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Prion protein PrP (PRNP) (NM_000311) Human Untagged Clone
CAT＃: SC110984
PRNP (untagged)-Human prion protein (PRNP), transcript variant 1
CNY 2,400.00
CNY 2,950.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AltPrP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PrP; PrP27-30; PrP33-35C; PrPc |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC110984 sequence for NM_000311 edited (data generated by NextGen Sequencing)
ATGGCGAACCTTGGCTGCTGGATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGGGC CTCTGCAAGAAGCGCCCGAAGCCTGGAGGATGGAACACTGGGGGCAGCCGATACCCGGGG CAGGGCAGCCCTGGAGGCAACCGCTACCCACCTCAGGGCGGTGGTGGCTGGGGGCAGCCT CATGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCCCATGGTGGTGGC TGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAGTCAGTGGAAC AAGCCGAGTAAGCCAAAAACCAACATGAAGCACATGGCTGGTGCTGCAGCAGCTGGGGCA GTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCATCATACAT TTCGGCAGTGACTATGAGGACCGTTACTATCGTGAAAACATGCACCGTTACCCCAACCAA GTGTACTACAGGCCCATGGATGAGTACAGCAACCAGAACAACTTTGTGCACGACTGCGTC AATATCACAATCAAGCAGCACACGGTCACCACAACCACCAAGGGGGAGAACTTCACCGAG ACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCAGATGTGTATCACCCAGTACGAGAGG GAATCTCAGGCCTATTACCAGAGAGGATCGAGCATGGTCCTCTTCTCCTCTCCACCTGTG ATCCTCCTGATCTCTTTCCTCATCTTCCTGATAGTGGGATGA Clone variation with respect to NM_000311.3 >OriGene 5' read for NM_000311 unedited
TTTGTATACGACTCACTATAGGGCGGCCGCGAATCGGCACGAGGCGACCGAGAGCAGTCA TTATGGCGAACCTTGGCTGCTGGATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGG GCCTCTGCAAGAAGCGCCCGAAGCCTGGAGGATGGAACACTGGGGGCAGCCGATACCCGG GGCAGGGCAGCCCTGGAGGCAACCGCTACCCACCTCAGGGCGGTGGTGGCTGGGGGCAGC CTCATGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCCCATGGTGGTG GCTGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAGTCAGTGGA ACAAGCCGAGTAAGCCAAAAACCAACATGAAGCACATGGCTGGTGCTGCAGCAGCTGGGG CAGTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCATCATAC ATTTCGGCAGTGACTATGAGGACCGTTACTATCGTGAAAACATGCACCGTTACCCCAACC AAGTGTACTACAGGCCCATGGATGAGTACAGCAACCAGAACAACTTTGTGCACGACTGCG TCAATATCACAATCAAGCAGCACACGGTCACCACAACCACCAAGGGGGAGAACTTCACCG AGACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCANATGTGTATCACCCAGTACGAGA GGGAATCTCAGGCCTATTACCAGAGGAGATCGAGCATGGTCCTCTTCTCCTCTCCACCTG GATCCTNCTGATCTCTTTCCTCATCTTCCTGATAGGGGGATGAGGAANGGTCTTNNCTGT TTNCACCATCTTNCTAAATCTTNTTCAGCTTGAGGGAGGCGGNATCCACCTGCACCCTTT TANGGGNGGGA >OriGene 3' read for NM_000311 unedited
NGGCTTCACTCTGAACCCGCGGCCGCATNCTAAGATCGAGTTTTTTTTTTTTTTTTTTGG TGCTCATCTTCGCTCGTTTAATTTCAGTCAGATATTAAACATTTACAATTTTTTTATATA ACAAAACAAGAACATGCAAAGTTACAAATATAGAAAATATAAAGTACATGCATATTTCAA AGACCTGTTAATGGTGTCCACTTTGGATTCTTACATGAAACGATTCAGTGCACATTGTAA GCCTAAGGACCACGCAAAAGGGTTTCCCACATATTAAGTATTCAGTACCTTACAAAAGTT AATGCATTAGACACTTCAGATGTTAACTGCTCTAAACAAAACTCCTAAGTCTGTCCTATG CAATATATATTTTATATACATATATATTTTTACATAGAATACTCACAAAGTGCAAGCCAA TAATAACATTGCAGAAAAGTAATACATATCTGCTAGGTGACAATATCAAACAATTCAGGG AATAATTTTACTTTAATTAACATTAACAGAATTTCTTTTTCCACTTCAAATCAATCATAT TTCTGTCATCTCCAACCTAAGATATTTTTTAGATTGTCTCCCTATTCTTTGATTCAAAAG CCAATTACAGAAACTATGAACTTGACCTAATTCTGGTTTTTGACAATTATGAGACAGAAA TAAAGAAATGCAAGCAGTTCTTTTCTTTGCACACTGACCATTTTTTAATTACATCATCCT CTATGATGATGGTGCTTTCACAACTGCAGCTCTCCTGTATGTCAAAATCATTCTGGTTTC CAGGTAAATGGACAAAGGAGATTTGCCTTCAGTGTCTAGAAAGCAATTACTTTTCAGCTG CCTTAATTACTATAGTTAAAGAAAGGATGCCCATATAGGGCCTTTAAACANTAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000311 |
| Insert Size | 1400 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000311.2, NP_000302.1 |
| RefSeq Size | 2483 bp |
| RefSeq ORF | 762 bp |
| Locus ID | 5621 |
| UniProt ID | P04156 |
| Domains | prion |
| Protein Families | ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane |
| Protein Pathways | Prion diseases |
| Gene Summary | The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 can all encode the same isoform (Prp). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The prion protein inhibits monocytic cell migration by stimulating ß1 integrin adhesion and uropod formation
,Richardson, DD;Tol, S;Valle-Encinas, E;Pleguezuelos, C;Bierings, R;Geerts, D;Fernandez-Borja, M;,
J. Cell. Sci.
,PubMed ID 26159734
[PRNP]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205438 | PRNP (Myc-DDK-tagged)-Human prion protein (PRNP), transcript variant 1 |
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| RC205438L1 | Lenti ORF clone of Human prion protein (PRNP), transcript variant 1, Myc-DDK-tagged |
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| RC205438L2 | Lenti ORF clone of Human prion protein (PRNP), transcript variant 1, mGFP tagged |
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| RC205438L3 | Lenti ORF clone of Human prion protein (PRNP), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
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| RC205438L4 | Lenti ORF clone of Human prion protein (PRNP), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
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| RG205438 | PRNP (tGFP-tagged) - Human prion protein (PRNP), transcript variant 1 |
CNY 4,000.00 |
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