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NMDAR2B (GRIN2B) (NM_000834) Human Tagged ORF Clone
CAT＃: RG223623
- TrueORF®
GRIN2B (tGFP-tagged) - Human glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B)
ORF Plasmid: DDK
"NM_000834" in other vectors (6)
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CNY 16,832.00
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Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Synonyms | DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B; NR2B; NR3 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG223623 representing NM_000834.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGAAGCCCAGAGCGGAGTGCTGTTCTCCCAAGTTCTGGTTGGTGTTGGCCGTCCTGGCCGTGTCAGGC AGCAGAGCTCGTTCTCAGAAGAGCCCCCCCAGCATTGGCATTGCTGTCATCCTCGTGGGCACTTCCGAC GAGGTGGCCATCAAGGATGCCCACGAGAAAGATGATTTCCACCATCTCTCCGTGGTACCCCGGGTGGAA CTGGTAGCCATGAATGAGACCGACCCAAAGAGCATCATCACCCGCATCTGTGATCTCATGTCTGACCGG AAGATCCAGGGGGTGGTGTTTGCTGATGACACAGACCAGGAAGCCATCGCCCAGATCCTCGATTTCATT TCAGCACAGACTCTCACCCCGATCCTGGGCATCCACGGGGGCTCCTCTATGATAATGGCAGATAAGGAT GAATCCTCCATGTTCTTCCAGTTTGGCCCATCAATTGAACAGCAAGCTTCCGTAATGCTCAACATCATG GAAGAATATGACTGGTACATCTTTTCTATCGTCACCACCTATTTCCCTGGCTACCAGGACTTTGTAAAC AAGATCCGCAGCACCATTGAGAATAGCTTTGTGGGCTGGGAGCTAGAGGAGGTCCTCCTACTGGACATG TCCCTGGACGATGGAGATTCTAAGATCCAGAATCAGCTCAAGAAACTTCAAAGCCCCATCATTCTTCTT TACTGTACCAAGGAAGAAGCCACCTACATCTTTGAAGTGGCCAACTCAGTAGGGCTGACTGGCTATGGC TACACGTGGATCGTGCCCAGTCTGGTGGCAGGGGATACAGACACAGTGCCTGCGGAGTTCCCCACTGGG CTCATCTCTGTATCATATGATGAATGGGACTATGGCCTCCCCGCCAGAGTGAGAGATGGAATTGCCATA ATCACCACTGCTGCTTCTGACATGCTGTCTGAGCACAGCTTCATCCCTGAGCCCAAAAGCAGTTGTTAC AACACCCACGAGAAGAGAATCTACCAGTCCAATATGCTAAATAGGTATCTGATCAATGTCACTTTTGAG GGGAGGAATTTGTCCTTCAGTGAAGATGGCTACCAGATGCACCCGAAACTGGTGATAATTCTTCTGAAC AAGGAGAGGAAGTGGGAAAGGGTGGGGAAGTGGAAAGACAAGTCCCTGCAGATGAAGTACTATGTGTGG CCCCGAATGTGTCCAGAGACTGAAGAGCAGGAGGATGACCATCTGAGCATTGTGACCCTGGAGGAGGCA CCATTTGTCATTGTGGAAAGTGTGGACCCTCTGAGTGGAACCTGCATGAGGAACACAGTCCCCTGCCAA AAACGCATAGTCACTGAGAATAAAACAGACGAGGAGCCGGGTTACATCAAAAAATGCTGCAAGGGGTTC TGTATTGACATCCTTAAGAAAATTTCTAAATCTGTGAAGTTCACCTATGACCTTTACCTGGTTACCAAT GGCAAGCATGGGAAGAAAATCAATGGAACCTGGAATGGTATGATTGGAGAGGTGGTCATGAAGAGGGCC TACATGGCAGTGGGCTCACTCACCATCAATGAGGAACGATCGGAGGTGGTCGACTTCTCTGTGCCCTTC ATAGAGACAGGCATCAGTGTCATGGTGTCACGCAGCAATGGGACTGTCTCACCTTCTGCCTTCTTAGAG CCATTCAGCGCTGACGTATGGGTGATGATGTTTGTGATGCTGCTCATCGTCTCAGCCGTGGCTGTCTTT GTCTTTGAGTACTTCAGCCCTGTGGGTTATAACAGGTGCCTCGCTGATGGCAGAGAGCCTGGTGGACCC TCTTTCACCATCGGCAAAGCTATTTGGTTGCTCTGGGGTCTGGTGTTTAACAACTCCGTACCTGTGCAG AACCCAAAGGGGACCACCTCCAAGATCATGGTGTCAGTGTGGGCCTTCTTTGCTGTCATCTTCCTGGCC