United States
Germany
Japan
United Kingdom
China
TBXAS1 (NM_001061) Human Untagged Clone
CAT＃: SC109823
TBXAS1 (untagged)-Human thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1
CNY 3,984.00
| Cited in 3 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC109823 sequence for NM_001061 edited (data generated by NextGen Sequencing)
ATGATGGAAGCCTTGGGGTTTCTAAAATTGGAAGTGAATGGCCCCATGGTGACGGTGGCC CTGTCAGTGGCTCTCTTGGCCCTCCTGAAATGGTACTCCACATCAGCATTCTCAAGACTG GAGAAGTTAGGCCTCAGACATCCCAAGCCTTCTCCTTTCATTGGAAACTTGACATTTTTC CGCCAGGGTTTTTGGGAAAGCCAAATGGAGCTCAGAAAGCTGTATGGACCTCTGTGTGGG TACTATCTTGGTCGTCGGATGTTTATTGTTATTTCTGAGCCAGACATGATCAAGCAGGTG TTGGTTGAGAACTTCAGTAACTTTACCAACAGAATGGCGTCGGGTTTGGAGTTCAAGTCG GTAGCCGACAGCGTTCTGTTTTTACGTGACAAAAGATGGGAAGAGGTCAGAGGTGCCCTG ATGTCTGCTTTCAGTCCTGAAAAGCTGAACGAGATGGTTCCCCTCATCAGCCAAGCCTGC GACCTTCTCCTGGCTCATTTAAAACGCTATGCGGAATCTGGGGACGCATTTGACATCCAG AGGTGCTACTGCAATTACACCACAGATGTGGTTGCCAGCGTCGCCTTTGGCACCCCGGTG GACTCCTGGCAGGCCCCTGAGGATCCCTTTGTGAAACACTGCAAGCGTTTCTTCGAATTC TGCATCCCCAGACCTATCCTGGTTTTACTCTTATCATTTCCATCCATAATGGTCCCACTG GCCCGGATTTTGCCCAATAAGAACCGAGACGAACTGAATGGCTTTTTTAACAAACTCATT AGGAATGTGATTGCCTTGCGGGACCAGCAAGCTGCCGAAGAGAGGCGGAGAGACTTCCTC CAAATGGTCCTGGATGCCCGACATTCTGCAAGTCCCATGGGCGTGCAAGACTTTGACATC GTCAGAGACGTTTTCTCCTCTACTGGGTGCAAGCCGAACCCTTCCCGGCAACACCAGCCC AGCCCTATGGCCAGGCCTTTGACTGTGGATGAGATTGTGGGCCAGGCCTTCATCTTCCTC ATCGCTGGCTATGAAATCATCACCAACACACTTTCTTTTGCCACCTACCTACTGGCCACC AACCCTGACTGCCAAGAGAAGCTTCTGAGAGAGGTAGACGTTTTTAAGGAGAAACACATG GCCCCTGAGTTCTGCAGCCTCGAGGAAGGCCTGCCCTATCTGGACATGGTGATTGCAGAG ACGCTGAGGATGTACCCGCCAGCTTTCAGATTCACACGGGAGGCAGCTCAGGACTGCGAG GTGCTGGGGCAGCGCATCCCCGCAGGCGCTGTGCTAGAGATGGCCGTGGGTGCCCTGCAC CATGACCCTGAGCACTGGCCAAGCCCGGAGACCTTCAACCCTGAAAGGTTCACGGCTGAG GCCCGGCAGCAGCACCGGCCCTTCACGTACCTGCCCTTCGGGGCCGGCCCACGGAGCTGC CTCGGGGTGCGTCTAGGGCTGCTTGAGGTCAAGTTGACACTGCTCCACGTGCTGCACAAG TTCCGGTTCCAAGCCTGCCCTGAGACCCAGGTACCGCTGCAGCTAGAATCCAAATCTGCC CTAGGTCCAAAAAATGGTGTCTATATCAAGATCGTATCCCGCTGA Clone variation with respect to NM_001061.4 >OriGene 5' read for NM_001061 unedited
TATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGCCTCGTGCCGAATTCGGCACGA GGGTGATGTTTGCTTGGTTGCCTGTTCCCTTTTCTACCTGCAGAGCACGGTTCCCATAAG GGCGGCGAGATCAGCCTCCTGTCTCATCTGGAAGACCACCACTCTGGGGTCTCAGAGGAA TGATGGAAGCCTTGGGGTTTCTAAAATTGGAAGTGAATGGCCCCATGGTGACGGTGGCCC TGTCAGTGGCTCTCTTGGCCCTCCTGAAATGGTACTCCACATCAGCATTCTCAAGACTGG AGAAGTTAGGCCTCAGACATCCCAAGCCTTCTCCTTTCATTGGAAACTTGACATTTTTCC GCCAGGGTTTTTGGGAAAGCCAAATGGAGCTCAGAAAGCTGTATGGACCTCTGTGTGGGT ACTATCTTGGTCGTCGGATGTTTATTGTTATTTCTGAGCCAGACATGATCAAGCAGGTGT TGGTTGAGAACTTCAGTAACTTTACCAACAGAATGGCGTCGGGTTTGGAGTTCAAGTCGG TAGCCGACAGCGTTCTGTTTTTACGTGACAAAAGATGGGAAGAGGTCAGAGGTGCCCTGA TGTCTGCTTTCAGTCCTGAAAAGCTGAACGAGATGGTTCCCCTCATCAGCCAAGCCTGCG ACCTTCTCCTGGCTCATTTAAAACGCTATGCGGAATCTGGGGACGCATTTGACTCCAGAG GTGCTACTGCAATTACCCACAGATGTGGTTGCCAGCGTCGCCTTGGCACCCCGTGGACTC CTGGNCAGCCCTTGAGATCCCTTTTGTGAACACTGCAGCGTTTCTTCGAATCTGCATCCC AGACTATNCNGGNTTTACTCTTATCATTTCTCCATATGGNCCACTGCCCCNGATTTTGCC AATAGACCGAGAGACT >OriGene 3' read for NM_001061 unedited
