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TRAF6 (NM_145803) Human Untagged Clone
CAT＃: SC109845
TRAF6 (untagged)-Human TNF receptor-associated factor 6 (TRAF6), transcript variant 1
CNY 5,840.00
| Cited in 2 publications. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MGC:3310; RNF85 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_145803 edited
GAATTCGGCACGAGCAGTGGCGTCCGCAGCTGGGGCTTGGCCTGCGGGCGGCCAGCGAAG GTGGCGAAGGCTCCCACTGGATCCAGAGTTTGCCGTCCAAGCAGCCTCGTCTCGGCGCGC AGTGTCTGTGTCCGTCCTCTACCAGCGCCTTGGCTGAGCGGAGTCGTGCGGTTGGTGGGG GAGCCCTGCCCTCCTGGTTCGGCCTCCCCGCGCACTAGAACGAGCAAGTGATAATCAAGT TACTATGAGTCTGCTAAACTGTGAAAACAGCTGTGGATCCAGCCAGTCTGAAAGTGACTG CTGTGTGGCCATGGCCAGCTCCTGTAGCGCTGTAACAAAAGATGATAGTGTGGGTGGAAC TGCCAGCACGGGGAACCTCTCCAGCTCATTTATGGAGGAGATCCAGGGATATGATGTAGA GTTTGACCCACCCCTGGAAAGCAAGTATGAATGCCCCATCTGCTTGATGGCATTACGAGA AGCAGTGCAAACGCCATGCGGCCATAGGTTCTGCAAAGCCTGCATCATAAAATCAATAAG GGATGCAGGTCACAAATGTCCAGTTGACAATGAAATACTGCTGGAAAATCAACTATTTCC AGACAATTTTGCAAAACGTGAGATTCTTTCTCTGATGGTGAAATGTCCAAATGAAGGTTG TTTGCACAAGATGGAACTGAGACATCTTGAGGATCATCAAGCACATTGTGAGTTTGCTCT TATGGATTGTCCCCAATGCCAGCGTCCCTTCCAAAAATTCCATATTAATATTCACATTCT GAAGGATTGTCCAAGGAGACAGGTTTCTTGTGACAACTGTGCTGCATCAATGGCATTTGA AGATAAAGAGATCCATGACCAGAACTGTCCTTTGGCAAATGTCATCTGTGAATACTGCAA TACTATACTCATCAGAGAACAGATGCCTAATCATTATGATCTAGACTGCCCTACAGCCCC AATTCCATGCACATTCAGTACTTTTGGTTGCCATGAAAAGATGCAGAGGAATCACTTGGC ACGCCACCTACAAGAGAACACCCAGTCACACATGAGAATGTTGGCCCAGGCTGTTCATAG TTTGAGCGTTATACCCGACTCTGGGTATATCTCAGAGGTCCGGAATTTCCAGGAAACTAT TCACCAGTTAGAGGGTCGCCTTGTAAGACAAGACCATCAAATCCGGGAGCTGACTGCTAA AATGGAAACTCAGAGTATGTATGTAAGTGAGCTCAAACGAACCATTCGAACCCTTGAGGA CAAAGTTGCTGAAATCGAAGCACAGCAGTGCAATGGAATTTATATTTGGAAGATTGGCAA CTTTGGAATGCATTTGAAATGTCAAGAAGAGGAGAAACCTGTTGTGATTCATAGCCCTGG ATTCTACACTGGCAAACCCGGGTACAAACTGTGCATGCGCTTGCACCTTCAGTTACCGAC TGCTCAGCGCTGTGCAAACTATATATCCCTTTTTGTCCACACAATGCAAGGAGAATATGA CAGCCACCTCCCTTGGCCCTTCCAGGGTACAATACGCCTTACAATTCTTGATCAGTCTGA AGCACCTGTAAGGCAAAACCACGAAGAGATAATGGATGCCAAACCAGAGCTGCTTGCTTT CCAGCGACCCACAATCCCACGGAACCCAAAAGGTTTTGGCTATGTAACTTTTATGCATCT GGAAGCCCTAAGACAAAGAACTTTCATTAAGGATGACACATTATTAGTGCGCTGTGAGGT CTCCACCCGCTTTGACATGGGTAGCCTTCGGAGGGAGGGTTTTCAGCCACGAAGTACTGA TGCAGGGGTATAGCTTGCCCTCACTTGCTCAAAAACAACTACCTGGAGAAAACAGTGCCT TTCCTTGCCCTGTTCTCAATAACATGCAAACAAACAAGCCACGGGAAATATGTAATATCT ACTAGTGAGTGTTGTTAGAGAGGTCACTTACTATTTCTTCCTGTTACAAATGATCTGAGG