AGCTACACTGCCAACTTAGCTGCCTTCATGATCCAAGAGGAATATGTGGACCAGGTTTCTGGCCTGAGC GACAAAAAGTTCCAGAGACCTAATGACTTCTCACCCCCTTTCCGCTTTGGGACCGTGCCCAACGGCAGC ACAGAGAGAAATATTCGCAATAACTATGCAGAAATGCATGCCTACATGGGAAAGTTCAACCAGAGGGGT GTAGATGATGCATTGCTCTCCCTGAAAACAGGGAAACTGGATGCCTTCATCTATGATGCAGCAGTGCTG AACTATATGGCAGGCAGAGATGAAGGCTGCAAGCTGGTGACCATTGGCAGTGGGAAGGTCTTTGCTTCC ACTGGCTATGGCATTGCCATCCAAAAAGATTCTGGGTGGAAGCGCCAGGTGGACCTTGCTATCCTGCAG CTCTTTGGAGATGGGGAGATGGAAGAACTGGAAGCTCTCTGGCTCACTGGCATTTGTCACAATGAGAAG AATGAGGTCATGAGCAGCCAGCTGGACATTGACAACATGGCAGGGGTCTTCTACATGTTGGGGGCGGCC ATGGCTCTCAGCCTCATCACCTTCATCTGCGAACACCTTTTCTATTGGCAGTTCCGACATTGCTTTATG GGTGTCTGTTCTGGCAAGCCTGGCATGGTCTTCTCCATCAGCAGAGGTATCTACAGCTGCATCCATGGG GTGGCGATCGAGGAGCGCCAGTCTGTAATGAACTCCCCCACTGCAACCATGAACAACACACACTCCAAC ATCCTGCGCCTGCTGCGCACGGCCAAGAACATGGCTAACCTGTCTGGTGTGAATGGCTCACCGCAGAGC GCCCTGGACTTCATCCGACGGGAGTCATCCGTCTATGACATCTCAGAGCACCGCCGCAGCTTCACGCAT TCTGACTGCAAATCCTACAACAACCCGCCCTGTGAGGAGAACCTCTTCAGTGACTACATCAGTGAGGTA GAGAGAACGTTCGGGAACCTGCAGCTGAAGGACAGCAACGTGTACCAAGATCACTACCACCATCACCAC CGGCCCCATAGTATTGGCAGTGCCAGCTCCATCGATGGGCTCTACGACTGTGACAACCCACCCTTCACC ACCCAGTCCAGGTCCATCAGCAAGAAGCCCCTGGACATCGGCCTCCCCTCCTCCAAGCACAGCCAGCTC AGTGACCTGTACGGCAAATTCTCCTTCAAGAGCGACCGCTACAGTGGCCACGACGACTTGATCCGCTCC GATGTCTCTGACATCTCAACCCACACCGTCACCTATGGGAACATCGAGGGCAATGCCGCCAAGAGGCGT AAGCAGCAATATAAGGACAGCCTGAAGAAGCGGCCTGCCTCGGCCAAGTCCCGCAGGGAGTTTGACGAG ATCGAGCTGGCCTACCGTCGCCGACCGCCCCGCTCCCCTGACCACAAGCGCTACTTCAGGGACAAGGAA GGGCTACGGGACTTCTACCTGGACCAGTTCCGAACAAAGGAGAACTCACCCCACTGGGAGCACGTAGAC CTGACCGACATCTACAAGGAGCGGAGTGATGACTTTAAGCGCGACTCCGTCAGCGGAGGAGGGCCCTGT ACCAACAGGTCTCACATCAAGCACGGGACGGGCGACAAACACGGCGTGGTCAGCGGGGTACCTGCACCT TGGGAGAAGAACCTGACCAACGTGGAGTGGGAGGACCGGTCCGGGGGCAACTTCTGCCGCAGCTGTCCC TCCAAGCTGCACAACTACTCCACGACGGTGACGGGTCAGAACTCGGGCAGGCAGGCGTGCATCCGGTGT GAGGCTTGCAAGAAAGCAGGCAACCTGTATGACATCAGTGAGGACAACTCCCTGCAGGAACTGGACCAG CCGGCTGCCCCAGTGGCGGTGACGTCAAACGCCTCCACCACTAAGTACCCTCAGAGCCCGACTAATTCC AAGGCCCAGAAGAAGAACCGGAACAAACTGCGCCGGCAGCACTCCTACGACACCTTCGTGGACCTGCAG AAGGAAGAAGCCGCCCTGGCCCCGCGCAGCGTAAGCCTGAAAGACAAGGGCCGATTCATGGATGGGAGC CCCTACGCCCACATGTTTGAGATGTCAGCTGGCGAGAGCACCTTTGCCAACAACAAGTCCTCAGTGCCC ACTGCCGGACATCACCACCACAACAACCCCGGCGGCGGGTACATGCTCAGCAAGTCGCTCTACCCTGAC CGGGTCACGCAAAACCCTTTCATCCCCACTTTTGGGGACGACCAGTGCTTGCTCCATGGCAGCAAATCC TACTTCTTCAGGCAGCCCACGGTGGCGGGGGCGTCGAAAGCCAGGCCGGACTTCCGGGCCCTTGTCACC AACAAGCCGGTGGTCTCGGCCCTTCATGGGGCCGTGCCAGCCCGTTTCCAGAAGGACATCTGTATAGGG AACCAGTCCAACCCCTGTGTGCCTAACAACAAAAACCCCAGGGCTTTCAATGGCTCCAGCAATGGGCAT GTTTATGAGAAACTTTCTAGTATTGAGTCTGATGTC ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG223623
