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REA (PHB2) (NM_007273) Human Untagged Clone
CAT＃: SC111193
PHB2 (untagged)-Human prohibitin 2 (PHB2), transcript variant 2
CNY 2,400.00
CNY 2,950.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BAP; Bap37; BCAP37; p22; PNAS-141; REA |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_007273, the custom clone sequence may differ by one or more nucleotides
ATGGCCCAGAACTTGAAGGACTTGGCGGGACGGCTGCCCGCCGGGCCCCGGGGCATGGGCACGGCCCTGA AGCTGTTGCTGGGGGCCGGCGCCGTGGCCTACGGTGTGCGCGAATCTGTGTTCACCGTGGAAGGCGGGCA CAGAGCCATCTTCTTCAATCGGATCGGTGGAGTGCAGCAGGACACTATCCTGGCCGAGGGCCTTCACTTC AGGATCCCTTGGTTCCAGTACCCCATTATCTATGACATTCGGGCCAGACCTCGAAAAATCTCCTCCCCTA CAGGCTCCAAAGACCTACAGATGGTGAATATCTCCCTGCGAGTGTTGTCTCGACCCAATGCTCAGGAGCT TCCTAGCATGTACCAGCGCCTAGGGCTGGACTACGAGGAACGAGTGTTGCCGTCCATTGTCAACGAGGTG CTCAAGAGTGTGGTGGCCAAGTTCAATGCCTCACAGCTGATCACCCAGCGGGCCCAGGTATCCCTGTTGA TCCGCCGGGAGCTGACAGAGAGGGCCAAGGACTTCAGCCTCATCCTGGATGATGTGGCCATCACAGAGCT GAGCTTTAGCCGAGAGTACACAGCTGCTGTAGAAGCCAAACAAGTGGCCCAGCAGGAGGCCCAGCGGGCC CAATTCTTGGTAGAAAAAGCAAAGCAGGAACAGCGGCAGAAAATTGTGCAGGCCGAGGGTGAGGCCGAGG CTGCCAAGATGCTTGGAGAAGCACTGAGCAAGAACCCTGGCTACATCAAACTTCGCAAGATTCGAGCAGC CCAGAATATCTCCAAGACGATCGCCACATCACAGAATCGTATCTATCTCACAGCTGACAACCTTGTGCTG AACCTACAGGATGAAAGTTTCACCAGGGGAAGTGACAGCCTCATCAAGGGTAAGAAATGA >OriGene 5' read for NM_007273 unedited
TTTGTAAACGACTCACTATAGGCGGCCCGCGAATTCGCACGAGGCTTTCGCCAGCCTTAC GGGCCCGAACCCTCGTGTGAAGGGTGCAGTACCTAAGCCGGAGCGGGGTAGAGGCGGGCC GGCACCCCCTTCTGACCTCCAGTGCCGCCGGCCTCAAGATCAGACATGGCCCAGAACTTG AAGGACTTGGCGGGACGGCTGCCCGCCGGGCCCCGGGGCATGGGCACGGCCCTGAAGCTG TTGCTGGGGGCCGGCGCCGTGGCCTACGGTGTGCGCGAATCTGTGTTCACCGTGGAAGGC GGGCACAGAGCCATCTTCTTCAATCGGATCGGTGGAGTGCAGCAGGACACTATCCTGGCC GAGGGCCTTCACTTCAGGATCCCTTGGTTCCAGTACCCCATTATCTATGACATTCGGGCC AGACCTCGAAAAATCTCCTCCCCTACAGGCTCCAAAGACCTACAGATGGTGAATATCTCC CTGCGAGTGTTGTCTCGACCCAATGCTCAGGAGCTTCCTAGCATGTACCAGCGCCTAGGG CTGGACTACGAGGAACGAGTGTTGCCGTCCATTGTCAACGAGGTGCTCAAGAGTGTGGTG GCCAAGTTCAATGCCTCACAGCTGATCACCCAGCGGGCCCAGGTATCCCTGGTTGATCCG CCGGGAGCTGACAGAGAGGGCCAAGGACTTCAGCCTCATCCTGGATGATGTGGCCATCAC AGAGCTGAGCTTTAGCCGAGAGTACACAGCTGCTGTAGAAGCAAACAAGTGGCCCAGCAG GAGGCCCCAGCGGCCCCCATTCTTGGTAGAAAAAGCAAGCANGAACAGCGCAGAAAATGT GCAGCCCCAGGGTGAGGCCCGAGCTGCCAAATGCTTGGAGAACACTGAGCAGAACCTGCT ACACAACTTGCAGAATT >OriGene 3' read for NM_007273 unedited
CTTTGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTCAGGTTAAGT AATAAAAATTATTGAGAATTCCTGGGTTGGTGTTTATCTCCTCCCAGCCTTGAGGGAGGG AACAACACTGTAGGAAATCACTTGAGAAATCACGCACTGTCCCCAACAGCCCCAGTTAAC ACAGGGAGGAGGAAAGTAATTCCCCAGAAAAGGGGCTAGTCTTCAGTCTTCCTTAATCCA AGAGGGGTTCAGGGAACCGGTGTGGGGGACCATCGCATGATACTGGGGCGGGGTAGGGCT GTGCTGGACCCCTGGCTGGCTCCTCAAAAACTGGAGAAGCAGATCCACTTCCTCTGGGGG TGGAGTTCTTGGTGACTAGGCTCATTTCTTACCCTTGATGAGGCTGTCACTTCCCCTGGT GAAACTTTCATCCTGTAGGTTCAGCACAAGGTTGTCAGCTGTGAGATAGATACGATTCTG TGATGTGGCGATCGTCTTGGAGATATTCTGGGCTGCTCGAATCTTGCGAAGTTTGATGTA GCCAGGGTTCTTGCTCAGTGCTTCTCCAAGCATCTTGGCAGCCTCGGCCTCACCCTCGGC CTGCACAATTTTCTGCCGCTGTTCCTGCTTTGCTTTTTCTACCAAGAATTGGGCCCGCTG GGCCTCCTGCTGGGCCACTTGTTTGGCTTCTACAGCAGCTGTGTACTCTCGGCTAAAGCT CAGCTCTGTGATGGCCACATCATCCAGGATGAGGCTGAAGTCCTTGGCCCTCTCTGTCAG CTCCGGNCGGATCAACAGGNATACCTNGGCCCGCTGGTGATCAGCTGTGAGCATTGAACT TGCCACCACACTCTTGAGCACCTCGTGACATGGACGGCACACTCGTTCTCGTAGTCAGCC TAGCGCTGNTACATGCTAGAGCTCTGACATTGGTCAGACACCTGCAGGAGATATACTCTG TAGCTTTGACTGA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_007273 |
| Insert Size | 1400 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_007273.3, NP_009204.1 |
| RefSeq Size | 1416 bp |
| RefSeq ORF | 900 bp |
| Locus ID | 11331 |
| Domains | Band_7 |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514).[UniProtKB/Swiss-Prot Function] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Mitochondrial Dysfunction Confers Resistance to Multiple Drugs in Caenorhabditis elegans
,Iryna O. Zubovych, Sarah Straud, and Michael G. Roth,
Mol. Biol. Cell, Mar 2010; 21: 956 - 969
[PHB2]
|
|
A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance
,Iryna Zubovych, Thomas Doundoulakis, Patrick G Harran, and Michael G Roth,
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15523-8.
[PHB2]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210710 | PHB2 (Myc-DDK-tagged)-Human prohibitin 2 (PHB2), transcript variant 2 |
CNY 2,400.00 |
|
| RC210710L1 | Lenti ORF clone of Human prohibitin 2 (PHB2), transcript variant 2, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC210710L2 | Lenti ORF clone of Human prohibitin 2 (PHB2), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC210710L3 | Lenti ORF clone of Human prohibitin 2 (PHB2), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC210710L4 | Lenti ORF clone of Human prohibitin 2 (PHB2), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG210710 | PHB2 (tGFP-tagged) - Human prohibitin 2 (PHB2), transcript variant 2 |
CNY 4,000.00 |