CAGTTTTTTCCTGGGAATCCACACGTTCCATGCTTTTTCAGAAATGTTAGGCCTGAAGTG CCTGTGGCATGTTGCAGCAGCTATTTTGCCAGTTAGTATACCTCTTTGTTGTACTTTCTT GGGCTTTTGCTCTGGTGTATTTTATTGTCAGAAAGTCCAGACTCAAGAGTACTAAACTTT TAATAATAATGGATTTTCCTTAAAACTTCAGTCTTTTTXXXXXXXXXXXXXXXXXXXXXX XTAGTATAAGCTTATAAAGGATCTAAAGATCCATCCACCATTTAAAGTTGTCTGGTAATG AGAGATGACGTTGTATCCCCCAGAGAGGCCAAATCAGAGTCGCCAGCCAGCGTTCTAGAT CAGCCTTAATTTCAAGAGAAAGCCAAGGACCTCATCTGCAGGGGAGTGTGGTTTTCAGCC CCAGCGAGTGTCACTTTGAACTTTCCCTTTGCTTTTTTCTCTCTTCTCCCTCCCCACCCA CCCTTAGGCTCCTGATCTGGTGAGTTTGTTATGGAGTGAAAATAAAAGTCAAGCAGAGAC CTTGTTTCCCGTGCCACCATTAGTACCACAAGCTCATGGCTAGTTACCACATTACTTCCT GGCAGTTTGTGTCCCTCAGCTGTGCCTTCCAACCAGCGCCTGAGAATCACTGCATACCAC CCTCTAGGTAGGGAAACCTACACTGCTGCTGTTCCTGTGATTATTTTACAATGAATAAAT AATTGTCAAGTTCCATTTAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_145803 unedited
GGATTTTGTAATCCGACTTACTATAGGGCGGCCGCGCAATTCGCACGAGCAGTGGCGTCC GCAGCTGGGGCTTGGCCTGCGGGCGGCCAGCGAAGGTGGCGAAGGCTCCCACTGGATCCA GAGTTTGCCGTCCAAGCAGCCTCGTCTCGGCGCGCAGTGTCTGTGTCCGTCCTCTACCAG CGCCTTGGCTGAGCGGAGTCGTGCGGTTGGTGGTGGAGCCCTGCCCTCCTGGTTCGGCCT CCCCGCGCACTAGAACGAGCAAGTGATAATCAAGTTACTATGAGTCTGCTAAACTGTGAA AACAGCTGTGGATCCAGCCAGTCTGAAAGTGACTGCTGTATTGGCCATGGCCAGCTCCTG TAGCGCTGTAACAAAAGATGATAGTGTGGGTGGAACTGCCAGCACGGGGAACCTCTCCAG CTCATTTATGGAGGAGATCCAGGGATATGATGTAGAGTTTGACCCACCCCTGGAAAGCAA GTATGAATGCCCCATCTGCTTGATGGCATTACGAGAAGCAGTGCAAACGCCATGCGGCCA TAGGTTCTGCAAAGCCTGCATCATAAAATCAATAAGGGATGCAGGTCACAAATGTCCAGT TGACAATGAAATACTGCTGGAAAATCAACTATTTCCAGACAATTTTGCAAAACGTGAGAT TCTTTCTCTGATGGTGAAATGTCCAAATGAAGGTTGTTTGCACAAGATGGAACTGAGACA TCTTGAGGATCATCAAGCACATTGTGAGTTTGCTCTTATGGATTGTCCCCAATGCCAGCG TCCCTTCCAAAAATTCATATTATATTCACATTCTGANAGATTGTCCAAGGAGACAGGTTT CTTGTGANCACTGTGCTGCATCAATGGCATTTNGAGATNAAGAGATCCATGACCAGAACT GTCCTTTGGGCAAGTCATCTGTGAATACTGCNATACTATACTCATCAAAGAACAGATGCC CTATCATTATGATCTAGACTGGCCTACAGCCCNATTCT >OriGene 3' genomic read for NM_145803 unedited
GACACTTATGTACGCGGCCGCATTTTANGATCGAGTTTTTTTTTTTTTTTTTTTAAATGG AACTTGACAATTATTTATTCATTGTAAAATAATCACAGGAACAGCAGCAGTGTAGGTTTC CCTACCTAGAGGGTGGTATGCAGTGATTCTCAGGCGCTGGTTGGAAGGCACAGCTGAGGG ACACAAACTGCCAGGAAGTAATGTGGTAACTAGCCATGAGCTTGTGGTACTAATGGTGGC ACGGGAAACAAGGTCTCTGCTTGACTTTTATTTTCACTCCATAACAAACTCACCAGATCA GGAGCCTAAGGGTGGGTGGGGAGGGAGAAGAGAGAAAAAAGCAAAGGGAAAGTTCAAAGT GACACTCGCTGGGGCTGAAAACCACACTCCCCTGCAGATGAGGTCCTTGGCTTTCTCTTG AAATTAAGGCTGATCTAGAACGCTGGCTGGCGACTCTGATTTGGCCTCTCTGGGGGATAC