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TMS1 (PYCARD) (NM_145182) Human Untagged Clone
CAT＃: SC110404
PYCARD (untagged)-Human PYD and CARD domain containing (PYCARD), transcript variant 2
CN¥ 2,400.00
CN¥ 3,990.00
| Cited in 1 publication. |
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CN¥ 1,999.00
CN¥ 2,700.00
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Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ASC; CARD5; TMS; TMS-1; TMS1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_145182 edited
GAATTCGGCACGAGGGGGGTGAGCGGCGGCAGCGGCCGGGGATCCTGGAGCCATGGGGCG CGCGCGCGACGCCATCCTGGATGCGCTGGAGAACCTGACCGCCGAGGAGCTCAAGAAGTT CAAGCTGAAGCTGCTGTCGGTGCCGCTGCGCGAGGGCTACGGGCGCATCCCGCGGGGCGC GCTGCTGTCCATGGACGCCTTGGACCTCACCGACAAGCTGGTCAGCTTCTACCTGGAGAC CTACGGCGCCGAGCTCACCGCTAACGTGCTGCGCGACATGGGCCTGCAGGAGATGGCCGG GCAGCTGCAGGCGGCCACGCACCAGGGCTCTGGAGCCGCGCCAGCTGGGATCCAGGCCCC TCCTCAGTCGGCAGCCAAGCCAGGCCTGCACTTTATAGACCAGCACCGGGCTGCGCTTAT CGCGAGGGTCACAAACGTTGAGTGGCTGCTGGATGCTCTGTACGGGAAGGTCCTGACGGA TGAGCAGTACCAGGCAGTGCGGGCCGAGCCCACCAACCCAAGCAAGATGCGGAAGCTCTT CAGTTTCACACCAGCCTGGAACTGGACCTGCAAGGACTTGCTCCTCCAGGCCCTAAGGGA GTCCCAGTCCTACCTGGTGGAGGACCTGGAGCGGAGCTGAGGCTCCTTCCCAGCAACACT CCGGTCAGCCCCTGGCAATCCCACCAAATCATCCTGAATCTGATCTTTTTATACACAATA TACGAAAAGCCAGCTTGAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_145182 unedited
GTTCAAAATTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGGGGTG AGCGGCGGCAGCGGCCGGGGATCCTGNGACCATGGGGCGCGCGCGCGACGCCATCCTGGA TGCGCTGGAGAACCTGACCGCCGAGGAGCTCAAGAAGTTCAAGCTGAAGCTGCTGTCGGT GCCGCTGCGCGAGGGCTACGGGCGCATCCCGCGGGGCGCGCTGCTGTCCATGGACGCCTT GGACCTCACCGACAAGCTGGTCAGCTTCTACCTGGAGACCTACGGCGCCGAGCTCACCGC TAACGTGCTGCGCGACATGGGCCTGCAGGAGATGGCCGGGCAGCTGCAGGCGGCCACGCA CCAGGGCTCTGGAGCCGCGCCAGCTGGGATCCAGGCCCCTCCTCAGTCGGCAGCCAAGCC AGGCCTGCACTTTATAGACCAGCACCGGGCTGCGCTTATCGCGAGGGTCACAAACGTTGA GTGGCTGCTGGATGCTCTGTACGGGAAGGTCCTGACGGATGAGCAGTACCAGGCAGTGCG GGCCGAGCCCACCAACCCAAGCAAGATGCGGAAGCTCTTCAGTTTCACACCAGCCTGGAA CTGGACCTGCAAGGACTTGCTCCTCCAGGCCCTAAGGGAGTCCCAGTCCTACCTGGTGGA GGACCTGGAGCGGAGCTGAGGCTCCTTCCCACAACACTCCGGTCAGCCCCTGGCAATCCC ACCAAATCATCCTGAATCTGATCTTTNTATACACAATATACGAAAAGCCAGCTTGAAAAA AAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAAAGATCC CNGGTGGCATCCCTGTGACCCTNNCCGTGCCTCTTCTGGCCCTGGAAAGTGCACTNCAGT GCCACCANNCTGTCTAATAAAATAAGTGCATCATTGCTGACTAGTGTCTATATATGG >OriGene 3' read for NM_145182 unedited
