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FACL4 (ACSL4) (NM_022977) Human Untagged Clone
CAT＃: SC109208
ACSL4 (untagged)-Human acyl-CoA synthetase long-chain family member 4 (ACSL4), transcript variant 2
CNY 5,216.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ACS4; FACL4; LACS4; MRX63; MRX68 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC109208 sequence for NM_022977 edited (data generated by NextGen Sequencing)
ATGAAACTTAAGCTAAATGTGCTCACCATTATTTTGCTGCCTGTCCACTTGTTAATAACA ATATACAGTGCCCTTATATTTATTCCATGGTATTTTCTTACCAATGCCAAGAAGAAAAAC GCTATGGCAAAGAGAATAAAAGCTAAGCCCACTTCAGACAAACCTGGAAGTCCATATCGC TCTGTCACACACTTCGACTCACTAGCTGTAATAGACATCCCTGGAGCAGATACTCTGGAT AAATTATTTGACCATGCTGTATCCAAGTTTGGGAAGAAGGACAGCCTTGGGACCAGGGAA ATCCTAAGTGAAGAAAATGAAATGCAGCCAAATGGAAAAGTTTTTAAGAAGTTAATTCTT GGGAATTATAAATGGATGAACTATCTTGAAGTGAATCGCAGAGTGAATAACTTTGGTAGT GGACTCACTGCACTGGGACTAAAACCAAAGAACACCATTGCCATCTTCTGTGAGACCAGG GCCGAATGGATGATTGCAGCACAGACCTGCTTTAAGTACAACTTTCCTCTTGTGACTTTA TATGCCACACTTGGCAAAGAAGCAGTAGTTCATGGGCTAAATGAATCTGAGGCTTCCTAT CTGATTACCAGTGTTGAACTTCTGGAAAGTAAACTTAAGACTGCATTGTTAGATATCAGT TGTGTTAAACATATCATTTATGTGGACAATAAGGCTATCAATAAAGCAGAGTACCCTGAA GGATTTGAGATTCACAGCATGCAATCAGTAGAAGAGTTGGGATCTAACCCAGAAAACTTG GGCATTCCTCCAAGTAGACCAACGCCTTCAGACATGGCCATTGTTATGTATACTAGTGGT TCTACTGGCCGACCTAAGGGAGTGATGATGCATCATAGCAATTTGATAGCTGGAATGACA GGCCAGTGTGAAAGAATACCTGGACTGGGACCGAAGGACACATATATTGGCTACTTGCCT TTGGCTCATGTGCTAGAACTGACAGCAGAGATATCTTGCTTTACCTATGGCTGCAGGATT GGATATTCTTCTCCGCTTACACTCTCTGACCAGTCCAGCAAAATTAAAAAAGGAAGCAAA GGAGACTGTACTGTACTGAAGCCCACACTTATGGCTGCTGTTCCGGAAATCATGGATAGA ATTTATAAGAATGTTATGAGCAAAGTCCAAGAGATGAATTATATTCAGAAAACTCTGTTC AAGATAGGGTATGATTACAAATTGGAACAGATCAAAAAGGGATATGATGCACCTCTTTGC AATCTGTTACTGTTTAAAAAGGTCAAGGCCCTGCTGGGAGGGAATGTCCGCATGATGCTG TCTGGAGGGGCCCCGCTATCTCCTCAGACACACCGATTCATGAATGTCTGCTTCTGCTGC CCAATTGGCCAGGGTTATGGACTGACAGAATCATGTGGTGCTGGGACAGTTACTGAAGTA ACTGACTATACTACTGGCAGAGTTGGAGCACCTCTTATTTGCTGTGAAATTAAGCTAAAA GACTGGCAAGAAGGCGGTTATACAATTAATGACAAGCCAAACCCCAGAGGTGAAATCGTA ATTGGTGGACAGAACATCTCCATGGGATATTTTAAAAATGAAGAGAAAACAGCAGAAGAT TATTCTGTGGATGAAAATGGACAAAGGTGGTTTTGCACTGGTGATATTGGAGAATTCCAT CCCGATGGATGTTTACAGATTATAGATCGTAAGAAAGATCTAGTGAAGTTACAAGCAGGA GAGTATGTATCTCTTGGGAAAGTAGAAGCTGCACTGAAGAATTGTCCACTTATTGACAAC ATCTGTGCTTTTGCCAAAAGTGATCAGTCCTATGTGATCAGTTTTGTGGTTCCTAACCAG AAAAGGTTGACACTTTTGGCACAACAGAAAGGGGTAGAAGGAACTTGGGTTGATATCTGC AATAATCCTGCTATGGAAGCTGAAATACTGAAAGAAATTCGAGAAGCTGCAAATGCCATG AAATTGGAGCGATTTGAAATTCCAATCAAGGTTCGATTAAGCCCAGAGCCATGGACCCCT GAAACTGGTTTGGTAACTGATGCTTTCAAACTGAAAAGGAAGGAGCTGAGGAACCATTAC CTCAAAGACATTGAACGAATGTATGGGGGCAAATAA Clone variation with respect to NM_022977.2 >OriGene 5' read for NM_022977 unedited