AACGTCATCTCTCATTACCAGACAACTTTAAATGGTGGATGGATCTTTAGATCCTTTATA AGCTTATACTAGTTGCGGGTCTCCCTGAGAACTAGATTCCACGATATTTTATATCTATAT ATAGGCCTTTAACAAATACATGATGGCACACAAAAAAATCATCTCCCTATTAGGAAAATC TGGTTACTTCCAGGATTCTACAGGATCCTTCTCAGAACCTGCAGTTGTTAGGCTACAGCA ACATACTCAAGCTAAGTTGTGATACAACCACTGTGACTTCTAATCCTAGTTGGGTGACCT CCTAAGTATCTCCCATCATCTCCCAAGTTTTAAAAAATTCTGATTTTTAGAATCAATTTT GGTCTTTTTAATCGAAATAAACAGAAGTATTCAAAAGACTGAAAACTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_145803 |
| Insert Size | 4000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_145803.1, NP_665802.1 |
| RefSeq Size | 2608 bp |
| RefSeq ORF | 1569 bp |
| Locus ID | 7189 |
| UniProt ID | Q9Y4K3 |
| Domains | zf-TRAF, RING, MATH |
| Protein Families | Druggable Genome |
| Protein Pathways | Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, Toll-like receptor signaling pathway, Ubiquitin mediated proteolysis |
| Gene Summary | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012] Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
,Zhou, Q;Wang, H;Schwartz, DM;Stoffels, M;Park, YH;Zhang, Y;Yang, D;Demirkaya, E;Takeuchi, M;Tsai, WL;Lyons, JJ;Yu, X;Ouyang, C;Chen, C;Chin, DT;Zaal, K;Chandrasekharappa, SC;P Hanson, E;Yu, Z;Mullikin, JC;Hasni, SA;Wertz, IE;Ombrello, AK;Stone, DL;Hoffmann, P;Jones, A;Barham, BK;Leavis, HL;van Royen-Kerkof, A;Sibley, C;Batu, ED;Gül, A;Siegel, RM;Boehm, M;Milner, JD;Ozen, S;Gadina, M;Chae, J;Laxer, RM;Kastner, DL;Aksentijevich, I;,
Nat. Genet.
,PubMed ID 26642243
[TRAF6]
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13q14 deletions in CLL involve cooperating tumor suppressors
,Alexey Palamarchuk, Alexey Efanov, Natalya Nazaryan, Urmila Santanam, Hansjuerg Alder, Laura Rassenti, Thomas Kipps, Carlo M. Croce, and Yuri Pekarsky,
Blood, May 2010; 115: 3916 - 3922
[TRAF6]
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| RC206042L3 | Lenti ORF clone of Human TNF receptor-associated factor 6 (TRAF6), transcript variant 1, Myc-DDK-tagged |
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| RC206042L4 | Lenti ORF clone of Human TNF receptor-associated factor 6 (TRAF6), transcript variant 1, mGFP tagged |
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| RG206042 | TRAF6 (tGFP-tagged) - Human TNF receptor-associated factor 6 (TRAF6), transcript variant 1 |
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