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AIF (AIFM1) (NM_004208) Human Untagged Clone
CAT＃: SC111098
AIFM1 (untagged)-Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1
CNY 4,576.00
CNY 7,220.00
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AIF; AUNX1; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; NADMR; NAMSD; PDCD8; SEMDHL |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC111098 sequence for NM_004208 edited (data generated by NextGen Sequencing)
ATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTG CGGACCGTGTGCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAGGCAACTTGTTCCAG CGATGGCATGTTCCTCTAGAACTCCAGATGACAAGACAAATGGCTAGCTCTGGTGCATCA GGGGGCAAAATCGATAATTCTGTGTTAGTCCTTATTGTGGGCTTATCAACAGTAGGAGCT GGTGCCTATGCCTACAAGACTATGAAAGAGGATGAAAAAAGATACAATGAAAGAATTTCA GGGTTAGGGCTGACACCAGAACAGAAACAGAAAAAGGCCGCGTTATCTGCTTCAGAAGGA GAGGAAGTTCCTCAAGACAAGGCGCCAAGTCATGTTCCTTTCCTGCTAATTGGTGGAGGC ACAGCTGCTTTTGCTGCAGCCAGATCCATCCGGGCTCGGGATCCTGGGGCCAGGGTACTG ATTGTATCTGAAGATCCTGAGCTGCCGTACATGCGACCTCCTCTTTCAAAAGAACTGTGG TTTTCAGATGACCCAAATGTCACAAAGACACTGCGATTCAAACAGTGGAATGGAAAAGAG AGAAGCATATATTTCCAGCCACCTTCTTTCTATGTCTCTGCTCAGGACCTGCCTCATATT GAGAATGGTGGTGTGGCTGTCCTCACTGGGAAGAAGGTAGTACAGCTGGATGTGAGAGAC AACATGGTGAAACTTAATGATGGCTCTCAAATAACCTATGAAAAGTGCTTGATTGCAACA GGAGGTACTCCAAGAAGTCTGTCTGCCATTGATAGGGCTGGAGCAGAGGTGAAGAGTAGA ACAACGCTTTTCAGAAAGATTGGAGACTTTAGAAGCTTGGAGAAGATTTCACGGGAAGTC AAATCAATTACGATTATCGGTGGGGGCTTCCTTGGTAGCGAACTGGCCTGTGCTCTTGGC AGAAAGGCTCGAGCCTTGGGCACAGAAGTGATTCAACTCTTCCCCGAGAAAGGAAATATG GGAAAGATCCTCCCCGAATACCTCAGCAACTGGACCATGGAAAAAGTCAGACGAGAGGGG GTTAAGGTGATGCCCAATGCTATTGTGCAATCCGTTGGAGTCAGCAGTGGCAAGTTACTT ATCAAGCTGAAAGACGGCAGGAAGGTAGAAACTGACCACATAGTGGCAGCTGTGGGCCTG GAGCCCAATGTTGAGTTGGCCAAGACTGGTGGCCTGGAAATAGACTCAGATTTTGGTGGC TTCCGGGTAAATGCAGAGCTACAAGCACGCTCTAACATCTGGGTGGCAGGAGATGCTGCA TGCTTCTACGATATAAAGTTGGGAAGGAGGCGGGTAGAGCACCATGATCACGCTGTTGTG AGTGGAAGATTGGCTGGAGAAAATATGACTGGAGCTGCTAAGCCGTACTGGCATCAGTCA ATGTTCTGGAGTGATTTGGGCCCCGATGTTGGCTATGAAGCTATTGGTCTTGTGGACAGT AGTTTGCCCACAGTTGGTGTTTTTGCAAAAGCAACTGCACAAGACAACCCCAAATCTGCC ACAGAGCAGTCAGGAACTGGTATCCGATCAGAGAGTGAGACAGAGTCCGAGGCCTCAGAA ATTACTATTCCTCCCAGCACCCCGGCAGTTCCACAGGCTCCCGTCCAGGGGGAGGACTAC GGCAAAGGTGTCATCTTCTACCTCAGGGACAAAGTGGTCGTGGGGATTGTGCTATGGAAC ATCTTTAACCGAATGCCAATAGCAAGGAAGATCATTAAGGACGGTGAGCAGCATGAAGAT CTCAATGAAGTAGCCAAACTATTCAACATTCATGAAGACTGA Clone variation with respect to NM_004208.3 >OriGene 5' read for NM_004208 unedited
