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PML Protein (PML) (NM_033240) Human Untagged Clone
CAT＃: SC109584
PML (untagged)-Human promyelocytic leukemia (PML), transcript variant 2
CNY 4,560.00
CNY 9,880.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MYL; PP8675; RNF71; TRIM19 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_033240 edited
GAATTCGGCACGAGGCTAAACCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCAC CCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAGCCCACCATGCCTC CCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAG CCCCCGCTTCGGAGGAGGAGTTCCAGTTTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCA AGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGG GCATGCAGTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGG ATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGGCAGATTGTGGATG CGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGC AGCTCCTCTGCGCCAAGTGCTTCGAGGCACACCAGTGGTTCCTCAAGCACGAGGCCCGGC CCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCA ACAACATCTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCC GAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGCAGCCACAGTGAGC TCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGC AGGCGCTGCAGGAGCAGGATAGTGCCTTTGGCGCGGTTCACGCGCAGATGCACGCGGCCG TCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCC AGGTGGTAGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGT ACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGATGCTGTGCTGCAGC GCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGG TGCTGGACATGCACGGTTTCCTGCGCCAGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCC AGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGG ACCTCAGCTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAG AGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGGATGTCTCCAATACAACGA CAGCCCAGAAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAAGGTCATCAAGATGGAGT CTGAGGAGGGGAAGGAGGCAAGGTTGGCTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCA CCTCCAAGGCAGTCTCACCACCCCACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCA TAGGAAGTGAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAG AGGAACGCGTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAAAACTCGGTGAGTG GCCCAGAAGTTCAGCCCAGGACTCCTGCCTCCCCCCATTTCAGGTCCCAGGGGGCACAGC CACAGCAGGTGACTCTCAGACTTGCCTTGCGCCTGGGGAATTTTCCAGTGAGGCATTGAG TCCCAAGCTGTGCTGAGGACAGTCTCCAAATGACAGCTGCATGCCTGGACCACCCCAGCC CTCCCACTACACCAGGGCCAGGAGCTCTTCTGAAATGCTGATAGCATGTGTCCAGAGCCC TGTCTCTTTTCTGGAATGTCCAAGACCTTTGTCTGGAGCTTCCTTATGCATTTTCTGTCC TCTAAGTCCTCAGTGAGGAGGGCTGGACAAGAATCCATTCCTTGGTTTATTACAGCCAGT GGGGGCCAGTGAAGGGGTGTCAGGCCACAGGGCAGCTATATAGGGGCCAAACAAGTGAGG TTTGACTCCATCCATGTAGAAAGATATATAAATCCATTCCACAGTGAAACAGGTGGCCTC GTGGGTAGTGACCCTTCTGTCCCTAGAGGTTTATTACTAGAGGCTGGACTATCACCTGTC CAGGGGAAAAGGGGATCTGAATAGAGTGAAAGGTTGGACTGGGTGGCCCCTGAGGTCTCT TCCAGCCCTCAGTCTGAGGTTCTGTATTGGAAAGTGCATGGAGCCCATGGAGACCGCCGA GCCACAGTCCTCGCCAGCCCACTCCTCGCCAGCCCACTCCTCGCCAGCCCACTCCTCGCC AGTCCAGTCTCTGCTGAGAGCACAAGGAGCCTCCAGCCTGCCCTGTGGCACATACCACCC CCCAGCTTGGCCTCCCCACCAGCCCGCTGAGCAGGCTGCCACCCCCGATGCTGAGCCTCA CAGCGAGCCTCCTGATCACCAGGAGCGCCCTGCCGTCCACCGTGGGATCCGCTACCTGTT GTACAGAGCACAGAGAGCCATCCGCCTTCGCCATGCCCTCCGCTTGCACCCTCAATTGCA TCGGGCCCCTATTCGGACTTGGTCTCCCCATGTGGTCCAAGCCAGCACTCCTGCCATCAC AGGGCCCCTCAACCATCCTGCCAATGCCCAGGAACATCCTGCCCAGCTGCAAAGGGGCAT CAGCCCACCCCACCGGATACGAGGGGCTGTGCGATCCCGCAGCCGCTCCCTCCGGGGCTC CTCCCATTTATCCCAGTGGCTCAACAACTTTTTTGCCCTCCCCTTCTCCTCCATGGCTTC CCAGCTTGACATGTCTTCCGTGGTGGGGGCAGGGGAAAGCAGAGCCCAGACTCTTGGAGC AGGTGTTCCCCCTGGGGACTCTGTCAGAGGCTCCATGGAGGCCTCTCAAGTCCAAGTGCC TCTGGAAGCCTCTCCAATTACATTCCCACCACCCTGTGCCCCAGAAAGGCCCCCCATCAG CCCAGTCCCAGGCGCCCGTCAAGCAGGCCTCTGAGAGTGCTACCCTTCTCTTGTAACCTT GCAGCCAACACCCCTGCCCGGCCCCTGAGCTGCCTCCTCCAGCCCATGCTCTTACAGGCC CTGCACAGAGTAGCACTCATTAATTCTTGGTTAAGGAATGAATCAACGAATGAATGGCTA TGCATGGACCTCTGGGCAGGGAGACCTGGGTCTTCTCTGGCTGAGAGGGGAAGGCTAAGG CATGGCTGAGATTCAAGCCACCATTCCAGGCCTCTTTGCCCAAGAAAGAAACTTCTGTCA CCCTTGCACTCTCCTGTATTCTGAGTCCCTGGCCAATAGCACAGCCTTCCATGCCCCGAC CCCCACCCCAAGCCTCTCCACTAGGCCTCTGCCAGGATCTAAGCCCATGAGCACAGGGAC TGGCTATCCCAAGACCTGGCAGATGTGGCTGCTCAATAAACACTTGTTGAACCATCAAAA AAAAAAAAAAAAAACTCGAC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_033240 |
| Insert Size | 3630 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_033240.2, NP_150243.2 |
| RefSeq Size | 3751 bp |
| RefSeq ORF | 1836 bp |
| Locus ID | 5371 |
| UniProt ID | P29590 |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis |
| Gene Summary | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (2, also known PML-2, PML-V and TRIM19beta) contains a distinct C-terminus compared to isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217953 | PML (Myc-DDK-tagged)-Human promyelocytic leukemia (PML), transcript variant 2 |
CNY 7,128.00 |
|
| RC217953L3 | Lenti-ORF clone of PML (Myc-DDK-tagged)-Human promyelocytic leukemia (PML), transcript variant 2 |
CNY 6,460.00 |
|
| RC217953L4 | Lenti-ORF clone of PML (mGFP-tagged)-Human promyelocytic leukemia (PML), transcript variant 2 |
CNY 6,460.00 |
|
| RG217953 | PML (tGFP-tagged) - Human promyelocytic leukemia (PML), transcript variant 2 |
CNY 5,040.00 |
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