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SHP1 (PTPN6) (NM_002831) Human Untagged Clone
CAT＃: SC109665
PTPN6 (untagged)-Human protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1
CNY 4,440.00
CNY 9,600.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC109665 sequence for NM_002831 edited (data generated by NextGen Sequencing)
ATGGTGAGGTGGTTTCACCGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGC CGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCTCG CTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTC TATGACCTGTATGGAGGGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACT CAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGCTG AACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCA GAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGC CAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCTCC CCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGT TTGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAG GAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGAATGCG GCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCC AAGGCTGGCTTCTGGGAGGAGTTTGAGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCAC CAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACATTCTC CCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGAC TACATCAATGCCAACTACATCAAGAACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACC TACATCGCCAGCCAGGGCTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGGCGTGG CAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAA TGCGTCCCATACTGGCCCGAGGTGGGCATGCAGCGTGCTTATGGGCCCTACTCTGTGACC AACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCCCGCTG GACAATGGAGACCTGATTCGGGAGATCTGGCATTACCAGTACCTGAGCTGGCCCGACCAT GGGGTCCCCAGTGAGCCTGGGGGTGTCCTCAGCTTCCTGGACCAGATCAACCAGCGGCAG GAAAGTCTGCCTCACGCAGGGCCCATCATCGTGCACTGCAGCGCCGGCATCGGCCGCACA GGCACCATCATTGTCATCGACATGCTCATGGAGAACATCTCCACCAAGGGCCTGGACTGT GACATTGACATCCAGAAGACCATCCAGATGGTGCGGGCGCAGCGCTCGGGCATGGTGCAG ACGGAGGCGCAGTACAAGTTCATCTACGTGGCCATCGCCCAGTTCATTGAAACCACTAAG AAGAAGCTGGAGGTCCTGCAGTCGCAGAAGGGCCAGGAGTCGGAGTACGGGAACATCACC TATCCCCCAGCCATGAAGAATGCCCATGCCAAGGCCTCCCGCACCTCGTCCAAACACAAG GAGGATGTGTATGAGAACCTGCACACTAAGAACAAGAGGGAGGAGAAAGTGAAGAAGCAG CGGTCAGCAGACAAGGAGAAGAGCAAGGGTTCCCTCAAGAGGAAGTGA Clone variation with respect to NM_002831.5 >OriGene 5' read for NM_002831 unedited
NGGTTCAAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCCCGGCAC TGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGCCTGCCCAGACTAGCTGCACCT CCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCCAGGATGGTGAGGTGGTTTCACC GAGACCTCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCT TCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGGTGGGGG ATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGG AGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGC AGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGCTGAACTGCTCCGATCCCACTA GTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCA AGGGCGAGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGC TTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACA TCAAGGTCATGTGCCGAGGGTGGACGCTCACGTGGNTTGGGTTTTTGGAGACCTTCGACA GCCTCACGNGACCTGGTGGAGCATTTAAGAGACCGGGGAATTGGGAGGAGGCCTCANNGC GCCTTTGTCTACCTGCGGCAGCCGTCTATGCACGAGGGGGTGAATGCGGCTGCATGGAAC CCCCGGGTGTGGGACTGACAAAAACCAGAAGTCCGAGATCACNCAGCTGTTGGGGNGGGA GGGGGTTNNNNNGAACTTGCAACCCGGGAGTGAACACTGCCCAGNNGGGC >OriGene 3' read for NM_002831 unedited
NAAACAACCGAGACACCCNCCCNNNNNNNNCTNNNNNNNNCNTTTTTATCTTTGNAACCN CGGNCCGCATNCTAGGATCGAGTTTTTTTTTTTTTTTTTTAACAGTGATCCCAGGGCTTT ATTTACAAGAGGAGAAGGGTTGGCCCTGCCTGGGGCCTGGCTGGGCTATATACAGGGTCA GGGAGAGGTGGGGGGGATGCAGCCATTTAAATTACAAAAGAATGGGGCACTCCTAGGTTC AGGTTGTGAGTCTGTCCATCGCGAAATGCTTCCACAGGGTCAGGGCTGAGGCATGGCCAC CTGAGGACAGCACCGCTCACTTCCTCTTGAGGGAACCCTTGCTCTTCTCCTTGTCTGCTG ACCGCTGCTTCTTCACTTTCTCCTCCCTCTTGTTCTTAGTGTGCAGGTTCTCATACACAT CCTCCTTGTGTTTGGACGAGGTGCGGGAGGCCTTGGCATGGGCATTCTTCATGGCTGGGG GATAGGTGATGTTCCCGTACTCCGACTCCTGGCCCTTCTGCGACTGCAGGACCTCCAGCT TCTTCTTAGTGGTTTCAATGAACTGGGCGATGGCCACGTAGATGAACTTGTACTGCGCCT CCGTCTGCACCATGCCCGAGCGCTGCGCCCGCACCATCTGGATGGTCTTCTGGATGTCAA TGTCACAGTCCAGGCCCTTGGTGGAGATGTTCTCCATGAGCATGTCGATGACAATGATGG TGCCCTGTGCGGCCGATGCCGGCGCTGCATTGCACATGATGGGCCCTGCGTGAAGCAGAC TTTCCTGCCGCTGGTTGATCTGGTCCAAGAAGCTGAGGACCCCCCCAGCTTACTGGGGAC CCCATGTCGGGCCAGCTCAGGTCCTGTTATGCCAAACTTCCCGAATCAGTCTCCATTGCC CACCGGGAAACCTGTAAGGTACGGATTTTGATTCCGGTGGGTCATGCTCCCCCAATGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002831 |
| Insert Size | 2050 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002831.3, NP_002822.2 |
| RefSeq Size | 2253 bp |
| RefSeq ORF | 1788 bp |
| Locus ID | 5777 |
| UniProt ID | P29350 |
| Domains | Y_phosphatase, SH2, PTPc_motif |
| Protein Families | Druggable Genome, Phosphatase, Stem cell - Pluripotency |
| Protein Pathways | Adherens junction, B cell receptor signaling pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway |
| Gene Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the predominant transcript and encodes the shortest isoform (1, also known as SHP-1). |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213896 | PTPN6 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1 |
CNY 4,432.00 |
|
| RC213896L1 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1, Myc-DDK-tagged |
CNY 6,832.00 |
|
| RC213896L2 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1, mGFP tagged |
CNY 6,832.00 |
|
| RC213896L3 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1, Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC213896L4 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1, mGFP tagged |
CNY 6,832.00 |
|
| RG213896 | PTPN6 (tGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1 |
CNY 6,032.00 |