TTTTAGGATTTTGTAATACGATCTCACTATAGGGCGGCCGCGAATCGGCACGAGGGAGAG GAAAGGGAAGGAGGAGGTCCCGAATAGCGGTCGCCGAAAGTTCCGGTGTGGAGGCCTGGC GGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTGCGGACCGTGTGCGTCCGAAGCCC GAGGCAGAGGAACCGGCTCCCAGGCAACTTGTTCCAGCGATGGCATGTTCCTCTAGAACT CCAGATGACAAGACAAATGGCTAGCTCTGGTGCATCAGGGGGCAAAATCGATAATTCTGT GTTAGTCCTTATTGTGGGCTTATCAACAGTAGGAGCTGGTGCCTATGCCTACAAGACTAT GAAAGAGGATGAAAAAAGATACAATGAAAGAATTTCAGGGTTAGGGCTGACACCAGAACA GAAACAGAAAAAGGCCGCGTTATCTGCTTCAGAAGGAGAGGAAGTTCCTCAAGACAAGGC GCCAAGTCATGTTCCTTTCCTGCTAATTGGTGGAGGCACAGCTGCTTTTGCTGCAGCCAG ATCCATCCGGGCTCGGGATCCTGGGGCCAGGGTACTGATTGTATCTGAAGATCCTGAGCT GCCGTACATGCGACCTCCTCTTTCAAAAGAACTGTGGTTTTCAGATGACCCACATGTCAC AAAGACACTGCGATTCAAACAGTGGAATGGAAAAGAGAGAAGCATATATTTCCAGCCACC TTCTTTCTATGTCTCTGCTCANGACCTGCCTCATATTGAGAATGGCGCTGTGGCTGTCCT CACTGTGAAGAAGTAGTACACCTGGATGTGACAGACAACAGGGTGAAACTTAATGATGGC TCTCCAATAACCTATGAAAAGTGCCTTGATTGCAACAAGTAGGTACTTCCAACAAGTCTG TCTTGCCATTGATACGCGCTGGAC >OriGene 3' read for NM_004208 unedited
ACCGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTAGAAGAACAGAATTTAT TTCACTATGTGAACATTAAGAATTTACCTACATAGTTGAAAATATTCACAAAGGACTTGA TCATTCACACTCATACACAGAGAAAGTCTGCTGAATAAAAAAATGCTCCTTTACCCATTC GACCTCCTCTCAGGGGCTGCAGTGGGTTTGCCAATTCCACTGTGGGGCTTCAGTCTTCAT GAATGTTGAATAGTTTTGCTACCTCCATTGGAAACTTATGCTGGCCCCCCGGGCCTTAAA AGAACCCCCCTGCTTTTGGGGCTTGGGGAAAAAAAAGGTTCAAAAAAAAAACCCCCCCAA CCCTTTTTTCTCTGGGGGGAAAAAAAAAAAAACCTTTTTCGGGGAAACCCCCCCCCCCCC GAGGAGGGATCCTTTTTAATAACCCCGGGGGGGGGGGGGGGAGGAAAAAAAAAATTTTTG TGGGCGGGGGGGCTCTTTTTTTTTTTTTTTTTTTTGGAGGGCAACACCCCCCCTCTTTCT TTTTTTGAGAAAAAAAAAAGGGGGTGTGTTTTTACCCTCATTTCTTTTCCAAAAAAACAC CCCGCGCGGGGGTGTTCTCCTCCCCCAAAAAACAAAAACTAATTTTTTATTCGGTACGCG CGGGGGGCGCTCCACCACACACAAACGAATTAGTGGGGCGAGGGGGGGCCGGCGAATACC AACACACTATTTTTCTTTTTTTTTTCTCTCTCTCCCCTCCCCCCCACCCCACCCGAGACG GGGGGGGGTGGCGGGGCCCCCCCCCCCCCCTCCTCTTATNTTTACACCAAAACAACCCAC CCTCCTCCTCTCCTCCCCCACTCAGATACTATATATGCATTCGCCGTCTCTCTCCCACTC TAATAAACCAAAAACT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004208 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004208.2, NP_004199.1 |
| RefSeq Size | 2215 bp |
| RefSeq ORF | 1842 bp |
| Locus ID | 9131 |
| UniProt ID | O95831 |
| Domains | pyr_redox |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Apoptosis |
| Gene Summary | This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015] Transcript Variant: This variant (1) encodes the longest isoform (AIF). |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC224064 | AIFM1 (Myc-DDK-tagged)-Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1 |
CNY 4,568.00 |
|
| RC224064L1 | Lenti ORF clone of Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged |
CNY 6,968.00 |
|
| RC224064L2 | Lenti ORF clone of Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC224064L3 | Lenti ORF clone of Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC224064L4 | Lenti ORF clone of Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG224064 | AIFM1 (tGFP-tagged) - Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1 |
CNY 6,168.00 |
