NRG3 (NM_001010848) Human Tagged ORF Clone
CAT#: RG224735
- TrueORF®
NRG3 (tGFP-tagged) - Human neuregulin 3 (NRG3), transcript variant 1
ORF Plasmid: DDK
"NM_001010848" in other vectors (4)
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CNY 9,752.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | TurboGFP |
Synonyms | HRG3; pro-NRG3 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RG224735 representing NM_001010848
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAGTGAAGGGGCGGCCGCTGCCTCGCCACCTGGTGCCGCTTCGGCAGCCGCCGCCTCGGCCGAGGAGG GCACCGCGGCGGCTGCGGCGGCGGCAGCGGCGGGCGGGGGCCCGGACGGCGGCGGCGAAGGGGCGGCCGA GCCCCCCCGGGAGTTACGCTGTAGCGACTGCATCGTGTGGAACCGGCAGCAGACGTGGCTGTGCGTGGTA CCTCTGTTCATCGGCTTCATCGGCCTGGGGCTCAGCCTCATGCTTCTCAAATGGATCGTGGTGGGCTCCG TCAAGGAGTACGTGCCCACCGACCTAGTGGACTCCAAGGGGATGGGCCAGGACCCCTTCTTCCTCTCCAA GCCCAGCTCTTTCCCCAAGGCCATGGAGACCACCACCACTACCACTTCCACCACGTCCCCCGCCACCCCC TCCGCCGGGGGTGCCGCCTCCTCCAGGACGCCCAACCGGATTAGCACTCGCCTGACCACCATCACGCGGG CGCCCACTCGCTTCCCCGGGCACCGGGTGCCCATCCGGGCCAGCCCGCGCTCCACCACAGCACGGAACAC TGCGGCCCCTGCGACGGTCCCGTCCACCACGGCCCCGTTCTTCAGTAGCAGCACGCTGGGCTCCCGACCC CCGGTGCCAGGAACTCCAAGTACCCAGGCAATGCCCTCCTGGCCTACTGCGGCATACGCTACCTCCTCCT ACCTTCACGATTCTACTCCCTCCTGGACCCTGTCTCCCTTTCAGGATGCTGCCTCCTCTTCTTCCTCTTC TTCCTCCTCCGCTACCACCACCACACCAGAAACTAGCACCAGCCCCAAATTTCATACGACGACATATTCC ACAGAGCGATCCGAGCACTTCAAACCCTGCCGAGACAAGGACCTTGCATACTGTCTCAATGATGGCGAGT GCTTTGTGATCGAAACCCTGACCGGATCCCATAAACACTGTCGGTGCAAAGAAGGCTACCAAGGAGTCCG TTGTGATCAATTTCTGCCGAAAACTGATTCCATCTTATCGGATCCAACAGACCACTTGGGGATTGAATTC ATGGAGAGTGAAGAAGTTTATCAAAGGCAGGTGCTGTCAATTTCATGTATCATCTTTGGAATTGTCATCG TGGGCATGTTCTGTGCAGCATTCTACTTCAAAAGCAAGAAACAAGCTAAACAAATCCAAGAGCAGCTGAA AGTGCCACAAAATGGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTG AAGAGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGA TGGAGTCAAGTTTTGTCGGCCCCCAGTCATTCCCTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGT CAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCAAAGAAGTGGCATGCTCCATAGGAATGCC TTCAGAAGGACACCCCCGTCACCCCGAAGTAGGCTAGGTGGAATTGTGGGACCAGCATATCAGCAACTCG AAGAATCAAGGATCCCAGACCAGGATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCA ACGAAATACATCAATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAA AAGGACCTGGTGGGCTATTCATCCACAAGGGCCAGTTCTGTGCCCATCATCCCTTCAGTGGGTTTAGAGG AAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTGCAAAAACTCCTATTCAGC TGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTG CTAGAAACTGTCCAGGAGCAGATCCGAATTCTGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCA GCGTAGAAACCGAGGACAGTGCAAGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGA ACGAGAGGCGCAATTTGTCTTAAGAAATGAAATACAAAGAGACTCTGCATTGACCAAG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >RG224735 representing NM_001010848
Red=Cloning site Green=Tags(s) MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVV PLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATP SAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRP PVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYS TERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEF MESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLV KSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNA FRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQ KDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKIL LETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK TRTRPLE - GFP Tag - V |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_001010848 |
ORF Size | 2088 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001010848.4 |
RefSeq Size | 3692 bp |
RefSeq ORF | 2091 bp |
Locus ID | 10718 |
UniProt ID | P56975 |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | ErbB signaling pathway |
Gene Summary | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC224735 | NRG3 (Myc-DDK-tagged)-Human neuregulin 3 (NRG3), transcript variant 1 |
CNY 8,152.00 |
|
RC224735L3 | Lenti-ORF clone of NRG3 (Myc-DDK-tagged)-Human neuregulin 3 (NRG3), transcript variant 1 |
CNY 5,890.00 |
|
RC224735L4 | Lenti-ORF clone of NRG3 (mGFP-tagged)-Human neuregulin 3 (NRG3), transcript variant 1 |
CNY 5,890.00 |
|
SC301476 | NRG3 (untagged)-Human neuregulin 3 (NRG3), transcript variant 1 |
CNY 7,656.00 |