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Septin 2 (SEPT2) (NM_001282973) Human Tagged ORF Clone
CAT＃: RG237793
- TrueORF®
SEPT2 (tGFP-tagged) - Human septin 2 (SEPT2), transcript variant 6
ORF Plasmid: DDK
"NM_001282973" in other vectors (2)
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CNY 4,370.00
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Specifications
| Product Data | |
| Tag | TurboGFP |
| Synonyms | DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3; SEPT2 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG237793 representing NM_001282973.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGTCTAAGCAACAGCCAACTCAGTTTATAAATCCAGAAACACCTGGCTATGTTGGATTTGCAAACCTC CCCAATCAAGTTCACCGAAAATCAGTGAAAAAAGGTTTTGAGTTCACACTGATGGTGGTCGGTGAATCA GGTCTAGGAAAATCGACTCTCATAAACAGCCTATTCCTAACTGATCTGTACCCAGAAAGAGTCATACCT GGAGCAGCAGCTTTGAACACAAGGAAAACACTTTTATGGGAAAAAATTGAAAGAACTGTCCAGATTGAG GCTTCAACTGTTGAAATTGAAGAGCGAGGGGTCAAGCTACGCCTGACAGTGGTAGATACCCCTGGCTAT GGTGACGCTATCAACTGCAGAGATTGTTTTAAGACAATTATCTCCTATATTGATGAGCAATTTGAGAGG TACCTGCATGACGAGAGCGGCTTGAACAGGCGGCACATCATTGATAATAGGGTGCATTGTTGCTTTTAC TTTATTTCACCTTTTGGACATGGACTTAAGCCCTTAGATGTGGCGTTTATGAAGGCAATACACAACAAG GTGAATATTGTGCCTGTCATTGCAAAAGCTGACACTCTCACCCTGAAGGAACGGGAGCGGCTGAAGAAA AGGATTCTGGATGAAATTGAAGAACATAACATCAAAATCTATCACTTACCTGATGCAGAATCAGATGAA GATGAAGATTTTAAAGAGCAGACTAGACTTCTCAAGGCTAGCATCCCATTCTCTGTGGTTGGATCCAAT CAGTTGATTGAAGCCAAAGGAAAGAAGGTCAGAGGCCGCCTCTACCCCTGGGGTGTTGTGGAAGTGGAG AACCCAGAGCACAATGACTTTCTGAAGCTGAGAACCATGCTCATCACCCACATGCAGGATCTCCAGGAG GTGACCCAGGACCTTCATTATGAAAACTTCCGTTCTGAGAGACTCAAGAGAGGCGGCAGGAAAGTGGAG AATGAGGACATGAATAAAGACCAGATCTTGCTGGAAAAAGAAGCTGAGCTCCGCCGCATGCAAGAGATG ATTGCAAGGATGCAGGCGCAGATGCAGATGCAGATGCAGGGCGGGGATGGCGATGGCGGGGCTCTCGGG CACCACGTG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG237793
Blue=ORF Red=Cloning site Green=Tag(s) MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVIP GAAALNTRKTLLWEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFER YLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKK RILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVE NPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVENEDMNKDQILLEKEAELRRMQEM IARMQAQMQMQMQGGDGDGGALGHHV TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001282973 |
| ORF Size | 1113 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reference Data | |
| RefSeq | NM_001282973.1, NP_001269902.1 |
| RefSeq Size | 3681 bp |
| RefSeq ORF | 1116 bp |
| Locus ID | 4735 |
| UniProt ID | Q15019 |
| MW | 43.1 kDa |
| Gene Summary | Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.[UniProtKB/Swiss-Prot Function] |
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