P protein (OCA2) (NM_001300984) Human Tagged ORF Clone

Specifications

Product Data
Type	Human Tagged ORF Clone
Tag	Myc-DDK
Synonyms	BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >RC239620 representing NM_001300984 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCATCTGGAGGGCAGAGACGGCAGGCGGTACCCCGGCGCGCCGGCGGTGGAGCTCCTGCAGACGTCCG TGCCCAGCGGACTCGCTGAACTTGTGGCCGGCAAGCGCAGGCTTCCTCGGGGAGCCGGTGGAGCTGACCC CTCGCACTCCTGCCCCAGGGGGGCTGCCGGGCAGAGCTCTTGGGCTCCTGCAGGCCAGGAGTTTGCTTCA TTCCTCACAAAAGGGAGGTCTCACTCTTCTTTGCCCCAGATGTCCAGCTCCAGGTCTAAAGATTCCTGCT TTACAGAAAACACTCCTTTGCTGAGGAATTCCTTACAGGAGAAAGGGTCACGGTGCATACCTGTTTACCA TCCAGAGTTCATCACTGCTGAAGAGTCTTGGGAAGACAGCTCTGCTGACTGGGAGCGAAGATACCTGCTA AGCAGGGAGGTGTCTGGTCTGTCTGCATCTGCCTCCTCCGAGAAGGGAGACCTTCTGGACAGCCCGCACA TCCGACTCCGTCTTTCCAAGCTGAGGCGCTGTGTGCAGTGGCTGAAAGTCATGGGCCTGTTTGCCTTTGT GGTGCTGTGTTCTATTTTGTTCAGCCTATATCCGGATCAAGGAAAGCTCTGGCAGCTGTTGGCCTTATCA CCGCTGGAGAACTACTCCGTGAACCTTAGCAGCCACGTGGACTCCACGCTGCTGCAGGTGGACCTGGCAG GGGCCCTAGTGGCCAGTGGGCCGAGTCGTCCTGGGAGGGAAGAGCACATCGTGGTGGAGCTGACCCAGGC TGACGCTTTGGGCTCCAGGTGGCGGCGGCCACAGCAGGTCACTCACAACTGGACGGTGTATTTAAATCCG AGGAGAAGCGAGCACTCAGTGATGAGCAGGACCTTTGAGGTACTGACCAGAGAGACGGTGTCCATCAGCA TCCGGGCCTCCCTGCAGCAGACCCAGGCTGTCCCTCTTTTGATGGCTCATCAGTACCTCCGCGGAAGTGT AGAAACCCAGGTGACCATCGCGACGGCCATCCTCGCGGGCGTCTACGCGCTGATCATATTTGAGAGACCC AGCCTGACCCATGTGGTGGAGTGGATTGATTTTGAGACGCTGGCCCTGCTGTTTGGCATGATGATCTTAG TAGCCATATTTTCAGAAACGGGATTTTTCGATTATTGTGCTGTAAAGGCATACCGGCTCTCCCGGGGACG GGTGTGGGCCATGATCATCATGCTCTGTCTCATCGCGGCCGTCCTCTCTGCCTTCTTGGACAACGTCACC ACCATGCTCCTCTTCACGCCTGTGACCATAAGGTTGTGTGAGGTGCTCAACCTTGATCCAAGACAAGTCC TGATTGCAGAAGTGATCTTCACAAACATTGGAGGAGCTGCCACTGCCATCGGGGACCCTCCAAATGTCAT TATTGTTTCCAACCAAGAGCTGAGGAAGATGGGCCTGGACTTTGCCGGATTCACTGCACACATGTTCATT GGGATTTGCCTTGTTCTCCTGGTCTGCTTTCCGCTCCTCAGACTCCTTTACTGGAACAGAAAGCTTTATA ACAAGGAACCCAGTGAGATTGTTGAACTGAAGCACGAGATTCACGTCTGGCGCCTGACTGCTCAGCGCAT CAGCCCGGCCAGCCGCGAGGAGACAGCTGTGCGCCGCCTGCTGCTGGGGAAGGTGCTGGCACTGGAGCAC CTGCTCGCCCGGAGGCTGCACACCTTCCACAGACAGATCTCACAGGAGGACAAAAATTGGGAGACCAATA TCCAAGAACTCCAAAAAAAGCATAGGATATCTGACGGGATTCTGCTCGCCAAATGCCTGACAGTGTTGGG ATTTGTTATCTTCATGTTTTTCCTCAATTCGTTTGTCCCTGGCATTCATCTTGATCTTGGATGGATTGCT ATTCTGGGTGCCATCTGGTTGCTAATTTTAGCTGATATTCATGATTTTGAGATAATTCTACACAGAGTGG AATGGGCAACCCTTCTGTTTTTTGCAGCGCTCTTTGTTCTGATGGAGGCATTGGCACATCTCCACTTAAT AGAATATGTTGGAGAACAAACTGCTTTGCTAATAAAGATGGTCCCAGAGGAGCAGCGCCTCATAGCCGCC ATTGTCCTGGTGGTGTGGGTCTCAGCCCTGGCGTCGTCCCTGATTGACAACATCCCGTTCACTGCTACCA TGATTCCCGTGCTCCTGAACCTGAGCCACGACCCTGAGGTTGGCCTGCCCGCACCGCCGCTCATGTATGC CCTGGCCTTCGGTGCTTGCCTGGGAGGTAACGGGACACTGATTGGCGCGTCGGCAAACGTCGTGTGTGCA GGGATTGCAGAACAGCATGGATATGGGTTCTCCTTCATGGAATTTTTCAGGCTGGGCTTCCCAATGATGG TTGTGTCCTGCACTGTTGGGATGTGTTATCTCCTTGTGGCTCATGTGGTGGTGGGATGGAAT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA Protein Sequence (showhide) >RC239620 representing NM_001300984 Red=Cloning site Green=Tags(s) MHLEGRDGRRYPGAPAVELLQTSVPSGLAELVAGKRRLPRGAGGADPSHSCPRGAAGQSSWAPAGQEFAS FLTKGRSHSSLPQMSSSRSKDSCFTENTPLLRNSLQEKGSRCIPVYHPEFITAEESWEDSSADWERRYLL SREVSGLSASASSEKGDLLDSPHIRLRLSKLRRCVQWLKVMGLFAFVVLCSILFSLYPDQGKLWQLLALS PLENYSVNLSSHVDSTLLQVDLAGALVASGPSRPGREEHIVVELTQADALGSRWRRPQQVTHNWTVYLNP RRSEHSVMSRTFEVLTRETVSISIRASLQQTQAVPLLMAHQYLRGSVETQVTIATAILAGVYALIIFERP SLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVT TMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFI GICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEH LLARRLHTFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIA ILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAA IVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCA GIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVVGWN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene      Plasmid Map
ACCN	NM_001300984
ORF Size	2442 bp
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001300984.2
RefSeq Size	3082 bp
RefSeq ORF	2445 bp
Locus ID	4948
UniProt ID	Q04671
Protein Families	Druggable Genome, Transmembrane
MW	91 kDa
Gene Summary	This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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