NQO1 (BC000906) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	DHQU; DIA4; DTD; NMOR1; NMORI; QR1
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC000906 edited GAATTCGGCACGAGGACCCCAGGATTCAGGCGTTGGGTCCCGCCCTTGTAGGCTGTCCAC CTCAAACGGGCCGGACAGGATATATAAGAGAGAATGCACCGTGCACTACACACGCGACTC CCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCCGGCCAGGGTCGC CCCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGCA GAAGAGCACTGATCGTACTGGCTCACTCAGAGAGGACGTCCTTCAACTATGCCATGAAGG AGGCTGCTGCAGCGGCTTTGAAGAAGAAAGGATGGGAGGTGGTGGAGTCGGACCTCTATG CCATGAACTTCAATCCCATCATTTCCAGAAAGGACATCACAGGTAAACTGAAGGACCCTG CGAACTTTCAGTATCCTGCCGAGTCTGTTCTGGCTTATAAAGAAGGCCATCTGAGCCCAG ATATTGTGGCTGAACAAAAGAAGCTGGAAGCCGCAGACCTTGTGATATTCCAGTTCCCCC TGCAGTGGTTTGGAGTCCCTGCCATTCTGAAAGGCTGGTTTGAGCGAGTGTTCATAGGAG AGTTTGCTTACACTTACGCTGCCATGTATGACAAAGGACCCTTCCGGAGTAAGAAGGCAG TGCTTTCCATCACCACTGGTGGCAGTGGCTCCATGTACTCTCTGCAAGGGATCCACGGGG ACATGAATGTCATTCTCTGGCCAATTCAGAGTGGCATTCTGCATTTCTGTGGCTTCCAAG TCTTAGAACCTCAACTGACATATAGCATTGGGCACACTCCAGCAGACGCCCGAATTCAAA TCCTGGAAGGATGGAAGAAACGCCTGGAGAATATTTGGGATGAGACACCACTGTATTTTG CTCCAAGCAGCCTCTTTGACCTAAACTTCCAGGCAGGATTCTTAATGAAAAAAGAGGTAC AGGATGAGGAGAAAAACAAGAAATTTGGCCTTTCTGTGGGCCATCACTTGGGCAAGTCCA TCCCAACTGACAACCAGATCAAAGCTAGAAAATGAGATTCCTTAGCCTGGATTTCCTTCT AACATGTTATCAAATCTGGGTATCTTTCCAGGCTTCCCTGACTTGCTTTAGTTTTTAAGA TTTGTGTTTTTCTTTTTCCACAAGGAATAAATGAGAGGGAATCGACTGTATTCGTGCATT TTTGGATCATTTTTAACTGATTCTTATGATTACTATCATGGCATATAACCAAAATCCGAC TGGGCTCAAGAGGCCACTTAGGGAAAGATGTAGAAAGATGCTAGAAAAATGTTCTTTAAA GGCATCTACACAATTTAATTCCTCTTTTTAGGGCTAAAGTTTTAGGGTACAGTTTGGCTA GGTATCATTCAACTCTCCAATGTTCTATTAATCACCTCTCTGTAGTTTATGGCAGAAGGG AATTGCTCAGAGAAGGAAAAGACTGAATCTACCTGCCCTAAGGGACTTAACTTGTTTGGT AGTTAGCCATCTAATGCTTGTTTATGATATTTCTTGCTTTCAATTACAAAGCAGTTACTA ATATGCCTAGCACAAGTACCACTCTTGGTCAGCTTTTGTTGTTTATATACAGTACACAGA TACCTTGAAAGGAAGAGCTAATAAATCTCTTCTTTGCTGCAGTCATCTACTTTTTTTTTA ATTAAAAAAAATTTTTTTTTGAAGCAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGG TGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCCAGCAATTCTCCTGCCTCAGC CTCCCTAGTAGCTGGGATGACAGGCGCCTGCCATCATGCCTGACTAATTTTTGTATTTTT AGTAGAGACGGCGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGA TCCGCCTACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGATCCACCACACCTGGCC CTTGCAATCTTCTACTTTAAGGTTTGCAGAGATAAACCAATAAATCCACACCGTACATCT GCAATATGAATTCAAGAAAGGAAATAGTACCTTCAATACTTAAAAATAGTCTTCCACAAA AAATACTTTATTTCTGATCTATACAAATTTTCAGAAGGTTATTTTCTTTATCATTGCTAA ACTGATGACTTACCATGGGATGGGGTCCAGTCCCATGACCTTGGGGTACAATTGTAAACC TAGAGTTTTATCAACTTTGGTGAACAGTTTTGGCATAATAGTCAATTTCTACTTCTGGAA GTCATCTCATTCCACTGTTGGTATTATATAATTCAAGGAGAATATGATAAAACACTGCCC TCTTGTGGTGCATTGAAAGAAGAGATGAGAAATGATGAAAAGGTTGCCTGAAAAATGGGA GACAGCCTCTTACTTGCCAAGAAAATGAAGGGATTGGACCGAGCTGGAAAACCTCCTTTA CCAGATGCTGACTGGCACTGGTGGTTTTTGCTCTCGACAGTATCCACAATAGCTGACGGC TGGGTGTTTCAGTTTGAAAATATTTTGTTGCCTTCATCTTCACTGCAATTTTGTGTAAAT TTCTCAAAGATCTGAATTAAATAAATAAAATTCATTTCTACAGACCCACAAAAAAAAAAA AAAAAAACTCGAC 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC000906 unedited AATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGACCCCAGNATTCAGGCGTT GGGTCCCGCCCTTGTAGGCTGTCCACCTCAAACGGGCCGGACAGGATATATAAGAGAGAA TGCACCGTGCACTACACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACC GAGAGCCTAGTTCCGGCCAGGGTCGCCCCGGCAACCACGAGCCCAGCCAATCAGCGCCCC GGACTGCACCAGAGCCATGGTCGGCAGAAGAGCACTGATCGTACTGGCTCACTCAGAGAG GACGTCCTTCAACTATGCCATGAAGGAGGCTGCTGCAGCGGCTTTGAAGAAGAAAGGATG GGAGGTGGTGGAGTCGGACCTCTATGCCATGAACTTCAATCCCATCATTTCCAGAAAGGA CATCACAGGTAAACTGAAGGACCCTGCGAACTTTCAGTATCCTGCCGAGTCTGTTCTGGC TTATAAAGAAGGCCATCTGAGCCCAGATATTGTGGCTGAACAAAAGAAGCTGGAAGCCGC AGACCTTGTGATATTCCAGTTCCCCCTGCAGTGGTTTGGAGTCCCTGCCATTCTGAAAGG CTGGTTTGAGCGAGTGTTCATAGGAGAGTTTGCTTACACTTACGCTGCCATGTATGACAA AGGACCCTTCCGGAGTAAGAAAGCAGTGCTTTCCATCACCACTGGTGGCAGTGGCTCCAT GTACTCTCTGCNAGGGGATCCACGGGACCATGAATGTCATTCTCTGGCCCATTCAGAAGT GCATTCTGCAATTTCTGTGGCTTNCCAGTCTTANAACCCTCACTGACATATAGCATTGGG CACACTNCAGCAGACGGCCGATTCAATCCTGNNAGGNATGGAGAAACGCTGNAGAATATT TGGGATGAGACACACTGTATTNTTGCTCAGCAGNCTCTTTGACTAACTNNCAGCNGATCT ATGNAAAAAAAGGCCGGGTGTAGAGAAACAGAAA
Restriction Sites	NotI-NotI
ACCN	BC000906
Insert Size	2700 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC000906.2
RefSeq Size	974 bp
RefSeq ORF	974 bp
Locus ID	1728
Protein Families	Druggable Genome
Gene Summary	This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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