Blue=ORF Red=Cloning site Green=Tag(s) MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVE LVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKD ESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDM SLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTG LISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFE GRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEA PFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN GKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLE PFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQ NPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGS TERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAS TGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAA MALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSN ILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEV ERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISKKPLDIGLPSSKHSQL SDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDE IELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPC TNRSHIKHGTGDKHGVVSGVPAPWEKNLTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRC EACKKAGNLYDISEDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQ KEEAALAPRSVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPARFQKDICIG NQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_000834 |
| ORF Size | 4452 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq Size | 6240 bp |
| RefSeq ORF | 4455 bp |
| Locus ID | 2904 |
| UniProt ID | Q13224 |
| Domains | lig_chan |
| Protein Families | Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane |
| Protein Pathways | Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Huntington's disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Systemic lupus erythematosus |
| MW | 166.4 kDa |
| Gene Summary | This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223623 | GRIN2B (Myc-DDK-tagged)-Human glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B) |
CNY 15,232.00 |
|
| RC223623L1 | Lenti ORF clone of Human glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), Myc-DDK-tagged |
CNY 17,632.00 |
|
| RC223623L2 | Lenti ORF clone of Human glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), mGFP tagged |
CNY 17,632.00 |
|
| RC223623L3 | Lenti ORF clone of Human glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), Myc-DDK-tagged |
CNY 17,632.00 |
|
| RC223623L4 | Lenti ORF clone of Human glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), mGFP tagged |
CNY 17,632.00 |
|
| SC119642 | GRIN2B (untagged)-Human glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B) |
CNY 10,160.00 |
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