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Cathepsin L (CTSL) (NM_145918) Human Untagged Clone
CAT＃: SC100267
CTSL1 (untagged)-Human cathepsin L1 (CTSL1), transcript variant 2
CNY 3,656.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CATL; CTSL1; MEP |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_145918, the custom clone sequence may differ by one or more nucleotides
ATGAATCCTACACTCATCCTTGCTGCCTTTTGCCTGGGAATTGCCTCAGCTACTCTAACATTTGATCACA GTTTAGAGGCACAGTGGACCAAGTGGAAGGCGATGCACAACAGATTATACGGCATGAATGAAGAAGGATG GAGGAGAGCAGTGTGGGAGAAGAACATGAAGATGATTGAACTGCACAATCAGGAATACAGGGAAGGGAAA CACAGCTTCACAATGGCCATGAACGCCTTTGGAGACATGACCAGTGAAGAATTCAGGCAGGTGATGAATG GCTTTCAAAACCGTAAGCCCAGGAAGGGGAAAGTGTTCCAGGAACCTCTGTTTTATGAGGCCCCCAGATC TGTGGATTGGAGAGAGAAAGGCTACGTGACTCCTGTGAAGAATCAGGGTCAGTGTGGTTCTTGTTGGGCT TTTAGTGCTACTGGTGCTCTTGAAGGACAGATGTTCCGGAAAACTGGGAGGCTTATCTCACTGAGTGAGC AGAATCTGGTAGACTGCTCTGGGCCTCAAGGCAATGAAGGCTGCAATGGTGGCCTAATGGATTATGCTTT CCAGTATGTTCAGGATAATGGAGGCCTGGACTCTGAGGAATCCTATCCATATGAGGCAACAGAAGAATCC TGTAAGTACAATCCCAAGTATTCTGTTGCTAATGACACCGGCTTTGTGGACATCCCTAAGCAGGAGAAGG CCCTGATGAAGGCAGTTGCAACTGTGGGGCCCATTTCTGTTGCTATTGATGCAGGTCATGAGTCCTTCCT GTTCTATAAAGAAGGCATTTATTTTGAGCCAGACTGTAGCAGTGAAGACATGGATCATGGTGTGCTGGTG GTTGGCTACGGATTTGAAAGCACAGAATCAGATAACAATAAATATTGGCTGGTGAAGAACAGCTGGGGTG AAGAATGGGGCATGGGTGGCTACGTAAAGATGGCCAAAGACCGGAGAAACCATTGTGGAATTGCCTCAGC AGCCAGCTACCCCACTGTGTGA >OriGene 5' read for NM_145918 unedited
GTTCAAAATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGCTCCGCAAC CTTGAGCGGCATCCGTGGAGTGCGCCTGCGCAGCTACNACCGCAGCAGGAAAGCGCCGCC GGCCAGGCCCAGCTGTGGCCGGACAGGGACTGGAAGAGAGGACGCGGTCGAGTTTTAAAA CATGAATCCTACACTCATCCTTGCTGCCTTTTGCCTGGGAATTGCCTCAGCTACTCTAAC ATTTGATCACAGTTTAGAGGCACAGTGGACCAAGTGGAAGGCGATGCACAACAGATTATA CGGCATGAATGAAGAAGGATGGAGGAGAGCAGTGTGGGAGAAGAACATGAAGATGATTGA ACTGCACAATCAGGAATACAGGGAAGGGAAACACAGCTTCACAATGGCCATGAACGCCTT TGGAGACATGACCAGTGAAGAATTCAGGCAGGTGATGAATGGCTTTCAAAACCGTAAGCC CAGGAAGGGGAAAGTGTTCCAGGAACCTCTGTTTTATGAGGCCCCCAGATCTGTGGATTG GAGAGAGAAAGGCTACGTGACTCCTGTGAAGAATCAGGGTCAGTGTGGTTCTTGTTGGGC TTTTAGTGCTACTGGTGCTCTTGAAGGACAGATGTTCCGGANAACTGGGAGGCTTATCTC ACTGAGTGAGCAGAATCTGGTAGACTGCTCTGGGCCTCAAGGCAATGAAGGCTGCAATGG TGGCCTAATGGATTATGCTTTCCAGTATGTTCAGGATAATGGAGGCCTGGACTCTGAGGA ATCCTATCCATATGAGGGCACAGAAGAATCCCTGTAGTACATCCCCCAGTATTCTGTTGC TAATGACACCGGCTTTTGTGGACATNCCTTTAGCAGGAGAAGCCCTGATGAAGGCAGTGC ACCTGTGGGCCCCATTTCTGGTGTATGGATGCAGNCACTGG >OriGene 3' read for NM_145918 unedited
GAACCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTACATTTGAAAATTAAATTTTATTTAAACAGGGAAAAATTTATACATCC TTTTAAAAACGAAAATGCAAAGTCAGTAAGGGAATCAATAATATAAACCTATTTATAGCA GTAATTAAAATAGAGGGAACATTTACCAGGGGGAAAATATCACAGAATTCAAATCACACT CGGATCTTCAATGATTCGAGGGGGTATCCGACACAGGGGGGGCTGGTAAACTGAAAATGA ATTCCTCCCATGCATGCGCCATCCCCAGTCAAGTCCTTCCTTATCACCGTCCACCAGCTC ACACAGTGGGGTAACTGGCTGCTGAGGCAATTCCACAATGGTTTCTCCGGTCTTTGGCCA TTTTTACGTAGCCACCCATGCCCCATTCTTCACCCCAGCTGTTTTTCACCAGCCAATATT TATTGGTATCTGATTCTGGGCTTTCAAATCCGTAGCCAACCACCAGCACACCATGATCCA TGTCTTCACTGCTACAGTCTGGCTCAAAATAAATGCCTTCTTTATAGAACAGGAAGGACT CATGACCTGCATCAATAGCAACAGAAATGGGCCCCACAGTTGCAACTGCCTTCATCAGGG GCCTTCTCTGCTTAGGGATGTCCACAAAGCCGGTGTCATTAGCAACAGATACTTGGGATN GACCTACAGGATTCCCCTGTTGCCTCATATGGATAGGATTNCCTCAAAGTCAGGGCTNCA TTATCCTGAAACTACTGGAAAGCATATTCCTTTAGGCCACATTGCAGGCTTTAATTGCCT TGAGGGCCAAAAAAGTCTACAAATTTTGCNACCTCAGGAAAAAGGCTCCCAGTTTTTCGG AACATTGGCTTTAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_145918 |
| Insert Size | 1500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_145918.1, NP_666023.1 |
| RefSeq Size | 1487 bp |
| RefSeq ORF | 1002 bp |
| Locus ID | 1514 |
| UniProt ID | P07711 |
| Domains | Pept_C1 |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Antigen processing and presentation, Lysosome |
| Gene Summary | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020] Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression
,Tholen, M;Wolanski, J;Stolze, B;Chiabudini, M;Gajda, M;Bronsert, P;Stickeler, E;Rospert, S;Reinheckel, T;,
J. Biol. Chem.
,PubMed ID 25957406
[CTSL]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223541 | CTSL1 (Myc-DDK-tagged)-Human cathepsin L1 (CTSL1), transcript variant 2 |
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| RC223541L3 | Lenti ORF clone of Human cathepsin L1 (CTSL1), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
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| RC223541L4 | Lenti ORF clone of Human cathepsin L1 (CTSL1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
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| RG223541 | CTSL1 (tGFP-tagged) - Human cathepsin L1 (CTSL1), transcript variant 2 |
CNY 4,000.00 |
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