAGCGCGTCGAAAGCCTGAGGAAAAAGCGGCCGCTTT TTCCATGGTTTGGACTGGATATCGGTGGAACTCTGGTCAAGCTGGTATATTTTGAACCCA AAGACATCACTGCTGAAGAAGAAGAGGAAGAAGTGGAAAGTCTTANAAGCATTCGGAAGT ACCTGACCTCCAATGTGGCTTATGGGTCTACAGGCATTCGGGACGTGCACCTCGAGCTGA AGGACCTGACTCTGTGTGGACGCAAAGGCAATCTGCACTTTATACGCTNTCCCACTCATG ACATGCCTGCNTTTATTCAAATGGGCAGAGATAAAAAACTTCTCGAGTCTCCACACTGTC TTTTGTGCCACTGGAGGTGGAGCGTACACATTTGAGCAGGATTTTCTCACAATAGGTGAT CTTCAGCTTTGCAAACTGGATGAACTAGATTGCTTGATCAAAGGAATTTATACATTGACT CCAGTCGATTCCATGGACGGTCACAGTGCTATTACCTTTGAAACCTGCTGATTCTGAAAA GTGTCAAAGTTACCATCTGATTTGAAAATCCGCATCCCTGCGTTTGGGGACATTGCCTCA GGGTACATCTTACCGATAT >OriGene 3' read for NM_024960 unedited
NNTTTACTCTGNNACCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTGAAA AAAACATGTTTTACAGTAAGTTCACACACAGGCTTAATGCAAACCAGAGTAATGCACAGA TGATTGCCAAGACCATATTGACAAATTGTGATTAGATTATAACGCATAGTAGCCTGCCTT ACATTCAGCAAGTTCAAACAGGACACAAAACCAGTCAACTGAACACAGAGCAGCTCTCTT CAGAAGCACTTCCAATGAGTGATGCAGAGATTTCAAAAATACAAAGCAGGCAACTTATAT ACAGCAAATCCTCACACTGCCTGGACATGTGCCACTTTTTTGTTGTTTTTAATATATTTT TCCTTCCTGGTTGCTAATTTAGACTGAATTCTTAAGGATTTATCTTGATGACTTAGAAAA ATACACCTGTCCTTTCTCACTTTGTTTCAGGTAGTACAGTCATGAAATTGAGTAAGTCTC TTAAAAAAATGAAAGTCCACAGATCCCATTGTGGAAGGTTTCAGGAACCCCTCCCCAGGT AATGATCACGGGATCTTCAACAGCTCAAGGAGTGCTCCAACAGCTCCAAAATAACCCTCG TGTTCCGAAAAAAGTGCTTTCAACTGCCCCTTGGACCAATAATCCAAAGCATATGCCAAA AGCCGCATGGCGATCGTATTAATTCTCAAGAAATTTCCAACAAATACCACCTGGTTAATG TTTTCATTAAGGGCACACATTCTTGCTATTGAGCCAATGTTGTTGGTGATGGTGATCAAA GTCGCTCTGGCCCAGTCCTCTTTACTGACAGCCTCTCGCTTCTCCTTGCTCATCATGTTT CCAAAGCTTGAAGCCACAGCCAGCCTGGCAGTCCAACCTCTCATATCCCCTCCATAATAT CTCGNACTAATTATCCACTTTGGNGT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_024960 |
| Insert Size | 1950 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_024960.3, NP_079236.3 |
| RefSeq Size | 1711 bp |
| RefSeq ORF | 840 bp |
| Locus ID | 80025 |
| UniProt ID | Q9BZ23 |
| Domains | Fumble |
| Protein Families | Druggable Genome |
| Protein Pathways | Metabolic pathways, Pantothenate and CoA biosynthesis |
| Gene Summary | This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (3) has an alternate first exon, and uses a downstream translation initiation site, compared to variant 1. The resulting protein (isoform 2) lacks an N-terminal segment compared to isoform 1, resulting in a shorter protein that shares identity through the C-terminus. Isoform 2 is not expressed in mitochondria. Variants 2, 3 and 7 encode isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217228 | PANK2 (Myc-DDK-tagged)-Human pantothenate kinase 2 (PANK2), transcript variant 3 |
CNY 2,400.00 |
|
| RC217228L3 | Lenti ORF clone of Human pantothenate kinase 2 (PANK2), transcript variant 3, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC217228L4 | Lenti ORF clone of Human pantothenate kinase 2 (PANK2), transcript variant 3, mGFP tagged |
CNY 5,890.00 |
|
| RG217228 | PANK2 (tGFP-tagged) - Human pantothenate kinase 2 (PANK2), transcript variant 3 |
CNY 4,370.00 |