AGCATTTTGTAATACGACTCACTTATAGGGCGGCCGCGATTCGGCACCAGGCCGCTGCGG CTTTTTCTCTGGCCTCCGCCGCGCGCTCCTCCTCGTCCCAGCGCTAGCGGGCACGCGGTT CCTTTTTGCGAGCTTTCCGAGTGCCAGGCGCCGGCCGGCTGCGAAGACGCGGTGGGCCGC CCCTCCGGCGTACTTTATTGTCGGCTTCCAAAGATTACTAACTTTTATCTGTATCACTAA GATTGAACTGCCTTGGCTGTACTGCTATTCTTACTGCTGCTTCTATTATTGCCTTCTTCA GCACAATAAGGCTTTCAAAAGCCAAAGAATAACAAGAAATAAGCACCATTTTAGAAGCCT TTCCACTATGAAACTTAAGCTAAATGTGCTCACCATTATTTTGCTGCCTGTCCACTTGTT AATAACAATATACAGTGCCCTTATATTTATTCCATGGTATTTTCTTACCAATGCCAAGAA GAAAAACGCTATGGCAAAGAGAATAAAAGCTAAGCCCACTTCAGACAAACCTGGAAGTCC ATATCGCTCTGTCACACACTTCGACTCACTAGCTGTAATAGACATCCCTGGAGCAGATAC TCTGGATAAATTATTTGACCATGCTGTATCCAAGTTTGGGAAGAAGGACAGCCTTGGGAC CAGGGAAATCCTAAGTGAAGAAAATGAAATGCAGCCAAATGGAAAAGTTNTTAAGAAGTT AATTCTTGGGAATTATAAATGGATGAACTATCTTGAAGTGAATCGCAGAGTGAATAACTT TGGTAGTGGACTCACTGCACTGNGACTAANACCAAAGACACCATTGCCATCTTCTGTGAG AACCAGGCCGAATGGATGATTGCAGCACAGACCTGCTNTAAGTACAAACTTNCTCTTGTG ACTTTTATGCCACACTTGGCAAGAAGCAGTAGTTATGGGCTAATGATCTGAGCTTCTACT GAT >OriGene 3' read for NM_022977 unedited
GCCGCAATTCACAGTCGAGCNCTTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAA ACATGGGGGGATTTATTTCTTAAAATTTGAGGGCAAACTTAAAAACCCGAACAAACAAAG CTTTTCATCCAGAATAAACACAAAATCTAAACAATTCTGCCATTCTGCCTTTCAACACAA AGCCCAAATCTCAACCCATTCTAACTTGCCCCTGCCCTCAAAACCCCAAATATTCGCTTC CCCCCCCCATAAGTCATACCCCTTTTCTCTGCCCCCCCCCCCCGCCCCTTCCCATTTTCC AAATCTGCTCCCCCCATAACAACCGCCCACTTCCCCCCCCCCGCCCTCCTCCCCAAACTA TTCCTTCCCCCCTCCACCTCCCTCCCTCCTTCATCCTATCTCCCCTCCCCGCCACACTGA CCTCGCCCCCTACCACTGCTCCCCTACCTATCCTCCCTCATCTTCTCTTCCTCCTCTCTA GCTCCCTTTTATCCCCCCACTCCCCCTTCAACCCCCCCCCCCAAACATACTCCCCCCCCC CATATACCCCCATACCTCCCCCTCTTCCCCCACTTCCCCTTTCCCTACTTTCTTCCCCCC CTACTCCCCCCCTTTTTTCCGCCCCCCCTCTCCCCCCCTTTCTCCCCCCCCTTTTTCCCC TCCCCACCCACCCTCTTCTTTCCTATTTTTTCGCCCCCCCCCCTCTAACCCCCATTTTCC CTTTCTCATTATCCACCCGCTTTTCCCTTCACACCTCCCCCCCCCCCATTTTCACCCTCT TATTCCCCCCATTTCCCATCCCCACTCAACTACTTTATCTCCCACCCACCTTTACCTTTT TCCTCCCACACGCCCCCCCCACTTTTTTTTCCACCATCCCCCACCTTTCCCTTTCCCACC CGTCACCGCGCCACCTTTCGACAATCAATTCAATCCCCACCCCCCTTCACCCCCGCGTTT TTCTATTCCCCCGCCCACATTCCCCCCCCCCCGTTTTATCCCCACCCCTTTCCTCTTTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_022977 |
| Insert Size | 5230 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_022977.1, NP_075266.1 |
| RefSeq Size | 5356 bp |
| RefSeq ORF | 2136 bp |
| Locus ID | 2182 |
| UniProt ID | O60488 |
| Domains | AMP-binding |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Adipocytokine signaling pathway, Fatty acid metabolism, Metabolic pathways, PPAR signaling pathway |
| Gene Summary | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016] Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Identification of ACSL4 as a biomarker and contributor of ferroptosis
,Yuan, H;Li, X;Zhang, X;Kang, R;Tang, D;,
Biochem. Biophys. Res. Commun.
,PubMed ID 27565726
[ACSL4]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221413 | ACSL4 (Myc-DDK-tagged)-Human acyl-CoA synthetase long-chain family member 4 (ACSL4), transcript variant 2 |
CNY 5,208.00 |
|
| RC221413L3 | Lenti ORF clone of Human acyl-CoA synthetase long-chain family member 4 (ACSL4), transcript variant 2, Myc-DDK-tagged |
CNY 7,700.00 |
|
| RC221413L4 | Lenti ORF clone of Human acyl-CoA synthetase long-chain family member 4 (ACSL4), transcript variant 2, mGFP tagged |
CNY 7,700.00 |
|
| RG221413 | ACSL4 (tGFP-tagged) - Human acyl-CoA synthetase long-chain family member 4 (ACSL4), transcript variant 2 |
CNY 6,808.00 |
