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Ku70 (XRCC6) (NM_001469) Human Untagged Clone
CAT＃: SC110901
XRCC6 (untagged)-Human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6)
CNY 4,544.00
| Cited in 2 publications. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CTC75; CTCBF; G22P1; KU70; ML8; TLAA |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC110901 sequence for NM_001469 edited (data generated by NextGen Sequencing)
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAA GAAGAGAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTTTT TTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT GACATGAGCATCCAGTGTATCCAAAGTGTGTACATCAGTAAGATCATAAGCAGTGATCGA GATCTCTTGGCTGTGGTGTTCTATGGTACCGAGAAAGACAAAAATTCAGTGAATTTTAAA AATATTTACGTCTTACAGGAGCTGGATAATCCAGGTGCAAAACGAATTCTAGAGCTTGAC CAGTTTAAGGGGCAGCAGGGACAAAAACGTTTCCAAGACATGATGGGCCACGGATCTGAC TACTCACTCAGTGAAGTGCTGTGGGTCTGTGCCAACCTCTTTAGTGATGTCCAATTCAAG ATGAGTCATAAGAGGATCATGCTGTTCACCAATGAAGACAACCCCCATGGCAATGACAGT GCCAAAGCCAGCCGGGCCAGGACCAAAGCCGGTGATCTCCGAGATACAGGCATCTTCCTT GACTTGATGCACCTGAAGAAACCTGGGGGCTTTGACATATCCTTGTTCTACAGAGATATC ATCAGCATAGCAGAGGATGAGGACCTCAGGGTTCACTTTGAGGAATCCAGCAAGCTAGAA GACCTGTTGCGGAAGGTTCGCGCCAAGGAGACCAGGAAGCGAGCACTCAGCAGGTTAAAG CTGAAGCTCAACAAAGATATAGTGATCTCTGTGGGCATTTATAATCTGGTCCAGAAGGCT CTCAAGCCTCCTCCAATAAAGCTCTATCGGGAAACAAATGAACCAGTGAAAACCAAGACC CGGACCTTTAATACAAGTACAGGCGGTTTGCTTCTGCCTAGCGATACCAAGAGGTCTCAG ATCTATGGGAGTCGTCAGATTATACTGGAGAAAGAGGAAACAGAAGAGCTAAAACGGTTT GATGATCCAGGTTTGATGCTCATGGGTTTCAAGCCGTTGGTACTGCTGAAGAAACACCAT TACCTGAGGCCCTCCCTGTTCGTGTACCCAGAGGAGTCGCTGGTGATTGGGAGCTCAACC CTGTTCAGTGCTCTGCTCATCAAGTGTCTGGAGAAGGAGGTTGCAGCATTGTGCAGATAC ACACCCCGCAGGAACATCCCTCCTTATTTTGTGGCTTTGGTGCCACAGGAAGAAGAGTTG GATGACCAGAAAATTCAGGTGACTCCTCCAGGCTTCCAGCTGGTCTTTTTACCCTTTGCT GATGATAAAAGGAAGATGCCCTTTACTGAAAAAATCATGGCAACTCCAGAGCAGGTGGGC AAGATGAAGGCTATCGTTGAGAAGCTTCGCTTCACATACAGAAGTGACAGCTTTGAGAAC CCCGTGCTGCAGCAGCACTTCAGGAACCTGGAGGCCTTGGCCTTGGATTTGATGGAGCCG GAACAAGCAGTGGACCTGACATTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCC TTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTT ACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCA GAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATG CTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTG GAAGCCCTCACCAAGCACTTCCAGGACTGA Clone variation with respect to NM_001469.3 >OriGene 5' read for NM_001469 unedited
TTTGTAATACGACTTACTATAGGGCGGCCGCGAATTCGGCACGAGGGTTGGTCGCTTCCC TGCGCCAAAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAACCGAGGG CGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTATAAATA TTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCA GAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGTGTATCCAAAGTGTGTACAT CAGTAAGATCATAAGCAGTGATCGAGATCTCTTGGCTGTGGTGTTCTATGGTACCGAGAA AGACAAAAATTCAGTGAATTTTAAAAATATTTACGTCTTACAGGAGCTGGATAATCCAGG TGCAAAACGAATTCTAGAGCTTGACCAGTTTAAGGGGCAGCAGGGACAAAAACGTTTCCA AGACATGATGGGCCACGGATCTGACTACTCACTCAGTGAAGTGCTGTGGGTCTGTGCCAA CCTCTTTAGTGATGTCCAATTCAAGATGAGTCATAAGAGGATCATGCTGTTCACCAATGA AGACAACCCCCATGGCAATGACAGTGCCAAAGCCAGCCGGGCCAGGACCAAAGCCGGTGA TCTCCGAGATACAGGCATCTTCCTTGACTTGATGCACCTGAAGAAACCTGGGGGCTNTGA CATATNNCTTGNTCTACAGAGATATCATCAGCATAGCAGAGGATGANGGACCTCAGGGNT TCACTTTNGAGAAATCCAGCAGCTANAAGACCTGTTGCCGGAAGGGTCGCGCCAAGGAGA CCCAGAAGCGAGCACTCAGCAGGTTAAAGCTGAAGCTCACAAAGATTTATGATCTCTTGG GCATTTATATC >OriGene 3' read for NM_001469 unedited
CTATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTATAGTACAAAC TTAGGGCTCTTTATTCAGGCAGTAAAGTAAGGAACAGCAAAGTGGGAGGGCTACACCATC ACCATGGCAACAGAAAGCCTCAAAAACATAAAGTCCCTCGACTTATGTCGGGTAGACTCT TCCTAGCTCAGGAGAAACACATTTTAACTGGCTGAGGACAAGGCCAGGCAGCCTGGCCAC ACTGCGGAAGGGCAGCTGGACGCGCGGCCTCTGGTCAGTCCTGGAAGTGCTTGGTGAGGG CTTCCAGCAGCTCCTGCTTCTTCAGCCCACTCTTCAGCCCGTAAGCCCGGCAGGCCTCTT TCAGCATGGGCACAGTGAACTTGCCCAGCGTACCCTTGCTGATGTGGGTCTTCAGCTCCT CTTCTGAATACTCCACCTTGGGCCTTTTGCTTCCAGAACCTTCATTATCGTGTTTTCTCT TGGTAACTTTCCCTTCAGGATTGTAATCTGGTGGGTAAACAAGCTCCTTAAACTCATCCA CCAAGGAGCCCAGTCTTTTATTCATTGCTTCAACCTTGGGCAATGTCAGGTCCACTGCTT GTTCCGGCTCCATCAAATCCAAGGCCAAGGCCTNCAGGTTCCTGAAGTGCTGCTGCAGCA CGGNGTTCTCANAGCTGTCACTTCTGTATGTGAAGCGAAGCTTCTCAACGATAGCCTTCA TCTTGCCCACCTGCGTCTGGAGTGCCATGATTNTTTCAGTAAAGGGCATCTTCCTTTTAT CATCAGCAAAGGGTAAAAAGACCAGCTGGAAGCCTGGAGGAGTCACCTNNGAATTTCTGG TCATCCAACTCTTNCTTCTGTGGGCACCAAAGCCACAATAAGGAGGGATGTNCCTGCGGG TGTGTATCTGCACATGCTGCACCCTCTTTNCAGACACTGAGAGCANACACTGNACAGGTT GAGCNCCCATACAGC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001469 |
| Insert Size | 2240 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001469.3, NP_001460.1 |
| RefSeq Size | 2156 bp |
| RefSeq ORF | 1830 bp |
| Locus ID | 2547 |
| UniProt ID | P12956 |
| Domains | SAP, Ku_C, Ku_N, ku |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Non-homologous end-joining |
| Gene Summary | The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). Variants 1 and 2 encode the same protein. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Use of phage display to identify novel mineralocorticoid receptor-interacting proteins
,Yang, J;Fuller, PJ;Morgan, J;Shibata, H;McDonnell, DP;Clyne, CD;Young, MJ;,
Mol. Endocrinol. July 2014
,PubMed ID 25000480
[XRCC6]
|
|
Host Protein Ku70 Binds and Protects HIV-1 Integrase from Proteasomal Degradation and Is Required for HIV Replication
,Yingfeng Zheng, Zhujun Ao, Binchen Wang, Kallesh Danappa Jayappa, and Xiaojian Yao,
J. Biol. Chem., May 2011; 286: 17722 - 17735
[XRCC6]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204048 | XRCC6 (Myc-DDK-tagged)-Human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6) |
CNY 4,536.00 |
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| RC204048L1 | Lenti ORF clone of Human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6), Myc-DDK-tagged |
CNY 6,936.00 |
|
| RC204048L2 | Lenti ORF clone of Human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6), mGFP tagged |
CNY 6,460.00 |
|
| RC204048L3 | Lenti ORF clone of Human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6), Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC204048L4 | Lenti ORF clone of Human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6), mGFP tagged |
CNY 6,936.00 |
|
| RG204048 | XRCC6 (tGFP-tagged) - Human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6) |
CNY 6,136.00 |