GCAACTTTCCAGGGCCAGGAAGNAGCACTGGGGNAGGGTCACAGGGATGCCACCCGGGAT CTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGNTTTTTTTTTTTTTT TTTTTTTTTCCAAGGGCAACAAACGTTTATTAAGCATTTAGGAAATGTTATGTAAAGAAC CTTTTATCCTTGCATGCCAGGCACTCTTTCAATCACTTCAGGGACATTTTTCCAAAATTC TGAACATCCACACTTAGGGTTTTCTTTGAATTTGGGGGGGCCCTCCCCCCACCCGGCAGC CTTTTGTGTCAGCGGGATACGATCTTGATATAAACACCATTTTTTGGACCTAGGGCAGAT TTGGATTCTAGCTGCAGCGGTACCTGGGTCTCAGGGCAGGCTTGGAACCGGAACTTGTGG NNNACGTGGAGCAGTGTCAACTTGACCTCAAGCAGCCCTAAACGCACCCCGAGGCAGCTC CGTGGGCCGGCCCCGAAGGGCAGGTACGTGAAGGGCCGGTGCTGCTGCCGGGCNCTCACC GTGAACCTTTCAGGGTTGAAGGTCTCCGGGCTTGGCCAGTGCTCAGGGTCATGGGGCAGG GCACCCACGGCCATCTCTAGCACANCGCCTGCGGGGATGCGCTTGCCCAGCACCTCGCAG TCCTGAGCTGCCTCCCGTGGGAATTGAAAGCTGGCGGGACATCCTCAGCGGTTCTGCAAT CACCATGTCCACAAAGNNNNACCCTCCTCGAGGCTGCAAACTCAGGGGCCATGGGTTTCT CTTAAAAACGTCTACCTCTTTCAAAACTTTTCTTGGCAATAAGGGTTGGGTGGCACGTAG GTAGTGGCAAAGAAAGAGGTGTGGGTGAAGATCTATTACCCACGATAGGAAAATGAAGGC TTGCCCACATTTCTTCCAGGCAAGGGCGGCATAGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001061 |
| Insert Size | 1960 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001061.2, NP_001052.1 |
| RefSeq Size | 1946 bp |
| RefSeq ORF | 1605 bp |
| Locus ID | 6916 |
| UniProt ID | P24557 |
| Domains | p450 |
| Protein Families | Druggable Genome, P450 |
| Protein Pathways | Arachidonic acid metabolism, Metabolic pathways |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Transcript Variant: This variant (1, also known as TXS-I) encodes isoform 1, which is also known as isoform TXS-I. Both variants 1 and 3 encode the same isoform. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is better supported by available conservation data and peptide data. This CCDS represents use of a downstream start codon, shortening the protein by a single amino acid. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Functional Role of the Conserved I-Helix Residue I346 in CYP5A1-Nanodiscs
,Meling, DD;Zelasko, S;Das, A;,
Biophysical Chemistry
[TBXAS1]
|
|
18ß-Glycyrrhetinic Acid Suppresses Cell Proliferation through Inhibiting Thromboxane Synthase in Non-Small Cell Lung Cancer
,Huang, RY;Chu, YL;Huang, QC;Chen, XM;Jiang, ZB;Zhang, X;Zeng, X;,
PLoS ONE e93690 9 4. April 2014
,PubMed ID 24695790
[TBXAS1]
|
|
Functional Investigations of Thromboxane Synthase (CYP5A1) in Lipid Bilayers of Nanodiscs
,Das, A;Varma, SS;Mularczyk, C;Meling, DD;,
Chembiochem
,PubMed ID 24623680
[TBXAS1]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208028 | TBXAS1 (Myc-DDK-tagged)-Human thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1 |
CNY 3,976.00 |
|
| RC208028L3 | Lenti ORF clone of Human thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC208028L4 | Lenti ORF clone of Human thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG208028 | TBXAS1 (tGFP-tagged) - Human thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1 |
CNY 5,576.00 |
|
| SC322621 | TBXAS1 (untagged)-Human thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1 |
CNY 2,950.00 |
