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Cytochrome P450 2D6 (CYP2D6) (NM_000106) Human Untagged Clone
CAT＃: SC104446
CYP2D6 (untagged)-Human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1
CNY 3,656.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_000106 edited
TCGGCACGAGGCCTGGTCCTCTGTGCCTGGTGGGGTGGGGGTGCCAGGTGTGTCCAGAGG AGCCCATTTGGTAGTGAGGCAGGTATGGGGCTAGAAGCACTGGTGCCCCTGGCCGTGATA GTGGCCATCTTCCTGCTCCTGGTGGACCTGATGCACCGGCGCCAACGCTGGGCTGCACGC TACTCACCAGGCCCCCTGCCACTGCCCGGGCTGGGCAACCTGCTGCATGTGGACTTCCAG AACACACCATACTGCTTCGACCAGTTGCGGCGCCGCTTCGGGGACGTGTTCAGCCTGCAG CTGGCCTGGACGCCGGTGGTCGTGCTCAATGGGCTGGCGGCCGTGCGCGAGGCGCTGGTG ACCCACGGCGAGGACACCGCCGACCGCCCGCCTGTGCCCATCACCCAGATCCTGGGTTTT GGGCCGCGTTCCCAAGGGGTGTTCCTGGTGCGCTATGGGCCCGCGTGGCGCGAGCAGAGG CGCTTCTCCGTCTCCACCTTGCGCAACTTGGGCCTGGGCAAGAAGTCGCTGGAGCAGTGG GTGACCGAGGAGGCCGCCTGCCTTTGTGCCGCCTTCGCCAACCACTCCGGACGCCCCTTT CGCCCCAACGGTCTCTTGGACAAAGCCGTGAGCAACGTGATCGCCTCCCTCACCTGCGGG CGCCGCTTCGAGTACGACGACCCTCGCTTCCTCAGGCTGCTGGACCTAGCTCAGGAGGGA CTGAAGGAGGAGTCGGGCTTTCTGCGCGAGGTGCTGAATGCTGTCCCCGTCCTCCTGCAT ATCCCAGCGCTGGCTGGCAAGGTCCTACGCTTCCAAAAGGCTTTCCTGACCCAGCTGGAT GAGCTGCTAACTGAGCACAGGATGACCTGGGACCCAGCCCAGCCCCCCCGAGACCTGACT GAGGCCTTCCTGGCAGAGATGGAGAAGGCCAAGGGGAACCCTGAGAGCAGCTTCAATGAT GAGAACCTGCGCATAGTGGTGGCTGACCTGTTCTCTGCCGGGATGGTGACCACCTCGACC ACGCTGGCCTGGGGCCTCCTGCTCATGATCCTACATCCGGATGTGCAGCGCCGTGTCCAA CAGGAGATCGACGACGTGATAGGGCAGGTGCGGCGACCAGAGATGGGTGACCAGGCTCAC ATGCCCTACACCACTGCCGTGATTCATGAGGTGCAGCGCTTTGGGGACATCGTCCCCCTG GGTGTGACCCATATGACATCCCGTGACATCGAAGTACAGGGCTTCCGCATCCCTAAGGGA ACGACACTCATCACCAACCTGTCATCGGTGCTGAAGGATGAGGCCGTCTGGGAGAAGCCC TTCCGCTTCCACCCCGAACACTTCCTGGATGCCCAGGGCCACTTTGTGAAGCCGGAGGCC TTCCTGCCTTTCTCAGCAGGCCGCCGTGCATGCCTCGGGGAGCCCCTGGCCCGCATGGAG CTCTTCCTCTTCTTCACCTCCCTGCTGCAGCACTTCAGCTTCTCGGTGCCCACTGGACAG CCCCGGCCCAGCCACCATGGTGTCTTTGCTTTCCTGGTGACCCCATCCCCCTATGAGCTT TGTGCTGTGCCCCGCTAGAATGGGGTACCTAGTCCCCAGCCTGCTCCCTAGCCAGAGGCT CTAATGTACAA >OriGene 5' read for NM_000106 unedited
NNNNNGGGGGNNNNNNCCCCCCNNGGNNCGGTTCAGATTTGTATACGACTCACTATAGGC GGCCGCGATTCGGCACGAGGCCTGGTCCTCTGTGCCTGGTGGGGTGGGGGTGCCAGGTGT GTCCAGAGGAGCCCATTTGGTAGTGAGGCAGGTATGGGGCTAGAAGCACTGGTGCCCCTG GCCGTGATAGTGGCCATCTTCCTGCTCCTGGTGGACCTGATGCACCGGCGCCAACGCTGG GCTGCACGCTACTCACCAGGCCCCCTGCCACTGCCCGGGCTGGGCAACCTGCTGCATGTG GACTTCCAGAACACACCATACTGCTTCGACCAGTTGCGGCGCCGCTTCGGGGACGTGTTC AGCCTGCAGCTGGCCTGGACGCCGGTGGTCGTGCTCAATGGGCTGGCGGCCGTGCGCGAG GCGCTGGTGACCCACGGCGAGGACACCGCCGACCGCCCGCCTGTGCCCATCACCCAGATC CTGNGTTTTGGGCCGCGTTCCCAAGGGGTGTTCCTGGTGCGCTATGGGCCCGCGTGGCGC GAGCAGAGGCGCTTCTCCGTCTCCACCTTGCGCAACTTGGGCCTGGGCAAGAAGTCGCTG