TTTGGGTATTTTATGAACCGCGCCGCATTCTANNGATCGGTTTTTTTTTTTTTTTTTTCA AGCTGGCTTTTCGTATATTGTGTATAAAAAGATCAGATTCAGGATGATTTGGTGGGATTG CCAGGGGCTGACCGGAGTGTTGCTGGGAAGGAGCCTCAGCTCCGCTCCAGGTCCTCCACC AGGTAGGACTGGGACTCCCTTAGGGCCTGGAGGAGCAAGTCCTTGCAGGTCCAGTTCCAG GCTGGTGTGAAACTGAAGAGCTTCCGCATCTTGCTTGGGTTGGTGGGCTCGGCCCGCACT GCCTGGTACTGCTCATCCGTCAGGACCTTCCCGTACAGAGCATCCAGCAGCCACTCAACG TTTGTGACCCTCGCGATAAGCGCAGCCCGGTGCTGGTCTATAAAGTGCAGGCCTGGCTTG GCTGCCGACTGAGGAGGGGCCTGGATCCCAGCTGGCGCGGCTCCAGAGCCCTGGTGCGTG GCCGCCTGCAGCTGCCCGGCCATCTCCTGCAGGCCCATGTCGCGCAGCACGTTAGCGGTG AGCTCGGCGCCGTAGGTCTCCAGGTAGAAGCTGACCAGCTTGTCGGTGAGGTCCAAGGCG TCCATGGACAGCAGCGCGCCCCGCGGGATGCGCCCGTAGCCCTCGCGCAGCGGCACCGAC CGCAGCTTCAGCTTGAACTTCTTGAGCTCCTCGGCGGTCAGGTTCTCCAGCGCATCCAGG AAGGCGTCGCGCGCGCGCCCCATGGCTCCAGGATCCCCGGCCGGTGGCGCCGCTCACCCC CCTTGACTCGAATTCGCGGCCGCCCTATTAGGAGTCGATTACAAAATTCTGACGGTTCAC TAAACGAGCTCTGCTTTTATAGAACCTCCCCCGGTACCACCCT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_145182 |
| Insert Size | 780 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_145182.1, NP_660183.1 |
| RefSeq Size | 879 bp |
| RefSeq ORF | 531 bp |
| Locus ID | 29108 |
| UniProt ID | Q9ULZ3 |
| Domains | PAAD_DAPIN |
| Protein Families | Druggable Genome |
| Protein Pathways | Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway |
| Gene Summary | This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) lacks an internal coding exon compared to variant 1. It maintains the same reading frame, and encodes a shorter isoform (b) missing a segment of 19 aa, compared to isoform a. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Methylation-mediated Silencing of TMS1 in Pancreatic Cancer and its Potential Contribution to Chemosensitivity
,KAVITHA RAMACHANDRAN, HEATHER MILLER, EDNA GORDIAN, CAIO ROCHA-LIMA, and RAKESH SINGAL,
Anticancer Res, Oct 2010; 30: 3919 - 3925
[PYCARD]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC224051 | PYCARD (Myc-DDK-tagged)-Human PYD and CARD domain containing (PYCARD), transcript variant 2 |
CN¥ 998.00 |
|
| RC224051L3 | Lenti-ORF clone of PYCARD (Myc-DDK-tagged)-Human PYD and CARD domain containing (PYCARD), transcript variant 2 |
CN¥ 5,890.00 |
|
| RC224051L4 | Lenti-ORF clone of PYCARD (mGFP-tagged)-Human PYD and CARD domain containing (PYCARD), transcript variant 2 |
CN¥ 5,890.00 |
|
| RG224051 | PYCARD (tGFP-tagged) - Human PYD and CARD domain containing (PYCARD), transcript variant 2 |
CN¥ 4,370.00 |