GAGCAGTGGGTGACCGAGGAGGCCGCCTGCCTTTGTGCCGCCTTCGCCAACCACTCCGGA CGCCCCTTTCGCCCCAACGGTCTCTTGGACAAAGCCGTGAGCAACGTGATCGCCTTCCTC ACCTGCGGGCGCCGCTTCGAGTACGACGACCCTCGCTTCCTCAGGCTGCTGGACCTAGCT CANGAGGGNACTGAGNGANGAGTCGGGCTTTCTGNCGCGAGGTGCTGAAATGCTGTCCCC GTCCTTCTGCATATCCCAGCGCTGGCTGGNNCAGGTCCTACGCTTCCAAAGGCTTNTCTG ACCCANCTGNATGAGCTGCTACTGAGCCAGGATGACCTGGGN >OriGene 3' read for NM_000106 unedited
NNTTTTACTCTGNAACCGCGGCCGCAATCTAANGATCGATTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTGGAACTACCACATTGCTTTATTGGACATTAAAACCTCTGGC TAAGGAACAAGCTGGGGACTAAGTACCCCATTTTAACGGGGCACAACACAAAACTCATAA GGGGATGGGGTCACCAAGAAAGCAAAAACACCCTGGGGGCTGGGCCCGGGCTGTCCAATG GGCACCCAAAAACTTAAATGCTTCACCAGGGAGGGGAAAAAAAAGAAAAACTCCATGCGG GCCAAGGGCTCCCCCAAGCATGCACCGGGGCCTGCTTAAAAAAGCAAGAAAGCCTCCCGC TTTACAAAATGGCCCTGGGCATTCAAAAAATGTTCCGGGTGGAAACCGAAAGGGTTTTTC CAAAAGGGCTTATTCTTTAACACCCAAAAAAAGTTGGGGAAGAATGTCCTTCCCTTAAGG AAGCGGAAACCCTGTACTTTGATGTCACGGGATGTCATATGGGTCACACCCAAGGGGACC ATGTCCCCAAAACGCTGCACCTCATGAATCACCGCAATGGTGTAAGGCATGTGAACCTGG TCACCCATTTTTGGTCGCCGCACCTGCCCTATTACGTTGTCGATCTCCTGTTGGACACCG GGCTTCACATTCCGATGTAAGATCATTAACAAGAAGCCCCAAGCCAACGTGGGTCGAAGT GGTCACCATTCCGGCAGAGAACAGGTCAACCACCACTATGCCGCAAGGTCTCATCATTGA AACTGCTCTTCAAGGGTTCCCTTGGCCTTCTTCATCTCTGCCAGAAAGCCTTAATCAGTC TCCGGGGGGGCCTGGGCCTGTGTCCAAGTCATCCTGGCCTCAATTAACACTATTCAGCTG GGGTCAGAAAGCCTTTTGGAAACCTAAGACCCTGCCAACACGCTGAATTCCCCAAGAAAC GA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000106 |
| Insert Size | 1494 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000106.4, NP_000097.2 |
| RefSeq Size | 1673 bp |
| RefSeq ORF | 1494 bp |
| Locus ID | 1565 |
| UniProt ID | P10635 |
| Domains | p450 |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Drug metabolism - cytochrome P450 |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] Transcript Variant: This variant (1) encodes the longer isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Biotransformation, Using Recombinant CYP450-Expressing Baker’s Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme
,Williams, I;Gatchie, L;Bharate, S;Chaudhuri, B;,
ACS Omega
[CYP2D6]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223749 | CYP2D6 (Myc-DDK-tagged)-Human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1 |
CNY 5,488.00 |
|
| RC223749L3 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC223749L4 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG223749 | CYP2D6 (tGFP-tagged) - Human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1 |
CNY 7,088.00 |
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